Cancer Missense Mutations Alter Binding Properties of Proteins and Their Interaction Networks

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Nishi, Hafumi ^a,e   Tyagi, Manoj ^b   Teng, Shaolei ^c   Shoemaker, Benjamin A ^a   Hashimoto, Kosuke ^d   Alexov, Emil ^c   Wuchty, Stefan ^a,f   Panchenko, Anna R ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CLEMSON UNIVERSITY   (United States)

^d RIKEN   (Japan)

^e YOKOHAMA CITY UNIVERSITY   (Japan)

^f Department of Computer Science and Center for Computational Science   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; TUMOR MARKER;

ARTICLE; CANCER GENETICS; CARCINOGENESIS; COMPLEX FORMATION; CONTROLLED STUDY; GENE MAPPING; GLIOBLASTOMA; HUMAN; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NERVOUS SYSTEM FUNCTION; PHENOTYPE; PHYSICAL CHEMISTRY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN METABOLISM; PROTEIN NUCLEIC ACID INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ARTIFICIAL INTELLIGENCE; BINDING SITES; DNA-BINDING PROTEINS; GLIOBLASTOMA; HUMANS; MODELS, BIOLOGICAL; MUTATION, MISSENSE; PHENOTYPE; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPS; PROTEIN STABILITY; THERMODYNAMICS;

EID: 84879157943     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066273     Document Type: Article

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