Growth-inhibiting and apoptosis-inducing activities of Myricanol from the bark of Myrica rubra in human lung adenocarcinoma A549 cells

Phytomedicine

Volumn 21, Issue 11, 2014, Pages 1490-1496

  Dai, G H ^a   Meng, G M ^b   Tong, Y L ^a   Chen, X ^a   Ren, Z M ^a   Wang, K ^c   Yang, F ^a  

^a Institute of Basic Medicine   (China)

^b TONGDE HOSPITAL OF ZHEJIANG PROVINCE   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Anti cancer activity; Apoptosis; Cell growth inhibition; Myricanol

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; FLUOROURACIL; MESSENGER RNA; MYRICANOL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; SILICA GEL; THYMIDINE; UNCLASSIFIED DRUG; HEPTANE DERIVATIVE; PLANT EXTRACT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BARK; CANCER INHIBITION; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; LUNG ADENOCARCINOMA; LUNG CANCER CELL LINE; MEDICINAL PLANT; MYRICA RUBRA; MYRICACEAE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SOLVENT EXTRACTION; WESTERN BLOTTING; ADENOCARCINOMA; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; LUNG TUMOR; PATHOLOGY; TUMOR CELL LINE;

MORELLA RUBRA; MYRICA; MYRICACEAE;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DIARYLHEPTANOIDS; HUMANS; LUNG NEOPLASMS; MYRICA; PLANT BARK; PLANT EXTRACTS;

EID: 84906937443     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.04.025     Document Type: Article

References (30)

1. M.I. Aguilar, R. Rovelo, J.G. Verjan, O. Illescas, A.E. Baeza, M. De La Fuente, I. Avila, and A. Navarrete Anti-inflammatory activities, triterpenoids, and diarylheptanoids of Alnus acuminata ssp. arguta Pharm. Biol. 49 10 2011 1052 1057
2. H. Akazawa, Y. Fujita, N. Banno, K. Watanabe, Y. Kimura, A. Manosroi, J. Manosroi, and T. Akihisa Three new cyclic diarylheptanoids and other phenolic compounds from the bark of Myrica rubra and their melanogenesis inhibitory and radical scavenging activities J. Oleo Sci. 59 4 2010 213 221
3. D. Divisi, S. Di Tommaso, S. Salvemini, M. Garramone, and R. Crisci Diet and cancer Acta Biomed. 77 2006 118 123
4. M.Q. Han, J.M. Su, H.Y. Huang, W.H. Long, L.P. Qin, P. Qin, W. Liu, and Z.Y. Sheng Prognostic analysis of advanced non small cell lung cancer treated by sequential chemo-radiation therapy combined with traditional Chinese medicine: a report of 54 cases Zhong Xi Yi Jie He Xue Bao 1 2003 195 198
5. + channel-mediated tumor cell proliferation and apoptosis Apoptosis 12 2007 1837 1846 (Pubitemid 47498238)
6. W. Huang, H. Zhang, K. Zou, J. Chen, X. Li, C. Liu, and N. Huang Total saponins of Tupistra chinensis induces apoptosis in A549 cells Neoplasma 59 6 2012 613 621
7. J. Ishida, M. Kozuka, H.-K. Wang, T. Konoshima, H. Tokuda, M. Okuda, X. Yang Mou, H. Nishino, N. Sakurai, K.-H. Lee, and M. Nagai Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis Cancer Lett. 159 2000 135 140
8. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and M.J. Thun Cancer statistics, 2009 CA Cancer J. Clin. 59 4 2009 225 249
9. J.R. Jones, M.D. Lebar, U.K. Jinwal, J.F. Abisambra, J. Koren, L. Blair, J.C. O'Leary, Z. Davey, J. Trotter, A.G. Johnson, E. Weeber, C.B. Eckman, B.J. Baker, and C.A. Dickey The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau J. Nat. Prod. 74 1 2011 38 44
10. K. Konno, R. Sawamura, Y. Sun, K. Yasukawa, T. Shimizu, W. Watanabe, M. Kato, R. Yamamoto, and M. Kurokawa Antiviral activities of diarylheptanoids isolated from Alpinia officinarum against respiratory syncytial virus, poliovirus, measles virus, and herpes simplex virus type 1 in vitro Nat. Prod. Commun. 6 12 2011 1881 1884
11. G. Korpanty, E. Smyth, and D.N. Carney Update on anti-angiogenic therapy in non-small cell lung cancer: are we making progress? J. Thorac. Dis. 3 1 2011 19 29
12. P.L. Kuo, Y.L. Hsu, T.C. Lin, and C.C. Lin Prodelphinidin B-2 3,3'-di-o-gallate from Myrica rubra inhibits proliferation of A549 carcinoma cells via blocking cell cycle progression and inducing apoptosis Eur. J. Pharmacol. 501 1-3 2004 41 48
13. W.Y. Li, S.W. Chan, D.J. Guo, M.K. Chung, T.Y. Leung, and P.H. Yu Water extract of Rheum officinale Baill. induces apoptosis in human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines J. Ethnopharmacol. 124 2 2009 251 256
14. Z. Liu, S. Ji, Y. Zhang, D. Meng, and X. Li Myricarborin A and n-butyl-alpha-l-rhamnopyranoside, two novel compounds from the bark of Myrica rubra Nat. Prod. Commun. 4 4 2009 513 516
15. H. Matsuda, M. Yamazaki, K. Matsuo, Y. Asanuma, and M. Kubo Anti-androgenic activity of Myricae Cortex - isolation of active constituents from bark of Myrica rubra Biol. Pharm. Bull. 24 3 2001 259 263 (Pubitemid 32237164)
16. K. Mochida Anti-influenza virus activity of Myrica rubra leaf ethanol extract evaluated using Madino-Darby canine kidney (MDCK) cells Biosci. Biotechnol. Biochem. 72 11 2008 3018 3020
17. S. Ohta, N. Sakurai, A. Kamogawa, Y. Yaguchi, T. Inoue, and M. Shinoda Protective effects of the bark of Myrica rubra Sieb. et Zucc. on experimental liver injuries Yakugaku Zasshi 112 4 1992 244 252
18. M. Olsson, and B. Zhivotovsky Caspases and cancer Cell Death Differ. 18 9 2011 1441 1449
19. J.C. Reed, and M. Pellecchia Apoptosis-based therapies for hematologic malignancies Blood 106 2005 408 418 (Pubitemid 40981231)
20. M.K. Roy, K. Nakahara, T.V. Na, G. Trakoontivakorn, M. Takenaka, S. Isobe, and T. Tsushida Baicalein, a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis Pharmazie 62 2 2007 149 153
21. J. Tao, T. Morikawa, I. Toguchida, S. Ando, H. Matsuda, and M. Yoshikawa Inhibitors of nitric oxide production from the bark of Myrica rubra: structures of new biphenyl type diarylheptanoid glycosides and taraxerane type triterpene Bioorg. Med. Chem. 10 12 2002 4005 4012 (Pubitemid 36164699)
22. Q.F. Tao, Y. Xu, R.Y. Lam, B. Schneider, H. Dou, P.S. Leung, S.Y. Shi, C.X. Zhou, L.X. Yang, R.P. Zhang, Y.C. Xiao, X. Wu, J. Stöckigt, S. Zeng, C.H. Cheng, and Y. Zhao Diarylheptanoids and a monoterpenoid from the rhizomes of Zingiber officinale: antioxidant and cytoprotective properties J. Nat. Prod. 71 1 2008 12 17 (Pubitemid 351236387)
23. M. Tene, H.K. Wabo, P. Kamnaing, A. Tsopmo, P. Tane, J.F. Ayafor, and O. Sterner Diarylheptanoids from Myrica arborea Phytochemistry 54 8 2000 975 978
24. Y. Tong, X.M. Zhou, S.J. Wang, Y. Yang, and Y.L. Cao Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves Arch. Pharm. Res. 32 4 2009 527 533
25. S.J. Wang, Y. Tong, S. Lu, R. Yang, X. Liao, Y.F. Xu, and X. Li Anti-inflammatory activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves Planta Med. 76 14 2010 1492 1496
26. L. Whyte, Y.Y. Huang, K. Torres, and R.G. Mehta Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses Cancer Res. 67 2007 12007 12017
27. J.W. Wilson, C. Booth, and C.S. Potten Apoptosis Gene 1998 Kluwer Academic Publisher Boston/Dordrecht/London
28. J.-b. Zhang, J.-x. Liu, D.-l. Di, and F. Zha Advances in studies on macrocyclic diarylheptanoids from natural products Chin. Tradit. Herb. Drugs 39 8 2008 1263 1268
29. L.-j. Zhang, Z.-g. Liu, D.-l. Meng, and M.-y. Xia Antitumor activities of the extracts from the bark of Myrica rubra Sieb. et Zucc. and myricetin J. Shenyang Pharm. Univ. 26 4 2009 307 311
30. Y. Zhao, M. Turlington, D.J. LaPar, D.R. Jones, D.A. Harris, I.L. Kron, L. Pu, and C.L. Lau Characterization of novel synthesized small molecular compounds against non-small cell lung cancer Ann. Thorac. Surg. 92 3 2011 1031 1037