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Volumn 7, Issue 8, 2012, Pages

Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter aβ or tau pathology

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN PROTEIN; TAU PROTEIN;

EID: 84864533900     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039566     Document Type: Article
Times cited : (33)

References (38)
  • 3
    • 0036895965 scopus 로고    scopus 로고
    • Heterozygous knock-out mice for brain-derived neurotrophic factor show a pathway-specific impairment of long-term potentiation but normal critical period for monocular deprivation
    • Bartoletti A, Cancedda L, Reid SW, Tessarollo L, Porciatti V, et al. ((2002)) Heterozygous knock-out mice for brain-derived neurotrophic factor show a pathway-specific impairment of long-term potentiation but normal critical period for monocular deprivation. J Neurosci 22:: 10072-10077.
    • (2002) J Neurosci , vol.22 , pp. 10072-10077
    • Bartoletti, A.1    Cancedda, L.2    Reid, S.W.3    Tessarollo, L.4    Porciatti, V.5
  • 4
    • 0042133327 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites
    • JA ZeilerSR, Tamowski S, Jones KR, ((2003)) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 23:: 6856-6865.
    • (2003) J Neurosci , vol.23 , pp. 6856-6865
    • JA Zeiler, S.R.1    Tamowski, S.2    Jones, K.R.3
  • 5
    • 34247856252 scopus 로고    scopus 로고
    • Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories
    • Heldt SA, Stanek L, Chhatwal JP, Ressler KJ, ((2007)) Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry 12:: 656-670.
    • (2007) Mol Psychiatry , vol.12 , pp. 656-670
    • Heldt, S.A.1    Stanek, L.2    Chhatwal, J.P.3    Ressler, K.J.4
  • 6
    • 3242666768 scopus 로고    scopus 로고
    • Essential role of brain-derived neurotrophic factor in adult hippocampal function
    • Monteggia LM, Barrot M, Powell CM, Berton O, Galanis V, et al. ((2004)) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci USA 101:: 10827-10832.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10827-10832
    • Monteggia, L.M.1    Barrot, M.2    Powell, C.M.3    Berton, O.4    Galanis, V.5
  • 7
    • 20744434559 scopus 로고    scopus 로고
    • Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease
    • Peng S, Wuu J, Mufson EJ, Fahnestock M, ((2005)) Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem 93:: 1412-1421.
    • (2005) J Neurochem , vol.93 , pp. 1412-1421
    • Peng, S.1    Wuu, J.2    Mufson, E.J.3    Fahnestock, M.4
  • 8
    • 0034728595 scopus 로고    scopus 로고
    • Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease
    • Holsinger RM, Schnarr J, Henry P, Castelo VT, Fahnestock M, ((2000)) Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain Res Mol Brain Res 76:: 347-354.
    • (2000) Brain Res Mol Brain Res , vol.76 , pp. 347-354
    • Holsinger, R.M.1    Schnarr, J.2    Henry, P.3    Castelo, V.T.4    Fahnestock, M.5
  • 9
    • 0030658839 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is reduced in Alzheimer's disease
    • Connor B, Young D, Yan Q, Faull RL, Synek B, et al. ((1997)) Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain Res Mol Brain Res 49:: 71-81.
    • (1997) Brain Res Mol Brain Res , vol.49 , pp. 71-81
    • Connor, B.1    Young, D.2    Yan, Q.3    Faull, R.L.4    Synek, B.5
  • 10
    • 53949111613 scopus 로고    scopus 로고
    • New insights into brain BDNF function in normal aging and Alzheimer disease
    • Tapia-Arancibia L, Aliaga E, Silhol M, Arancibia S, ((2008)) New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res Rev 59:: 201-220.
    • (2008) Brain Res Rev , vol.59 , pp. 201-220
    • Tapia-Arancibia, L.1    Aliaga, E.2    Silhol, M.3    Arancibia, S.4
  • 11
    • 70449716895 scopus 로고    scopus 로고
    • Dual response of BDNF to sublethal concentrations of β-amyloid peptides in cultured cortical neurons
    • Aliaga E, Silhol M, Bonneau N, Maurice T, Arancibia S, et al. ((2010)) Dual response of BDNF to sublethal concentrations of β-amyloid peptides in cultured cortical neurons. Neurobiol Dis 37:: 208-217.
    • (2010) Neurobiol Dis , vol.37 , pp. 208-217
    • Aliaga, E.1    Silhol, M.2    Bonneau, N.3    Maurice, T.4    Arancibia, S.5
  • 12
    • 3342908640 scopus 로고    scopus 로고
    • Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons
    • Tong L, Balazs R, Thornton PL, Cotman CW, ((2004)) Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci 24:: 6799-6809.
    • (2004) J Neurosci , vol.24 , pp. 6799-6809
    • Tong, L.1    Balazs, R.2    Thornton, P.L.3    Cotman, C.W.4
  • 13
    • 33847787591 scopus 로고    scopus 로고
    • Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells
    • Garzon DJ, Fahnestock M, ((2007)) Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells. J Neurosci 27:: 2628-2635.
    • (2007) J Neurosci , vol.27 , pp. 2628-2635
    • Garzon, D.J.1    Fahnestock, M.2
  • 14
    • 78049404433 scopus 로고    scopus 로고
    • Oligomeric amyloid-{beta} inhibits the proteolytic conversion of brain-derived neurotrophic factor (BDNF), AMPA receptor trafficking, and classical conditioning
    • Zheng Z, Sabirzhanov B, Keifer J, ((2010)) Oligomeric amyloid-{beta} inhibits the proteolytic conversion of brain-derived neurotrophic factor (BDNF), AMPA receptor trafficking, and classical conditioning. J Biol Chem 285:: 34708-34717.
    • (2010) J Biol Chem , vol.285 , pp. 34708-34717
    • Zheng, Z.1    Sabirzhanov, B.2    Keifer, J.3
  • 15
    • 33748140773 scopus 로고    scopus 로고
    • Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan
    • Akatsu H, Yamagata HD, Kawamata J, Kamino K, Takeda M, et al. ((2006)) Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan. Dement Geriatr Cogn Disord 22:: 216-222.
    • (2006) Dement Geriatr Cogn Disord , vol.22 , pp. 216-222
    • Akatsu, H.1    Yamagata, H.D.2    Kawamata, J.3    Kamino, K.4    Takeda, M.5
  • 16
    • 34249937951 scopus 로고    scopus 로고
    • Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease
    • Huang R, Huang J, Cathcart H, Smith S, Poduslo SE, ((2007)) Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease. J Med Genet 44:: e66.
    • (2007) J Med Genet , vol.44
    • Huang, R.1    Huang, J.2    Cathcart, H.3    Smith, S.4    Poduslo, S.E.5
  • 18
    • 0035134990 scopus 로고    scopus 로고
    • A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease
    • Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, et al. ((2001)) A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiatry 6:: 83-86.
    • (2001) Mol Psychiatry , vol.6 , pp. 83-86
    • Kunugi, H.1    Ueki, A.2    Otsuka, M.3    Isse, K.4    Hirasawa, H.5
  • 19
    • 73949140716 scopus 로고    scopus 로고
    • Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis
    • Fukumoto N, Fujii T, Combarros O, Kamboh MI, Tsai S-J, et al. ((2010)) Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis. Am J Med Genet B Neuropsychiatr Genet 153B:: 235-242.
    • (2010) Am J Med Genet B Neuropsychiatr Genet , vol.153 B , pp. 235-242
    • Fukumoto, N.1    Fujii, T.2    Combarros, O.3    Kamboh, M.I.4    Tsai, S.-J.5
  • 20
    • 19344362136 scopus 로고    scopus 로고
    • Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism
    • Olin D, MacMurray J, Comings DE, ((2005)) Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism. Neurosci Lett 381: 275-278.
    • (2005) Neurosci Lett , vol.381 , pp. 275-278
    • Olin, D.1    MacMurray, J.2    Comings, D.E.3
  • 21
    • 49349113732 scopus 로고    scopus 로고
    • Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats
    • (null)
    • Arancibia S, Silhol M, Moulière F, Meffre J, (null), et al ((2008)) Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats. Neurobiol Dis 31:: 316-326.
    • (2008) Neurobiol Dis , vol.31 , pp. 316-326
    • Arancibia, S.1    Silhol, M.2    Moulière, F.3    Meffre, J.4
  • 22
    • 51349117345 scopus 로고    scopus 로고
    • NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons
    • Matrone C, Ciotti MT, Mercanti D, Marolda R, Calissano P, ((2008)) NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons. Proc Natl Acad Sci USA 105:: 13139-13144.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13139-13144
    • Matrone, C.1    Ciotti, M.T.2    Mercanti, D.3    Marolda, R.4    Calissano, P.5
  • 23
    • 25844490528 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 Kinase signalling mechanism
    • Elliott E, Atlas R, Lange A, Ginzburg I, ((2005)) Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 Kinase signalling mechanism. Eur J Neurosci 22:: 1081-1089.
    • (2005) Eur J Neurosci , vol.22 , pp. 1081-1089
    • Elliott, E.1    Atlas, R.2    Lange, A.3    Ginzburg, I.4
  • 24
    • 0028274040 scopus 로고
    • Mice lacking brain-derived neurotrophic factor develop with sensory deficits
    • Ernfors P, Lee KF, Jaenisch R, ((1994)) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368:: 147-150.
    • (1994) Nature , vol.368 , pp. 147-150
    • Ernfors, P.1    Lee, K.F.2    Jaenisch, R.3
  • 25
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
    • Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, et al. ((2003)) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:: 409-421.
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5
  • 26
    • 14544304591 scopus 로고    scopus 로고
    • Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease
    • Oddo S, Caccamo A, Green KN, Liang K, Tran L, et al. ((2005)) Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci USA 102:: 3046-3051.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 3046-3051
    • Oddo, S.1    Caccamo, A.2    Green, K.N.3    Liang, K.4    Tran, L.5
  • 28
    • 0033974624 scopus 로고    scopus 로고
    • Expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the somatosensory cortex of the mature rat: coexpression with high-affinity neurotrophin receptors
    • Pitts AF, Miller MW, ((2000)) Expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the somatosensory cortex of the mature rat: coexpression with high-affinity neurotrophin receptors. J Comp Neurol 418:: 241-254.
    • (2000) J Comp Neurol , vol.418 , pp. 241-254
    • Pitts, A.F.1    Miller, M.W.2
  • 29
    • 58149267462 scopus 로고    scopus 로고
    • Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
    • Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, et al. ((2008)) Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci 28:: 11500-11510.
    • (2008) J Neurosci , vol.28 , pp. 11500-11510
    • Green, K.N.1    Steffan, J.S.2    Martinez-Coria, H.3    Sun, X.4    Schreiber, S.S.5
  • 30
    • 79955413534 scopus 로고    scopus 로고
    • ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo
    • Green KN, Khashwji H, Estrada T, LaFerla FM, ((2011)) ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo. Ann Neurol 69:: 831-844.
    • (2011) Ann Neurol , vol.69 , pp. 831-844
    • Green, K.N.1    Khashwji, H.2    Estrada, T.3    LaFerla, F.M.4
  • 31
    • 71849109591 scopus 로고    scopus 로고
    • brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression
    • Rohe M, Synowitz M, Glass R, Paul SM, Nykjaer A, et al. ((2009)) brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression. J Neurosci 29:: 15472-15478.
    • (2009) J Neurosci , vol.29 , pp. 15472-15478
    • Rohe, M.1    Synowitz, M.2    Glass, R.3    Paul, S.M.4    Nykjaer, A.5
  • 32
    • 0034651078 scopus 로고    scopus 로고
    • BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain
    • Mamounas LA, Altar CA, Blue ME, Kaplan DR, Tessarollo L, et al. ((2000)) BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. J Neurosci 20:: 771-782.
    • (2000) J Neurosci , vol.20 , pp. 771-782
    • Mamounas, L.A.1    Altar, C.A.2    Blue, M.E.3    Kaplan, D.R.4    Tessarollo, L.5
  • 33
    • 0036959504 scopus 로고    scopus 로고
    • Regulation of promoter activity of the APP gene by cytokines and growth factors: implications in Alzheimer's disease
    • Ge Y-W, Lahiri DK, ((2002)) Regulation of promoter activity of the APP gene by cytokines and growth factors: implications in Alzheimer's disease. Ann N Y Acad Sci 973:: 463-467.
    • (2002) Ann N Y Acad Sci , vol.973 , pp. 463-467
    • Ge, Y.-W.1    Lahiri, D.K.2
  • 34
    • 0034776083 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor stimulates beta-amyloid gene promoter activity by a Ras-dependent/AP-1-independent mechanism in SH-SY5Y neuroblastoma cells
    • Ruiz-León Y, Pascual A, ((2001)) Brain-derived neurotrophic factor stimulates beta-amyloid gene promoter activity by a Ras-dependent/AP-1-independent mechanism in SH-SY5Y neuroblastoma cells. J Neurochem 79:: 278-285.
    • (2001) J Neurochem , vol.79 , pp. 278-285
    • Ruiz-León, Y.1    Pascual, A.2
  • 35
    • 36349025159 scopus 로고    scopus 로고
    • SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1
    • Schmidt V, Sporbert A, Rohe M, Reimer T, Rehm A, et al. ((2007)) SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J Biol Chem 282:: 32956-32964.
    • (2007) J Biol Chem , vol.282 , pp. 32956-32964
    • Schmidt, V.1    Sporbert, A.2    Rohe, M.3    Reimer, T.4    Rehm, A.5
  • 37
    • 62049083420 scopus 로고    scopus 로고
    • Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
    • Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, et al. ((2009)) Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med 15:: 331-337.
    • (2009) Nat Med , vol.15 , pp. 331-337
    • Nagahara, A.H.1    Merrill, D.A.2    Coppola, G.3    Tsukada, S.4    Schroeder, B.E.5
  • 38
    • 58149267462 scopus 로고    scopus 로고
    • Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
    • Green K, Steffan J, Martinez-Coria H, ((2008)) Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci.
    • (2008) J Neurosci
    • Green, K.1    Steffan, J.2    Martinez-Coria, H.3


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