Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy

International Immunopharmacology

Volumn 26, Issue 1, 2015, Pages 221-228

  Zhao, Jie ^a   Sun, Ye ^b   Shi, Peiliang ^b   Dong, Jian Ning ^a   Zuo, Lu Gen ^a   Wang, Hong Gang ^a   Gong, Jian Feng ^a   Li, Yi ^a   Gu, Li Li ^a   Li, Ning ^a   Li, Jie Shou ^a   Zhu, Wei Ming ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Autophagy; Celastrol; Colitis; Inflammation

Indexed keywords

3 METHYLADENINE; BETA ACTIN; CELASTROL; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MYELOPEROXIDASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P70; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; IL10 PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; PEROXIDASE; TARGET OF RAPAMYCIN KINASE; TRIPTERINE; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASCENDING COLON; AUTOPHAGY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DOWN REGULATION; DRUG EFFICACY; EXPERIMENTAL COLITIS; HISTOPATHOLOGY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; COLON; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AUTOPHAGY; BLOTTING, WESTERN; COLON; CROHN DISEASE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-10; MICE, INBRED C57BL; MICE, KNOCKOUT; PEROXIDASE; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRITERPENES;

EID: 84926625663     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.03.033     Document Type: Article

References (41)

1. A. Kaser, S. Zeissig, and R.S. Blumberg Inflammatory bowel disease Annu. Rev. Immunol. 28 2010 573 621
2. R.J. Xavier, and D.K. Podolsky Unravelling the pathogenesis of inflammatory bowel disease Nature 448 2007 427 434
3. S. Randall-Demllo, M. Chieppa, and R. Eri Intestinal epithelium and autophagy: partners in gut homeostasis Front. Immunol. 4 2013 301
4. H. Wang, J. Dong, P. Shi, J. Liu, L. Zuo, and Y. Li Anti-mouse CD52 mAb ameliorates intestinal epithelial barrier function in IL-10 knockout mice with spontaneous chronic colitis Immunology 144 2015 254 262
5. P.R. Carter, M.N. Watts, M. Kosloski-Davidson, K. Prasai, M.B. Grisham, and N.R. Harris Iron status, anemia, and plasma erythropoietin levels in acute and chronic mouse models of colitis Inflamm. Bowel Dis. 19 2013 1260 1265
6. H. Yin, X. Li, B. Zhang, T. Liu, B. Yuan, and Q. Ni Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis Immunology 139 2013 494 502
7. J.A. Goettel, A.H. Scott, D. Olivares-Villagomez, M.K. Washington, R. Chaturvedi, and K.T. Wilson KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-gamma production Gastroenterology 140 2011 265 274
8. Z. Zhai, F. Wu, F. Dong, A.Y. Chuang, J.S. Messer, and D.L. Boone Human autophagy gene ATG16L1 is post-transcriptionally regulated by MIR142-3p Autophagy 10 2014 468 479
9. E. Hoefkens, K. Nys, J.M. John, K. Van Steen, I. Arijs, and J. Van der Goten Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress Autophagy 9 2013 2046 2055
10. F.L. van de Veerdonk, and C.A. Dinarello Deficient autophagy unravels the ROS paradox in chronic granulomatous disease Autophagy 10 2014 1141 1142
11. H.T. Nguyen, P. Lapaquette, M.A. Bringer, and A. Darfeuille-Michaud Autophagy and Crohn's disease J. Innate Immunol. 5 2013 434 443
12. R. Marion-Letellier, M. Raman, G. Savoye, P. Dechelotte, and S. Ghosh Nutrient modulation of autophagy: implications for inflammatory bowel diseases Inflamm. Bowel Dis. 19 2013 205 212
13. M.E. Shaker, S.A. Ashamallah, and M.E. Houssen Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis Chem. Biol. Interact. 210 2014 26 33
14. J.H. Lee, Y.S. Won, K.H. Park, M.K. Lee, H. Tachibana, and K. Yamada Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling Apoptosis 17 2012 1275 1286
15. D. Wang, Y. Ma, Z. Li, K. Kang, X. Sun, and S. Pan The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia/reperfusion injury in mice Autophagy 8 2012 954 962
16. U.P. Singh, S. Singh, D.D. Taub, and J.J. Lillard Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10-/- mice J. Immunol. 171 2003 1401 1406
17. Y. Li, Y. Tian, W. Zhu, J. Gong, W. Zhang, and C. Yu Triptolide induces suppressor of cytokine signaling-3 expression and promotes lamina propria mononuclear cells apoptosis in Crohn's colitis Int. Immunopharmacol. 16 2013 268 274
18. J. Dong, H. Wang, G. Wu, J. Zhao, L. Zhang, and L. Zuo Oral treatment with SEW2871, a sphingosine-1-phosphate type 1 receptor agonist, ameliorates experimental colitis in interleukin-10 gene deficient mice Clin. Exp. Immunol. 177 2014 94 101
19. K. Nys, P. Agostinis, and S. Vermeire Autophagy: a new target or an old strategy for the treatment of Crohn's disease? Nat. Rev. Gastroenterol. Hepatol. 10 2013 395 401
20. H. Wang, J. Dong, L. Zuo, J. Liu, W. Zhu, and Y. Li Anti-mouse CD52 monoclonal antibody ameliorates iron-deficient anaemia in IL-10 knockout mice Br. J. Nutr. 111 2014 987 995
21. T.S. Plantinga, L.A. Joosten, J.W. van der Meer, and M.G. Netea Modulation of inflammation by autophagy: consequences for Crohn's disease Curr. Opin. Pharmacol. 12 2012 497 502
22. M. Parkes, J.C. Barrett, N.J. Prescott, M. Tremelling, C.A. Anderson, and S.A. Fisher Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility Nat. Genet. 39 2007 830 832
23. V. Deretic, and B. Levine Autophagy, immunity, and microbial adaptations Cell Host Microbe 5 2009 527 549
24. B. Tang, J. Cai, L. Sun, Y. Li, J. Qu, and B.J. Snider Proteasome inhibitors activate autophagy involving inhibition of PI3K-Akt-mTOR pathway as an anti-oxidation defense in human RPE cells PLoS ONE 9 2014 e103364
25. R. Chen, Y. Zou, D. Mao, D. Sun, G. Gao, and J. Shi The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation J. Cell Biol. 206 2014 173 182
26. X. Bai, and Y. Jiang Key factors in mTOR regulation Cell. Mol. Life Sci. 67 2010 239 253
27. L.M. Zanphorlin, F.R. Alves, and C.H. Ramos The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90 kDa heat shock protein Hsp90alpha, a chaperone implicated in the stabilization of the tumor phenotype Biochim. Biophys. Acta 1840 2014 3145 3152
28. X. Pang, Z. Yi, J. Zhang, B. Lu, B. Sung, and W. Qu Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway Cancer Res. 70 2010 1951 1959
29. G.F. Pinna, M. Fiorucci, J.M. Reimund, N. Taquet, Y. Arondel, and C.D. Muller Celastrol inhibits pro-inflammatory cytokine secretion in Crohn's disease biopsies Biochem. Biophys. Res. Commun. 322 2004 778 786
30. A.C. Allison, R. Cacabelos, V.R. Lombardi, X.A. Alvarez, and C. Vigo Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease Prog. Neuropsychopharmacol. Biol. Psychiatry 25 2001 1341 1357
31. Y.N. Deng, J. Shi, J. Liu, and Q.M. Qu Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy Neurochem. Int. 63 2013 1 9
32. H.W. Lee, K.S. Jang, and K.H. Chun Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy BMB Rep. 47 2014 697 702
33. C. Sokollik, M. Ang, and N. Jones Autophagy: a primer for the gastroenterologist/hepatologist Can. J. Gastroenterol. 25 2011 667 674
34. A. Murthy, Y. Li, I. Peng, M. Reichelt, A.K. Katakam, and R. Noubade A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3 Nature 506 2014 456 462
35. A. Gardet, and R.J. Xavier Common alleles that influence autophagy and the risk for inflammatory bowel disease Curr. Opin. Immunol. 24 2012 522 529
36. R.J. Xavier, A. Huett, and J.D. Rioux Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis Gut 57 2008 717 720
37. C. Nathan, and A. Cunningham-Bussel Beyond oxidative stress: an immunologist's guide to reactive oxygen species Nat. Rev. Immunol. 13 2013 349 361
38. X. Qin How NOD2 and autophagy may be related to Crohn's disease? A view shifted from live microbes to luminal bacterial debris J. Crohn's Colitis 8 2014 88
39. A. de Luca, S.P. Smeekens, A. Casagrande, R. Iannitti, K.L. Conway, and M.S. Gresnigt IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans Proc. Natl. Acad. Sci. U. S. A. 111 2014 3526 3531
40. T.S. Stappenbeck, J.D. Rioux, A. Mizoguchi, T. Saitoh, A. Huett, and A. Darfeuille-Michaud Crohn disease: a current perspective on genetics, autophagy and immunity Autophagy 7 2011 355 374
41. S. Garcia-Maurino, A. Alcaide, and C. Dominguez Pharmacological control of autophagy: therapeutic perspectives in inflammatory bowel disease and colorectal cancer Curr. Pharm. Des. 18 2012 3853 3873