Iron status, anemia, and plasma erythropoietin levels in acute and chronic mouse models of colitis

Inflammatory Bowel Diseases

Volumn 19, Issue 6, 2013, Pages 1260-1265

  Carter, Patsy R ^a   Watts, Megan N ^a   Kosloski Davidson, Melissa ^a   Prasai, Kanchanjunga ^a   Grisham, Matthew B ^b   Harris, Norman R ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Anemia; Colitis; Erythropoietin; Iron

Indexed keywords

ERYTHROPOIETIN; HEMOGLOBIN; IRON; TRANSFERRIN;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; CONTROLLED STUDY; DISEASE SEVERITY; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON DEFICIENCY; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SPLEEN;

ACUTE DISEASE; ANEMIA; ANIMALS; CHRONIC DISEASE; COLITIS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-10; IRON; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTES;

EID: 84879195829     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0b013e3182813466     Document Type: Article

References (22)

1. Goodhand JR, Kamperidis N, Rao A, et al. Prevalence and management of anemia in children, adolescents, and adults with inflammatory bowel disease. Inflamm Bowel Dis. 2012;18:513-519.
2. Tsitsika A, Stamoulakatou A, Kafritsa Y, et al. Erythropoietin levels in children and adolescents with inflammatory bowel disease. J Pediatr Hematol Oncol. 2005;27:93-96.
3. Bayraktar UD, Bayraktar S. Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. World J Gastroenterol. 2010;16: 2720-2725.
4. de Silva AD, Tsironi E, Feakins RM, et al. Efficacy and tolerability of oral iron therapy in inflammatory bowel disease: a prospective, comparative trial. Aliment Pharmacol Ther. 2005;22:1097-1105.
5. Wells CW, Lewis S, Barton JR, et al. Effects of changes in hemoglobin level on quality of life and cognitive function in inflammatory bowel disease patients. Inflamm Bowel Dis. 2006;12:123-130.
6. Gisbert JP, Bermejo F, Pajares R, et al. Oral and intravenous iron treatment in inflammatory bowel disease: hematological response and quality of life improvement. Inflamm Bowel Dis. 2009;15:1485-1491.
7. Harris NR, Carter PR, Lee S, et al. Association between blood flow and inflammatory state in a T-cell transfer model of inflammatory bowel disease in mice. Inflamm Bowel Dis. 2010;16:776-782.
8. Harris NR, Carter PR, Yadav AS, et al. Relationship between inflammation and tissue hypoxia in a mouse model of chronic colitis. Inflamm Bowel Dis. 2011;17:742-746.
9. Ostanin DV, Bao J, Koboziev I, et al. T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. Am J Physiol Gastrointest Liver Physiol. 2009;296:G135-G146.
10. Harris NR, Carter PR, Watts MN, et al. Relationship among circulating leukocytes, platelets, and microvascular responses during induction of chronic colitis. Pathophysiology. 2011;18:305-311.
11. Carter PR, McElhatten RM, Zhang S, et al. Thromboxane-prostanoid receptor expression and antagonism in dextran-sodium sulfate-induced colitis. Inflamm Res. 2011;60:87-92.
12. Lee S, Carter PR, Watts MN, et al. Effects of the endothelin-converting enzyme inhibitor SM-19712 in a mouse model of dextran sodium sulfate-induced colitis. Inflamm Bowel Dis. 2009;15:1007-1013.
13. Johnstone D, Milward EA. Genome-wide microarray analysis of brain gene expression in mice on a short-term high iron diet. Neurochem Int. 2010;56:856-863.
14. Uritski R, Barshack I, Bilkis I, et al. Dietary iron affects inflammatory status in a rat model of colitis. J Nutr. 2004;134:2251-2255.
15. Okada Y, Maeda N, Takakura S, et al. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interferon-gamma and interleukin-1beta suppression. Biol Pharm Bull. 2011;34: 1823-1827.
16. Schubert TE, Obermaier F, Ugocsai P, et al. Murine models of anaemia of inflammation: extramedullary haematopoiesis represents a species specific difference to human anaemia of inflammation that can be eliminated by splenectomy. Int J Immunopathol Pharmacol. 2008;21: 577-584.
17. Cuzzocrea S, Mazzon E, Di Paola R, et al. Erythropoietin reduces the development of experimental inflammatory bowel disease. J Pharmacol Exp Ther. 2004;311:1272-1280.
18. Aghdassi E, Carrier J, Cullen J, et al. Effect of iron supplementation on oxidative stress and intestinal inflammation in rats with acute colitis. Dig Dis Sci. 2001;46:1088-1094.
19. Carrier J, Aghdassi E, Platt I, et al. Effect of oral iron supplementation on oxidative stress and colonic inflammation in rats with induced colitis. Aliment Pharmacol Ther. 2001;15:1989-1999.
20. Seril DN, Liao J, Ho KL, et al. Dietary iron supplementation enhances DSS-induced colitis and associated colorectal carcinoma development in mice. Dig Dis Sci. 2002;47:1266-1278.
21. Seril DN, Liao J, Yang CS, et al. Systemic iron supplementation replenishes iron stores without enhancing colon carcinogenesis in murine models of ulcerative colitis: comparison with iron-enriched diet. Dig Dis Sci. 2005; 50:696-707.
22. Werner T, Wagner SJ, Martinez I, et al. Depletion of luminal iron alters the gut microbiota and prevents Crohn's disease-like ileitis. Gut. 2011;60: 325-333. Diseases