Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic Tau clearance

ACS Chemical Biology

Volumn 10, Issue 4, 2015, Pages 1099-1109

  Martin, Mackenzie D ^a   Calcul, Laurent ^b   Smith, Courtney ^b   Jinwal, Umesh K ^a   Fontaine, Sarah N ^a   Darling, April ^a   Seeley, Kent ^b   Wojtas, Lukasz ^b   Narayan, Malathi ^a   Gestwicki, Jason E ^c   Smith, Garry R ^d   Reitz, Allen B ^d   Baker, Bill J ^b   Dickey, Chad A ^a,b,e  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Pennsylvania Biotechnology Center   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYRICANOL; NATURAL PRODUCT; TAU PROTEIN; UNCLASSIFIED DRUG; EPITOPE; HEPTANE DERIVATIVE; MOLECULAR LIBRARY;

ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN SLICE; CATALYSIS; CHIRALITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DERIVATIZATION; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; EX VIVO STUDY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEOMICS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TAUOPATHY; ANIMAL; BRAIN; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR LIBRARY; MOLECULARLY TARGETED THERAPY; PHARMACOLOGY; STEREOISOMERISM; SYNTHESIS; TAUOPATHIES; TRANSGENIC MOUSE;

MORELLA CERIFERA;

ANIMALS; AUTOPHAGY; BRAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; DIARYLHEPTANOIDS; EPITOPES; HEK293 CELLS; HUMANS; MALE; MICE, TRANSGENIC; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; TAU PROTEINS; TAUOPATHIES;

EID: 84928403118     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb501013w     Document Type: Article

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