Extrapolating the effect of deleterious nsSNPs in the binding adaptability of flavopiridol with CDK7 protein: A molecular dynamics approach

Human Genomics

Volumn 7, Issue 1, 2013, Pages

  George Priya Doss, C ^a   Nagasundaram, N ^a   Chakraborty, Chiranjib ^b,c   Chen, Luonan ^d,e   Zhu, Hailong ^b  

^a VIT UNIVERSITY   (India)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^c GALGOTIAS UNIVERSITY   (India)

^d Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^e INSTITUTE OF INDUSTRIAL SCIENCE   (Japan)

Author keywords

CDK7; Docking; Flavopiridol; Molecular dynamics; NsSNPs

Indexed keywords

ARGININE; CYCLIN DEPENDENT KINASE 7; FLAVOPIRIDOL; HISTIDINE; ISOLEUCINE; METHIONINE; MUTANT PROTEIN; THREONINE; AMINO ACID; CYCLIN DEPENDENT KINASE; CYCLIN-DEPENDENT KINASE-ACTIVATING KINASE; FLAVONOID; PIPERIDINE DERIVATIVE; PROTEIN BINDING;

AMINO ACID SUBSTITUTION; ARTICLE; ATOM; BINDING AFFINITY; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG TARGETING; GENE DELETION; GENE MUTATION; GENE ONTOLOGY; HIDDEN MARKOV MODEL; MOLECULAR DYNAMICS; MUTANT; NONSYNONYMOUS SINGLE NUCLEOTIDE POLYMORPHISM; PREDICTION; PROTEIN FUNCTION; PROTEIN STABILITY; SINGLE NUCLEOTIDE POLYMORPHISM; CHEMISTRY; COMPUTER PROGRAM; GENETICS; HUMAN; HYDROGEN BOND; METABOLISM; PROTEIN SECONDARY STRUCTURE; STATIC ELECTRICITY; THERMODYNAMICS;

AMINO ACIDS; COMPUTER SIMULATION; CYCLIN-DEPENDENT KINASES; FLAVONOIDS; HUMANS; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; PIPERIDINES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SOFTWARE; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 84896279000     PISSN: 14739542     EISSN: 14797364     Source Type: Journal    
DOI: 10.1186/1479-7364-7-10     Document Type: Article

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