-
1
-
-
84975742565
-
A map of human genome variation from population-scale sequencing
-
Altshuler, D. et al. (2010) A map of human genome variation from population-scale sequencing. Nature, 467, 1061-1073.
-
(2010)
Nature
, vol.467
, pp. 1061-1073
-
-
Altshuler, D.1
-
2
-
-
0025234587
-
PH-induced denaturation of proteins: A single salt bridge contributes 3-5 kcal/mol to the free energy of folding of T4 lysozyme
-
Anderson, D.E. et al (1990) pH-induced denaturation of proteins: a single salt bridge contributes 3-5 kcal/mol to the free energy of folding of T4 lysozyme. Biochemistry, 29, 2403-2408.
-
(1990)
Biochemistry
, vol.29
, pp. 2403-2408
-
-
Anderson, D.E.1
-
3
-
-
80051794613
-
Deep mutational scanning: Assessing protein function on a massive scale
-
Araya, C.L. and Fowler, D.M. (2011) Deep mutational scanning: assessing protein function on a massive scale. Trends Biotechnol, 29, 435-442.
-
(2011)
Trends Biotechnol
, vol.29
, pp. 435-442
-
-
Araya, C.L.1
Fowler, D.M.2
-
4
-
-
0025049135
-
Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis
-
Ashkenazi, A. et al. (1990) Mapping the CD4 binding site for human immunodeficiency virus by alanine-scanning mutagenesis. Proc. Natl. Acad. Sei. 'USA., 87, 7150-7154.
-
(1990)
Proc. Natl. Acad. Sei. 'Usa.
, vol.87
, pp. 7150-7154
-
-
Ashkenazi, A.1
-
5
-
-
0025765004
-
A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor
-
Bass, S.H. et al. (1991) A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor. Proc. Natl. Acad. Sei. 'USA., 88, 4498-4502.
-
(1991)
Proc. Natl. Acad. Sei. 'Usa.
, vol.88
, pp. 4498-4502
-
-
Bass, S.H.1
-
6
-
-
0033980446
-
Deleterious effects of beta-branched residues in the SI specificity pocket of Streptomyces griseus proteinase B (SGPB): Crystal structures of the turkey ovomucoid third domain variants Ilel 81, Vail 81, Thrl 81, and Serl8I in complex with SGPB
-
Bateman, K.S. et al. (2000) Deleterious effects of beta-branched residues in the SI specificity pocket of Streptomyces griseus proteinase B (SGPB): crystal structures of the turkey ovomucoid third domain variants Ilel 81, Vail 81, Thrl 81, and Serl8I in complex with SGPB. Protein Sei, 9, 83-94.
-
(2000)
Protein Sei
, vol.9
, pp. 83-94
-
-
Bateman, K.S.1
-
7
-
-
0035951311
-
Contribution of peptide bonds to inhibitor-protease binding: Crystal structures of the turkey ovomucoid third domain backbone variants OMTKY3-Prol8I and OMTKY3-psi(COO)-Leul8I in complex with Streptomyces griseus proteinase B (SGPB) and the structure of the free inhibitor, OMTKY-3-psi(CH2NH2+)-Aspl9I
-
Bateman, K.S. et al. (2001) Contribution of peptide bonds to inhibitor-protease binding: crystal structures of the turkey ovomucoid third domain backbone variants OMTKY3-Prol8I and OMTKY3-psi(COO)-Leul8I in complex with Streptomyces griseus proteinase B (SGPB) and the structure of the free inhibitor, OMTKY-3-psi(CH2NH2+)-Aspl9I. J. Mol. Biol, 305, 839-849.
-
(2001)
J. Mol. Biol
, vol.305
, pp. 839-849
-
-
Bateman, K.S.1
-
8
-
-
58149247893
-
Predicting free energy changes using structural ensembles
-
Benedix, A. et al. (2009) Predicting free energy changes using structural ensembles. Nat. Methods, 6, 3-4.
-
(2009)
Nat. Methods
, vol.6
, pp. 3-4
-
-
Benedix, A.1
-
9
-
-
0032479179
-
Anatomy of hot spots in protein interfaces
-
Bogan, A.A. and Thorn, K.S. (1998) Anatomy of hot spots in protein interfaces. J. Mol. Biol, 280, 1-9.
-
(1998)
J. Mol. Biol
, vol.280
, pp. 1-9
-
-
Bogan, A.A.1
Thorn, K.S.2
-
10
-
-
0029592773
-
A new DNA sequence assembly program
-
Bonfield, J.K. et al. (1995) A new DNA sequence assembly program. Nucleic Acids Res., 23, 4992-4999.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 4992-4999
-
-
Bonfield, J.K.1
-
11
-
-
75149186552
-
Mutational robustness can facilitate adaptation
-
Draghi, J.A. et al (2010) Mutational robustness can facilitate adaptation. Nature, 463, 353-355.
-
(2010)
Nature
, vol.463
, pp. 353-355
-
-
Draghi, J.A.1
-
12
-
-
0020480240
-
Thermodynamics and kinetics of single residue replacements in avian ovomucoid third domains: Effect on inhibitor interactions with serine proteinases
-
Empie, M.W. and Laskowski, M. (1982) Thermodynamics and kinetics of single residue replacements in avian ovomucoid third domains: effect on inhibitor interactions with serine proteinases. Biochemistry, 21, 2274-2284.
-
(1982)
Biochemistry
, vol.21
, pp. 2274-2284
-
-
Empie, M.W.1
Laskowski, M.2
-
13
-
-
77956544553
-
Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing
-
Ernst, A. et al (2010) Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing. Mol Biosyst., 6, 1782-1790.
-
(2010)
Mol Biosyst.
, vol.6
, pp. 1782-1790
-
-
Ernst, A.1
-
14
-
-
34248583079
-
The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1)
-
Farady, CJ. et al (2007) The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1). J. Mol Biol, 369, 1041-1051.
-
(2007)
J. Mol Biol
, vol.369
, pp. 1041-1051
-
-
Farady, C.J.1
-
15
-
-
0029856410
-
Hydrogen bonding and solvent structure in an antigen-antibody interface. Crystal structures and thermodynamic characterization of three Fv mutants complexed with lysozyme
-
Fields, B.A. et al (1996) Hydrogen bonding and solvent structure in an antigen-antibody interface. Crystal structures and thermodynamic characterization of three Fv mutants complexed with lysozyme. Biochemistry, 35, 15494-15503.
-
(1996)
Biochemistry
, vol.35
, pp. 15494-15503
-
-
Fields, B.A.1
-
16
-
-
84859765617
-
Role of the biomolecular energy gap in protein design, structure, and evolution
-
Fleishman, S.J. and Baker, D. (2012) Role of the biomolecular energy gap in protein design, structure, and evolution. Cell, 149, 262-273.
-
(2012)
Cell
, vol.149
, pp. 262-273
-
-
Fleishman, S.J.1
Baker, D.2
-
17
-
-
79956017135
-
Computational design of proteins targeting the conserved stem region of influenza hemagglutinin
-
Fleishman, S.J. et al (2011) Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. Science, 332, 816-821.
-
(2011)
Science
, vol.332
, pp. 816-821
-
-
Fleishman, S.J.1
-
18
-
-
0031933416
-
Antigen distortion allows influenza virus to escape neutralization
-
Fleury, D. et al (1998) Antigen distortion allows influenza virus to escape neutralization. Nat. Struct. Biol, 5, 119-123.
-
(1998)
Nat. Struct. Biol
, vol.5
, pp. 119-123
-
-
Fleury, D.1
-
19
-
-
77956338533
-
High-resolution mapping of protein sequence-function relationships
-
Fowler, D.M. et al (2010) High-resolution mapping of protein sequence-function relationships. Nat. Methods, 7, 741-746.
-
(2010)
Nat. Methods
, vol.7
, pp. 741-746
-
-
Fowler, D.M.1
-
20
-
-
84866354446
-
Protein-protein docking and hot-spot prediction for drug discovery
-
In Press
-
Grosdidier, S. and Fernandez-Recio, J. (2012) Protein-protein docking and hot-spot prediction for drug discovery. Curr. Pharm. Des, In Press.
-
(2012)
Curr. Pharm. des
-
-
Grosdidier, S.1
Fernandez-Recio, J.2
-
21
-
-
55649090573
-
Identification of hot-spot residues in protein-protein interactions by computational docking
-
Grosdidier, S. and Fernandez-Recio, J. (2008) Identification of hot-spot residues in protein-protein interactions by computational docking. BMC Bioinformatics, 9, 447.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 447
-
-
Grosdidier, S.1
Fernandez-Recio, J.2
-
22
-
-
0036291145
-
Predicting changes in the stability of proteins and protein complexes: A study of more than 1000 mutations
-
Guerois, R. et al (2002) Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations. J. Mol Biol, 320, 369-387.
-
(2002)
J. Mol Biol
, vol.320
, pp. 369-387
-
-
Guerois, R.1
-
23
-
-
34447101383
-
On the dynamic nature of the transition state for protein-protein association as determined by double-mutant cycle analysis and simulation
-
Harel, M. et al (2007) On the dynamic nature of the transition state for protein-protein association as determined by double-mutant cycle analysis and simulation. J. Mol Biol, 371, 180-196.
-
(2007)
J. Mol Biol
, vol.371
, pp. 180-196
-
-
Harel, M.1
-
24
-
-
55549143692
-
Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d
-
Haspel, N. et al (2008) Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d. Protein Sei., 17, 1894-1906.
-
(2008)
Protein Sei.
, vol.17
, pp. 1894-1906
-
-
Haspel, N.1
-
25
-
-
0033574398
-
The crystal structures of the complexes between bovine beta-trypsin and ten PI variants of BPTI
-
Helland, R. et al (1999) The crystal structures of the complexes between bovine beta-trypsin and ten PI variants of BPTI. J. Mol Biol, 287, 923-942.
-
(1999)
J. Mol Biol
, vol.287
, pp. 923-942
-
-
Helland, R.1
-
26
-
-
79952588669
-
Assessing the performance of the MM/PBSA and MM/GBSA methods. 1. The accuracy of binding free energy calculations based on molecular dynamics simulations
-
Hou, T. et al (2011) Assessing the performance of the MM/PBSA and MM/GBSA methods. 1. The accuracy of binding free energy calculations based on molecular dynamics simulations. J. Chem. Inf. Model, 51, 69-82.
-
(2011)
J. Chem. Inf. Model
, vol.51
, pp. 69-82
-
-
Hou, T.1
-
27
-
-
0038780573
-
Structural insights into the catalytic mechanism of cyclo-philin A
-
Howard, B.R et al (2003) Structural insights into the catalytic mechanism of cyclo-philin A. Nat. Struct. Biol, 10, 475-481.
-
(2003)
Nat. Struct. Biol
, vol.10
, pp. 475-481
-
-
Howard, B.R.1
-
28
-
-
0032488808
-
The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex
-
Huang, M. et al (1998) The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex. J. Mol Biol, 275, 873-894.
-
(1998)
J. Mol Biol
, vol.275
, pp. 873-894
-
-
Huang, M.1
-
29
-
-
78650800242
-
Accounting for conformational entropy in predicting binding free energies of protein-protein interactions
-
Kamisetty, H. et al (2011) Accounting for conformational entropy in predicting binding free energies of protein-protein interactions. Proteins, 79, 444-462.
-
(2011)
Proteins
, vol.79
, pp. 444-462
-
-
Kamisetty, H.1
-
30
-
-
27344432508
-
Effects of interface mutations on association modes and electron-transfer rates between proteins
-
Kang, S.A. and Crane, B.R. (2005) Effects of interface mutations on association modes and electron-transfer rates between proteins. Proc. Natl Acad. Sei USA., 102, 15465-15470.
-
(2005)
Proc. Natl Acad. Sei USA.
, vol.102
, pp. 15465-15470
-
-
Kang, S.A.1
Crane, B.R.2
-
31
-
-
79952177781
-
A structure-based benchmark for protein-protein binding affinity
-
Kastritis, P.L. et al (2011) A structure-based benchmark for protein-protein binding affinity. Protein Sei, 20, 482-491.
-
(2011)
Protein Sei
, vol.20
, pp. 482-491
-
-
Kastritis, P.L.1
-
32
-
-
44149113954
-
Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases./
-
Keeble, A.H. et al (2008) Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases./. Mol Biol, 379, 745-759.
-
(2008)
Mol Biol
, vol.379
, pp. 745-759
-
-
Keeble, A.H.1
-
33
-
-
0029093452
-
Analysis of the factor Vila binding site on human tissue factor: Effects of tissue factor mutations on the kinetics and thermodynamics of binding
-
Kelley, R.F. et al (1995) Analysis of the factor Vila binding site on human tissue factor: effects of tissue factor mutations on the kinetics and thermodynamics of binding. Biochemistry, 34, 10383-10392.
-
(1995)
Biochemistry
, vol.34
, pp. 10383-10392
-
-
Kelley, R.F.1
-
34
-
-
3042594710
-
Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex
-
Kiel, C. et al (2004) Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex. Proc. Natl. Acad. Sei USA., 101, 9223-9228.
-
(2004)
Proc. Natl. Acad. Sei USA.
, vol.101
, pp. 9223-9228
-
-
Kiel, C.1
-
35
-
-
0037195144
-
A simple physical model for binding energy hot spots in protein-protein complexes
-
Kortemme, T. and Baker, D. (2002) A simple physical model for binding energy hot spots in protein-protein complexes. Proc. Natl Acad. Sei. USA., 99, 14116-14121.
-
(2002)
Proc. Natl Acad. Sei. USA.
, vol.99
, pp. 14116-14121
-
-
Kortemme, T.1
Baker, D.2
-
36
-
-
1042298843
-
Computational design of protein-protein interactions
-
Kortemme, T. and Baker, D. (2004) Computational design of protein-protein interactions. Curr. Opin. Chem. Biol, 8, 91-97.
-
(2004)
Curr. Opin. Chem. Biol
, vol.8
, pp. 91-97
-
-
Kortemme, T.1
Baker, D.2
-
37
-
-
41949085434
-
Structure analysis of bone morphogenetic protein-2 type i receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome
-
Kotzsch, A. et al (2008) Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J. Biol Chem., 283, 5876-5887.
-
(2008)
J. Biol Chem.
, vol.283
, pp. 5876-5887
-
-
Kotzsch, A.1
-
38
-
-
0033612211
-
Interscaffolding additivity: Binding of PI variants of bovine pancreatic trypsin inhibitor to four serine proteases
-
Krowarsch, D. et al (1999) Interscaffolding additivity: binding of PI variants of bovine pancreatic trypsin inhibitor to four serine proteases. J. Mol Biol, 289, 175-186.
-
(1999)
J. Mol Biol
, vol.289
, pp. 175-186
-
-
Krowarsch, D.1
-
39
-
-
33644878621
-
PINT: Protein-protein interactions thermodynamic database
-
Kumar, M.D. and Gromiha, M.M. (2006) PINT: protein-protein interactions thermodynamic database. Nucleic Acids Res., 34 (Database issue), D195-198.
-
(2006)
Nucleic Acids Res.
, vol.34
, Issue.DATABASE ISSUE
-
-
Kumar, M.D.1
Gromiha, M.M.2
-
40
-
-
84867015346
-
Computer-aided antibody design
-
In Press
-
Kuroda, D. et al. (2012) Computer-aided antibody design. Protein Eng. Des. Sel, In Press.
-
(2012)
Protein Eng. Des. Sel
-
-
Kuroda, D.1
-
41
-
-
0034719147
-
Analysis of antibody A6 binding to the extracellular interferon gamma receptor alpha-chain by alanine-scanning mutagenesis and random mutagenesis with phage display
-
Lang, S. et al. (2000) Analysis of antibody A6 binding to the extracellular interferon gamma receptor alpha-chain by alanine-scanning mutagenesis and random mutagenesis with phage display. Biochemistry, 39, 15674-15685.
-
(2000)
Biochemistry
, vol.39
, pp. 15674-15685
-
-
Lang, S.1
-
42
-
-
77957921373
-
A simple definition of structural regions in proteins and its use in analyzing interface evolution
-
Levy, E.D. (2010) A simple definition of structural regions in proteins and its use in analyzing interface evolution. J. Mol. Biol, 403, 660-670.
-
(2010)
J. Mol. Biol
, vol.403
, pp. 660-670
-
-
Levy, E.D.1
-
43
-
-
0030867940
-
Protein-protein interaction specificity of Im9 for the endonucle-ase toxin colicin E9 defined by homologue-scanning mutagenesis
-
Li, W. et al. (1997) Protein-protein interaction specificity of Im9 for the endonucle-ase toxin colicin E9 defined by homologue-scanning mutagenesis. J. Biol. Chem., 272, 22253-22258.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22253-22258
-
-
Li, W.1
-
44
-
-
0031581824
-
Binding of amino acid side-chains to SI cavities of serine proteinases
-
Lu, W. et al. (1997) Binding of amino acid side-chains to SI cavities of serine proteinases. J. Mol. Biol., 266, 441-461.
-
(1997)
J. Mol. Biol.
, vol.266
, pp. 441-461
-
-
Lu, W.1
-
45
-
-
0035852744
-
Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases
-
Lu, S.M. et al. (2001) Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases. Proc. Natl. Acad. Sei USA., 98, 1410-1415.
-
(2001)
Proc. Natl. Acad. Sei USA.
, vol.98
, pp. 1410-1415
-
-
Lu, S.M.1
-
46
-
-
70350334391
-
Computer-aided design of functional protein interactions
-
Mandell, DJ. and Kortemme, T. (2009) Computer-aided design of functional protein interactions. Nat. Chem. Biol, 5, 797-807.
-
(2009)
Nat. Chem. Biol
, vol.5
, pp. 797-807
-
-
Mandell, D.J.1
Kortemme, T.2
-
47
-
-
84857490154
-
Kinetic rate constant prediction supports the conformational selection mechanism of protein binding
-
Moal, I.H. and Bates, P.A. (2012) Kinetic rate constant prediction supports the conformational selection mechanism of protein binding. PLoS Comput. Biol, 8, el002351.
-
(2012)
PLoS Comput. Biol
, vol.8
-
-
Moal, I.H.1
Bates, P.A.2
-
48
-
-
80054900286
-
Protein-protein binding affinity prediction on a diverse set of structures
-
Moal, I.H. et al (2011) Protein-protein binding affinity prediction on a diverse set of structures. Bioinformatics, 27, 3002-3009.
-
(2011)
Bioinformatics
, vol.27
, pp. 3002-3009
-
-
Moal, I.H.1
-
49
-
-
34548779127
-
Hot spots - A review of the protein-protein interface determinant amino-acid residues
-
Moreira, I.S. et al (2007) Hot spots-a review of the protein-protein interface determinant amino-acid residues. Proteins, 68, 803-812.
-
(2007)
Proteins
, vol.68
, pp. 803-812
-
-
Moreira, I.S.1
-
50
-
-
24344495780
-
Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis
-
Pal, G. et al (2005) Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis. Protein Set, 14, 2405-2413.
-
(2005)
Protein Set
, vol.14
, pp. 2405-2413
-
-
Pal, G.1
-
51
-
-
0034967691
-
The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity
-
Pasternak, A. et al (2001) The energetic cost of induced fit catalysis: crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity. Protein Sei, 10, 1331-1342.
-
(2001)
Protein Sei
, vol.10
, pp. 1331-1342
-
-
Pasternak, A.1
-
52
-
-
0031024397
-
Interscaffolding additivity. Association of PI variants of eglin c and of turkey ovomucoid third domain with serine proteinases
-
Qasim, M.A. et al (1997) Interscaffolding additivity. Association of PI variants of eglin c and of turkey ovomucoid third domain with serine proteinases. Biochemistry, 36, 1598-1607.
-
(1997)
Biochemistry
, vol.36
, pp. 1598-1607
-
-
Qasim, M.A.1
-
53
-
-
7244239029
-
Binding, proteolytic, and crystallographic analyses of mutations at the protease-inhibitor interface of the subtilisin BPN'/chymotryp-sin inhibitor 2 complex
-
Radisky, E.S. et al (2004) Binding, proteolytic, and crystallographic analyses of mutations at the protease-inhibitor interface of the subtilisin BPN'/chymotryp-sin inhibitor 2 complex. Biochemistry, 43, 13648-13656.
-
(2004)
Biochemistry
, vol.43
, pp. 13648-13656
-
-
Radisky, E.S.1
-
54
-
-
18244402180
-
Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2
-
Radisky, E.S. et al (2005) Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2. Biochemistry, 44, 6823-6830.
-
(2005)
Biochemistry
, vol.44
, pp. 6823-6830
-
-
Radisky, E.S.1
-
55
-
-
11844296052
-
The modular architecture of protein-protein binding interfaces
-
Reichmann, D. et al (2005) The modular architecture of protein-protein binding interfaces. Proc. Natl. Acad. Sei. USA., 102, 57-62.
-
(2005)
Proc. Natl. Acad. Sei. USA.
, vol.102
, pp. 57-62
-
-
Reichmann, D.1
-
56
-
-
33845661569
-
Binding hot spots in the TEM1-BLIP interface in light of its modular architecture
-
Reichmann, D. et al (2007) Binding hot spots in the TEM1-BLIP interface in light of its modular architecture. J. Mol Biol, 365, 663-679.
-
(2007)
J. Mol Biol
, vol.365
, pp. 663-679
-
-
Reichmann, D.1
-
57
-
-
51549107071
-
Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface
-
Reynolds, K.A. et al (2008) Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. J. Mol Biol, 382, 1265-1275.
-
(2008)
J. Mol Biol
, vol.382
, pp. 1265-1275
-
-
Reynolds, K.A.1
-
58
-
-
0029056922
-
Energetics of protein-protein interactions: Analysis of the barnase-barstar interface by single mutations and double mutant cycles
-
Schreiber, G. and Fersht, A.R. (1995) Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles. J. Mol Biol, 248, 478-486.
-
(1995)
J. Mol Biol
, vol.248
, pp. 478-486
-
-
Schreiber, G.1
Fersht, A.R.2
-
59
-
-
0033923367
-
Rational design of faster associating and tighter binding protein complexes
-
Selzer, T. et al (2000) Rational design of faster associating and tighter binding protein complexes. Nat. Struct. Biol, 7, 537-541.
-
(2000)
Nat. Struct. Biol
, vol.7
, pp. 537-541
-
-
Selzer, T.1
-
60
-
-
0035066602
-
ASEdb: A database of alanine mutations and their effects on the free energy of binding in protein interactions
-
Thorn, K.S. and Bogan, A.A. (2001) ASEdb: a database of alanine mutations and their effects on the free energy of binding in protein interactions. Bioinformatics, 17, 284-285.
-
(2001)
Bioinformatics
, vol.17
, pp. 284-285
-
-
Thorn, K.S.1
Bogan, A.A.2
-
61
-
-
45749087347
-
Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: A multi-modal approach
-
Tischkowitz, M. et al (2008) Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach. Eur. J. Hum. Genet., 16, 820-832.
-
(2008)
Eur. J. Hum. Genet.
, vol.16
, pp. 820-832
-
-
Tischkowitz, M.1
-
62
-
-
11144331052
-
Computational prediction of binding hotspots
-
Tong, W. et al (2004) Computational prediction of binding hotspots. Conf. Proc. IEEE Eng. Med. Biol. Soc, 4, 2980-2983.
-
(2004)
Conf. Proc. IEEE Eng. Med. Biol. Soc
, vol.4
, pp. 2980-2983
-
-
Tong, W.1
-
63
-
-
66349094681
-
Identification of computational hot spots in protein interfaces: Combining solvent accessibility and inter-residue potentials improves the accuracy
-
Tuncbag, N. et al (2009) Identification of computational hot spots in protein interfaces: combining solvent accessibility and inter-residue potentials improves the accuracy. Bioinformatics, 25, 1513-1520.
-
(2009)
Bioinformatics
, vol.25
, pp. 1513-1520
-
-
Tuncbag, N.1
-
64
-
-
0033548664
-
Structural response to mutation at a protein-protein interface
-
Vaughan, C.K. et al (1999) Structural response to mutation at a protein-protein interface. J. Mol Biol, 286, 1487-1506.
-
(1999)
J. Mol Biol
, vol.286
, pp. 1487-1506
-
-
Vaughan, C.K.1
-
65
-
-
65249090946
-
Selected-fit versus induced-fit protein binding: Kinetic differences and mutational analysis
-
Weikl, T.R. and von Deuster, C. (2009) Selected-fit versus induced-fit protein binding: kinetic differences and mutational analysis. Proteins, 75, 104-110.
-
(2009)
Proteins
, vol.75
, pp. 104-110
-
-
Weikl, T.R.1
Von Deuster, C.2
-
66
-
-
0034255454
-
Rapid mapping of protein functional epitopes by combinatorial alanine scanning
-
Weiss, G.A. et al (2000) Rapid mapping of protein functional epitopes by combinatorial alanine scanning. Proc. Natl. Acad. Sei USA., 97, 8950-8954.
-
(2000)
Proc. Natl. Acad. Sei USA.
, vol.97
, pp. 8950-8954
-
-
Weiss, G.A.1
-
67
-
-
84862025262
-
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
-
Whitehead, T.A. et al (2012) Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing. Nat. Biotechnol, 30, 543-548.
-
(2012)
Nat. Biotechnol
, vol.30
, pp. 543-548
-
-
Whitehead, T.A.1
-
68
-
-
84862016979
-
Next-generation protein engineering targets influenza
-
Wodak, SJ. (2012) Next-generation protein engineering targets influenza. Nat. Biotechnol, 30, 502-504.
-
(2012)
Nat. Biotechnol
, vol.30
, pp. 502-504
-
-
Wodak, S.J.1
-
69
-
-
80052942203
-
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing
-
Wu, X. et al (2011) Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science, 333, 1593-1602.
-
(2011)
Science
, vol.333
, pp. 1593-1602
-
-
Wu, X.1
-
70
-
-
77950651626
-
APIS: Accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility
-
Xia, J.F. et al (2010) APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility. BMC Bioinformatics, 11, 174.
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 174
-
-
Xia, J.F.1
|