Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: Correlation dynamics and zinc binding

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 12, 2014, Pages 3286-3297

  Xu, Liang ^a   Chen, Yonggang ^a   Wang, Xiaojuan ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Alzheimer's disease; Amyloid peptide; Free energy; Molecular dynamics simulations; Mutation

Indexed keywords

AMYLOID BETA PROTEIN[1-16]; AMYLOID BETA PROTEIN[1-42]; GLYCOPROTEIN; MONOMER; MUTANT PROTEIN; PROTEIN D7H; PROTEIN D7N; PROTEIN H6R; UNCLASSIFIED DRUG; ZINC ION; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-16); AMYLOID BETA-PROTEIN (17-42); AMYLOID PRECURSOR PROTEIN; PEPTIDE FRAGMENT; ZINC;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENERGY; GENE MUTATION; HUMAN; METAL BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SOLVATION FREE ENERGY; THERMODYNAMICS; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; ENERGY TRANSFER; GENETICS; KINETICS; METABOLISM; MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEINOSIS; SOLUBILITY; SURFACE PROPERTY;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; BINDING SITES; ENERGY TRANSFER; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PEPTIDE FRAGMENTS; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; SOLUBILITY; SURFACE PROPERTIES; ZINC;

EID: 84928225116     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24669     Document Type: Article

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