Social interaction rescues memory deficit in an animal model of Alzheimer’s disease by increasing BDNF-Dependent Hippocampal Neurogenesis

Journal of Neuroscience

Volumn 34, Issue 49, 2014, Pages 16207-16219

  Hsiao, Ya Hsin ^a   Hung, Hui Chi ^a   Chen, Shun Hua ^a   Gean, Po Wu ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Adult neurogenesis; Alzheimer s disease; APP PS1 mice; BDNF; Memory decline; Social interaction

Indexed keywords

7, 8 DIHYDROXYFLAVONE; AMYLOID PRECURSOR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; DIPHTHERIA TOXIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LENTIVIRUS VECTOR; MESSENGER RNA; METHYLAZOXYMETHANOL ACETATE; PRESENILIN 1; RETROVIRUS VECTOR; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; 6,7-DIHYDROXYFLAVONE; FLAVONE DERIVATIVE; PRESENILIN 1, MOUSE;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRDU ASSAY; CELL COUNT; CLINICAL PHARMACOLOGY; CONTROLLED STUDY; DENTATE GYRUS; FEAR; FREEZING; GAIN OF FUNCTION MUTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HIPPOCAMPUS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LOSS OF FUNCTION MUTATION; MALE; MEMORY CONSOLIDATION; MORRIS WATER MAZE TEST; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OPEN FIELD BEHAVIOR; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOCIAL INTERACTION; SOCIAL INTERACTION TEST; SPATIAL DISCRIMINATION; WALKING SPEED; WESTERN BLOTTING; ANIMAL; ANIMAL BEHAVIOR; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENE SILENCING; GENETICS; GROWTH, DEVELOPMENT AND AGING; MEMORY DISORDERS; METABOLISM; PHYSIOLOGY; SOCIAL BEHAVIOR; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; DENTATE GYRUS; DIPHTHERIA TOXIN; DISEASE MODELS, ANIMAL; FLAVONES; GENE KNOCKDOWN TECHNIQUES; HIPPOCAMPUS; HOUSING, ANIMAL; MALE; MEMORY DISORDERS; METHYLAZOXYMETHANOL ACETATE; MICE; MICE, TRANSGENIC; NEUROGENESIS; PRESENILIN-1; SOCIAL BEHAVIOR;

EID: 84914694795     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0747-14.2014     Document Type: Article

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