Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling

Apoptosis

Volumn 17, Issue 12, 2012, Pages 1275-1286

  Lee, Ju Hye ^a   Won, Yeong Seon ^a   Park, Ki Hun ^b   Lee, Mi Kyung ^a   Tachibana, Hirofumi ^c   Yamada, Koji ^c   Seo, Kwon Il ^a  

^a Sunchon National University   (South Korea)

^b Gyeongsang National University   (South Korea)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Apoptosis inducing factor; B16 melanoma; Celastrol; Reactive oxygen species

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; APOPTOSIS INDUCING FACTOR; CASPASE; CELASTROL; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME METABOLISM; IN VIVO STUDY; MELANOMA; MELANOMA CELL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TISSUE CULTURE;

APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; HUMANS; MELANOMA; MITOCHONDRIA; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84872054236     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0767-5     Document Type: Article

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