In silico and in vitro investigations of the mutability of disease-causing missense mutation sites in spermine synthase

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Zhang, Zhe ^a   Norris, Joy ^b   Schwartz, Charles ^a,b   Alexov, Emil ^a  

^a CLEMSON UNIVERSITY   (United States)

^b GREENWOOD GENETIC CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA; SPERMINE SYNTHASE;

AMINO ACID SUBSTITUTION; ARTICLE; COMPUTER ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME STABILITY; ENZYME STRUCTURE; GENETIC CONSERVATION; HYDROGEN BOND; IN VITRO STUDY; IONIZATION; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NONSYNONYMOUS SINGLE NUCLEOTIDE POLYMORPHISM; PREDICTION; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; WILD TYPE; BIOLOGY; CELL STRAIN HEK293; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; X LINKED MENTAL RETARDATION;

COMPUTATIONAL BIOLOGY; DNA MUTATIONAL ANALYSIS; ENZYME STABILITY; HEK293 CELLS; HUMANS; HYDROGEN BONDING; MENTAL RETARDATION, X-LINKED; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SPERMINE SYNTHASE;

EID: 79957582046     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020373     Document Type: Article

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