메뉴 건너뛰기




Volumn , Issue 59, 2000, Pages 213-222

Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; TAU PROTEIN; TUBULIN; PHOSPHATASE;

EID: 0033624418     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6781-6_22     Document Type: Review
Times cited : (57)

References (47)
  • 1
    • 0023200370 scopus 로고
    • Histopathological criteria for progressive dementia disorders: Clinical-pathological correlation and classification by multivariate data analysis
    • Alafuzoff I, Iqbal K, Friden H, Adolfsson R, Winblad B (1987) Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis. Acta Neuropathol (Berl) 74: 209-225
    • (1987) Acta Neuropathol (Berl) , vol.74 , pp. 209-225
    • Alafuzoff, I.1    Iqbal, K.2    Friden, H.3    Adolfsson, R.4    Winblad, B.5
  • 2
    • 0028227962 scopus 로고
    • Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
    • Alonso A del C, Zaidi T, Grundke-Iqbal I, Iqbal K (1994) Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci USA 91: 5562-5566
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5562-5566
    • Del C Alonso, A.1    Zaidi, T.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 3
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • Alonso A del C, Grundke-Iqbal I, Iqbal K (1996) Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 2: 783-787
    • (1996) Nat Med , vol.2 , pp. 783-787
    • Del C Alonso, A.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 4
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of MAPI and MAP2 and the disassembly of microtubules by the abnormal tau
    • Alonso A del C, Grundke-Iqbal I, Barra HS, Iqbal K (1997) Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of MAPI and MAP2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci USA 94: 298-303
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 298-303
    • Alonso A Del, C.1    Grundke-Iqbal, I.2    Barra, H.S.3    Iqbal, K.4
  • 5
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • Arigada PA, Growdon JH, Hedley-White ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42: 631-639
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arigada, P.A.1    Growdon, J.H.2    Hedley-White, E.T.3    Hyman, B.T.4
  • 7
    • 0026030994 scopus 로고
    • Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease
    • Bancher C, Grundke-Iqbal I, Iqbal K, Fried VA, Smith HT, Wisniewski HM (1991) Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease. Brain Res 539: 11-18
    • (1991) Brain Res , vol.539 , pp. 11-18
    • Bancher, C.1    Grundke-Iqbal, I.2    Iqbal, K.3    Fried, V.A.4    Smith, H.T.5    Wisniewski, H.M.6
  • 8
    • 0024393488 scopus 로고
    • About the presence of paired helical filaments in dystrophic neuntes participating in the plaque formation
    • Barcikowska M, Wisniewski HM, Bancher C, Grundke-Iqbal I (1989) About the presence of paired helical filaments in dystrophic neuntes participating in the plaque formation. Acta Neuropathol 78: 225-231
    • (1989) Acta Neuropathol , vol.78 , pp. 225-231
    • Barcikowska, M.1    Wisniewski, H.M.2    Bancher, C.3    Grundke-Iqbal, I.4
  • 9
    • 0022595501 scopus 로고
    • Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
    • Braak H, Braak E, Grundke-Iqbal I, Iqbal K (1986) Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett 65: 351-355
    • (1986) Neurosci Lett , vol.65 , pp. 351-355
    • Braak, H.1    Braak, E.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 11
    • 0030713963 scopus 로고    scopus 로고
    • Genetics of aging
    • Finch C, Tanzi RE (1997) Genetics of aging. Science 278: 407-411
    • (1997) Science , vol.278 , pp. 407-411
    • Finch, C.1    Tanzi, R.E.2
  • 12
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner GG, Wong CW (1984) Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 122: 1131-1135
    • (1984) Biochem Biophys Res Commun , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 13
    • 0027214404 scopus 로고
    • Phosphoprotein phosphatase activities in Alzheimer disease
    • Gong C-X, Singh TJ, Grundke-Iqbal I, Iqbal K (1993) Phosphoprotein phosphatase activities in Alzheimer disease. J Neurochem 61: 921-927
    • (1993) J Neurochem , vol.61 , pp. 921-927
    • Gong, C.-X.1    Singh, T.J.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 14
    • 0028044722 scopus 로고
    • Alzheimer disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase 2B (calcineurin)
    • Gong C-X, Singh TJ, Grundke-Iqbal I, Iqbal K (1994a) Alzheimer disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase 2B (calcineurin). J Neurochem 62: 803-806
    • (1994) J Neurochem , vol.62 , pp. 803-806
    • Gong, C.-X.1    Singh, T.J.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 15
    • 0028064431 scopus 로고
    • Dephosphorylation of Alzheimer disease abnormally phosphorylated tau by protein phosphatase-2A
    • Gong C-X, Grundke-Iqbal I, Iqbal K (1994b) Dephosphorylation of Alzheimer disease abnormally phosphorylated tau by protein phosphatase-2A. Neurosci 61: 765-772
    • (1994) Neurosci , vol.61 , pp. 765-772
    • Gong, C.-X.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 16
    • 0028350740 scopus 로고
    • Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease
    • Gong C-X, Grundke-Iqbal I, Damuni Z, Iqbal K (1994c) Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease. FEBS Lett 341: 94-98
    • (1994) FEBS Lett , vol.341 , pp. 94-98
    • Gong, C.-X.1    Grundke-Iqbal, I.2    Damuni, Z.3    Iqbal, K.4
  • 17
    • 0029113874 scopus 로고
    • Phosphatase activity toward abnormally phosphorylated: Decrease in Alzheimer disease brain
    • Gong C-X, Shaikh S, Wang J-Z, Zaidi T, Grundke-Iqbal I, Iqbal K (1995) Phosphatase activity toward abnormally phosphorylated: decrease in Alzheimer disease brain. J Neurochem 65: 732-738
    • (1995) J Neurochem , vol.65 , pp. 732-738
    • Gong, C.-X.1    Shaikh, S.2    Wang, J.-Z.3    Zaidi, T.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 20
    • 0032561415 scopus 로고    scopus 로고
    • Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
    • Hasegawa M, Smith MJ, Goedert M (1998) Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly. FEBS Lett 437: 207-210
    • (1998) FEBS Lett , vol.437 , pp. 207-210
    • Hasegawa, M.1    Smith, M.J.2    Goedert, M.3
  • 21
    • 0032484089 scopus 로고    scopus 로고
    • Mutation-specific impairments in distinct tau isoforms of hereditary FTDP-17
    • Hong M, et al (1998) Mutation-specific impairments in distinct tau isoforms of hereditary FTDP-17. Science 282: 1914-1918
    • (1998) Science , vol.282 , pp. 1914-1918
    • Hong, M.1
  • 22
    • 0032543684 scopus 로고    scopus 로고
    • Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
    • Hutton M, et al (1998) Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393: 702-705
    • (1998) Nature , vol.393 , pp. 702-705
    • Hutton, M.1
  • 25
    • 0028361538 scopus 로고
    • Alzheimer paired helical filaments: Restoration of the biological activity by dephosphorylation
    • Iqbal K, Zaidi T, Bancher C, Grundke-Iqbal I (1994) Alzheimer paired helical filaments: Restoration of the biological activity by dephosphorylation. FEBS Lett 349: 104-108
    • (1994) FEBS Lett , vol.349 , pp. 104-108
    • Iqbal, K.1    Zaidi, T.2    Bancher, C.3    Grundke-Iqbal, I.4
  • 26
    • 0026694783 scopus 로고
    • Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: A radioimmuno-slot-blot assay for nanograms of the protein
    • Khatoon S, Grundke-Iqbal I, Iqbal K (1992) Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein. J Neurochem 59: 750-753
    • (1992) J Neurochem , vol.59 , pp. 750-753
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 27
    • 0028095224 scopus 로고
    • Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains
    • Khatoon S, Grundke-Iqbal I, Iqbal K (1994) Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains. FEBS Lett 351: 80-84
    • (1994) FEBS Lett , vol.351 , pp. 80-84
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 28
    • 0028852644 scopus 로고
    • Guanosine triphosphate binding to β-subunit of tubulin in Alzheimer's disease brain: Role of microtubule-associated protein
    • Khatoon S, Grundke-Iqbal I, Iqbal K (1995) Guanosine triphosphate binding to β-subunit of tubulin in Alzheimer's disease brain: Role of microtubule-associated protein. J Neurochem 64: 777-787
    • (1995) J Neurochem , vol.64 , pp. 777-787
    • Khatoon, S.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 29
    • 0001120692 scopus 로고
    • Alzheimer's disease: An electron microscopical study
    • Kidd M (1964) Alzheimer's disease: an electron microscopical study. Brain 87: 307-320
    • (1964) Brain , vol.87 , pp. 307-320
    • Kidd, M.1
  • 30
    • 0027361281 scopus 로고
    • Microtubule associated protein tau: Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
    • Köpke E, Tung Y-C, Shaikh S, Alonso A del C, Iqbal K, Grundke-Iqbal I (1993) Microtubule associated protein tau: abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem 268: 24374-24383
    • (1993) J Biol Chem , vol.268 , pp. 24374-24383
    • Köpke, E.1    Tung, Y.-C.2    Shaikh, S.3    Del C Alonso, A.4    Iqbal, K.5    Grundke-Iqbal, I.6
  • 31
    • 0021338217 scopus 로고
    • Phosphorylation affects the ability of tau protein to promote microtubule assembly
    • Lindwall G, Cole RD (1984) Phosphorylation affects the ability of tau protein to promote microtubule assembly. J Biol Chem 259: 5301-5305
    • (1984) J Biol Chem , vol.259 , pp. 5301-5305
    • Lindwall, G.1    Cole, R.D.2
  • 32
    • 0033028074 scopus 로고    scopus 로고
    • Neurons may live for decades with neurofibrillary tangles
    • Morsch R, Simon W, Coleman PD (1999) Neurons may live for decades with neurofibrillary tangles. J Neuropathol Exp Neurol 58: 188-197
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 188-197
    • Morsch, R.1    Simon, W.2    Coleman, P.D.3
  • 33
    • 0027978340 scopus 로고
    • cdc2 in the hippocampus of patients with Alzheimer disease and normal aged individuals
    • cdc2 in the hippocampus of patients with Alzheimer disease and normal aged individuals. Brain Res 655: 70-76
    • (1994) Brain Res , vol.655 , pp. 70-76
    • Pei, J.-J.1    Sersen, E.2    Iqbal, K.3    Grundke-Iqbal, I.4
  • 36
    • 0032540459 scopus 로고    scopus 로고
    • The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: The role of protein phosphatases
    • Tanaka T, Zhong J, Iqbal K, Trenkner E, Grundke-Iqbal I (1998) The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases. FEBS Lett 426: 248-254
    • (1998) FEBS Lett , vol.426 , pp. 248-254
    • Tanaka, T.1    Zhong, J.2    Iqbal, K.3    Trenkner, E.4    Grundke-Iqbal, I.5
  • 38
    • 78651158156 scopus 로고
    • Ultrastructural studies in Alzheimer's presenile dementia
    • Terry RD, Gonatas NK, Weiss M (1964) Ultrastructural studies in Alzheimer's presenile dementia. Am J Pathol 44: 269-297
    • (1964) Am J Pathol , vol.44 , pp. 269-297
    • Terry, R.D.1    Gonatas, N.K.2    Weiss, M.3
  • 39
    • 0014851803 scopus 로고
    • Observations on the brains of demented old people
    • Tomlinson BE, Blessed G, Roth M (1970) Observations on the brains of demented old people. J Neurol Sci 11: 205-242
    • (1970) J Neurol Sci , vol.11 , pp. 205-242
    • Tomlinson, B.E.1    Blessed, G.2    Roth, M.3
  • 41
    • 0028902487 scopus 로고
    • Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B
    • Wang J-Z, Gong C-X, Zaidi T, Grundke-Iqbal I, Iqbal K (1995) Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J Biol Chem 270: 4854-4860
    • (1995) J Biol Chem , vol.270 , pp. 4854-4860
    • Wang, J.-Z.1    Gong, C.-X.2    Zaidi, T.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 42
    • 0029815467 scopus 로고    scopus 로고
    • Glycosylation of microtubule-associated protein tau: An abnormal post-translational modification in Alzheimer's disease
    • Wang J-Z, Grundke-Iqbal I, Iqbal K (1996a) Glycosylation of microtubule-associated protein tau: An abnormal post-translational modification in Alzheimer's disease. Nat Med 2: 871-875
    • (1996) Nat Med , vol.2 , pp. 871-875
    • Wang, J.-Z.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 43
    • 0029995590 scopus 로고    scopus 로고
    • Restoration of biological activity of Alzheimer abnormally phosphorylated by dephosphorylation with protein phosphatase-2A, -2B and -1
    • Wang J-Z, Grundke-Iqbal I, Iqbal K (1996b) Restoration of biological activity of Alzheimer abnormally phosphorylated by dephosphorylation with protein phosphatase-2A, -2B and -1. Mol Brain Res 38: 200-208
    • (1996) Mol Brain Res , vol.38 , pp. 200-208
    • Wang, J.-Z.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 45
    • 0014382446 scopus 로고
    • The colchicine binding protein of mammalian brain and its relation to microtubules
    • Weisenberg RC, Borisy GC, Taylor EW (1968) The colchicine binding protein of mammalian brain and its relation to microtubules. Biochemistry 7: 4466-4477
    • (1968) Biochemistry , vol.7 , pp. 4466-4477
    • Weisenberg, R.C.1    Borisy, G.C.2    Taylor, E.W.3
  • 46
    • 0017201915 scopus 로고
    • Tubulin-nucleotide interactions during the polymerization and depolymerization of microtubules
    • Weisenberg RC, Denny WJ, Dickinson PJ (1976) Tubulin-nucleotide interactions during the polymerization and depolymerization of microtubules. Biochemistry 15: 4248-4254
    • (1976) Biochemistry , vol.15 , pp. 4248-4254
    • Weisenberg, R.C.1    Denny, W.J.2    Dickinson, P.J.3
  • 47
    • 0015870176 scopus 로고
    • Morphology of the aging brain, human and animal
    • Wisniewski HM, Terry RD (1973) Morphology of the aging brain, human and animal. Prog Brain Res 40: 184-186
    • (1973) Prog Brain Res , vol.40 , pp. 184-186
    • Wisniewski, H.M.1    Terry, R.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.