pH-selective mutagenesis of protein-protein interfaces: In silico design of therapeutic antibodies with prolonged half-life

Proteins: Structure, Function and Bioinformatics

Volumn 81, Issue 4, 2013, Pages 704-714

  Spassov, Velin Z ^a   Yan, Lisa ^a  

^a ACCELRYS INC   (United States)

Author keywords

Antibody; Binding affinity; CHARMm; FcRn; Generalized born; ImG immunoglobulin G; Mutation; Neonatal Fc receptor; pH; Protein ionization; Scanning mutagenesis

Indexed keywords

ALANINE; ANTIBODY; FC RECEPTOR; IMMUNOGLOBULIN G; OVOMUCOID; PROTEINASE; PROTEINASE B; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; COMPUTER MODEL; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG HALF LIFE; ENERGY; MOLECULAR MECHANICS; MOLECULAR MODEL; MUTAGENESIS; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN PROTEIN INTERACTION; STRUCTURAL HOMOLOGY; VIRTUAL REALITY; WILD TYPE;

ANIMALS; COMPUTER SIMULATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; MUTAGENESIS; MUTATION; OVOMUCIN; PROTEIN BINDING; RECEPTORS, FC; SERINE ENDOPEPTIDASES; THERMODYNAMICS; TURKEY;

EID: 84874816539     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24230     Document Type: Article

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