KSR1 protects from Interleukin-10 deficiency-induced colitis in mice by suppressing t-lymphocyte interferon-γ production

Gastroenterology

Volumn 140, Issue 1, 2011, Pages 265-274

  Goettel, Jeremy A ^a   Scott Algood, Holly M ^a,b   Olivares Villagómez, Danyvid ^a   Washington, M Kay ^a   Chaturvedi, Rupesh ^a,b   Wilson, Keith T ^a,b   Van Kaer, Luc ^a   Polk, D Brent ^a  

^a MONROE CARELL JR CHILDREN S HOSPITAL AT VANDERBILT   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

IFN ; IL 10; IL 17A; KSR1

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 17; KINASE SUPPRESSOR OF RAS 1; NEUTRALIZING ANTIBODY; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; COLITIS; COLON MUCOSA; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HEMATOPOIESIS; HISTOPATHOLOGY; IMMUNOMODULATION; INFLAMMATION; KNOCKOUT MOUSE; MOUSE; MUCOSA CELL; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; TH1 CELL; TH17 CELL; WILD TYPE;

EID: 78650505681     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.09.041     Document Type: Article

References (49)

1. F. Balkwill, and A. Mantovani Inflammation and cancer: back to Virchow? Lancet 357 2001 539 545
2. S.H. Itzkowitz, and X. Yio Inflammation and cancer IV Colorectal cancer in inflammatory bowel disease: the role of inflammation Am J Physiol Gastrointest Liver Physiol 287 2004 G7 G17
3. D. Rennick, N. Davidson, and D. Berg Interleukin-10 gene knock-out mice: a model of chronic inflammation Clin Immunol Immunopathol 76 1995 S174 S178
4. T. Scheinin, D.M. Butler, and F. Salway Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis Clin Exp Immunol 133 2003 38 43
5. D.F. Fiorentino, M.W. Bond, and T.R. Mosmann Two types of mouse T helper cell. IV Th2 clones secrete a factor that inhibits cytokine production by Th1 clones J Exp Med 170 1989 2081 2095
6. C.L. Maynard, L.E. Harrington, and K.M. Janowski Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10 Nat Immunol 8 2007 931 941
7. R. Khn, J. Lhler, and D. Rennick Interleukin-10-deficient mice develop chronic enterocolitis Cell 75 1993 263 274
8. R.K. Sellon, S. Tonkonogy, and M. Schultz Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice Infect Immun 66 1998 5224 5231
9. Y. Zhang, B. Yao, and S. Delikat Kinase suppressor of Ras is ceramide-activated protein kinase Cell 89 1997 63 72
10. N.R. Michaud, M. Therrien, and A. Cacace KSR stimulates Raf-1 activity in a kinase-independent manner Proc Natl Acad Sci U S A 94 1997 12792 12796
11. M. Zafrullah, X. Yin, and A. Haimovitz-Friedman Kinase suppressor of Ras transphosphorylates c-Raf-1 Biochem Biophys Res Commun 390 2009 434 440
12. F. Yan, S.K. John, and D.B. Polk Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor Cancer Res 61 2001 8668 8675
13. F. Yan, S.K. John, and G. Wilson Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation J Clin Invest 114 2004 1272 1280
14. C. Becker, M.C. Fantini, and M.F. Neurath High resolution colonoscopy in live mice Nat Protoc 1 2006 2900 2904
15. R.J. Kennedy, M. Hoper, and K. Deodhar Interleukin 10-deficient colitis: new similarities to human inflammatory bowel disease Br J Surg 87 2000 1346 1351
16. D. Olivares-Villagmez, Y.V. Mendez-Fernandez, and V.V. Parekh Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease Proc Natl Acad Sci U S A 105 2008 17931 17936
17. R. Heuschkel, C. Salvestrini, and R.M. Beattie Guidelines for the management of growth failure in childhood inflammatory bowel disease Inflamm Bowel Dis 14 2008 839 849
18. T.T. MacDonald, P. Hutchings, and M.Y. Choy Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine Clin Exp Immunol 81 1990 301 305
19. E. Breese, C.P. Braegger, and C.J. Corrigan Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa Immunology 78 1993 127 131
20. C.A. Murphy, C.L. Langrish, and Y. Chen Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation J Exp Med 198 2003 1951 1957
21. D.J. Cua, J. Sherlock, and Y. Chen Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 2003 744 748
22. C.L. Langrish, Y. Chen, and W.M. Blumenschein IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 201 2005 233 240
23. M.I. Koenders, L.A. Joosten, and W.B. van den Berg Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis Ann Rheum Dis 65 Suppl 3 2006 iii29 iii33
24. H. Kebir, K. Kreymborg, and I. Ifergan Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation Nat Med 13 2007 1173 1175
25. Y. Yagi, A. Andoh, and O. Inatomi Inflammatory responses induced by interleukin-17 family members in human colonic subepithelial myofibroblasts J Gastroenterol 42 2007 746 753
26. A. Nguyen, W.R. Burack, and J.L. Stock Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo Mol Cell Biol 22 2002 3035 3045
27. X. Wang, and G.P. Studzinski Kinase suppressor of RAS (KSR) amplifies the differentiation signal provided by low concentrations 1,25-dihydroxyvitamin D3 J Cell Physiol 198 2004 333 342
28. X. Wang, T.-T. Wang, and J.H. White Induction of kinase suppressor of RAS-1(KSR-1) gene by 1, alpha25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5′-flanking region Oncogene 25 2006 7078 7085
29. E. Giurisato, J. Lin, and A. Harding The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse Mol Cell Biol 29 2009 1554 1564
30. D.C. Savage, R. Dubos, and R.W. Schaedler The gastrointestinal epithelium and its autochthonous bacterial flora J Exp Med 127 1968 67 76
31. S. Bamba, C.-Y. Lee, and M. Brittan Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice J Pathol 209 2006 265 273
32. S. Fujino, A. Andoh, and S. Bamba Increased expression of interleukin 17 in inflammatory bowel disease Gut 52 2003 65 70 (Pubitemid 36020767)
33. S. Nakae, A. Nambu, and K. Sudo Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice J Immunol 171 2003 6173 6177
34. Y. Komiyama, S. Nakae, and T. Matsuki IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis J Immunol 177 2006 566 573
35. S. Haak, A.L. Croxford, and K. Kreymborg IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice J Clin Invest 119 2009 61 69
36. T. Sugimoto, S. Stewart, and M. Han The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation EMBO J 17 1998 1717 1727
37. S. Ory, M. Zhou, and T.P. Conrads Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites Curr Biol 13 2003 1356 1364
38. S. Stewart, M. Sundaram, and Y. Zhang Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization Mol Cell Biol 19 1999 5523 5534
39. R. Trotta, D. Ciarlariello, and J. Dal Col The PP2A inhibitor SET regulates natural killer cell IFN-gamma production J Exp Med 204 2007 2397 2405
40. B. Stockinger, M. Veldhoen, and B. Martin Th17 T cells: linking innate and adaptive immunity Semin Immunol 19 2007 353 361
41. S. Kalyan, and A.W. Chow Linking innate and adaptive immunity: human Vgamma9Vdelta2 T cells enhance CD40 expression and HMGB-1 secretion Mediators Inflamm 2009 2009 819408
42. M. Pletneva, H. Fan, and J.J. Park IFN-producing killer dendritic cells are antigen-presenting cells endowed with T-cell cross-priming capacity Cancer Res 69 2009 6607 6614
43. C.F. Krieglstein, W.H. Cerwinka, and A.G. Sprague Collagen-binding integrin alpha1beta1 regulates intestinal inflammation in experimental colitis J Clin Invest 110 2002 1773 1782
44. M.T. Cantorna Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease Prog Biophys Mol Biol 92 2006 60 64
45. E. Ginanjar, Sumariyono, and S. Setiati Vitamin D and autoimmune disease Acta Med Indones 39 2007 133 141
46. N. Naderi, A. Farnood, and M. Habibi Association of vitamin D receptor gene polymorphisms in Iranian patients with inflammatory bowel disease J Gastroenterol Hepatol 23 2008 1816 1822
47. T.-T. Wang, B. Dabbas, and D. Laperriere Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease J Biol Chem 285 2010 2227 2231
48. M. Froicu, V. Weaver, and T.A. Wynn A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases Mol Endocrinol 17 2003 2386 2392
49. M. Froicu, Y. Zhu, and M.T. Cantorna Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice Immunology 117 2006 310 318