Proteasome inhibitors activate autophagy involving inhibition of PI3K-Akt-mTOR pathway as an anti-oxidation defense in human RPE cells

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Tang, Bingrong ^a,b   Cai, Jingjing ^a,b   Sun, Lin ^a,b   Li, Yiping ^c   Qu, Jia ^a,b   Snider, Barbara Joy ^d   Wu, Shengzhou ^a,b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b BEIJING HOSPITAL   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; ATG7 PROTEIN; AUTOPHAGY PROTEIN 5; BAFILOMYCIN A1; BARRIER TO AUTOINTEGRATION FACTOR; CELL PROTEIN; EPOXOMICIN; LACTACYSTIN BETA LACTONE; MAMMALIAN TARGET OF RAPAMYCIN; MENADIONE; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P62; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ATG5 PROTEIN, HUMAN; ATG7 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PROTEASOME INHIBITOR; TARGET OF RAPAMYCIN KINASE; UBIQUITIN PROTEIN LIGASE;

ARTICLE; AUTOPHAGY; CELL PROTECTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LYSOSOME; OXIDATIVE STRESS; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN TARGETING; RETINA CELL; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION;

AUTOPHAGY; CELL LINE; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEASOME INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84904896551     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103364     Document Type: Article

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