On human disease-causing amino acid variants: Statistical study of sequence and structural patterns

Human Mutation

Volumn 36, Issue 5, 2015, Pages 524-534

  Petukh, Marharyta ^a   Kucukkal, Tugba G ^a   Alexov, Emil ^a  

^a CLEMSON UNIVERSITY   (United States)

Author keywords

Amino acid variations; Disease mutations; Hydrogen bond; Structure

Indexed keywords

AMINO ACID; MULTIPROTEIN COMPLEX; PROTEIN BINDING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; DISEASE ASSOCIATION; DISULFIDE BOND; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MUTATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; THERMODYNAMICS; BIOLOGY; CHEMISTRY; GENETIC ASSOCIATION STUDY; GENETIC DATABASE; METABOLISM; PROCEDURES; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; STATISTICAL MODEL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; GENETIC ASSOCIATION STUDIES; HUMANS; HYDROGEN BONDING; MODELS, STATISTICAL; MULTIPROTEIN COMPLEXES; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84928215189     PISSN: 10597794     EISSN: 10981004     Source Type: Journal    
DOI: 10.1002/humu.22770     Document Type: Article

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