Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Chen, Wei Ting ^a,c   Hong, Chen Jee ^a,d   Lin, Ya Tzu ^a   Chang, Wen Han ^a   Huang, He Ting ^a   Liao, Jhih Ying ^a   Chang, Yu Jen ^b   Hsieh, Yi Fang ^a   Cheng, Chih Ya ^a   Liu, Hsiu Chih ^a,d   Chen, Yun Ru ^b   Cheng, Irene H ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c ACADEMIA SINICA   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; ASPARTIC ACID; COPPER; HISTIDINE; OLIGOMER; ZINC; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; PEPTIDE FRAGMENT;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BIOCHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; EMBRYO; ETHNICITY; FEMALE; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; MEMORY DISORDER; MINI MENTAL STATE EXAMINATION; MOLECULAR WEIGHT; MUTATIONAL ANALYSIS; NEUROFILAMENT; NEUROTOXICITY; OLIGOMERIZATION; ONSET AGE; OXIDATION REDUCTION POTENTIAL; PATHOGENICITY; PERSECUTORY DELUSION; POLYMERASE CHAIN REACTION; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SLOW BRAIN WAVE; SLURRED SPEECH; TAIWANESE; TRANSMISSION ELECTRON MICROSCOPY; WECHSLER INTELLIGENCE SCALE; ALZHEIMER DISEASE; CASE REPORT; CELL CULTURE; CELL STRAIN HEK293; CHEMISTRY; GENETICS; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; POLYMERIZATION; TAIWAN;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ASPARTIC ACID; BASE SEQUENCE; CELLS, CULTURED; COPPER; FEMALE; HEK293 CELLS; HISTIDINE; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; POLYMERIZATION; TAIWAN; ZINC;

EID: 84860434786     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035807     Document Type: Article

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