Effects of Zn2+ binding on the structural and dynamic properties of amyloid Β peptide associated with Alzheimer's disease: Asp1 or Glu11?

ACS Chemical Neuroscience

Volumn 4, Issue 11, 2013, Pages 1458-1468

  Xu, Liang ^a   Wang, Xiaojuan ^a   Wang, Xicheng ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Alzheimer's disease; free energy calculation; Markov state model; metal ions; molecular dynamics simulations

Indexed keywords

AMYLOID BETA PROTEIN; HISTIDINE; ZINC ION; ASPARTIC ACID; GLUTAMIC ACID; ZINC;

ALZHEIMER DISEASE; AQUEOUS SOLUTION; ARTICLE; DYNAMICS; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVATIONAL STUDY; PRIORITY JOURNAL; QUANTUM MECHANICS; BIOLOGICAL MODEL; CHEMISTRY; GENETICS; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROBABILITY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEOSTASIS DEFICIENCY; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ASPARTIC ACID; GLUTAMIC ACID; HUMANS; MARKOV CHAINS; MODELS, GENETIC; MOLECULAR DYNAMICS SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEOSTASIS DEFICIENCIES; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 84888354585     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn4001445     Document Type: Article

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