The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Aβ fibril formation without increasing protofibril formation

Journal of Biological Chemistry

Volumn 282, Issue 7, 2007, Pages 4916-4923

  Hori, Yukiko ^a   Hashimoto, Tadafumi ^a   Wakutani, Yosuke ^b   Urakami, Katsuya ^b   Nakashima, Kenji ^b   Condron, Margaret M ^c   Tsubuki, Satoshi ^d   Saido, Takaomi C ^d   Teplow, David B ^c   Iwatsubo, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GENE ENCODING; METABOLISM; PEPTIDES;

AUTOSOMAL DOMINANT MUTATIONS; BIOPHYSICAL EFFECTS; PATHOGENIC EFFECTS; PRESENILINS;

DISEASES;

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; MUTANT PROTEIN; AMYLOID; AMYLOID PRECURSOR PROTEIN; PEPTIDE; PRESENILIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; GENE MUTATION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; MISSENSE MUTATION; ULTRASTRUCTURE;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; HUMANS; KINETICS; MUTATION, MISSENSE; PEPTIDES; PRESENILINS;

EID: 33947505097     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M608220200     Document Type: Article

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