-
1
-
-
0001633495
-
Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia growth and development study, multicenter AIDS cohort study, multicenter hemophilia cohort study, San Francisco city cohort, ALIVE study
-
Dean M, Carrington M, Winkler C, Huttley GA, Smith MW, Allikmets R, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia growth and development study, multicenter AIDS cohort study, multicenter hemophilia cohort study, San Francisco city cohort, ALIVE study. Science. 1996;273:1856-62.
-
(1996)
Science
, vol.273
, pp. 1856-1862
-
-
Dean, M.1
Carrington, M.2
Winkler, C.3
Huttley, G.A.4
Smith, M.W.5
Allikmets, R.6
-
2
-
-
15844388931
-
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
-
Liu R, Paxton WA, Choe S, Ceradini D, Martin SR, Horuk R, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 1996;86:367-77.
-
(1996)
Cell
, vol.86
, pp. 367-377
-
-
Liu, R.1
Paxton, W.A.2
Choe, S.3
Ceradini, D.4
Martin, S.R.5
Horuk, R.6
-
3
-
-
60549090253
-
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
-
Hütter G, Nowak D, Mossner M, Ganepola S, Müssig A, Allers K, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360:692-8.
-
(2009)
N Engl J Med
, vol.360
, pp. 692-698
-
-
Hütter, G.1
Nowak, D.2
Mossner, M.3
Ganepola, S.4
Müssig, A.5
Allers, K.6
-
4
-
-
79953117041
-
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
-
Allers K, Hütter G, Hofmann J, Loddenkemper C, Rieger K, Thiel E, et al. Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood. 2011;117:2791-9.
-
(2011)
Blood
, vol.117
, pp. 2791-2799
-
-
Allers, K.1
Hütter, G.2
Hofmann, J.3
Loddenkemper, C.4
Rieger, K.5
Thiel, E.6
-
5
-
-
84878503062
-
Challenges in detecting HIV persistence during potentially curative interventions: A study of the Berlin patient
-
Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, et al. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog. 2013;9:e1003347.
-
(2013)
PLoS Pathog
, vol.9
, pp. e1003347
-
-
Yukl, S.A.1
Boritz, E.2
Busch, M.3
Bentsen, C.4
Chun, T.W.5
Douek, D.6
-
6
-
-
27844602105
-
The geographic spread of the CCR5 Delta32 HIV-resistance allele
-
Novembre J, Galvani AP, Slatkin M. The geographic spread of the CCR5 Delta32 HIV-resistance allele. PLoS Biol. 2005;3:e339.
-
(2005)
PLoS Biol
, vol.3
, pp. e339
-
-
Novembre, J.1
Galvani, A.P.2
Slatkin, M.3
-
7
-
-
33748094648
-
The Black Death and AIDS: CCR5-Delta32 in genetics and history
-
Cohn Jr SK, Weaver LT. The Black Death and AIDS: CCR5-Delta32 in genetics and history. QJM. 2006;99:497-503.
-
(2006)
QJM
, vol.99
, pp. 497-503
-
-
Cohn, S.K.1
Weaver, L.T.2
-
8
-
-
0037510038
-
Enhancing gene targeting with designed zinc finger nucleases
-
Bibikova M, Beumer K, Trautman JK, Carroll D. Enhancing gene targeting with designed zinc finger nucleases. Science. 2003;300:764.
-
(2003)
Science
, vol.300
, pp. 764
-
-
Bibikova, M.1
Beumer, K.2
Trautman, J.K.3
Carroll, D.4
-
9
-
-
55549129245
-
Progress and prospects: Zinc-finger nucleases as gene therapy agents
-
Carroll D. Progress and prospects: zinc-finger nucleases as gene therapy agents. Gene Ther. 2008;15:1463-8.
-
(2008)
Gene Ther
, vol.15
, pp. 1463-1468
-
-
Carroll, D.1
-
10
-
-
18944373328
-
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
-
Urnov FD, Miller JC, Lee YL, Beausejour CM, Rock JM, Augustus S, et al. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature. 2005;435:646-51.
-
(2005)
Nature
, vol.435
, pp. 646-651
-
-
Urnov, F.D.1
Miller, J.C.2
Lee, Y.L.3
Beausejour, C.M.4
Rock, J.M.5
Augustus, S.6
-
11
-
-
44449120801
-
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases
-
Santiago Y, Chan E, Liu PQ, Orlando S, Zhang L, Urnov FD, et al. Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases. Proc Natl Acad Sci. 2008;105:5809-14.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 5809-5814
-
-
Santiago, Y.1
Chan, E.2
Liu, P.Q.3
Orlando, S.4
Zhang, L.5
Urnov, F.D.6
-
12
-
-
77955867185
-
Genome editing with engineered zinc finger nucleases
-
Urnov FD, Rebar EJ, Holmes MC, Zhang HS, Gregory PD. Genome editing with engineered zinc finger nucleases. Nat Rev Genet. 2010;11:636-46.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 636-646
-
-
Urnov, F.D.1
Rebar, E.J.2
Holmes, M.C.3
Zhang, H.S.4
Gregory, P.D.5
-
13
-
-
46949095221
-
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
-
Perez EE, Wang J, Miller JC, Jouvenot Y, Kim KA, Liu O, et al. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotech. 2008;7:808-16.
-
(2008)
Nat Biotech
, vol.7
, pp. 808-816
-
-
Perez, E.E.1
Wang, J.2
Miller, J.C.3
Jouvenot, Y.4
Kim, K.A.5
Liu, O.6
-
14
-
-
78650735673
-
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
-
Holt N, Wang J, Kim K, Friedman G, Wang X, Taupin V, et al. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol. 2010;28:839-47.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 839-847
-
-
Holt, N.1
Wang, J.2
Kim, K.3
Friedman, G.4
Wang, X.5
Taupin, V.6
-
15
-
-
0038523969
-
Chimeric nucleases stimulate gene targeting in human cells
-
Porteus MH, Baltimore D. Chimeric nucleases stimulate gene targeting in human cells. Science. 2003;300:763.
-
(2003)
Science
, vol.300
, pp. 763
-
-
Porteus, M.H.1
Baltimore, D.2
-
16
-
-
33847682924
-
Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases
-
Moehle EA, Rock JM, Lee YL, Jouvenot Y, DeKelver RC, Gregory PD, et al. Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases. Proc Natl Acad Sci U S A. 2007;104:3055-60.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3055-3060
-
-
Moehle, E.A.1
Rock, J.M.2
Lee, Y.L.3
Jouvenot, Y.4
DeKelver, R.C.5
Gregory, P.D.6
-
17
-
-
47349097567
-
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification
-
Maeder ML, Thibodeau-Beganny S, Osiak A, Wright DA, Anthony RM, Eichtinger M, et al. Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell. 2008;31:294-301.
-
(2008)
Mol Cell
, vol.31
, pp. 294-301
-
-
Maeder, M.L.1
Thibodeau-Beganny, S.2
Osiak, A.3
Wright, D.A.4
Anthony, R.M.5
Eichtinger, M.6
-
18
-
-
77955157281
-
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome
-
DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, et al. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res. 2010;8:1133-42.
-
(2010)
Genome Res
, vol.8
, pp. 1133-1142
-
-
DeKelver, R.C.1
Choi, V.M.2
Moehle, E.A.3
Paschon, D.E.4
Hockemeyer, D.5
Meijsing, S.H.6
-
19
-
-
69049104003
-
Targeted manipulation of mammalian genomes using designed zinc finger nucleases
-
Kandavelou K, Ramalingam S, London V, Mani M, Wu J, Alexeev V, et al. Targeted manipulation of mammalian genomes using designed zinc finger nucleases. Biochem Biophys Res Commun. 2009;388:56-61.
-
(2009)
Biochem Biophys Res Commun
, vol.388
, pp. 56-61
-
-
Kandavelou, K.1
Ramalingam, S.2
London, V.3
Mani, M.4
Wu, J.5
Alexeev, V.6
-
20
-
-
77950572073
-
Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform
-
Benabdallah BF, Allard E, Yao S, Friedman G, Friedman G, Gregory PD, et al. Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform. Cytotherapy. 2010;12:394-49.
-
(2010)
Cytotherapy
, vol.12
, pp. 394-449
-
-
Benabdallah, B.F.1
Allard, E.2
Yao, S.3
Friedman, G.4
Friedman, G.5
Gregory, P.D.6
-
21
-
-
79960833952
-
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
-
Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell. 2011;146:318-31.
-
(2011)
Cell
, vol.146
, pp. 318-331
-
-
Soldner, F.1
Laganière, J.2
Cheng, A.W.3
Hockemeyer, D.4
Gao, Q.5
Alagappan, R.6
-
22
-
-
0017119380
-
Fibroblast precursors in normal and irradiated mouse hematopoietic organs
-
Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol. 1976;4:267-74.
-
(1976)
Exp Hematol
, vol.4
, pp. 267-274
-
-
Friedenstein, A.J.1
Gorskaja, J.F.2
Kulagina, N.N.3
-
23
-
-
0018947660
-
Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny
-
Castro-Malaspina H, Gay RE, Resnick G, Kapoor N, Meyers P, Chiarieri D, et al. Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood. 1980;56:289-301.
-
(1980)
Blood
, vol.56
, pp. 289-301
-
-
Castro-Malaspina, H.1
Gay, R.E.2
Resnick, G.3
Kapoor, N.4
Meyers, P.5
Chiarieri, D.6
-
24
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-76.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
25
-
-
84885920900
-
Targeted transgene insertion into the AAVS1 locus driven by baculoviral vector-mediated zinc finger nuclease expression in human-induced pluripotent stem cells
-
Tay FC, Tan WK, Goh SL, Ramachandra CJ, Lau CH, Zhu H, et al. Targeted transgene insertion into the AAVS1 locus driven by baculoviral vector-mediated zinc finger nuclease expression in human-induced pluripotent stem cells. J Gene Med. 2013;15:384-95.
-
(2013)
J Gene Med
, vol.15
, pp. 384-395
-
-
Tay, F.C.1
Tan, W.K.2
Goh, S.L.3
Ramachandra, C.J.4
Lau, C.H.5
Zhu, H.6
-
26
-
-
84863116293
-
Generation of CD34+ cells from CCR5-disrupted human embryonic and induced pluripotent stem cells
-
Yao Y, Nashun B, Zhou T, Qin L, Qin L, Zhao S, et al. Generation of CD34+ cells from CCR5-disrupted human embryonic and induced pluripotent stem cells. Hum Gene Ther. 2012;23:23842.
-
(2012)
Hum Gene Ther
, vol.23
, pp. 23842
-
-
Yao, Y.1
Nashun, B.2
Zhou, T.3
Qin, L.4
Qin, L.5
Zhao, S.6
-
27
-
-
84895528015
-
Isolation of single-base genome-edited human iPS cells without antibiotic selection
-
Miyaoka Y, Chan AH, Judge LM, Yoo J, Huang M, Nguyen TD, et al. Isolation of single-base genome-edited human iPS cells without antibiotic selection. Nat Methods. 2014;11:291-3.
-
(2014)
Nat Methods
, vol.11
, pp. 291-293
-
-
Miyaoka, Y.1
Chan, A.H.2
Judge, L.M.3
Yoo, J.4
Huang, M.5
Nguyen, T.D.6
-
28
-
-
84873339687
-
Generation and genetic engineering of human induced pluripotent stem cells using designed zinc finger nucleases
-
Ramalingam S, London V, Kandavelou K, Cebotaru L, Guggino W, Civin C, et al. Generation and genetic engineering of human induced pluripotent stem cells using designed zinc finger nucleases. Stem Cells Dev. 2013;22:595-610.
-
(2013)
Stem Cells Dev
, vol.22
, pp. 595-610
-
-
Ramalingam, S.1
London, V.2
Kandavelou, K.3
Cebotaru, L.4
Guggino, W.5
Civin, C.6
-
29
-
-
71449125977
-
Forcing cells to change lineages
-
Graf T, Enver T. Forcing cells to change lineages. Nature. 2009;462:587-94.
-
(2009)
Nature
, vol.462
, pp. 587-594
-
-
Graf, T.1
Enver, T.2
-
30
-
-
78649471039
-
Direct conversion of human fibroblasts to multilineage blood progenitors
-
Szabo E, Rampalli S, Risueño RM, Schnerch A, Mitchell R, Fiebig-Comyn A, et al. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature. 2010;468:521-6.
-
(2010)
Nature
, vol.468
, pp. 521-526
-
-
Szabo, E.1
Rampalli, S.2
Risueño, R.M.3
Schnerch, A.4
Mitchell, R.5
Fiebig-Comyn, A.6
-
31
-
-
4444263350
-
Isolation of a highly clonogenic and multipotential subfraction of adult stem cells from bone marrow stroma
-
Smith JR, Pochampally R, Perry A, Hsu SC, Prockop DJ. Isolation of a highly clonogenic and multipotential subfraction of adult stem cells from bone marrow stroma. Stem Cells. 2001;22:823-31.
-
(2001)
Stem Cells
, vol.22
, pp. 823-831
-
-
Smith, J.R.1
Pochampally, R.2
Perry, A.3
Hsu, S.C.4
Prockop, D.J.5
-
32
-
-
34948849730
-
Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts
-
Capelli C, Domenghini M, Borleri G, Bellavita P, Poma R, Carobbio A, et al. Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts. Bone Marrow Transplant. 2007;40:785-91.
-
(2007)
Bone Marrow Transplant
, vol.40
, pp. 785-791
-
-
Capelli, C.1
Domenghini, M.2
Borleri, G.3
Bellavita, P.4
Poma, R.5
Carobbio, A.6
-
33
-
-
10744229444
-
Transdifferentiation of cultured tubular cells induced by hypoxia
-
Manotham K, Tanaka T, Matsumoto M, Ohse T, Inagi R, Miyata T, et al. Transdifferentiation of cultured tubular cells induced by hypoxia. Kidney Int. 2004;65:871-80.
-
(2004)
Kidney Int
, vol.65
, pp. 871-880
-
-
Manotham, K.1
Tanaka, T.2
Matsumoto, M.3
Ohse, T.4
Inagi, R.5
Miyata, T.6
-
35
-
-
67650045497
-
Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly
-
Kim HJ, Lee HJ, Kim H, Cho SW, Kim JS. Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly. Genome Res. 2009;19:1279-88.
-
(2009)
Genome Res
, vol.19
, pp. 1279-1288
-
-
Kim, H.J.1
Lee, H.J.2
Kim, H.3
Cho, S.W.4
Kim, J.S.5
-
36
-
-
35948946526
-
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
-
Lombardo A, Genovese P, Beausejour CM, Colleoni S, Lee YL, KimKA, et al. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol. 2007;25:1298-306.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1298-1306
-
-
Lombardo, A.1
Genovese, P.2
Beausejour, C.M.3
Colleoni, S.4
Lee, Y.L.5
Kim, K.A.6
-
37
-
-
84874185862
-
Magnetic separation and antibiotics selection enable enrichment of cells with ZFN/TALEN-induced mutations
-
Kim H, Kim MS, Wee G, Lee CI, Kim H, Kim JS. Magnetic separation and antibiotics selection enable enrichment of cells with ZFN/TALEN-induced mutations. PLoS One. 2013;8:e56476.
-
(2013)
PLoS One
, vol.8
, pp. e56476
-
-
Kim, H.1
Kim, M.S.2
Wee, G.3
Lee, C.I.4
Kim, H.5
Kim, J.S.6
-
38
-
-
84895487305
-
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
-
Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med. 2014;370:901-10.
-
(2014)
N Engl J Med
, vol.370
, pp. 901-910
-
-
Tebas, P.1
Stein, D.2
Tang, W.W.3
Frank, I.4
Wang, S.Q.5
Lee, G.6
-
39
-
-
84875420616
-
Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5
-
Maier DA, Brennan AL, Jiang S, Binder-Scholl GK, Lee G, Plesa G, et al. Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5. Hum Gene Ther. 2013;24:245-58.
-
(2013)
Hum Gene Ther
, vol.24
, pp. 245-258
-
-
Maier, D.A.1
Brennan, A.L.2
Jiang, S.3
Binder-Scholl, G.K.4
Lee, G.5
Plesa, G.6
-
40
-
-
84878528467
-
Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases
-
Li L, Krymskaya L, Wang J, Henley J, Rao A, Cao LF, et al. Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases. Mol Ther. 2013;21:1259-69.
-
(2013)
Mol Ther
, vol.21
, pp. 1259-1269
-
-
Li, L.1
Krymskaya, L.2
Wang, J.3
Henley, J.4
Rao, A.5
Cao, L.F.6
-
41
-
-
0032079497
-
High CD34(+) cell counts decrease hematologic toxicity of autologous peripheral blood progenitor cell transplantation
-
Ketterer N, Salles G, Raba M, Espinouse D, Sonet A, Tremisi P, et al. High CD34(+) cell counts decrease hematologic toxicity of autologous peripheral blood progenitor cell transplantation. Blood. 1998;91:3148-55.
-
(1998)
Blood
, vol.91
, pp. 3148-3155
-
-
Ketterer, N.1
Salles, G.2
Raba, M.3
Espinouse, D.4
Sonet, A.5
Tremisi, P.6
-
42
-
-
84903729497
-
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
-
Ye L, Wang J, Beyer AI, Teque F, Cradick TJ, Qi Z, et al. Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection. Proc Natl Acad Sci U S A. 2014;111:9591-6.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 9591-9596
-
-
Ye, L.1
Wang, J.2
Beyer, A.I.3
Teque, F.4
Cradick, T.J.5
Qi, Z.6
-
43
-
-
84904437964
-
Molecular evidence for OCT4 induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors
-
Mitchell R, Szabo E, Shapovalova Z, Aslostovar L, Makondo K, Bhatia M. Molecular evidence for OCT4 induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors. Stem Cells. 2014;32:2178-87.
-
(2014)
Stem Cells
, vol.32
, pp. 2178-2187
-
-
Mitchell, R.1
Szabo, E.2
Shapovalova, Z.3
Aslostovar, L.4
Makondo, K.5
Bhatia, M.6
|