-
1
-
-
80054071524
-
Molecularly targeted therapies in unresectable-metastatic gastric cancer: a systematic review
-
Zagouri, F., Papadimitriou, C. A., Dimopoulos, M. A. and Pectasides, D. (2011) Molecularly targeted therapies in unresectable-metastatic gastric cancer: a systematic review. Cancer Treat. Rev. 37, 599-610.
-
(2011)
Cancer Treat. Rev.
, vol.37
, pp. 599-610
-
-
Zagouri, F.1
Papadimitriou, C.A.2
Dimopoulos, M.A.3
Pectasides, D.4
-
2
-
-
34248661283
-
Chemotherapy of advanced gastric cancer
-
Rivera, F., Vega-Villegas, M. E. and Lopez-Brea, M. F. (2007) Chemotherapy of advanced gastric cancer. Cancer Treat. Rev. 33, 315-324.
-
(2007)
Cancer Treat. Rev.
, vol.33
, pp. 315-324
-
-
Rivera, F.1
Vega-Villegas, M.E.2
Lopez-Brea, M.F.3
-
3
-
-
67650318738
-
Development of targeted therapies in advanced gastric cancer: promising exploratory steps in a new era
-
Wagner, A. D. and Moehler, M. (2009) Development of targeted therapies in advanced gastric cancer: promising exploratory steps in a new era. Curr. Opin. Oncol. 21, 381-385.
-
(2009)
Curr. Opin. Oncol.
, vol.21
, pp. 381-385
-
-
Wagner, A.D.1
Moehler, M.2
-
4
-
-
84858993892
-
Current status of targeted therapies in advanced gastric cancer
-
De Vita, F., Giuliani, F., Silvestris, N., Rossetti, S., Pizzolorusso, A., Santabarbara, G., Galizia, G., Colucci, G., Ciardiello, F. and Orditura, M. (2012) Current status of targeted therapies in advanced gastric cancer. Expert Opin. Ther. Targets 16, S29-34.
-
(2012)
Expert Opin. Ther. Targets
, vol.16
, pp. S29-34
-
-
De Vita, F.1
Giuliani, F.2
Silvestris, N.3
Rossetti, S.4
Pizzolorusso, A.5
Santabarbara, G.6
Galizia, G.7
Colucci, G.8
Ciardiello, F.9
Orditura, M.10
-
5
-
-
84864569908
-
Molecules of natural origin, semi-synthesis and synthesis with anti-inflammatory and anticancer utilities
-
Lourenco, A. M., Ferreira, L. M. and Branco, P. S. (2012) Molecules of natural origin, semi-synthesis and synthesis with anti-inflammatory and anticancer utilities. Curr. Pharm. Des. 18, 3979-4046.
-
(2012)
Curr. Pharm. Des.
, vol.18
, pp. 3979-4046
-
-
Lourenco, A.M.1
Ferreira, L.M.2
Branco, P.S.3
-
6
-
-
84862779635
-
Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: potential role in prevention and therapy of cancer
-
Shanmugam, M. K., Nguyen, A. H., Kumar, A. P., Tan, B. K. and Sethi, G. (2012) Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: potential role in prevention and therapy of cancer. Cancer Lett. 320, 158-170.
-
(2012)
Cancer Lett
, vol.320
, pp. 158-170
-
-
Shanmugam, M.K.1
Nguyen, A.H.2
Kumar, A.P.3
Tan, B.K.4
Sethi, G.5
-
7
-
-
19544390715
-
Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects
-
Setty, A. R. and Sigal, L. H. (2005) Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. Semin. Arthritis. Rheum. 34, 773-784.
-
(2005)
Semin. Arthritis. Rheum.
, vol.34
, pp. 773-784
-
-
Setty, A.R.1
Sigal, L.H.2
-
8
-
-
0025005788
-
The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria
-
Sassa, H., Takaishi, Y. and Terada, H. (1990) The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria. Biochem. Biophys. Res. Commun. 172, 890-897.
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.172
, pp. 890-897
-
-
Sassa, H.1
Takaishi, Y.2
Terada, H.3
-
9
-
-
0032535180
-
Novel cytokine release inhibitors Part III: Truncated analogs of tripterine
-
He, W., Huang, F. C., Gavai, A., Chan, W. K., Amato, G., Yu, K. T. and Zilberstein, A. (1998) Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine. Bioorg. Med. Chem. Lett. 8, 3659-3664.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 3659-3664
-
-
He, W.1
Huang, F.C.2
Gavai, A.3
Chan, W.K.4
Amato, G.5
Yu, K.T.6
Zilberstein, A.7
-
10
-
-
0034752311
-
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease
-
Allison, A. C., Cacabelos, R., Lombardi, V. R., Alvarez, X. A. and Vigo, C. (2001) Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341-1357.
-
(2001)
Prog. Neuropsychopharmacol. Biol. Psychiatry
, vol.25
, pp. 1341-1357
-
-
Allison, A.C.1
Cacabelos, R.2
Lombardi, V.R.3
Alvarez, X.A.4
Vigo, C.5
-
11
-
-
0030928255
-
Effect of tripterine on collagen-induced arthritis in rats
-
Li, H., Jia, Y. F., Pan, Y., Pan, D. J., Li, D. and Zhang, L. X. (1997) Effect of tripterine on collagen-induced arthritis in rats. Zhongguo Yao Li Xue Bao. 18, 270-273.
-
(1997)
Zhongguo Yao Li Xue Bao
, vol.18
, pp. 270-273
-
-
Li, H.1
Jia, Y.F.2
Pan, Y.3
Pan, D.J.4
Li, D.5
Zhang, L.X.6
-
12
-
-
79951853010
-
Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer
-
Kannaiyan, R., Shanmugam, M. K. and Sethi, G. (2011) Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. Cancer Lett. 303, 9-20.
-
(2011)
Cancer Lett
, vol.303
, pp. 9-20
-
-
Kannaiyan, R.1
Shanmugam, M.K.2
Sethi, G.3
-
13
-
-
38349153572
-
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
-
Zhang, T., Hamza, A., Cao, X., Wang, B., Yu, S., Zhan, C. G. and Sun, D. (2008) A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol. Cancer Ther. 7, 162-170.
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 162-170
-
-
Zhang, T.1
Hamza, A.2
Cao, X.3
Wang, B.4
Yu, S.5
Zhan, C.G.6
Sun, D.7
-
14
-
-
84862944939
-
Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome ER stress and Hsp90
-
Wang, W. B., Feng, L. X., Yue, Q. X., Wu, W. Y., Guan, S. H., Jiang, B. H., Yang, M., Liu, X. and Guo, D. A. (2012) Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90. J. Cell. Physiol. 227, 2196-2206.
-
(2012)
J. Cell. Physiol.
, vol.227
, pp. 2196-2206
-
-
Wang, W.B.1
Feng, L.X.2
Yue, Q.X.3
Wu, W.Y.4
Guan, S.H.5
Jiang, B.H.6
Yang, M.7
Liu, X.8
Guo, D.A.9
-
15
-
-
33947598693
-
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation
-
Sethi, G., Ahn, K. S., Pandey, M. K. and Aggarwal, B. B. (2007) Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation. Blood 109, 2727-2735.
-
(2007)
Blood
, vol.109
, pp. 2727-2735
-
-
Sethi, G.1
Ahn, K.S.2
Pandey, M.K.3
Aggarwal, B.B.4
-
16
-
-
77950234271
-
Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway
-
Pang, X., Yi, Z., Zhang, J., Lu, B., Sung, B., Qu, W., Aggarwal, B. B. and Liu, M. (2010) Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. Cancer Res. 70, 1951-1959.
-
(2010)
Cancer Res
, vol.70
, pp. 1951-1959
-
-
Pang, X.1
Yi, Z.2
Zhang, J.3
Lu, B.4
Sung, B.5
Qu, W.6
Aggarwal, B.B.7
Liu, M.8
-
17
-
-
84872054236
-
Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling
-
Lee, J. H., Won, Y. S., Park, K. H., Lee, M. K., Tachibana, H., Yamada, K. and Seo, K. I. (2012) Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling. Apoptosis. 17, 1275-1286.
-
(2012)
Apoptosis
, vol.17
, pp. 1275-1286
-
-
Lee, J.H.1
Won, Y.S.2
Park, K.H.3
Lee, M.K.4
Tachibana, H.5
Yamada, K.6
Seo, K.I.7
-
18
-
-
77954917015
-
Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway
-
Zhu, H., Liu, X. W., Cai, T. Y., Cao, J., Tu, C. X., Lu, W., He, Q. J. and Yang, B. (2010) Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway. J. Pharmacol. Exp. Ther. 334, 489-499.
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.334
, pp. 489-499
-
-
Zhu, H.1
Liu, X.W.2
Cai, T.Y.3
Cao, J.4
Tu, C.X.5
Lu, W.6
He, Q.J.7
Yang, B.8
-
19
-
-
42649088411
-
Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression
-
Huang, Y., Zhou, Y., Fan, Y. and Zhou, D. (2008) Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Cancer Lett. 264, 101-106.
-
(2008)
Cancer Lett
, vol.264
, pp. 101-106
-
-
Huang, Y.1
Zhou, Y.2
Fan, Y.3
Zhou, D.4
-
20
-
-
80055034613
-
Quantitative proteomics reveals cellular targets of celastrol
-
Hansen, J., Palmfeldt, J., Vang, S., Corydon, T. J., Gregersen, N. and Bross, P. (2011) Quantitative proteomics reveals cellular targets of celastrol. PloS One 6, e26634.
-
(2011)
PloS One
, vol.6
-
-
Hansen, J.1
Palmfeldt, J.2
Vang, S.3
Corydon, T.J.4
Gregersen, N.5
Bross, P.6
-
21
-
-
82955162775
-
Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
-
Kannaiyan, R., Manu, K. A., Chen, L., Li, F., Rajendran, P., Subramaniam, A., Lam, P., Kumar, A. P. and Sethi, G. (2011) Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways. Apoptosis 16, 1028-1041.
-
(2011)
Apoptosis
, vol.16
, pp. 1028-1041
-
-
Kannaiyan, R.1
Manu, K.A.2
Chen, L.3
Li, F.4
Rajendran, P.5
Subramaniam, A.6
Lam, P.7
Kumar, A.P.8
Sethi, G.9
-
22
-
-
84869016069
-
Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF
-
Ko, A., Shin, J. Y., Seo, J., Lee, K. D., Lee, E. W., Lee, M. S., Lee, H. W., Choi, I. J., Jeong, J. S., Chun, K. H. and Song, J. (2012) Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF. J. Natl. Cancer Inst. 104, 1660-1672.
-
(2012)
J. Natl. Cancer Inst.
, vol.104
, pp. 1660-1672
-
-
Ko, A.1
Shin, J.Y.2
Seo, J.3
Lee, K.D.4
Lee, E.W.5
Lee, M.S.6
Lee, H.W.7
Choi, I.J.8
Jeong, J.S.9
Chun, K.H.10
Song, J.11
-
23
-
-
77958451114
-
Multidisciplinary management of gastric cancer
-
Jiang, Y. and Ajani, J. A. (2010) Multidisciplinary management of gastric cancer. Curr. Opin. Gastroenterol. 26, 640-646.
-
(2010)
Curr. Opin. Gastroenterol.
, vol.26
, pp. 640-646
-
-
Jiang, Y.1
Ajani, J.A.2
-
24
-
-
49049122096
-
The treatment of advanced gastric cancer: current strategies and future perspectives
-
Cervantes, A., Rosello, S., Roda, D. and Rodriguez-Braun, E. (2008) The treatment of advanced gastric cancer: current strategies and future perspectives. Ann. Oncol. 19 Suppl 5, v103-107.
-
(2008)
Ann. Oncol
, vol.19
, pp. v103-107
-
-
Cervantes, A.1
Rosello, S.2
Roda, D.3
Rodriguez-Braun, E.4
-
25
-
-
81355164590
-
Alterations in cell proliferation related gene expressions in gastric cancer
-
Kim, K., Chun, K. H., Suh, P. G. and Kim, I. H. (2011) Alterations in cell proliferation related gene expressions in gastric cancer. Crit. Rev. Eukaryot. Gene Expr. 21, 237-254.
-
(2011)
Crit. Rev. Eukaryot. Gene Expr.
, vol.21
, pp. 237-254
-
-
Kim, K.1
Chun, K.H.2
Suh, P.G.3
Kim, I.H.4
-
26
-
-
73849110612
-
Celastrol synergistically enhances temozolomide cytotoxicity in melanoma cells
-
Chen, M., Rose, A. E., Doudican, N., Osman, I. and Orlow, S. J. (2009) Celastrol synergistically enhances temozolomide cytotoxicity in melanoma cells. Mol. Cancer Res. 7, 1946-1953.
-
(2009)
Mol. Cancer Res.
, vol.7
, pp. 1946-1953
-
-
Chen, M.1
Rose, A.E.2
Doudican, N.3
Osman, I.4
Orlow, S.J.5
-
27
-
-
78751506175
-
Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers
-
Raja, S. M., Clubb, R. J., Ortega-Cava, C., Williams, S. H., Bailey, T. A., Duan, L., Zhao, X., Reddi, A. L., Nyong, A. M., Natarajan, A., Band, V. and Band, H. (2011) Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers. Cancer Biol. Ther. 11, 263-276.
-
(2011)
Cancer Biol. Ther.
, vol.11
, pp. 263-276
-
-
Raja, S.M.1
Clubb, R.J.2
Ortega-Cava, C.3
Williams, S.H.4
Bailey, T.A.5
Duan, L.6
Zhao, X.7
Reddi, A.L.8
Nyong, A.M.9
Natarajan, A.10
Band, V.11
Band, H.12
-
28
-
-
84878050153
-
Celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-kappaB activity
-
Sha, M., Ye, J., Zhang, L. X., Luan, Z. Y. and Chen, Y. B. (2013) Celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-kappaB activity. Cancer Cell Int. 13, 50.
-
(2013)
Cancer Cell Int
, vol.13
, pp. 50
-
-
Sha, M.1
Ye, J.2
Zhang, L.X.3
Luan, Z.Y.4
Chen, Y.B.5
-
29
-
-
84873109651
-
Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development
-
Jain, M. V., Paczulla, A. M., Klonisch, T., Dimgba, F. N., Rao, S. B., Roberg, K., Schweizer, F., Lengerke, C., Davoodpour, P., Palicharla, V. R., Maddika, S. and Los, M. (2013) Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J. Cell. Mol. Med. 17, 12-29.
-
(2013)
J. Cell. Mol. Med.
, vol.17
, pp. 12-29
-
-
Jain, M.V.1
Paczulla, A.M.2
Klonisch, T.3
Dimgba, F.N.4
Rao, S.B.5
Roberg, K.6
Schweizer, F.7
Lengerke, C.8
Davoodpour, P.9
Palicharla, V.R.10
Maddika, S.11
Los, M.12
-
30
-
-
84882796035
-
Natural products targeting autophagy via the PI3K/Akt/mTOR pathway as anticancer agents
-
Sun, H., Wang, Z. and Yakisich, J. S. (2012) Natural products targeting autophagy via the PI3K/Akt/mTOR pathway as anticancer agents. Anticancer Agents Med. Chem. 13, 1048-1056.
-
(2012)
Anticancer Agents Med. Chem.
, vol.13
, pp. 1048-1056
-
-
Sun, H.1
Wang, Z.2
Yakisich, J.S.3
-
31
-
-
84873313731
-
Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway
-
Kim, J. H., Lee, J. O., Lee, S. K., Kim, N., You, G. Y., Moon, J. W., Sha, J., Kim, S. J., Park, S. H. and Kim, H. S. (2012) Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53-polo like kinase 2 (PLK-2) pathway. Cellular Signal. 25, 805-813.
-
(2012)
Cellular Signal
, vol.25
, pp. 805-813
-
-
Kim, J.H.1
Lee, J.O.2
Lee, S.K.3
Kim, N.4
You, G.Y.5
Moon, J.W.6
Sha, J.7
Kim, S.J.8
Park, S.H.9
Kim, H.S.10
-
32
-
-
77249102098
-
Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression
-
Kim, S. J., Choi, I. J., Cheong, T. C., Lee, S. J., Lotan, R., Park, S. H. and Chun, K. H. (2010) Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression. Gastroenterology 138, 1035-1045.
-
(2010)
Gastroenterology
, vol.138
, pp. 1035-1045
-
-
Kim, S.J.1
Choi, I.J.2
Cheong, T.C.3
Lee, S.J.4
Lotan, R.5
Park, S.H.6
Chun, K.H.7
-
33
-
-
71849116316
-
Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents
-
Cheong, T. C., Shin, J. Y. and Chun, K. H. (2010) Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agents. Cancer Sci. 101, 94-102.
-
(2010)
Cancer Sci
, vol.101
, pp. 94-102
-
-
Cheong, T.C.1
Shin, J.Y.2
Chun, K.H.3
-
34
-
-
84862824887
-
STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy
-
Ahn, Y. H., Yi, H., Shin, J. Y., Lee, K. D., Shin, S. P., Lee, S. J., Song, J. and Chun, K. H. (2012) STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy. Clin. Exp. Metastasis 29, 359-369.
-
(2012)
Clin. Exp. Metastasis
, vol.29
, pp. 359-369
-
-
Ahn, Y.H.1
Yi, H.2
Shin, J.Y.3
Lee, K.D.4
Shin, S.P.5
Lee, S.J.6
Song, J.7
Chun, K.H.8
-
35
-
-
84863458530
-
Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression
-
Wang, Y. G., Kim, S. J., Baek, J. H., Lee, H. W., Jeong, S. Y. and Chun, K. H. (2012) Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression. Exp. Mol. Med. 44, 387-393.
-
(2012)
Exp. Mol. Med.
, vol.44
, pp. 387-393
-
-
Wang, Y.G.1
Kim, S.J.2
Baek, J.H.3
Lee, H.W.4
Jeong, S.Y.5
Chun, K.H.6
|