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Volumn 10, Issue 7, 2013, Pages 395-401

Autophagy: A new target or an old strategy for the treatment of Crohn's disease?

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; CERTOLIZUMAB PEGOL; CURCUMIN; ETANERCEPT; EVEROLIMUS; GOLIMUMAB; HYDROXYCHLOROQUINE; INFLIXIMAB; MERCAPTOPURINE; RAPAMYCIN; TUMOR NECROSIS FACTOR ANTIBODY;

EID: 84879993550     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2013.66     Document Type: Review
Times cited : (44)

References (85)
  • 1
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins, L. et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119-124 (2012).
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1
  • 2
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke, A. et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 42, 1118-1125 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 1118-1125
    • Franke, A.1
  • 3
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett, J. C. et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40, 955-962 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 955-962
    • Barrett, J.C.1
  • 4
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe, J. et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 39, 207-211 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 207-211
    • Hampe, J.1
  • 5
    • 34347338690 scopus 로고    scopus 로고
    • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    • Parkes, M. et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat. Genet. 39, 830-832 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 830-832
    • Parkes, M.1
  • 6
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606 (2001).
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1
  • 7
    • 79955790354 scopus 로고    scopus 로고
    • Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease
    • Henckaerts, L. et al. Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease. Inflamm. Bowel Dis. 17, 1392-1397 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 1392-1397
    • Henckaerts, L.1
  • 8
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • Mizushima, N. & Komatsu, M. Autophagy: renovation of cells and tissues. Cell 147, 728-741 (2011).
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 9
    • 84877628647 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • Choi, A. M., Ryter, S. W. & Levine, B. Autophagy in human health and disease. N. Engl. J. Med. 368, 651-662 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 651-662
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 11
    • 84857039937 scopus 로고    scopus 로고
    • Autophagy as an innate immunity paradigm: Expanding the scope and repertoire of pattern recognition receptors
    • Deretic, V. Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors. Curr. Opin. Immunol. 24, 21-31 (2012).
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 21-31
    • Deretic, V.1
  • 12
    • 76249112828 scopus 로고    scopus 로고
    • Autophagy protects against Sindbis virus infection of the central nervous system
    • Orvedahl, A. et al. Autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Microbe 7, 115-127 (2010).
    • (2010) Cell Host Microbe , vol.7 , pp. 115-127
    • Orvedahl, A.1
  • 13
    • 84865220380 scopus 로고    scopus 로고
    • Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway
    • Watson, R. O., Manzanillo, P. S. & Cox, J. S. Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. Cell 150, 803-815 (2012).
    • (2012) Cell , vol.150 , pp. 803-815
    • Watson, R.O.1    Manzanillo, P.S.2    Cox, J.S.3
  • 14
    • 68349143052 scopus 로고    scopus 로고
    • Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy
    • Dupont, N. et al. Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe 6, 137-149 (2009).
    • (2009) Cell Host Microbe , vol.6 , pp. 137-149
    • Dupont, N.1
  • 15
    • 70349652310 scopus 로고    scopus 로고
    • Listeria monocytogenes ActA-mediated escape from autophagic recognition
    • Yoshikawa, Y. et al. Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat. Cell Biol. 11, 1233-1240 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1233-1240
    • Yoshikawa, Y.1
  • 16
    • 84857071710 scopus 로고    scopus 로고
    • Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion
    • Thurston, T. L., Wandel, M. P., von Muhlinen, N., Foeglein, A. & Randow, F. Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature 482, 414-418 (2012).
    • (2012) Nature , vol.482 , pp. 414-418
    • Thurston, T.L.1    Wandel, M.P.2    Von Muhlinen, N.3    Foeglein, A.4    Randow, F.5
  • 17
    • 34250802980 scopus 로고    scopus 로고
    • Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy
    • Alonso, S., Pethe, K., Russell, D. G. & Purdy, G. E. Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy. Proc. Natl Acad. Sci. USA 104, 6031-6036 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6031-6036
    • Alonso, S.1    Pethe, K.2    Russell, D.G.3    Purdy, G.E.4
  • 18
    • 77949997805 scopus 로고    scopus 로고
    • Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties
    • Ponpuak, M. et al. Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity 32, 329-341 (2010).
    • (2010) Immunity , vol.32 , pp. 329-341
    • Ponpuak, M.1
  • 19
    • 79955777383 scopus 로고    scopus 로고
    • A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection
    • Kim, B. H. et al. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Science 332, 717-721 (2011).
    • (2011) Science , vol.332 , pp. 717-721
    • Kim, B.H.1
  • 20
    • 34447643958 scopus 로고    scopus 로고
    • Toll-like receptor 4 is a sensor for autophagy associated with innate immunity
    • Xu, Y. et al. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27, 135-144 (2007).
    • (2007) Immunity , vol.27 , pp. 135-144
    • Xu, Y.1
  • 22
    • 57749100267 scopus 로고    scopus 로고
    • MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
    • Shi, C. S. & Kehrl, J. H. MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. J. Biol. Chem. 283, 33175-33182 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 33175-33182
    • Shi, C.S.1    Kehrl, J.H.2
  • 23
    • 70649102264 scopus 로고    scopus 로고
    • Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease
    • de Vries, H. S. et al. Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease. PLoS ONE 4, e7818 (2009).
    • (2009) PLoS ONE , vol.4
    • De Vries, H.S.1
  • 24
    • 84861964286 scopus 로고    scopus 로고
    • Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
    • Iliev, I. D. et al. Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science 336, 1314-1317 (2012).
    • (2012) Science , vol.336 , pp. 1314-1317
    • Iliev, I.D.1
  • 25
    • 33947134377 scopus 로고    scopus 로고
    • Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    • Lee, H. K., Lund, J. M., Ramanathan, B., Mizushima, N. & Iwasaki, A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315, 1398-1401 (2007).
    • (2007) Science , vol.315 , pp. 1398-1401
    • Lee, H.K.1    Lund, J.M.2    Ramanathan, B.3    Mizushima, N.4    Iwasaki, A.5
  • 27
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
    • Saitoh, T. et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature 456, 264-268 (2008).
    • (2008) Nature , vol.456 , pp. 264-268
    • Saitoh, T.1
  • 28
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou, R., Yazdi, A. S., Menu, P. & Tschopp, J. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225 (2011).
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 29
    • 77149152566 scopus 로고    scopus 로고
    • Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation
    • Manjithaya, R., Anjard, C., Loomis, W. F. & Subramani, S. Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation. J. Cell Biol. 188, 537-546 (2010).
    • (2010) J. Cell Biol. , vol.188 , pp. 537-546
    • Manjithaya, R.1    Anjard, C.2    Loomis, W.F.3    Subramani, S.4
  • 30
    • 83755181759 scopus 로고    scopus 로고
    • Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice
    • Michaud, M. et al. Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science 334, 1573-1577 (2011).
    • (2011) Science , vol.334 , pp. 1573-1577
    • Michaud, M.1
  • 31
    • 82455210868 scopus 로고    scopus 로고
    • Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β
    • Dupont, N. et al. Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β. EMBO J. 30, 4701-4711 (2011).
    • (2011) EMBO J. , vol.30 , pp. 4701-4711
    • Dupont, N.1
  • 32
    • 84857195479 scopus 로고    scopus 로고
    • Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    • Shi, C. S. et al. Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat. Immunol. 13, 255-263 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 255-263
    • Shi, C.S.1
  • 33
    • 80051550866 scopus 로고    scopus 로고
    • Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
    • Plantinga, T. S. et al. Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut 60, 1229-1235 (2011).
    • (2011) Gut , vol.60 , pp. 1229-1235
    • Plantinga, T.S.1
  • 34
    • 79953176280 scopus 로고    scopus 로고
    • Autophagy controls IL-1β secretion by targeting pro-IL-1β for degradation
    • Harris, J. et al. Autophagy controls IL-1β secretion by targeting pro-IL-1β for degradation. J. Biol. Chem. 286, 9587-9597 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 9587-9597
    • Harris, J.1
  • 35
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • Nedjic, J., Aichinger, M., Emmerich, J., Mizushima, N. & Klein, L. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 455, 396-400 (2008).
    • (2008) Nature , vol.455 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3    Mizushima, N.4    Klein, L.5
  • 36
    • 84865279637 scopus 로고    scopus 로고
    • The contribution of autophagy to lymphocyte survival and homeostasis
    • McLeod, I. X., Jia, W. & He, Y. W. The contribution of autophagy to lymphocyte survival and homeostasis. Immunol. Rev. 249, 195-204 (2012).
    • (2012) Immunol. Rev. , vol.249 , pp. 195-204
    • McLeod, I.X.1    Jia, W.2    He, Y.W.3
  • 37
    • 84878633889 scopus 로고    scopus 로고
    • Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions
    • Strisciuglio, C. et al. Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions. J. Crohns Colitis http://dx.doi.org/10.1016/ j.crohns.2012.08.009.
    • J. Crohns Colitis
    • Strisciuglio, C.1
  • 38
    • 84861615385 scopus 로고    scopus 로고
    • Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse
    • Wildenberg, M. E. et al. Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse. Gastroenterology 142, 1493-1503 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 1493-1503
    • Wildenberg, M.E.1
  • 39
    • 84860516885 scopus 로고    scopus 로고
    • TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts
    • Connor, A. M., Mahomed, N., Gandhi, R., Keystone, E. C. & Berger, S. A. TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts. Arthritis Res. Ther. 14, R62 (2012).
    • (2012) Arthritis Res. Ther. , vol.14
    • Connor, A.M.1    Mahomed, N.2    Gandhi, R.3    Keystone, E.C.4    Berger, S.A.5
  • 40
    • 79952800563 scopus 로고    scopus 로고
    • TNF-α induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells
    • Keller, C. W. et al. TNF-α induces macroautophagy and regulates MHC class II expression in human skeletal muscle cells. J. Biol. Chem. 286, 3970-3980 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 3970-3980
    • Keller, C.W.1
  • 41
    • 33747863220 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and TNF-α regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells
    • Jia, G., Cheng, G., Gangahar, D. M. & Agrawal, D. K. Insulin-like growth factor-1 and TNF-α regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells. Immunol. Cell Biol. 84, 448-454 (2006).
    • (2006) Immunol. Cell Biol. , vol.84 , pp. 448-454
    • Jia, G.1    Cheng, G.2    Gangahar, D.M.3    Agrawal, D.K.4
  • 42
    • 77953274576 scopus 로고    scopus 로고
    • How tumour necrosis factor blockers interfere with tuberculosis immunity
    • Harris, J. & Keane, J. How tumour necrosis factor blockers interfere with tuberculosis immunity. Clin. Exp. Immunol. 161, 1-9 (2010).
    • (2010) Clin. Exp. Immunol. , vol.161 , pp. 1-9
    • Harris, J.1    Keane, J.2
  • 43
    • 84869217908 scopus 로고    scopus 로고
    • Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation
    • Castillo, E. F. et al. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc. Natl Acad. Sci. USA 109, E3168-E3176 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109
    • Castillo, E.F.1
  • 44
    • 84866346322 scopus 로고    scopus 로고
    • Intestinal epithelial cells with impaired autophagy lose their adhesive capacity in the presence of TNF-α
    • Saito, M. et al. Intestinal epithelial cells with impaired autophagy lose their adhesive capacity in the presence of TNF-α. Dig. Dis. Sci. 57, 2022-2030 (2012).
    • (2012) Dig. Dis. Sci. , vol.57 , pp. 2022-2030
    • Saito, M.1
  • 45
    • 0038047689 scopus 로고    scopus 로고
    • Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease
    • Van den Brande, J. M. et al. Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease. Gastroenterology 124, 1774-1785 (2003).
    • (2003) Gastroenterology , vol.124 , pp. 1774-1785
    • Van Den Brande, J.M.1
  • 46
    • 84895852433 scopus 로고    scopus 로고
    • ATG16L1 genotype is associated with response to anti-TNF in vitro [abstract P668]
    • Wildenberg, M. et al. ATG16L1 genotype is associated with response to anti-TNF in vitro [abstract P668]. J. Crohns Colitis 7 (Suppl. 1), S279 (2013).
    • (2013) J. Crohns Colitis , vol.7 , Issue.SUPPL. 1
    • Wildenberg, M.1
  • 48
    • 40049104027 scopus 로고    scopus 로고
    • Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes
    • Petit, E. et al. Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes. Toxicol. in Vitro 22, 632-642 (2008).
    • (2008) Toxicol. in Vitro , vol.22 , pp. 632-642
    • Petit, E.1
  • 49
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer, G., Marino, G. & Levine, B. Autophagy and the integrated stress response. Mol. Cell 40, 280-293 (2010).
    • (2010) Mol. Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Marino, G.2    Levine, B.3
  • 50
    • 84863098088 scopus 로고    scopus 로고
    • Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde?
    • Zhou, S. et al. Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde? Cancer Lett. 323, 115-127 (2012).
    • (2012) Cancer Lett. , vol.323 , pp. 115-127
    • Zhou, S.1
  • 51
    • 78651272184 scopus 로고    scopus 로고
    • Use of complementary and alternative medicine by patients with inflammatory bowel disease
    • Hilsden, R. J., Verhoef, M. J., Rasmussen, H., Porcino, A. & deBruyn, J. C. Use of complementary and alternative medicine by patients with inflammatory bowel disease. Inflamm. Bowel Dis. 17, 655-662 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 655-662
    • Hilsden, R.J.1    Verhoef, M.J.2    Rasmussen, H.3    Porcino, A.4    Debruyn, J.C.5
  • 52
    • 84859121115 scopus 로고    scopus 로고
    • Curcumin and inflammatory bowel disease: Biological mechanisms and clinical implication
    • Ali, T., Shakir, F. & Morton, J. Curcumin and inflammatory bowel disease: biological mechanisms and clinical implication. Digestion 85, 249-255 (2012).
    • (2012) Digestion , vol.85 , pp. 249-255
    • Ali, T.1    Shakir, F.2    Morton, J.3
  • 53
    • 0033862619 scopus 로고    scopus 로고
    • Cytotoxicity antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa
    • Ramsewak, R. S., DeWitt, D. L. & Nair, M. G. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomedicine 7, 303-308 (2000).
    • (2000) Phytomedicine , vol.7 , pp. 303-308
    • Ramsewak, R.S.1    Dewitt, D.L.2    Nair, M.G.3
  • 55
    • 55949117806 scopus 로고    scopus 로고
    • Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    • Aggarwal, B. B. & Harikumar, K. B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int. J. Biochem. Cell Biol. 41, 40-59 (2009).
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 40-59
    • Aggarwal, B.B.1    Harikumar, K.B.2
  • 56
  • 57
    • 70449520196 scopus 로고    scopus 로고
    • Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti-inflammatory activity in rat colitis model
    • Yadav, V. R., Suresh, S., Devi, K. & Yadav, S. Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti-inflammatory activity in rat colitis model. AAPS PharmSciTech 10, 752-762 (2009).
    • (2009) AAPS PharmSciTech , vol.10 , pp. 752-762
    • Yadav, V.R.1    Suresh, S.2    Devi, K.3    Yadav, S.4
  • 58
    • 84862596482 scopus 로고    scopus 로고
    • Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage
    • Han, J. et al. Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage. Autophagy 8, 812-825 (2012).
    • (2012) Autophagy , vol.8 , pp. 812-825
    • Han, J.1
  • 59
    • 79954571967 scopus 로고    scopus 로고
    • Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
    • Alavez, S., Vantipalli, M. C., Zucker, D. J., Klang, I. M. & Lithgow, G. J. Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature 472, 226-229 (2011).
    • (2011) Nature , vol.472 , pp. 226-229
    • Alavez, S.1    Vantipalli, M.C.2    Zucker, D.J.3    Klang, I.M.4    Lithgow, G.J.5
  • 60
  • 61
    • 71749096160 scopus 로고    scopus 로고
    • Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies
    • Solomon, V. R. & Lee, H. Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies. Eur. J. Pharmacol. 625, 220-233 (2009).
    • (2009) Eur. J. Pharmacol. , vol.625 , pp. 220-233
    • Solomon, V.R.1    Lee, H.2
  • 62
    • 79953242027 scopus 로고    scopus 로고
    • Paradoxical aspects of rapamycin immunobiology in transplantation
    • Ferrer, I. R., Araki, K. & Ford, M. L. Paradoxical aspects of rapamycin immunobiology in transplantation. Am. J. Transplant. 11, 654-659 (2011).
    • (2011) Am. J. Transplant. , vol.11 , pp. 654-659
    • Ferrer, I.R.1    Araki, K.2    Ford, M.L.3
  • 63
    • 0028986784 scopus 로고
    • Hydroxychloroquine (Plaquenil) for recurrence prevention of Crohn's disease after curative surgery
    • Louis, E. & Belaiche, J. Hydroxychloroquine (Plaquenil) for recurrence prevention of Crohn's disease after curative surgery. Gastroenterol. Clin. Biol. 19, 233-234 (1995).
    • (1995) Gastroenterol. Clin. Biol. , vol.19 , pp. 233-234
    • Louis, E.1    Belaiche, J.2
  • 64
    • 56449100492 scopus 로고    scopus 로고
    • SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways
    • Glinsky, G. V. SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways. Cell Cycle 7, 3564-3576 (2008).
    • (2008) Cell Cycle , vol.7 , pp. 3564-3576
    • Glinsky, G.V.1
  • 65
    • 50249111131 scopus 로고    scopus 로고
    • Use of sirolimus (rapamycin) to treat refractory Crohn's disease
    • Massey, D. C., Bredin, F. & Parkes, M. Use of sirolimus (rapamycin) to treat refractory Crohn's disease. Gut 57, 1294-1296 (2008).
    • (2008) Gut , vol.57 , pp. 1294-1296
    • Massey, D.C.1    Bredin, F.2    Parkes, M.3
  • 66
    • 84874226167 scopus 로고    scopus 로고
    • MTOR and metabolic pathways in T cell quiescence and functional activation
    • Yang, K. & Chi, H. mTOR and metabolic pathways in T cell quiescence and functional activation. Semin. Immunol. 24, 421-428 (2013).
    • (2013) Semin. Immunol. , vol.24 , pp. 421-428
    • Yang, K.1    Chi, H.2
  • 67
    • 84869091726 scopus 로고    scopus 로고
    • Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury
    • Nakagawa, S., Nishihara, K., Inui, K. & Masuda, S. Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury. Eur. J. Pharmacol. 696, 143-154 (2012).
    • (2012) Eur. J. Pharmacol. , vol.696 , pp. 143-154
    • Nakagawa, S.1    Nishihara, K.2    Inui, K.3    Masuda, S.4
  • 68
    • 47949110435 scopus 로고    scopus 로고
    • Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: A 3-month, double-blind, randomised, placebo-controlled, parallel-group, proof-of-concept study
    • Bruyn, G. A. et al. Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: a 3-month, double-blind, randomised, placebo-controlled, parallel-group, proof-of-concept study. Ann. Rheum. Dis. 67, 1090-1095 (2008).
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 1090-1095
    • Bruyn, G.A.1
  • 69
    • 50649125243 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease
    • Reinisch, W. et al. A multicenter, randomized, double-blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease. Am. J. Gastroenterol. 103, 2284-2292 (2008).
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 2284-2292
    • Reinisch, W.1
  • 70
    • 84864544220 scopus 로고    scopus 로고
    • Pharmacological control of autophagy: Therapeutic perspectives in inflammatory bowel disease and colorectal cancer
    • Garcia-Maurino, S., Alcaide, A. & Dominguez, C. Pharmacological control of autophagy: therapeutic perspectives in inflammatory bowel disease and colorectal cancer. Curr. Pharm. Des. 18, 3853-3873 (2012).
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 3853-3873
    • Garcia-Maurino, S.1    Alcaide, A.2    Dominguez, C.3
  • 71
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell, K. et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456, 259-263 (2008).
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1
  • 72
    • 84863894144 scopus 로고    scopus 로고
    • Towards a novel molecular classification of IBD
    • Vermeire, S. Towards a novel molecular classification of IBD. Dig. Dis. 30, 425-427 (2012).
    • (2012) Dig. Dis. , vol.30 , pp. 425-427
    • Vermeire, S.1
  • 73
    • 27744574836 scopus 로고    scopus 로고
    • A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine
    • Dubinsky, M. C. et al. A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine. Am. J. Gastroenterol. 100, 2239-2247 (2005).
    • (2005) Am. J. Gastroenterol. , vol.100 , pp. 2239-2247
    • Dubinsky, M.C.1
  • 74
    • 62949219864 scopus 로고    scopus 로고
    • Biological therapies for inflammatory bowel diseases
    • Rutgeerts, P., Vermeire, S. & Van, A. G. Biological therapies for inflammatory bowel diseases. Gastroenterology 136, 1182-1197 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1182-1197
    • Rutgeerts, P.1    Vermeire, S.2    Van, A.G.3
  • 75
    • 57149132666 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase pharmacogenetics: Autophagy as a mechanism for variant allozyme degradation
    • Li, F., Wang, L., Burgess, R. J. & Weinshilboum, R. M. Thiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation. Pharmacogenet. Genomics 18, 1083-1094 (2008).
    • (2008) Pharmacogenet. Genomics , vol.18 , pp. 1083-1094
    • Li, F.1    Wang, L.2    Burgess, R.J.3    Weinshilboum, R.M.4
  • 76
    • 61549100261 scopus 로고    scopus 로고
    • Using genetic information for the identification, classification and treatment of Crohn's disease: Are we there yet?
    • Weersma, R. K. & Wijmenga, C. Using genetic information for the identification, classification and treatment of Crohn's disease: are we there yet? Expert. Rev. Gastroenterol. Hepatol. 2, 719-721 (2008).
    • (2008) Expert. Rev. Gastroenterol. Hepatol. , vol.2 , pp. 719-721
    • Weersma, R.K.1    Wijmenga, C.2
  • 77
    • 77956027655 scopus 로고    scopus 로고
    • The genetics of inflammatory bowel disease: Diagnostic and therapeutic implications
    • Cuffari, C. The genetics of inflammatory bowel disease: diagnostic and therapeutic implications. World J. Pediatr. 6, 203-209 (2010).
    • (2010) World J. Pediatr. , vol.6 , pp. 203-209
    • Cuffari, C.1
  • 78
    • 33748304132 scopus 로고    scopus 로고
    • Review article: Genetic susceptibility and application of genetic testing in clinical management of inflammatory bowel disease
    • Vermeire, S. Review article: genetic susceptibility and application of genetic testing in clinical management of inflammatory bowel disease. Aliment. Pharmacol. Ther. 24 (Suppl. 3), 2-10 (2006).
    • (2006) Aliment. Pharmacol. Ther. , vol.24 , Issue.SUPPL. 3 , pp. 2-10
    • Vermeire, S.1
  • 79
    • 77950988234 scopus 로고    scopus 로고
    • Infliximab, azathioprine, or combination therapy for Crohn's disease
    • Colombel, J. F. et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N. Engl. J. Med. 362, 1383-1395 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1383-1395
    • Colombel, J.F.1
  • 80
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • White, E. Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer 12, 401-410 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 401-410
    • White, E.1
  • 81
    • 84863937981 scopus 로고    scopus 로고
    • Second-generation corticosteroids for the treatment of Crohn's disease and ulcerative colitis: More effective and less side effects?
    • De Cassan, C., Fiorino, G. & Danese, S. Second-generation corticosteroids for the treatment of Crohn's disease and ulcerative colitis: more effective and less side effects? Dig. Dis. 30, 368-375 (2012).
    • (2012) Dig. Dis. , vol.30 , pp. 368-375
    • De Cassan, C.1    Fiorino, G.2    Danese, S.3
  • 82
    • 11144291378 scopus 로고    scopus 로고
    • Management of ulcerative colitis and Crohn's disease
    • Baert, F. et al. Management of ulcerative colitis and Crohn's disease. Acta Clin. Belg. 59, 304-314 (2004).
    • (2004) Acta Clin. Belg. , vol.59 , pp. 304-314
    • Baert, F.1
  • 84
    • 78650485624 scopus 로고    scopus 로고
    • Management of inflammatory bowel disease with infliximab and other anti-tumor necrosis factor alpha therapies
    • Magro, F. & Portela, F. Management of inflammatory bowel disease with infliximab and other anti-tumor necrosis factor alpha therapies. BioDrugs 24 (Suppl. 1), 3-14 (2010).
    • (2010) BioDrugs , vol.24 , Issue.SUPPL. 1 , pp. 3-14
    • Magro, F.1    Portela, F.2
  • 85
    • 84867693650 scopus 로고    scopus 로고
    • New drug therapies on the horizon for IBD
    • Perrier, C. & Rutgeerts, P. New drug therapies on the horizon for IBD. Dig. Dis. 30 (Suppl. 1), 100-105 (2012).
    • (2012) Dig. Dis. , vol.30 , Issue.SUPPL. 1 , pp. 100-105
    • Perrier, C.1    Rutgeerts, P.2


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