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Volumn 25, Issue 12, 2011, Pages 667-674

Autophagy: A primer for the gastroenterologist/hepatologist

Author keywords

Acute pancreatitis; Alpha 1 antitrypsin deficiency; Autophagy; Cancer; Crohn's disease; Cystic fibrosis; Ischemia reperfusion injury

Indexed keywords

ALPHA 1 ANTITRYPSIN; AMIODARONE; ANTINEOPLASTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARBAMAZEPINE; CISPLATIN; IMMUNOSUPPRESSIVE AGENT; LITHIUM; LOPERAMIDE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OPIATE AGONIST; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; VALPROIC ACID;

EID: 84455171553     PISSN: 08357900     EISSN: None     Source Type: Journal    
DOI: 10.1155/2011/581264     Document Type: Review
Times cited : (12)

References (87)
  • 2
    • 0026584008 scopus 로고
    • Autophagy and other vacuolar protein degradation mechanisms
    • Seglen PO, Bohley P. Autophagy and other vacuolar protein degradation mechanisms. Experientia 1992;48:158-72.
    • (1992) Experientia , vol.48 , pp. 158-172
    • Seglen, P.O.1    Bohley, P.2
  • 3
    • 0030983504 scopus 로고    scopus 로고
    • Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
    • DOI 10.1016/S0378-1119(97)00084-X, PII S037811199700084X
    • Matsuura A, Tsukada M, Wada Y, Ohsumi Y. Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene 1997;192:245-50. (Pubitemid 27268249)
    • (1997) Gene , vol.192 , Issue.2 , pp. 245-250
    • Matsuura, A.1    Tsukada, M.2    Wada, Y.3    Ohsumi, Y.4
  • 4
    • 0032545292 scopus 로고    scopus 로고
    • A new protein conjugation system in human: The counterpart of the yeast Apg12p conjugation system essential for autophagy
    • DOI 10.1074/jbc.273.51.33889
    • Mizushima N, Sugita H, Yoshimori T, Ohsumi Y. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem 1998;273:33889-92. (Pubitemid 29008848)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.51 , pp. 33889-33892
    • Mizushima, N.1    Sugita, H.2    Yoshimori, T.3    Ohsumi, Y.4
  • 5
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000;19:5720-8.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3
  • 6
    • 0035911162 scopus 로고    scopus 로고
    • Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
    • Mizushima N, Yamamoto A, Hatano M, et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 2001;152:657-68.
    • (2001) J Cell Biol , vol.152 , pp. 657-668
    • Mizushima, N.1    Yamamoto, A.2    Hatano, M.3
  • 8
    • 43949143804 scopus 로고    scopus 로고
    • The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy
    • Fujita N, Itoh T, Omori H, Fukuda M, Noda T, Yoshimori T. The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell 2008;19:2092-100.
    • (2008) Mol Biol Cell , vol.19 , pp. 2092-2100
    • Fujita, N.1    Itoh, T.2    Omori, H.3    Fukuda, M.4    Noda, T.5    Yoshimori, T.6
  • 9
    • 0034707036 scopus 로고    scopus 로고
    • A ubiquitin-like system mediates protein lipidation
    • Ichimura Y, Kirisako T, Takao T, et al. A ubiquitin-like system mediates protein lipidation. Nature 2000;408:488-92.
    • (2000) Nature , vol.408 , pp. 488-492
    • Ichimura, Y.1    Kirisako, T.2    Takao, T.3
  • 10
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • Klionsky DJ, Abeliovich H, Agostinis P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008;4:151-75.
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1    Abeliovich, H.2    Agostinis, P.3
  • 11
    • 0014148066 scopus 로고
    • Participation of lysosomes in cellular autophagy induced in rat liver by glucagon
    • Deter RL, Baudhuin P, de Duve C. Participation of lysosomes in cellular autophagy induced in rat liver by glucagon. J Cell Biol 1967;35:C11-C16.
    • (1967) J Cell Biol , vol.35
    • Deter, R.L.1    Baudhuin, P.2    De Duve, C.3
  • 12
    • 0017816161 scopus 로고
    • Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy
    • Pfeifer U. Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy. J Cell Biol 1978;78:152-67. (Pubitemid 8369897)
    • (1978) Journal of Cell Biology , vol.78 , Issue.1 , pp. 152-167
    • Pfeifer, U.1
  • 13
    • 0017697151 scopus 로고
    • Induction of autophagy by amino-acid deprivation in perfused rat liver
    • DOI 10.1038/270174a0
    • Mortimore GE, Schworer CM. Induction of autophagy by amino-acid deprivation in perfused rat liver. Nature 1977;270:174-6. (Pubitemid 8209074)
    • (1977) Nature , vol.270 , Issue.5633 , pp. 174-176
    • Mortimore, G.E.1    Schworer, C.M.2
  • 14
    • 0032512636 scopus 로고    scopus 로고
    • Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
    • DOI 10.1074/jbc.273.7.3963
    • Noda T, Ohsumi Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem 1998;273:3963-6. (Pubitemid 28103257)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.7 , pp. 3963-3966
    • Noda, T.1    Ohsumi, Y.2
  • 15
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
    • DOI 10.1016/S0092-8674(03)00929-2
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115:577-90. (Pubitemid 37506046)
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 18
    • 44949237240 scopus 로고    scopus 로고
    • JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy
    • DOI 10.1016/j.molcel.2008.06.001, PII S1097276508003894
    • Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008;30:678-88. (Pubitemid 351818252)
    • (2008) Molecular Cell , vol.30 , Issue.6 , pp. 678-688
    • Wei, Y.1    Pattingre, S.2    Sinha, S.3    Bassik, M.4    Levine, B.5
  • 19
    • 61849102389 scopus 로고    scopus 로고
    • DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
    • Zalckvar E, Berissi H, Mizrachy L, et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep 2009;10:285-92.
    • (2009) EMBO Rep , vol.10 , pp. 285-292
    • Zalckvar, E.1    Berissi, H.2    Mizrachy, L.3
  • 20
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: An innocent convict?
    • DOI 10.1172/JCI26390
    • Levine B, Yuan J. Autophagy in cell death: An innocent convict? J Clin Invest 2005;115:2679-88. (Pubitemid 41434392)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.10 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 22
    • 41449098293 scopus 로고    scopus 로고
    • Downregulation of autophagy by herpesvirus Bcl-2 homologs
    • Liang C, E X, Jung JU. Downregulation of autophagy by herpesvirus Bcl-2 homologs. Autophagy 2008;4:268-72. (Pubitemid 351458084)
    • (2008) Autophagy , vol.4 , Issue.3 , pp. 268-272
    • Liang, C.1    Xiaofei, E.2    Jung, J.U.3
  • 24
    • 57649184088 scopus 로고    scopus 로고
    • Control of autophagy by oncogenes and tumor suppressor genes
    • Maiuri MC, Tasdemir E, Criollo A, et al. Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ 2009;16:87-93.
    • (2009) Cell Death Differ , vol.16 , pp. 87-93
    • Maiuri, M.C.1    Tasdemir, E.2    Criollo, A.3
  • 26
  • 27
    • 53049103308 scopus 로고    scopus 로고
    • Structural basis for sorting mechanism of p62 in selective autophagy
    • Ichimura Y, Kumanomidou T, Sou YS, et al. Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem 2008;283:22847-57.
    • (2008) J Biol Chem , vol.283 , pp. 22847-22857
    • Ichimura, Y.1    Kumanomidou, T.2    Sou, Y.S.3
  • 28
    • 78651282673 scopus 로고    scopus 로고
    • P62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding
    • Itakura E, Mizushima N. p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol 2011;192:17-27.
    • (2011) J Cell Biol , vol.192 , pp. 17-27
    • Itakura, E.1    Mizushima, N.2
  • 29
    • 33744958258 scopus 로고    scopus 로고
    • Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole
    • DOI 10.1074/jbc.M509157200
    • Birmingham CL, Smith AC, Bakowski MA, Yoshimori T, Brumell JH. Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J Biol Chem 2006;281:11374-83. (Pubitemid 43855562)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.16 , pp. 11374-11383
    • Birmingham, C.L.1    Smith, A.C.2    Bakowski, M.A.3    Yoshimori, T.4    Brumell, J.H.5
  • 30
    • 34250820407 scopus 로고    scopus 로고
    • The autophagic pathway: A cell survival strategy against the bacterial pore-forming toxin Vibrio cholerae cytolysin
    • Saka HA, Gutierrez MG, Bocco JL, Colombo MI. The autophagic pathway: A cell survival strategy against the bacterial pore-forming toxin Vibrio cholerae cytolysin. Autophagy 2007;3:363-5. (Pubitemid 46986344)
    • (2007) Autophagy , vol.3 , Issue.4 , pp. 363-365
    • Saka, H.A.1    Gutierrez, M.G.2    Bocco, J.L.3    Colombo, M.I.4
  • 31
    • 23844514084 scopus 로고    scopus 로고
    • Modulation of host cell signal transduction pathways by Helicobacter pylori infection
    • Ceponis PJ, Jones NL. Modulation of host cell signal transduction pathways by Helicobacter pylori infection. Can J Gastroenterol 2005;19:415-20. (Pubitemid 41149884)
    • (2005) Canadian Journal of Gastroenterology , vol.19 , Issue.7 , pp. 415-420
    • Ceponis, P.J.M.1    Jones, N.L.2
  • 33
    • 65249135604 scopus 로고    scopus 로고
    • Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells
    • Terebiznik MR, Raju D, Vazquez CL, et al. Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy 2009;5:370-9.
    • (2009) Autophagy , vol.5 , pp. 370-379
    • Terebiznik, M.R.1    Raju, D.2    Vazquez, C.L.3
  • 34
    • 67649607465 scopus 로고    scopus 로고
    • Autophagy, immunity, and microbial adaptations
    • Deretic V, Levine B. Autophagy, immunity, and microbial adaptations. Cell Host Microbe 2009;5:527-49.
    • (2009) Cell Host Microbe , vol.5 , pp. 527-549
    • Deretic, V.1    Levine, B.2
  • 35
    • 13244256806 scopus 로고    scopus 로고
    • Escape of intracellular Shigella from autophagy
    • DOI 10.1126/science.1106036
    • Ogawa M, Yoshimori T, Suzuki T, Sagara H, Mizushima N, Sasakawa C. Escape of intracellular Shigella from autophagy. Science 2005;307:727-31. (Pubitemid 40194643)
    • (2005) Science , vol.307 , Issue.5710 , pp. 727-731
    • Ogawa, M.1    Yoshimori, T.2    Suzuki, T.3    Sagara, H.4    Mizushima, N.5    Sasakawa, C.6
  • 36
    • 77749292148 scopus 로고    scopus 로고
    • The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
    • Sir D, Tian Y, Chen WL, Ann DK, Yen TS, Ou JH. The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc Natl Acad Sci USA 2010;107:4383-8.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4383-4388
    • Sir, D.1    Tian, Y.2    Chen, W.L.3    Ann, D.K.4    Yen, T.S.5    Ou, J.H.6
  • 37
    • 79251512287 scopus 로고    scopus 로고
    • Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes
    • Shrivastava S, Raychoudhuri A, Steele R, Ray R, Ray RB. Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes. Hepatology 2011;53:406-14.
    • (2011) Hepatology , vol.53 , pp. 406-414
    • Shrivastava, S.1    Raychoudhuri, A.2    Steele, R.3    Ray, R.4    Ray, R.B.5
  • 38
    • 69549135689 scopus 로고    scopus 로고
    • The autophagy machinery is required to initiate hepatitis C virus replication
    • Dreux M, Gastaminza P, Wieland SF, Chisari FV. The autophagy machinery is required to initiate hepatitis C virus replication. Proc Natl Acad Sci USA 2009;106:14046-51.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14046-14051
    • Dreux, M.1    Gastaminza, P.2    Wieland, S.F.3    Chisari, F.V.4
  • 40
    • 54849421128 scopus 로고    scopus 로고
    • Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
    • Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS One 2008;3:e3391.
    • (2008) PLoS One , vol.3
    • Kuballa, P.1    Huett, A.2    Rioux, J.D.3    Daly, M.J.4    Xavier, R.J.5
  • 41
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    • Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008;456:264-8.
    • (2008) Nature , vol.456 , pp. 264-268
    • Saitoh, T.1    Fujita, N.2    Jang, M.H.3
  • 42
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008;456:259-63.
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3
  • 43
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    • Cadwell K, Patel KK, Maloney NS, et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 2010;141:1135-45.
    • (2010) Cell , vol.141 , pp. 1135-1145
    • Cadwell, K.1    Patel, K.K.2    Maloney, N.S.3
  • 45
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos LH, Carneiro LA, Ramjeet M, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2010;11:55-62.
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1    Carneiro, L.A.2    Ramjeet, M.3
  • 46
    • 77957682295 scopus 로고    scopus 로고
    • ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis
    • Homer CR, Richmond AL, Rebert NA, Achkar JP, McDonald C. ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology 2010;139:1630-41.
    • (2010) Gastroenterology , vol.139 , pp. 1630-1641
    • Homer, C.R.1    Richmond, A.L.2    Rebert, N.A.3    Achkar, J.P.4    McDonald, C.5
  • 47
    • 33846224369 scopus 로고    scopus 로고
    • Antigen-Loading Compartments for Major Histocompatibility Complex Class II Molecules Continuously Receive Input from Autophagosomes
    • DOI 10.1016/j.immuni.2006.10.018, PII S1074761306005255
    • Schmid D, Pypaert M, Munz C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 2007;26:79-92. (Pubitemid 46109341)
    • (2007) Immunity , vol.26 , Issue.1 , pp. 79-92
    • Schmid, D.1    Pypaert, M.2    Munz, C.3
  • 48
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney R, Baker J, Brain O, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 2010;16:90-7.
    • (2010) Nat Med , vol.16 , pp. 90-97
    • Cooney, R.1    Baker, J.2    Brain, O.3
  • 49
    • 33748506089 scopus 로고    scopus 로고
    • Human IRGM induces autophagy to eliminate intracellular mycobacteria
    • DOI 10.1126/science.1129577
    • Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 2006;313:1438-41. (Pubitemid 44360272)
    • (2006) Science , vol.313 , Issue.5792 , pp. 1438-1441
    • Singh, S.B.1    Davis, A.S.2    Taylor, G.A.3    Deretic, V.4
  • 50
    • 50449091647 scopus 로고    scopus 로고
    • Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
    • McCarroll SA, Huett A, Kuballa P, et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 2008;40:1107-12.
    • (2008) Nat Genet , vol.40 , pp. 1107-1112
    • McCarroll, S.A.1    Huett, A.2    Kuballa, P.3
  • 51
    • 79952134938 scopus 로고    scopus 로고
    • A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease
    • Brest P, Lapaquette P, Souidi M, et al. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat Genet 2011;43:242-5.
    • (2011) Nat Genet , vol.43 , pp. 242-245
    • Brest, P.1    Lapaquette, P.2    Souidi, M.3
  • 53
    • 70449426665 scopus 로고    scopus 로고
    • Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis
    • Mareninova OA, Hermann K, French SW, et al. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. J Clin Invest 2009;119:3340-55.
    • (2009) J Clin Invest , vol.119 , pp. 3340-3355
    • Mareninova, O.A.1    Hermann, K.2    French, S.W.3
  • 54
    • 79953144994 scopus 로고    scopus 로고
    • Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death
    • Grasso D, Ropolo A, Lo RA, at al. Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death. J Biol Chem 2011;286:8308-24.
    • (2011) J Biol Chem , vol.286 , pp. 8308-8324
    • Grasso, D.1    Ropolo, A.2    Lo, R.A.3
  • 55
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 2009;15:5308-16.
    • (2009) Clin Cancer Res , vol.15 , pp. 5308-5316
    • White, E.1    DiPaola, R.S.2
  • 57
    • 56449107131 scopus 로고    scopus 로고
    • Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma
    • Ding ZB, Shi YH, Zhou J, et al. Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res 2008;68:9167-75.
    • (2008) Cancer Res , vol.68 , pp. 9167-9175
    • Ding, Z.B.1    Shi, Y.H.2    Zhou, J.3
  • 58
    • 1242296021 scopus 로고    scopus 로고
    • Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability
    • DOI 10.1038/sj.onc.1207178
    • Ionov Y, Nowak N, Perucho M, Markowitz S, Cowell JK. Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability. Oncogene 2004;23:639-45. (Pubitemid 38241265)
    • (2004) Oncogene , vol.23 , Issue.3 , pp. 639-645
    • Ionov, Y.1    Nowak, N.2    Perucho, M.3    Markowitz, S.4    Cowell, J.K.5
  • 59
    • 45049083880 scopus 로고    scopus 로고
    • Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability
    • Kim MS, Jeong EG, Ahn CH, Kim SS, Lee SH, Yoo NJ. Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability. Hum Pathol 2008;39:1059-63.
    • (2008) Hum Pathol , vol.39 , pp. 1059-1063
    • Kim, M.S.1    Jeong, E.G.2    Ahn, C.H.3    Kim, S.S.4    Lee, S.H.5    Yoo, N.J.6
  • 60
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • Liang C, Feng P, Ku B, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006;8:688-99.
    • (2006) Nat Cell Biol , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3
  • 61
    • 57349087153 scopus 로고    scopus 로고
    • Pivotal role of mTOR signaling in hepatocellular carcinoma
    • Villanueva A, Chiang DY, Newell P, et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 2008;135:1972-83.
    • (2008) Gastroenterology , vol.135 , pp. 1972-1983
    • Villanueva, A.1    Chiang, D.Y.2    Newell, P.3
  • 63
    • 77950624678 scopus 로고    scopus 로고
    • Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma
    • Toso C, Merani S, Bigam DL, Shapiro AM, Kneteman NM. Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma. Hepatology 2010;51:1237-43.
    • (2010) Hepatology , vol.51 , pp. 1237-1243
    • Toso, C.1    Merani, S.2    Bigam, D.L.3    Shapiro, A.M.4    Kneteman, N.M.5
  • 64
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K, Mathew R, Beaudoin B, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006;10:51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3
  • 65
    • 40449086885 scopus 로고    scopus 로고
    • Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
    • DOI 10.1158/0008-5472.CAN-07-0562
    • Apel A, Herr I, Schwarz H, Rodemann HP, Mayer A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 2008;68:1485-94. (Pubitemid 351346857)
    • (2008) Cancer Research , vol.68 , Issue.5 , pp. 1485-1494
    • Apel, A.1    Herr, I.2    Schwarz, H.3    Rodemann, H.P.4    Mayer, A.5
  • 66
    • 33750565745 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells
    • DOI 10.1158/0008-5472.CAN-06-0802
    • Cao C, Subhawong T, Albert JM, et al. Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells. Cancer Res 2006;66:10040-7. (Pubitemid 44672057)
    • (2006) Cancer Research , vol.66 , Issue.20 , pp. 10040-10047
    • Cao, C.1    Subhawong, T.2    Albert, J.M.3    Kim, K.W.4    Geng, L.5    Sekhar, K.R.6    Gi, Y.J.7    Lu, B.8
  • 69
    • 77950509348 scopus 로고    scopus 로고
    • Autophagy and tumorigenesis
    • Chen N, Debnath J. Autophagy and tumorigenesis. FEBS Lett 2010;584:1427-35.
    • (2010) FEBS Lett , vol.584 , pp. 1427-1435
    • Chen, N.1    Debnath, J.2
  • 70
    • 28244499949 scopus 로고    scopus 로고
    • 1-antitrypsin Z in the endoplasmic reticulum activities caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response
    • DOI 10.1074/jbc.M508652200
    • Hidvegi T, Schmidt BZ, Hale P, Perlmutter DH. Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response. J Biol Chem 2005;280:39002-15. (Pubitemid 41713850)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.47 , pp. 39002-39015
    • Hidvegi, T.1    Schmidt, B.Z.2    Hale, P.3    Perlmutter, D.H.4
  • 71
    • 0033671965 scopus 로고    scopus 로고
    • Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response
    • Teckman JH, Perlmutter DH. Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response. Am J Physiol Gastrointest Liver Physiol 2000;279:G961-74.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279
    • Teckman, J.H.1    Perlmutter, D.H.2
  • 72
    • 77954597127 scopus 로고    scopus 로고
    • An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis
    • Hidvegi T, Ewing M, Hale P, et al. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science 2010;329:229-32.
    • (2010) Science , vol.329 , pp. 229-232
    • Hidvegi, T.1    Ewing, M.2    Hale, P.3
  • 73
    • 77956396747 scopus 로고    scopus 로고
    • Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
    • Luciani A, Villella VR, Esposito S, et al. Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat Cell Biol 2010;12:863-75.
    • (2010) Nat Cell Biol , vol.12 , pp. 863-875
    • Luciani, A.1    Villella, V.R.2    Esposito, S.3
  • 74
    • 47249102033 scopus 로고    scopus 로고
    • Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation
    • Maiuri L, Luciani A, Giardino I, et al. Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation. J Immunol 2008;180:7697-705.
    • (2008) J Immunol , vol.180 , pp. 7697-7705
    • Maiuri, L.1    Luciani, A.2    Giardino, I.3
  • 75
    • 70149091116 scopus 로고    scopus 로고
    • SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation
    • Luciani A, Villella VR, Vasaturo A, et al. SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation. J Immunol 2009;183:2775-84.
    • (2009) J Immunol , vol.183 , pp. 2775-2784
    • Luciani, A.1    Villella, V.R.2    Vasaturo, A.3
  • 76
    • 68949194361 scopus 로고    scopus 로고
    • Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury
    • Cardinal J, Pan P, Dhupar R, et al. Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury. Hepatology 2009;50:565-74.
    • (2009) Hepatology , vol.50 , pp. 565-574
    • Cardinal, J.1    Pan, P.2    Dhupar, R.3
  • 77
    • 65249154907 scopus 로고    scopus 로고
    • Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation
    • Gotoh K, Lu Z, Morita M, et al. Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. Autophagy 2009;5:351-60.
    • (2009) Autophagy , vol.5 , pp. 351-360
    • Gotoh, K.1    Lu, Z.2    Morita, M.3
  • 78
    • 0022970945 scopus 로고
    • Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
    • Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986;74:1124-36. (Pubitemid 17174962)
    • (1986) Circulation , vol.74 , Issue.5 , pp. 1124-1136
    • Murry, C.E.1    Jennings, R.B.2    Reimer, K.A.3
  • 79
    • 70349829009 scopus 로고    scopus 로고
    • Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapy
    • Domart MC, Esposti DD, Sebagh M, et al. Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapy. J Hepatol 2009;51:881-9.
    • (2009) J Hepatol , vol.51 , pp. 881-889
    • Domart, M.C.1    Esposti, D.D.2    Sebagh, M.3
  • 81
    • 0842289171 scopus 로고    scopus 로고
    • A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning
    • Clavien PA, Selzner M, Rudiger HA, et al. A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning. Ann Surg 2003;238:843-50.
    • (2003) Ann Surg , vol.238 , pp. 843-850
    • Clavien, P.A.1    Selzner, M.2    Rudiger, H.A.3
  • 83
    • 75149129643 scopus 로고    scopus 로고
    • Autophagy is induced by ischemic preconditioning in human livers formerly treated by chemotherapy to limit necrosis
    • Esposti DD, Domart MC, Sebagh M, et al. Autophagy is induced by ischemic preconditioning in human livers formerly treated by chemotherapy to limit necrosis. Autophagy 2010;6:172-4.
    • (2010) Autophagy , vol.6 , pp. 172-174
    • Esposti, D.D.1    Domart, M.C.2    Sebagh, M.3
  • 84
    • 37649024076 scopus 로고    scopus 로고
    • Small molecule regulators of autophagy identified by an image-based high-throughput screen
    • Zhang L, Yu J, Pan H, et al. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci USA 2007;104:19023-8.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19023-19028
    • Zhang, L.1    Yu, J.2    Pan, H.3
  • 85
    • 67549135481 scopus 로고    scopus 로고
    • Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy
    • Laane E, Tamm KP, Buentke E, et al. Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ 2009;16:1018-29.
    • (2009) Cell Death Differ , vol.16 , pp. 1018-1029
    • Laane, E.1    Tamm, K.P.2    Buentke, E.3
  • 86
    • 60849100558 scopus 로고    scopus 로고
    • Epstein-Barr virus, rapamycin, and host immune responses
    • Krams SM, Martinez OM. Epstein-Barr virus, rapamycin, and host immune responses. Curr Opin Organ Transplant 2008;13:563-8.
    • (2008) Curr Opin Organ Transplant , vol.13 , pp. 563-568
    • Krams, S.M.1    Martinez, O.M.2
  • 87
    • 37849042536 scopus 로고    scopus 로고
    • A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
    • Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum Mol Genet 2008;17:170-8.
    • (2008) Hum Mol Genet , vol.17 , pp. 170-178
    • Sarkar, S.1    Krishna, G.2    Imarisio, S.3    Saiki, S.4    O'Kane, C.J.5    Rubinsztein, D.C.6


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