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Volumn 6, Issue FEB, 2015, Pages

Augmenting antitumor immune responses with epigenetic modifying agents

Author keywords

Antigen presentation; Epigenetics; Histone acetylation; Methylation; Tumor immunotherapy

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; CD28 ANTIGEN; CLADRIBINE; CLOFARABINE; CP 4200; CURCUMIN; CYTOSINE DERIVATIVE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DISULFIRAM; EPIGALLOCATECHIN GALLATE; EQUOL; FLUDARABINE; GENISTEIN; HYDRALAZINE; IM25; N PHTHALOYLTRYPTOPHAN; NANAOMYCIN A; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PANOBINOSTAT; PARTHENOLIDE; PROCAINAMIDE; PROCAINE; PROGRAMMED DEATH 1 LIGAND 2; PROGRAMMED DEATH 1 RECEPTOR; RESVERATROL; SGI 110; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT; ZEBULARINE;

EID: 84926617120     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00029     Document Type: Review
Times cited : (179)

References (179)
  • 1
    • 84900860388 scopus 로고    scopus 로고
    • Demethylation of the miR-146a promoter by 5-Aza-2'-deoxycytidine correlates with delayed progression of castration-resistant prostate cancer
    • Wang X, Gao H, Ren L, Gu J, Zhang Y, Zhang Y. Demethylation of the miR-146a promoter by 5-Aza-2'-deoxycytidine correlates with delayed progression of castration-resistant prostate cancer. BMC Cancer (2014) 14:308. doi:10.1186/1471-2407-14-308
    • (2014) BMC Cancer , vol.14 , pp. 308
    • Wang, X.1    Gao, H.2    Ren, L.3    Gu, J.4    Zhang, Y.5    Zhang, Y.6
  • 2
    • 40049094942 scopus 로고    scopus 로고
    • Mammalian DNA methyltransferases: a structural perspective
    • Cheng X, Blumenthal RM. Mammalian DNA methyltransferases: a structural perspective. Structure (2008) 16:341-50. doi:10.1016/j.str.2008.01.004
    • (2008) Structure , vol.16 , pp. 341-350
    • Cheng, X.1    Blumenthal, R.M.2
  • 3
    • 0029075074 scopus 로고
    • CpG islands and genes
    • Cross SH, Bird AP. CpG islands and genes. Curr Opin Genet Dev (1995) 5:309-14. doi:10.1016/0959-437X(95)80044-1
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 309-314
    • Cross, S.H.1    Bird, A.P.2
  • 4
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: epigenetics joins genetics
    • Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet (2000) 16:168-74. doi:10.1016/S0168-9525(99)01971-X
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 5
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer (2004) 4:143-53. doi:10.1038/nrc1279
    • (2004) Nat Rev Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 6
    • 0027378582 scopus 로고
    • Role for DNA methylation in genomic imprinting
    • Li E, Beard C, Jaenisch R. Role for DNA methylation in genomic imprinting. Nature (1993) 366:362-5. doi:10.1038/366362a0
    • (1993) Nature , vol.366 , pp. 362-365
    • Li, E.1    Beard, C.2    Jaenisch, R.3
  • 7
  • 8
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: provocative insights from epigenomics
    • Suzuki MM, Bird A. DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet (2008) 9:465-76. doi:10.1038/nrg2341
    • (2008) Nat Rev Genet , vol.9 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 9
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell (1980) 20:85-93. doi:10.1016/0092-8674(80)90237-8
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 10
    • 0037068379 scopus 로고    scopus 로고
    • 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy
    • Christman JK. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene (2002) 21:5483-95. doi:10.1038/sj.onc.1205699
    • (2002) Oncogene , vol.21 , pp. 5483-5495
    • Christman, J.K.1
  • 11
    • 34447123203 scopus 로고    scopus 로고
    • Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides
    • Yoo CB, Jeong S, Egger G, Liang G, Phiasivongsa P, Tang C, et al. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res (2007) 67:6400-8. doi:10.1158/0008-5472.CAN-07-0251
    • (2007) Cancer Res , vol.67 , pp. 6400-6408
    • Yoo, C.B.1    Jeong, S.2    Egger, G.3    Liang, G.4    Phiasivongsa, P.5    Tang, C.6
  • 12
    • 0036965821 scopus 로고    scopus 로고
    • Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases
    • Zhou L, Cheng X, Connolly BA, Dickman MJ, Hurd PJ, Hornby DP. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol (2002) 321:591-9. doi:10.1016/S0022-2836(02)00676-9
    • (2002) J Mol Biol , vol.321 , pp. 591-599
    • Zhou, L.1    Cheng, X.2    Connolly, B.A.3    Dickman, M.J.4    Hurd, P.J.5    Hornby, D.P.6
  • 13
    • 77952178901 scopus 로고    scopus 로고
    • Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy
    • Brueckner B, Rius M, Markelova MR, Fichtner I, Hals PA, Sandvold ML, et al. Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy. Mol Cancer Ther (2010) 9:1256-64. doi:10.1158/1535-7163.MCT-09-1202
    • (2010) Mol Cancer Ther , vol.9 , pp. 1256-1264
    • Brueckner, B.1    Rius, M.2    Markelova, M.R.3    Fichtner, I.4    Hals, P.A.5    Sandvold, M.L.6
  • 14
    • 0038509118 scopus 로고    scopus 로고
    • Mechanism of action of purine analogues in chronic lymphocytic leukaemia
    • Pettitt AR. Mechanism of action of purine analogues in chronic lymphocytic leukaemia. Br J Haematol (2003) 121:692-702. doi:10.1046/j.1365-2141.2003.04336.x
    • (2003) Br J Haematol , vol.121 , pp. 692-702
    • Pettitt, A.R.1
  • 15
    • 9144222570 scopus 로고    scopus 로고
    • Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia
    • Jeha S, Gandhi V, Chan KW, Mcdonald L, Ramirez I, Madden R, et al. Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia. Blood (2004) 103:784-9. doi:10.1182/blood-2003-06-2122
    • (2004) Blood , vol.103 , pp. 784-789
    • Jeha, S.1    Gandhi, V.2    Chan, K.W.3    Mcdonald, L.4    Ramirez, I.5    Madden, R.6
  • 16
    • 0023936754 scopus 로고
    • Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity
    • Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. J Immunol (1988) 140:2197-200.
    • (1988) J Immunol , vol.140 , pp. 2197-2200
    • Cornacchia, E.1    Golbus, J.2    Maybaum, J.3    Strahler, J.4    Hanash, S.5    Richardson, B.6
  • 17
    • 0041939756 scopus 로고    scopus 로고
    • Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells
    • Villar-Garea A, Fraga MF, Espada J, Esteller M. Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res (2003) 63:4984-9.
    • (2003) Cancer Res , vol.63 , pp. 4984-4989
    • Villar-Garea, A.1    Fraga, M.F.2    Espada, J.3    Esteller, M.4
  • 18
    • 70349665204 scopus 로고    scopus 로고
    • High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth
    • Iljin K, Ketola K, Vainio P, Halonen P, Kohonen P, Fey V, et al. High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res (2009) 15:6070-8. doi:10.1158/1078-0432.CCR-09-1035
    • (2009) Clin Cancer Res , vol.15 , pp. 6070-6078
    • Iljin, K.1    Ketola, K.2    Vainio, P.3    Halonen, P.4    Kohonen, P.5    Fey, V.6
  • 19
    • 22244435605 scopus 로고    scopus 로고
    • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    • Brueckner B, Garcia Boy R, Siedlecki P, Musch T, Kliem HC, Zielenkiewicz P, et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res (2005) 65:6305-11. doi:10.1158/0008-5472.CAN-04-2957
    • (2005) Cancer Res , vol.65 , pp. 6305-6311
    • Brueckner, B.1    Garcia Boy, R.2    Siedlecki, P.3    Musch, T.4    Kliem, H.C.5    Zielenkiewicz, P.6
  • 20
    • 78650972028 scopus 로고    scopus 로고
    • Identification of novel DNA methylation inhibitors via a two-component reporter gene system
    • Lin YS, Shaw AY, Wang SG, Hsu CC, Teng IW, Tseng MJ, et al. Identification of novel DNA methylation inhibitors via a two-component reporter gene system. J Biomed Sci (2011) 18:3. doi:10.1186/1423-0127-18-3
    • (2011) J Biomed Sci , vol.18 , pp. 3
    • Lin, Y.S.1    Shaw, A.Y.2    Wang, S.G.3    Hsu, C.C.4    Teng, I.W.5    Tseng, M.J.6
  • 21
    • 78649676706 scopus 로고    scopus 로고
    • Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells
    • Kuck D, Caulfield T, Lyko F, Medina-Franco JL. Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells. Mol Cancer Ther (2010) 9:3015-23. doi:10.1158/1535-7163.MCT-10-0609
    • (2010) Mol Cancer Ther , vol.9 , pp. 3015-3023
    • Kuck, D.1    Caulfield, T.2    Lyko, F.3    Medina-Franco, J.L.4
  • 22
    • 74549216395 scopus 로고    scopus 로고
    • Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-cell translocation gene 3 in prostate cancer
    • Majid S, Dar AA, Shahryari V, Hirata H, Ahmad A, Saini S, et al. Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-cell translocation gene 3 in prostate cancer. Cancer (2010) 116:66-76. doi:10.1002/cncr.24662
    • (2010) Cancer , vol.116 , pp. 66-76
    • Majid, S.1    Dar, A.A.2    Shahryari, V.3    Hirata, H.4    Ahmad, A.5    Saini, S.6
  • 23
    • 84869444019 scopus 로고    scopus 로고
    • Epigenetic modulation of BRCA1 and BRCA2 gene expression by equol in breast cancer cell lines
    • Bosviel R, Durif J, Dechelotte P, Bignon YJ, Bernard-Gallon D. Epigenetic modulation of BRCA1 and BRCA2 gene expression by equol in breast cancer cell lines. Br J Nutr (2012) 108:1187-93. doi:10.1017/S000711451100657X
    • (2012) Br J Nutr , vol.108 , pp. 1187-1193
    • Bosviel, R.1    Durif, J.2    Dechelotte, P.3    Bignon, Y.J.4    Bernard-Gallon, D.5
  • 25
    • 25144507259 scopus 로고    scopus 로고
    • Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
    • Lee WJ, Shim JY, Zhu BT. Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol Pharmacol (2005) 68:1018-30. doi:10.1124/mol.104.008367
    • (2005) Mol Pharmacol , vol.68 , pp. 1018-1030
    • Lee, W.J.1    Shim, J.Y.2    Zhu, B.T.3
  • 26
    • 84861215508 scopus 로고    scopus 로고
    • Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation
    • Lee H, Zhang P, Herrmann A, Yang C, Xin H, Wang Z, et al. Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation. Proc Natl Acad Sci U S A (2012) 109:7765-9. doi:10.1073/pnas.1205132109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 7765-7769
    • Lee, H.1    Zhang, P.2    Herrmann, A.3    Yang, C.4    Xin, H.5    Wang, Z.6
  • 27
    • 65649091667 scopus 로고    scopus 로고
    • Modulation of DNA methylation by a sesquiterpene lactone parthenolide
    • Liu Z, Liu S, Xie Z, Pavlovicz RE, Wu J, Chen P, et al. Modulation of DNA methylation by a sesquiterpene lactone parthenolide. J Pharmacol Exp Ther (2009) 329:505-14. doi:10.1124/jpet.108.147934
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 505-514
    • Liu, Z.1    Liu, S.2    Xie, Z.3    Pavlovicz, R.E.4    Wu, J.5    Chen, P.6
  • 28
    • 0013773866 scopus 로고
    • 5-Azacytidine, a new, highly effective cancerostatic
    • Sorm F, Piskala A, Cihak A, Vesely J. 5-Azacytidine, a new, highly effective cancerostatic. Experientia (1964) 20:202-3. doi:10.1007/BF02135399
    • (1964) Experientia , vol.20 , pp. 202-203
    • Sorm, F.1    Piskala, A.2    Cihak, A.3    Vesely, J.4
  • 29
    • 0014241870 scopus 로고
    • Effect of 5-aza-2'-deoxycytidine against leukemic and hemopoietic tissues in AKR mice
    • Sorm F, Vesely J. Effect of 5-aza-2'-deoxycytidine against leukemic and hemopoietic tissues in AKR mice. Neoplasma (1968) 15:339-43.
    • (1968) Neoplasma , vol.15 , pp. 339-343
    • Sorm, F.1    Vesely, J.2
  • 30
    • 0025167607 scopus 로고
    • Comparison of antineoplastic activity of cytosine arabinoside and 5-aza-2'-deoxycytidine against human leukemic cells of different phenotype
    • Momparler RL, Onetto-Pothier N, Momparler LF. Comparison of antineoplastic activity of cytosine arabinoside and 5-aza-2'-deoxycytidine against human leukemic cells of different phenotype. Leuk Res (1990) 14:755-60. doi:10.1016/0145-2126(90)90068-K
    • (1990) Leuk Res , vol.14 , pp. 755-760
    • Momparler, R.L.1    Onetto-Pothier, N.2    Momparler, L.F.3
  • 31
    • 84876247103 scopus 로고    scopus 로고
    • Effect of histone deacetylase and DNA methyltransferase inhibitors on the expression of the androgen receptor gene in androgen-independent prostate cancer cell lines
    • Fialova B, Smesny Trtkova K, Paskova L, Langova K, Kolar Z. Effect of histone deacetylase and DNA methyltransferase inhibitors on the expression of the androgen receptor gene in androgen-independent prostate cancer cell lines. Oncol Rep (2013) 29:2039-45. doi:10.3892/or.2013.2344
    • (2013) Oncol Rep , vol.29 , pp. 2039-2045
    • Fialova, B.1    Smesny Trtkova, K.2    Paskova, L.3    Langova, K.4    Kolar, Z.5
  • 32
    • 77955975878 scopus 로고    scopus 로고
    • 5-Azacitidine restores and amplifies the bicalutamide response on preclinical models of androgen receptor expressing or deficient prostate tumors
    • Gravina GL, Marampon F, Di Staso M, Bonfili P, Vitturini A, Jannini EA, et al. 5-Azacitidine restores and amplifies the bicalutamide response on preclinical models of androgen receptor expressing or deficient prostate tumors. Prostate (2010) 70:1166-78. doi:10.1002/pros.21151
    • (2010) Prostate , vol.70 , pp. 1166-1178
    • Gravina, G.L.1    Marampon, F.2    Di Staso, M.3    Bonfili, P.4    Vitturini, A.5    Jannini, E.A.6
  • 33
    • 77952203695 scopus 로고    scopus 로고
    • S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth
    • Chuang JC, Warner SL, Vollmer D, Vankayalapati H, Redkar S, Bearss DJ, et al. S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol Cancer Ther (2010) 9:1443-50. doi:10.1158/1535-7163.MCT-09-1048
    • (2010) Mol Cancer Ther , vol.9 , pp. 1443-1450
    • Chuang, J.C.1    Warner, S.L.2    Vollmer, D.3    Vankayalapati, H.4    Redkar, S.5    Bearss, D.J.6
  • 34
    • 26644460450 scopus 로고    scopus 로고
    • Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology
    • Marquez VE, Barchi JJ Jr, Kelley JA, Rao KV, Agbaria R, Ben-Kasus T, et al. Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology. Nucleosides Nucleotides Nucleic Acids (2005) 24:305-18. doi:10.1081/NCN-200059765
    • (2005) Nucleosides Nucleotides Nucleic Acids , vol.24 , pp. 305-318
    • Marquez, V.E.1    Barchi, J.J.2    Kelley, J.A.3    Rao, K.V.4    Agbaria, R.5    Ben-Kasus, T.6
  • 35
    • 77950867869 scopus 로고    scopus 로고
    • Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells
    • Billam M, Sobolewski MD, Davidson NE. Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells. Breast Cancer Res Treat (2010) 120:581-92. doi:10.1007/s10549-009-0420-3
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 581-592
    • Billam, M.1    Sobolewski, M.D.2    Davidson, N.E.3
  • 36
    • 84889566398 scopus 로고    scopus 로고
    • Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress
    • Yang PM, Lin YT, Shun CT, Lin SH, Wei TT, Chuang SH, et al. Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress. Sci Rep (2013) 3:3219. doi:10.1038/srep03219
    • (2013) Sci Rep , vol.3 , pp. 3219
    • Yang, P.M.1    Lin, Y.T.2    Shun, C.T.3    Lin, S.H.4    Wei, T.T.5    Chuang, S.H.6
  • 38
    • 84862840809 scopus 로고    scopus 로고
    • Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas-and NK cell-mediated cell death
    • Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, et al. Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas-and NK cell-mediated cell death. Int J Oncol (2012) 41:83-91. doi:10.3892/ijo.2012.1438
    • (2012) Int J Oncol , vol.41 , pp. 83-91
    • Yamanegi, K.1    Yamane, J.2    Kobayashi, K.3    Kato-Kogoe, N.4    Ohyama, H.5    Nakasho, K.6
  • 40
    • 28844497663 scopus 로고    scopus 로고
    • Procainamide is a specific inhibitor of DNA methyltransferase 1
    • Lee BH, Yegnasubramanian S, Lin X, Nelson WG. Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem (2005) 280:40749-56. doi:10.1074/jbc.M505593200
    • (2005) J Biol Chem , vol.280 , pp. 40749-40756
    • Lee, B.H.1    Yegnasubramanian, S.2    Lin, X.3    Nelson, W.G.4
  • 41
    • 10744225448 scopus 로고    scopus 로고
    • Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy
    • Segura-Pacheco B, Trejo-Becerril C, Perez-Cardenas E, Taja-Chayeb L, Mariscal I, Chavez A, et al. Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy. Clin Cancer Res (2003) 9:1596-603.
    • (2003) Clin Cancer Res , vol.9 , pp. 1596-1603
    • Segura-Pacheco, B.1    Trejo-Becerril, C.2    Perez-Cardenas, E.3    Taja-Chayeb, L.4    Mariscal, I.5    Chavez, A.6
  • 43
    • 79957971986 scopus 로고    scopus 로고
    • Methylation of NEUROG1 in serum is a sensitive marker for the detection of early colorectal cancer
    • Herbst A, Rahmig K, Stieber P, Philipp A, Jung A, Ofner A, et al. Methylation of NEUROG1 in serum is a sensitive marker for the detection of early colorectal cancer. Am J Gastroenterol (2011) 106:1110-8. doi:10.1038/ajg.2011.6
    • (2011) Am J Gastroenterol , vol.106 , pp. 1110-1118
    • Herbst, A.1    Rahmig, K.2    Stieber, P.3    Philipp, A.4    Jung, A.5    Ofner, A.6
  • 44
    • 46049103996 scopus 로고    scopus 로고
    • Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells
    • Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y, et al. Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells. Int J Cancer (2008) 123:552-60. doi:10.1002/ijc.23590
    • (2008) Int J Cancer , vol.123 , pp. 552-560
    • Kikuno, N.1    Shiina, H.2    Urakami, S.3    Kawamoto, K.4    Hirata, H.5    Tanaka, Y.6
  • 45
    • 13444306459 scopus 로고    scopus 로고
    • Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
    • Nebbioso A, Clarke N, Voltz E, Germain E, Ambrosino C, Bontempo P, et al. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nat Med (2005) 11:77-84. doi:10.1038/nm1161
    • (2005) Nat Med , vol.11 , pp. 77-84
    • Nebbioso, A.1    Clarke, N.2    Voltz, E.3    Germain, E.4    Ambrosino, C.5    Bontempo, P.6
  • 46
    • 84891098660 scopus 로고    scopus 로고
    • The anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) on the aggressive phenotypes of ovarian carcinoma cells
    • Chen S, Zhao Y, Gou WF, Zhao S, Takano Y, Zheng HC. The anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) on the aggressive phenotypes of ovarian carcinoma cells. PLoS One (2013) 8:e79781. doi:10.1371/journal.pone.0079781
    • (2013) PLoS One , vol.8
    • Chen, S.1    Zhao, Y.2    Gou, W.F.3    Zhao, S.4    Takano, Y.5    Zheng, H.C.6
  • 47
    • 80052927231 scopus 로고    scopus 로고
    • Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy
    • Chen MY, Liao WS, Lu Z, Bornmann WG, Hennessey V, Washington MN, et al. Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy. Cancer (2011) 117:4424-38. doi:10.1002/cncr.26073
    • (2011) Cancer , vol.117 , pp. 4424-4438
    • Chen, M.Y.1    Liao, W.S.2    Lu, Z.3    Bornmann, W.G.4    Hennessey, V.5    Washington, M.N.6
  • 48
    • 84885639981 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (SAHA) causes tumor growth slowdown and triggers autophagy in glioblastoma stem cells
    • Chiao MT, Cheng WY, Yang YC, Shen CC, Ko JL. Suberoylanilide hydroxamic acid (SAHA) causes tumor growth slowdown and triggers autophagy in glioblastoma stem cells. Autophagy (2013) 9:1509-26. doi:10.4161/auto.25664
    • (2013) Autophagy , vol.9 , pp. 1509-1526
    • Chiao, M.T.1    Cheng, W.Y.2    Yang, Y.C.3    Shen, C.C.4    Ko, J.L.5
  • 49
    • 4344666663 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
    • Nakata S, Yoshida T, Horinaka M, Shiraishi T, Wakada M, Sakai T. Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells. Oncogene (2004) 23:6261-71. doi:10.1038/sj.onc.1207830
    • (2004) Oncogene , vol.23 , pp. 6261-6271
    • Nakata, S.1    Yoshida, T.2    Horinaka, M.3    Shiraishi, T.4    Wakada, M.5    Sakai, T.6
  • 50
    • 33646517941 scopus 로고    scopus 로고
    • SAHA-sensitized prostate cancer cells to TNFalpha-related apoptosis-inducing ligand (TRAIL): mechanisms leading to synergistic apoptosis
    • Lakshmikanthan V, Kaddour-Djebbar I, Lewis RW, Kumar MV. SAHA-sensitized prostate cancer cells to TNFalpha-related apoptosis-inducing ligand (TRAIL): mechanisms leading to synergistic apoptosis. Int J Cancer (2006) 119:221-8. doi:10.1002/ijc.21824
    • (2006) Int J Cancer , vol.119 , pp. 221-228
    • Lakshmikanthan, V.1    Kaddour-Djebbar, I.2    Lewis, R.W.3    Kumar, M.V.4
  • 51
    • 34347226747 scopus 로고    scopus 로고
    • Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines
    • Lillehammer T, Engesaeter BO, Prasmickaite L, Maelandsmo GM, Fodstad O, Engebraaten O. Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines. J Gene Med (2007) 9:440-51. doi:10.1002/jgm.1036
    • (2007) J Gene Med , vol.9 , pp. 440-451
    • Lillehammer, T.1    Engesaeter, B.O.2    Prasmickaite, L.3    Maelandsmo, G.M.4    Fodstad, O.5    Engebraaten, O.6
  • 52
    • 68749089762 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation
    • Carlisi D, Lauricella M, D'anneo A, Emanuele S, Angileri L, Di Fazio P, et al. The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation. Eur J Cancer (2009) 45:2425-38. doi:10.1016/j.ejca.2009.06.024
    • (2009) Eur J Cancer , vol.45 , pp. 2425-2438
    • Carlisi, D.1    Lauricella, M.2    D'anneo, A.3    Emanuele, S.4    Angileri, L.5    Di Fazio, P.6
  • 53
    • 84855862321 scopus 로고    scopus 로고
    • SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells
    • Lauricella M, Ciraolo A, Carlisi D, Vento R, Tesoriere G. SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells. Biochimie (2012) 94:287-99. doi:10.1016/j.biochi.2011.06.031
    • (2012) Biochimie , vol.94 , pp. 287-299
    • Lauricella, M.1    Ciraolo, A.2    Carlisi, D.3    Vento, R.4    Tesoriere, G.5
  • 54
    • 84897477361 scopus 로고    scopus 로고
    • Epigenetic regulation of the TRAIL/Apo2L apoptotic pathway by histone deacetylase inhibitors: an attractive approach to bypass melanoma immunotherapy resistance
    • Jazirehi AR, Arle D. Epigenetic regulation of the TRAIL/Apo2L apoptotic pathway by histone deacetylase inhibitors: an attractive approach to bypass melanoma immunotherapy resistance. Am J Clin Exp Immunol (2013) 2:55-74.
    • (2013) Am J Clin Exp Immunol , vol.2 , pp. 55-74
    • Jazirehi, A.R.1    Arle, D.2
  • 55
    • 67651121842 scopus 로고    scopus 로고
    • The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy
    • Ellis L, Bots M, Lindemann RK, Bolden JE, Newbold A, Cluse LA, et al. The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy. Blood (2009) 114:380-93. doi:10.1182/blood-2008-10-182758
    • (2009) Blood , vol.114 , pp. 380-393
    • Ellis, L.1    Bots, M.2    Lindemann, R.K.3    Bolden, J.E.4    Newbold, A.5    Cluse, L.A.6
  • 56
    • 84887994817 scopus 로고    scopus 로고
    • The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity
    • Woods DM, Woan K, Cheng F, Wang H, Perez-Villarroel P, Lee C, et al. The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity. Melanoma Res (2013) 23(5):341-8. doi:10.1097/CMR.0b013e328364c0ed
    • (2013) Melanoma Res , vol.23 , Issue.5 , pp. 341-348
    • Woods, D.M.1    Woan, K.2    Cheng, F.3    Wang, H.4    Perez-Villarroel, P.5    Lee, C.6
  • 57
    • 78751512281 scopus 로고    scopus 로고
    • Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model
    • Belinsky SA, Grimes MJ, Picchi MA, Mitchell HD, Stidley CA, Tesfaigzi Y, et al. Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model. Cancer Res (2011) 71:454-62. doi:10.1158/0008-5472.CAN-10-3184
    • (2011) Cancer Res , vol.71 , pp. 454-462
    • Belinsky, S.A.1    Grimes, M.J.2    Picchi, M.A.3    Mitchell, H.D.4    Stidley, C.A.5    Tesfaigzi, Y.6
  • 58
    • 84906239824 scopus 로고    scopus 로고
    • SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome
    • Tellez CS, Grimes MJ, Picchi MA, Liu Y, March TH, Reed MD, et al. SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome. Int J Cancer (2014) 135:2223-31. doi:10.1002/ijc.28865
    • (2014) Int J Cancer , vol.135 , pp. 2223-2231
    • Tellez, C.S.1    Grimes, M.J.2    Picchi, M.A.3    Liu, Y.4    March, T.H.5    Reed, M.D.6
  • 59
    • 72249110437 scopus 로고    scopus 로고
    • Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the department of defense prostate cancer clinical trial consortium and University of Chicago phase 2 consortium
    • Bradley D, Rathkopf D, Dunn R, Stadler WM, Liu G, Smith DC, et al. Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the department of defense prostate cancer clinical trial consortium and University of Chicago phase 2 consortium. Cancer (2009) 115:5541-9. doi:10.1002/cncr.24597
    • (2009) Cancer , vol.115 , pp. 5541-5549
    • Bradley, D.1    Rathkopf, D.2    Dunn, R.3    Stadler, W.M.4    Liu, G.5    Smith, D.C.6
  • 60
    • 67349228774 scopus 로고    scopus 로고
    • Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges
    • Atadja P. Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges. Cancer Lett (2009) 280:233-41. doi:10.1016/j.canlet.2009.02.019
    • (2009) Cancer Lett , vol.280 , pp. 233-241
    • Atadja, P.1
  • 61
    • 1642453460 scopus 로고    scopus 로고
    • Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101
    • Plumb JA, Finn PW, Williams RJ, Bandara MJ, Romero MR, Watkins CJ, et al. Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101. Mol Cancer Ther (2003) 2:721-8.
    • (2003) Mol Cancer Ther , vol.2 , pp. 721-728
    • Plumb, J.A.1    Finn, P.W.2    Williams, R.J.3    Bandara, M.J.4    Romero, M.R.5    Watkins, C.J.6
  • 62
    • 33745087150 scopus 로고    scopus 로고
    • CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo
    • Buggy JJ, Cao ZA, Bass KE, Verner E, Balasubramanian S, Liu L, et al. CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. Mol Cancer Ther (2006) 5:1309-17. doi:10.1158/1535-7163.MCT-05-0442
    • (2006) Mol Cancer Ther , vol.5 , pp. 1309-1317
    • Buggy, J.J.1    Cao, Z.A.2    Bass, K.E.3    Verner, E.4    Balasubramanian, S.5    Liu, L.6
  • 63
    • 33646495294 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo
    • Leoni F, Fossati G, Lewis EC, Lee JK, Porro G, Pagani P, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med (2005) 11:1-15. doi:10.2119/2006-00005.Dinarello
    • (2005) Mol Med , vol.11 , pp. 1-15
    • Leoni, F.1    Fossati, G.2    Lewis, E.C.3    Lee, J.K.4    Porro, G.5    Pagani, P.6
  • 64
    • 77951685547 scopus 로고    scopus 로고
    • The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells
    • Mandl-Weber S, Meinel FG, Jankowsky R, Oduncu F, Schmidmaier R, Baumann P. The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. Br J Haematol (2010) 149:518-28. doi:10.1111/j.1365-2141.2010.08124.x
    • (2010) Br J Haematol , vol.149 , pp. 518-528
    • Mandl-Weber, S.1    Meinel, F.G.2    Jankowsky, R.3    Oduncu, F.4    Schmidmaier, R.5    Baumann, P.6
  • 65
    • 72549086620 scopus 로고    scopus 로고
    • JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity
    • Arts J, King P, Marien A, Floren W, Belien A, Janssen L, et al. JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. Clin Cancer Res (2009) 15:6841-51. doi:10.1158/1078-0432.CCR-09-0547
    • (2009) Clin Cancer Res , vol.15 , pp. 6841-6851
    • Arts, J.1    King, P.2    Marien, A.3    Floren, W.4    Belien, A.5    Janssen, L.6
  • 66
    • 77949714263 scopus 로고    scopus 로고
    • SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer
    • Novotny-Diermayr V, Sangthongpitag K, Hu CY, Wu X, Sausgruber N, Yeo P, et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol Cancer Ther (2010) 9:642-52. doi:10.1158/1535-7163.MCT-09-0689
    • (2010) Mol Cancer Ther , vol.9 , pp. 642-652
    • Novotny-Diermayr, V.1    Sangthongpitag, K.2    Hu, C.Y.3    Wu, X.4    Sausgruber, N.5    Yeo, P.6
  • 67
    • 0141593496 scopus 로고    scopus 로고
    • NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
    • Catley L, Weisberg E, Tai YT, Atadja P, Remiszewski S, Hideshima T, et al. NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood (2003) 102:2615-22. doi:10.1182/blood-2003-01-0233
    • (2003) Blood , vol.102 , pp. 2615-2622
    • Catley, L.1    Weisberg, E.2    Tai, Y.T.3    Atadja, P.4    Remiszewski, S.5    Hideshima, T.6
  • 68
    • 0034905872 scopus 로고    scopus 로고
    • Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase
    • Butler LM, Webb Y, Agus DB, Higgins B, Tolentino TR, Kutko MC, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res (2001) 7:962-70.
    • (2001) Clin Cancer Res , vol.7 , pp. 962-970
    • Butler, L.M.1    Webb, Y.2    Agus, D.B.3    Higgins, B.4    Tolentino, T.R.5    Kutko, M.C.6
  • 69
    • 78650390271 scopus 로고    scopus 로고
    • Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrim idine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor
    • Moffat D, Patel S, Day F, Belfield A, Donald A, Rowlands M, et al. Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrim idine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor. J Med Chem (2010) 53:8663-78. doi:10.1021/jm101177s
    • (2010) J Med Chem , vol.53 , pp. 8663-8678
    • Moffat, D.1    Patel, S.2    Day, F.3    Belfield, A.4    Donald, A.5    Rowlands, M.6
  • 70
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov (2006) 5:769-84. doi:10.1038/nrd2133
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 71
    • 0029294663 scopus 로고
    • Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function
    • Yoshida M, Horinouchi S, Beppu T. Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays (1995) 17:423-30. doi:10.1002/bies.950170510
    • (1995) Bioessays , vol.17 , pp. 423-430
    • Yoshida, M.1    Horinouchi, S.2    Beppu, T.3
  • 72
    • 0033561497 scopus 로고    scopus 로고
    • Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase
    • Kim YB, Lee KH, Sugita K, Yoshida M, Horinouchi S. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene (1999) 18:2461-70. doi:10.1038/sj.onc.1202564
    • (1999) Oncogene , vol.18 , pp. 2461-2470
    • Kim, Y.B.1    Lee, K.H.2    Sugita, K.3    Yoshida, M.4    Horinouchi, S.5
  • 73
    • 57749101152 scopus 로고    scopus 로고
    • Specific activity of class II histone deacetylases in human breast cancer cells
    • Duong V, Bret C, Altucci L, Mai A, Duraffourd C, Loubersac J, et al. Specific activity of class II histone deacetylases in human breast cancer cells. Mol Cancer Res (2008) 6:1908-19. doi:10.1158/1541-7786.MCR-08-0299
    • (2008) Mol Cancer Res , vol.6 , pp. 1908-1919
    • Duong, V.1    Bret, C.2    Altucci, L.3    Mai, A.4    Duraffourd, C.5    Loubersac, J.6
  • 74
    • 78650575875 scopus 로고    scopus 로고
    • Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents
    • Namdar M, Perez G, Ngo L, Marks PA. Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proc Natl Acad Sci U S A (2010) 107:20003-8. doi:10.1073/pnas.1013754107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 20003-20008
    • Namdar, M.1    Perez, G.2    Ngo, L.3    Marks, P.A.4
  • 75
    • 43749109171 scopus 로고    scopus 로고
    • A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas
    • Balasubramanian S, Ramos J, Luo W, Sirisawad M, Verner E, Buggy JJ. A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia (2008) 22:1026-34. doi:10.1038/leu.2008.9
    • (2008) Leukemia , vol.22 , pp. 1026-1034
    • Balasubramanian, S.1    Ramos, J.2    Luo, W.3    Sirisawad, M.4    Verner, E.5    Buggy, J.J.6
  • 76
    • 33645817023 scopus 로고    scopus 로고
    • Anticancer activity of MS-275, a novel histone deacetylase inhibitor, against human endometrial cancer cells
    • Takai N, Ueda T, Nishida M, Nasu K, Narahara H. Anticancer activity of MS-275, a novel histone deacetylase inhibitor, against human endometrial cancer cells. Anticancer Res (2006) 26:939-45.
    • (2006) Anticancer Res , vol.26 , pp. 939-945
    • Takai, N.1    Ueda, T.2    Nishida, M.3    Nasu, K.4    Narahara, H.5
  • 77
    • 0141996376 scopus 로고    scopus 로고
    • Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma
    • Kraker AJ, Mizzen CA, Hartl BG, Miin J, Allis CD, Merriman RL. Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. Mol Cancer Ther (2003) 2:401-8.
    • (2003) Mol Cancer Ther , vol.2 , pp. 401-408
    • Kraker, A.J.1    Mizzen, C.A.2    Hartl, B.G.3    Miin, J.4    Allis, C.D.5    Merriman, R.L.6
  • 78
    • 42249084230 scopus 로고    scopus 로고
    • MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo
    • Fournel M, Bonfils C, Hou Y, Yan PT, Trachy-Bourget MC, Kalita A, et al. MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther (2008) 7:759-68. doi:10.1158/1535-7163.MCT-07-2026
    • (2008) Mol Cancer Ther , vol.7 , pp. 759-768
    • Fournel, M.1    Bonfils, C.2    Hou, Y.3    Yan, P.T.4    Trachy-Bourget, M.C.5    Kalita, A.6
  • 79
    • 84859787650 scopus 로고    scopus 로고
    • Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity
    • Ning ZQ, Li ZB, Newman MJ, Shan S, Wang XH, Pan DS, et al. Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother Pharmacol (2012) 69:901-9. doi:10.1007/s00280-011-1766-x
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 901-909
    • Ning, Z.Q.1    Li, Z.B.2    Newman, M.J.3    Shan, S.4    Wang, X.H.5    Pan, D.S.6
  • 80
    • 33748958614 scopus 로고    scopus 로고
    • The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines
    • Savickiene J, Borutinskaite VV, Treigyte G, Magnusson KE, Navakauskiene R. The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines. Eur J Pharmacol (2006) 549:9-18. doi:10.1016/j.ejphar.2006.08.010
    • (2006) Eur J Pharmacol , vol.549 , pp. 9-18
    • Savickiene, J.1    Borutinskaite, V.V.2    Treigyte, G.3    Magnusson, K.E.4    Navakauskiene, R.5
  • 81
    • 84860240276 scopus 로고    scopus 로고
    • HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation
    • Yeung A, Bhargava RK, Ahn R, Bahna S, Kang NH, Lacoul A, et al. HDAC inhibitor M344 suppresses MCF-7 breast cancer cell proliferation. Biomed Pharmacother (2012) 66:232-6. doi:10.1016/j.biopha.2011.06.007
    • (2012) Biomed Pharmacother , vol.66 , pp. 232-236
    • Yeung, A.1    Bhargava, R.K.2    Ahn, R.3    Bahna, S.4    Kang, N.H.5    Lacoul, A.6
  • 82
    • 18244383806 scopus 로고    scopus 로고
    • Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
    • Gottlicher M, Minucci S, Zhu P, Kramer OH, Schimpf A, Giavara S, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J (2001) 20:6969-78. doi:10.1093/emboj/20.24.6969
    • (2001) EMBO J , vol.20 , pp. 6969-6978
    • Gottlicher, M.1    Minucci, S.2    Zhu, P.3    Kramer, O.H.4    Schimpf, A.5    Giavara, S.6
  • 83
    • 0038676409 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity by butyrate
    • Davie JR. Inhibition of histone deacetylase activity by butyrate. J Nutr (2003) 133:2485S-93S.
    • (2003) J Nutr , vol.133 , pp. 2485S-2493S
    • Davie, J.R.1
  • 84
    • 0017886958 scopus 로고
    • Sodium butyrate inhibits histone deacetylation in cultured cells
    • Candido EP, Reeves R, Davie JR. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell (1978) 14:105-13. doi:10.1016/0092-8674(78)90305-7
    • (1978) Cell , vol.14 , pp. 105-113
    • Candido, E.P.1    Reeves, R.2    Davie, J.R.3
  • 85
    • 0028258610 scopus 로고
    • FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity
    • Ueda H, Nakajima H, Hori Y, Fujita T, Nishimura M, Goto T, et al. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J Antibiot (Tokyo) (1994) 47:301-10. doi:10.7164/antibiotics.47.301
    • (1994) J Antibiot (Tokyo) , vol.47 , pp. 301-310
    • Ueda, H.1    Nakajima, H.2    Hori, Y.3    Fujita, T.4    Nishimura, M.5    Goto, T.6
  • 86
    • 0027378351 scopus 로고
    • Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase
    • Kijima M, Yoshida M, Sugita K, Horinouchi S, Beppu T. Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. J Biol Chem (1993) 268:22429-35.
    • (1993) J Biol Chem , vol.268 , pp. 22429-22435
    • Kijima, M.1    Yoshida, M.2    Sugita, K.3    Horinouchi, S.4    Beppu, T.5
  • 87
    • 0034326799 scopus 로고    scopus 로고
    • Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin
    • Han JW, Ahn SH, Park SH, Wang SY, Bae GU, Seo DW, et al. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res (2000) 60:6068-74.
    • (2000) Cancer Res , vol.60 , pp. 6068-6074
    • Han, J.W.1    Ahn, S.H.2    Park, S.H.3    Wang, S.Y.4    Bae, G.U.5    Seo, D.W.6
  • 88
    • 84858339102 scopus 로고    scopus 로고
    • Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment
    • Peled T, Shoham H, Aschengrau D, Yackoubov D, Frei G, Rosenheimer GN, et al. Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment. Exp Hematol (2012) 40(342-355):e341. doi:10.1016/j.exphem.2011.12.005
    • (2012) Exp Hematol , vol.40 , Issue.342-355
    • Peled, T.1    Shoham, H.2    Aschengrau, D.3    Yackoubov, D.4    Frei, G.5    Rosenheimer, G.N.6
  • 90
    • 29144501185 scopus 로고    scopus 로고
    • Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
    • Napper AD, Hixon J, Mcdonagh T, Keavey K, Pons JF, Barker J, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem (2005) 48:8045-54. doi:10.1021/jm050522v
    • (2005) J Med Chem , vol.48 , pp. 8045-8054
    • Napper, A.D.1    Hixon, J.2    Mcdonagh, T.3    Keavey, K.4    Pons, J.F.5    Barker, J.6
  • 91
    • 55449104382 scopus 로고    scopus 로고
    • The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases
    • Olaharski AJ, Rine J, Marshall BL, Babiarz J, Zhang L, Verdin E, et al. The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet (2005) 1:e77. doi:10.1371/journal.pgen.0010077
    • (2005) PLoS Genet , vol.1
    • Olaharski, A.J.1    Rine, J.2    Marshall, B.L.3    Babiarz, J.4    Zhang, L.5    Verdin, E.6
  • 92
    • 84876473075 scopus 로고    scopus 로고
    • Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner
    • McCarthy AR, Sachweh MC, Higgins M, Campbell J, Drummond CJ, Van Leeuwen IM, et al. Tenovin-D3, a novel small-molecule inhibitor of sirtuin SirT2, increases p21 (CDKN1A) expression in a p53-independent manner. Mol Cancer Ther (2013) 12:352-60. doi:10.1158/1535-7163.MCT-12-0900
    • (2013) Mol Cancer Ther , vol.12 , pp. 352-360
    • McCarthy, A.R.1    Sachweh, M.C.2    Higgins, M.3    Campbell, J.4    Drummond, C.J.5    Van Leeuwen, I.M.6
  • 93
    • 84871662210 scopus 로고    scopus 로고
    • Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells
    • Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, et al. Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. J Med Chem (2012) 55:10937-47. doi:10.1021/jm3011614
    • (2012) J Med Chem , vol.55 , pp. 10937-10947
    • Rotili, D.1    Tarantino, D.2    Nebbioso, A.3    Paolini, C.4    Huidobro, C.5    Lara, E.6
  • 94
    • 84894490851 scopus 로고    scopus 로고
    • A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer
    • Hoffmann G, Breitenbucher F, Schuler M, Ehrenhofer-Murray AE. A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. J Biol Chem (2014) 289:5208-16. doi:10.1074/jbc.M113.487736
    • (2014) J Biol Chem , vol.289 , pp. 5208-5216
    • Hoffmann, G.1    Breitenbucher, F.2    Schuler, M.3    Ehrenhofer-Murray, A.E.4
  • 95
    • 33646254136 scopus 로고    scopus 로고
    • Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
    • Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res (2006) 66:4368-77. doi:10.1158/0008-5472.CAN-05-3617
    • (2006) Cancer Res , vol.66 , pp. 4368-4377
    • Heltweg, B.1    Gatbonton, T.2    Schuler, A.D.3    Posakony, J.4    Li, H.5    Goehle, S.6
  • 96
    • 0035914304 scopus 로고    scopus 로고
    • Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
    • Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem (2001) 276:38837-43. doi:10.1074/jbc.M106779200
    • (2001) J Biol Chem , vol.276 , pp. 38837-38843
    • Grozinger, C.M.1    Chao, E.D.2    Blackwell, H.E.3    Moazed, D.4    Schreiber, S.L.5
  • 97
    • 60149091562 scopus 로고    scopus 로고
    • Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect
    • Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, et al. Salermide, a sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene (2009) 28:781-91. doi:10.1038/onc.2008.436
    • (2009) Oncogene , vol.28 , pp. 781-791
    • Lara, E.1    Mai, A.2    Calvanese, V.3    Altucci, L.4    Lopez-Nieva, P.5    Martinez-Chantar, M.L.6
  • 98
    • 42949114938 scopus 로고    scopus 로고
    • Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
    • Lain S, Hollick JJ, Campbell J, Staples OD, Higgins M, Aoubala M, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell (2008) 13:454-63. doi:10.1016/j.ccr.2008.03.004
    • (2008) Cancer Cell , vol.13 , pp. 454-463
    • Lain, S.1    Hollick, J.J.2    Campbell, J.3    Staples, O.D.4    Higgins, M.5    Aoubala, M.6
  • 99
    • 84879092346 scopus 로고    scopus 로고
    • Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
    • Lobera M, Madauss KP, Pohlhaus DT, Wright QG, Trocha M, Schmidt DR, et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol (2013) 9:319-25. doi:10.1038/nchembio.1223
    • (2013) Nat Chem Biol , vol.9 , pp. 319-325
    • Lobera, M.1    Madauss, K.P.2    Pohlhaus, D.T.3    Wright, Q.G.4    Trocha, M.5    Schmidt, D.R.6
  • 100
    • 33847657556 scopus 로고    scopus 로고
    • Psammaplin A is a natural prodrug that inhibits class I histone deacetylase
    • Kim DH, Shin J, Kwon HJ. Psammaplin A is a natural prodrug that inhibits class I histone deacetylase. Exp Mol Med (2007) 39:47-55. doi:10.1038/emm.2007.6
    • (2007) Exp Mol Med , vol.39 , pp. 47-55
    • Kim, D.H.1    Shin, J.2    Kwon, H.J.3
  • 101
    • 84870024675 scopus 로고    scopus 로고
    • Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth
    • Bergman JA, Woan K, Perez-Villarroel P, Villagra A, Sotomayor EM, Kozikowski AP. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem (2012) 55:9891-9. doi:10.1021/jm301098e
    • (2012) J Med Chem , vol.55 , pp. 9891-9899
    • Bergman, J.A.1    Woan, K.2    Perez-Villarroel, P.3    Villagra, A.4    Sotomayor, E.M.5    Kozikowski, A.P.6
  • 102
    • 84880655164 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma
    • Wells CE, Bhaskara S, Stengel KR, Zhao Y, Sirbu B, Chagot B, et al. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One (2013) 8:e68915. doi:10.1371/journal.pone.0068915
    • (2013) PLoS One , vol.8
    • Wells, C.E.1    Bhaskara, S.2    Stengel, K.R.3    Zhao, Y.4    Sirbu, B.5    Chagot, B.6
  • 103
    • 0038079767 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1
    • Rosato RR, Almenara JA, Grant S. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1. Cancer Res (2003) 63:3637-45.
    • (2003) Cancer Res , vol.63 , pp. 3637-3645
    • Rosato, R.R.1    Almenara, J.A.2    Grant, S.3
  • 104
    • 0033822112 scopus 로고    scopus 로고
    • P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228
    • Sandor V, Senderowicz A, Mertins S, Sackett D, Sausville E, Blagosklonny MV, et al. P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228. Br J Cancer (2000) 83:817-25. doi:10.1054/bjoc.2000.1327
    • (2000) Br J Cancer , vol.83 , pp. 817-825
    • Sandor, V.1    Senderowicz, A.2    Mertins, S.3    Sackett, D.4    Sausville, E.5    Blagosklonny, M.V.6
  • 105
    • 84865037340 scopus 로고    scopus 로고
    • Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells
    • Wang J, Kim TH, Ahn MY, Lee J, Jung JH, Choi WS, et al. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol (2012) 41:1101-9. doi:10.3892/ijo.2012.1534
    • (2012) Int J Oncol , vol.41 , pp. 1101-1109
    • Wang, J.1    Kim, T.H.2    Ahn, M.Y.3    Lee, J.4    Jung, J.H.5    Choi, W.S.6
  • 107
    • 84885183510 scopus 로고    scopus 로고
    • Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model
    • Reed MD, Tellez CS, Grimes MJ, Picchi MA, Tessema M, Cheng YS, et al. Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model. Br J Cancer (2013) 109:1775-81. doi:10.1038/bjc.2013.575
    • (2013) Br J Cancer , vol.109 , pp. 1775-1781
    • Reed, M.D.1    Tellez, C.S.2    Grimes, M.J.3    Picchi, M.A.4    Tessema, M.5    Cheng, Y.S.6
  • 108
    • 84901325916 scopus 로고    scopus 로고
    • Novel epigenetic target therapy for prostate cancer: a preclinical study
    • Naldi I, Taranta M, Gherardini L, Pelosi G, Viglione F, Grimaldi S, et al. Novel epigenetic target therapy for prostate cancer: a preclinical study. PLoS One (2014) 9:e98101. doi:10.1371/journal.pone.0098101
    • (2014) PLoS One , vol.9
    • Naldi, I.1    Taranta, M.2    Gherardini, L.3    Pelosi, G.4    Viglione, F.5    Grimaldi, S.6
  • 109
    • 80051604949 scopus 로고    scopus 로고
    • Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML
    • Scandura JM, Roboz GJ, Moh M, Morawa E, Brenet F, Bose JR, et al. Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML. Blood (2011) 118:1472-80. doi:10.1182/blood-2010-11-320093
    • (2011) Blood , vol.118 , pp. 1472-1480
    • Scandura, J.M.1    Roboz, G.J.2    Moh, M.3    Morawa, E.4    Brenet, F.5    Bose, J.R.6
  • 110
    • 84920374465 scopus 로고    scopus 로고
    • Phase I/II study of azacitidine, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel-based therapy
    • Singal R, Ramachandran K, Gordian E, Quintero C, Zhao W, Reis IM. Phase I/II study of azacitidine, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel-based therapy. Clin Genitourin Cancer (2015) 13(1):22-31. doi:10.1016/j.clgc.2014.07.008
    • (2015) Clin Genitourin Cancer , vol.13 , Issue.1 , pp. 22-31
    • Singal, R.1    Ramachandran, K.2    Gordian, E.3    Quintero, C.4    Zhao, W.5    Reis, I.M.6
  • 111
    • 34548395116 scopus 로고    scopus 로고
    • A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors
    • Candelaria M, Gallardo-Rincon D, Arce C, Cetina L, Aguilar-Ponce JL, Arrieta O, et al. A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors. Ann Oncol (2007) 18:1529-38. doi:10.1093/annonc/mdm204
    • (2007) Ann Oncol , vol.18 , pp. 1529-1538
    • Candelaria, M.1    Gallardo-Rincon, D.2    Arce, C.3    Cetina, L.4    Aguilar-Ponce, J.L.5    Arrieta, O.6
  • 112
    • 84939894917 scopus 로고    scopus 로고
    • Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide)
    • Xia C, Leon-Ferre R, Laux D, Deutsch J, Smith BJ, Frees M, et al. Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide). Cancer Chemother Pharmacol (2014) 74:691-7. doi:10.1007/s00280-014-2501-1
    • (2014) Cancer Chemother Pharmacol , vol.74 , pp. 691-697
    • Xia, C.1    Leon-Ferre, R.2    Laux, D.3    Deutsch, J.4    Smith, B.J.5    Frees, M.6
  • 113
    • 33847786883 scopus 로고    scopus 로고
    • A proof-of-principle study of epigenetic therapy added to neoadjuvant doxorubicin cyclophosphamide for locally advanced breast cancer
    • Arce C, Perez-Plasencia C, Gonzalez-Fierro A, De La Cruz-Hernandez E, Revilla-Vazquez A, Chavez-Blanco A, et al. A proof-of-principle study of epigenetic therapy added to neoadjuvant doxorubicin cyclophosphamide for locally advanced breast cancer. PLoS One (2006) 1:e98. doi:10.1371/journal.pone.0000098
    • (2006) PLoS One , vol.1
    • Arce, C.1    Perez-Plasencia, C.2    Gonzalez-Fierro, A.3    De La Cruz-Hernandez, E.4    Revilla-Vazquez, A.5    Chavez-Blanco, A.6
  • 114
    • 84862738480 scopus 로고    scopus 로고
    • BET domain co-regulators in obesity, inflammation and cancer
    • Belkina AC, Denis GV. BET domain co-regulators in obesity, inflammation and cancer. Nat Rev Cancer (2012) 12:465-77. doi:10.1038/nrc3256
    • (2012) Nat Rev Cancer , vol.12 , pp. 465-477
    • Belkina, A.C.1    Denis, G.V.2
  • 115
    • 0037609173 scopus 로고
    • The importance of dosage in the intradermal immunization against transplantable neoplasms
    • Gross L. The importance of dosage in the intradermal immunization against transplantable neoplasms. Cancer Res (1943) 3:770-8.
    • (1943) Cancer Res , vol.3 , pp. 770-778
    • Gross, L.1
  • 116
    • 0942288397 scopus 로고    scopus 로고
    • Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters
    • Gotter J, Brors B, Hergenhahn M, Kyewski B. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med (2004) 199:155-66. doi:10.1084/jem.20031677
    • (2004) J Exp Med , vol.199 , pp. 155-166
    • Gotter, J.1    Brors, B.2    Hergenhahn, M.3    Kyewski, B.4
  • 119
    • 50349087907 scopus 로고    scopus 로고
    • Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer
    • Woloszynska-Read A, Mhawech-Fauceglia P, Yu J, Odunsi K, Karpf AR. Intertumor and intratumor NY-ESO-1 expression heterogeneity is associated with promoter-specific and global DNA methylation status in ovarian cancer. Clin Cancer Res (2008) 14:3283-90. doi:10.1158/1078-0432.CCR-07-5279
    • (2008) Clin Cancer Res , vol.14 , pp. 3283-3290
    • Woloszynska-Read, A.1    Mhawech-Fauceglia, P.2    Yu, J.3    Odunsi, K.4    Karpf, A.R.5
  • 120
    • 18144429106 scopus 로고    scopus 로고
    • Cancer/testis antigens and gametogenesis: a review and "brain-storming" session
    • Kalejs M, Erenpreisa J. Cancer/testis antigens and gametogenesis: a review and "brain-storming" session. Cancer Cell Int (2005) 5:4. doi:10.1186/1475-2867-5-4
    • (2005) Cancer Cell Int , vol.5 , pp. 4
    • Kalejs, M.1    Erenpreisa, J.2
  • 122
    • 84891887628 scopus 로고    scopus 로고
    • Cause and consequence of cancer/testis antigen activation in cancer
    • Whitehurst AW. Cause and consequence of cancer/testis antigen activation in cancer. Annu Rev Pharmacol Toxicol (2014) 54:251-72. doi:10.1146/annurev-pharmtox-011112-140326
    • (2014) Annu Rev Pharmacol Toxicol , vol.54 , pp. 251-272
    • Whitehurst, A.W.1
  • 123
    • 78349240805 scopus 로고    scopus 로고
    • Expression of cancer/testis antigens in prostate cancer is associated with disease progression
    • Suyama T, Shiraishi T, Zeng Y, Yu W, Parekh N, Vessella RL, et al. Expression of cancer/testis antigens in prostate cancer is associated with disease progression. Prostate (2010) 70:1778-87. doi:10.1002/pros.21214
    • (2010) Prostate , vol.70 , pp. 1778-1787
    • Suyama, T.1    Shiraishi, T.2    Zeng, Y.3    Yu, W.4    Parekh, N.5    Vessella, R.L.6
  • 124
    • 80155131086 scopus 로고    scopus 로고
    • Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer
    • Smith HA, Cronk RJ, Lang JM, Mcneel DG. Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer. Cancer Res (2011) 71:6785-95. doi:10.1158/0008-5472.CAN-11-2127
    • (2011) Cancer Res , vol.71 , pp. 6785-6795
    • Smith, H.A.1    Cronk, R.J.2    Lang, J.M.3    Mcneel, D.G.4
  • 126
    • 36849022167 scopus 로고    scopus 로고
    • Inducible expression of a prostate cancer-testis antigen, SSX-2, following treatment with a DNA methylation inhibitor
    • Dubovsky JA, McNeel DG. Inducible expression of a prostate cancer-testis antigen, SSX-2, following treatment with a DNA methylation inhibitor. Prostate (2007) 67:1781-90. doi:10.1002/pros.20665
    • (2007) Prostate , vol.67 , pp. 1781-1790
    • Dubovsky, J.A.1    McNeel, D.G.2
  • 127
    • 0026322151 scopus 로고
    • A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    • van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van Den Eynde B, et al. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science (1991) 254:1643-7. doi:10.1126/science.1840703
    • (1991) Science , vol.254 , pp. 1643-1647
    • van der Bruggen, P.1    Traversari, C.2    Chomez, P.3    Lurquin, C.4    De Plaen, E.5    Van Den Eynde, B.6
  • 129
    • 0028328854 scopus 로고
    • Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine
    • Weber J, Salgaller M, Samid D, Johnson B, Herlyn M, Lassam N, et al. Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine. Cancer Res (1994) 54:1766-71.
    • (1994) Cancer Res , vol.54 , pp. 1766-1771
    • Weber, J.1    Salgaller, M.2    Samid, D.3    Johnson, B.4    Herlyn, M.5    Lassam, N.6
  • 130
    • 84899892697 scopus 로고    scopus 로고
    • Development of a T cell receptor targeting an HLA-A*0201 restricted epitope from the cancer-testis antigen SSX2 for adoptive immunotherapy of cancer
    • Abate-Daga D, Speiser DE, Chinnasamy N, Zheng Z, Xu H, Feldman SA, et al. Development of a T cell receptor targeting an HLA-A*0201 restricted epitope from the cancer-testis antigen SSX2 for adoptive immunotherapy of cancer. PLoS One (2014) 9:e93321. doi:10.1371/journal.pone.0093321
    • (2014) PLoS One , vol.9
    • Abate-Daga, D.1    Speiser, D.E.2    Chinnasamy, N.3    Zheng, Z.4    Xu, H.5    Feldman, S.A.6
  • 131
    • 0037068358 scopus 로고    scopus 로고
    • Reactivating the expression of methylation silenced genes in human cancer
    • Karpf AR, Jones DA. Reactivating the expression of methylation silenced genes in human cancer. Oncogene (2002) 21:5496-503. doi:10.1038/sj.onc.1205602
    • (2002) Oncogene , vol.21 , pp. 5496-5503
    • Karpf, A.R.1    Jones, D.A.2
  • 132
    • 0029957792 scopus 로고    scopus 로고
    • The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation
    • De Smet C, De Backer O, Faraoni I, Lurquin C, Brasseur F, Boon T. The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. Proc Natl Acad Sci U S A (1996) 93:7149-53. doi:10.1073/pnas.93.14.7149
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 7149-7153
    • De Smet, C.1    De Backer, O.2    Faraoni, I.3    Lurquin, C.4    Brasseur, F.5    Boon, T.6
  • 133
    • 3042707323 scopus 로고    scopus 로고
    • Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
    • Yu J, Ni M, Xu J, Zhang H, Gao B, Gu J, et al. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer (2002) 2:29. doi:10.1186/1471-2407-2-29
    • (2002) BMC Cancer , vol.2 , pp. 29
    • Yu, J.1    Ni, M.2    Xu, J.3    Zhang, H.4    Gao, B.5    Gu, J.6
  • 134
    • 13144290928 scopus 로고    scopus 로고
    • Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma
    • Yu J, Zhang H, Gu J, Lin S, Li J, Lu W, et al. Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. BMC Cancer (2004) 4:65. doi:10.1186/1471-2407-4-65
    • (2004) BMC Cancer , vol.4 , pp. 65
    • Yu, J.1    Zhang, H.2    Gu, J.3    Lin, S.4    Li, J.5    Lu, W.6
  • 135
    • 33750584813 scopus 로고    scopus 로고
    • Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b
    • James SR, Link PA, Karpf AR. Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b. Oncogene (2006) 25:6975-85. doi:10.1038/sj.onc.1209678
    • (2006) Oncogene , vol.25 , pp. 6975-6985
    • James, S.R.1    Link, P.A.2    Karpf, A.R.3
  • 136
    • 79958822224 scopus 로고    scopus 로고
    • Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer
    • Rao M, Chinnasamy N, Hong JA, Zhang Y, Zhang M, Xi S, et al. Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer. Cancer Res (2011) 71:4192-204. doi:10.1158/0008-5472.CAN-10-2442
    • (2011) Cancer Res , vol.71 , pp. 4192-4204
    • Rao, M.1    Chinnasamy, N.2    Hong, J.A.3    Zhang, Y.4    Zhang, M.5    Xi, S.6
  • 137
    • 33744507681 scopus 로고    scopus 로고
    • Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells
    • Loriot A, De Plaen E, Boon T, De Smet C. Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells. J Biol Chem (2006) 281:10118-26. doi:10.1074/jbc.M510469200
    • (2006) J Biol Chem , vol.281 , pp. 10118-10126
    • Loriot, A.1    De Plaen, E.2    Boon, T.3    De Smet, C.4
  • 138
    • 42549133624 scopus 로고    scopus 로고
    • The DNA demethylating agent 5-aza-2'-deoxycytidine activates NY-ESO-1 antigenicity in orthotopic human glioma
    • Natsume A, Wakabayashi T, Tsujimura K, Shimato S, Ito M, Kuzushima K, et al. The DNA demethylating agent 5-aza-2'-deoxycytidine activates NY-ESO-1 antigenicity in orthotopic human glioma. Int J Cancer (2008) 122:2542-53. doi:10.1002/ijc.23407
    • (2008) Int J Cancer , vol.122 , pp. 2542-2553
    • Natsume, A.1    Wakabayashi, T.2    Tsujimura, K.3    Shimato, S.4    Ito, M.5    Kuzushima, K.6
  • 139
    • 77952952304 scopus 로고    scopus 로고
    • The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells
    • Almstedt M, Blagitko-Dorfs N, Duque-Afonso J, Karbach J, Pfeifer D, Jager E, et al. The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells. Leuk Res (2010) 34:899-905. doi:10.1016/j.leukres.2010.02.004
    • (2010) Leuk Res , vol.34 , pp. 899-905
    • Almstedt, M.1    Blagitko-Dorfs, N.2    Duque-Afonso, J.3    Karbach, J.4    Pfeifer, D.5    Jager, E.6
  • 140
    • 84896820241 scopus 로고    scopus 로고
    • Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers
    • Li H, Chiappinelli KB, Guzzetta AA, Easwaran H, Yen RW, Vatapalli R, et al. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget (2014) 5:587-98.
    • (2014) Oncotarget , vol.5 , pp. 587-598
    • Li, H.1    Chiappinelli, K.B.2    Guzzetta, A.A.3    Easwaran, H.4    Yen, R.W.5    Vatapalli, R.6
  • 141
    • 0035126974 scopus 로고    scopus 로고
    • Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1
    • Weiser TS, Guo ZS, Ohnmacht GA, Parkhurst ML, Tong-On P, Marincola FM, et al. Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1. J Immunother (2001) 24:151-61. doi:10.1097/00002371-200103000-00010
    • (2001) J Immunother , vol.24 , pp. 151-161
    • Weiser, T.S.1    Guo, Z.S.2    Ohnmacht, G.A.3    Parkhurst, M.L.4    Tong-On, P.5    Marincola, F.M.6
  • 143
    • 84865553406 scopus 로고    scopus 로고
    • Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity
    • Toor AA, Payne KK, Chung HM, Sabo RT, Hazlett AF, Kmieciak M, et al. Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity. Br J Haematol (2012) 158:700-11. doi:10.1111/j.1365-2141.2012.09225.x
    • (2012) Br J Haematol , vol.158 , pp. 700-711
    • Toor, A.A.1    Payne, K.K.2    Chung, H.M.3    Sabo, R.T.4    Hazlett, A.F.5    Kmieciak, M.6
  • 144
    • 84873991752 scopus 로고    scopus 로고
    • Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
    • Morgan RA, Chinnasamy N, Abate-Daga D, Gros A, Robbins PF, Zheng Z, et al. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother (2013) 36:133-51. doi:10.1097/CJI.0b013e3182829903
    • (2013) J Immunother , vol.36 , pp. 133-151
    • Morgan, R.A.1    Chinnasamy, N.2    Abate-Daga, D.3    Gros, A.4    Robbins, P.F.5    Zheng, Z.6
  • 145
    • 84883529774 scopus 로고    scopus 로고
    • Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors
    • Kortenhorst MS, Wissing MD, Rodriguez R, Kachhap SK, Jans JJ, Van Der Groep P, et al. Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors. Epigenetics (2013) 8:907-20. doi:10.4161/epi.25574
    • (2013) Epigenetics , vol.8 , pp. 907-920
    • Kortenhorst, M.S.1    Wissing, M.D.2    Rodriguez, R.3    Kachhap, S.K.4    Jans, J.J.5    Van Der Groep, P.6
  • 146
    • 27944441722 scopus 로고    scopus 로고
    • Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis
    • Watson NF, Ramage JM, Madjd Z, Spendlove I, Ellis IO, Scholefield JH, et al. Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis. Int J Cancer (2006) 118:6-10. doi:10.1002/ijc.21303
    • (2006) Int J Cancer , vol.118 , pp. 6-10
    • Watson, N.F.1    Ramage, J.M.2    Madjd, Z.3    Spendlove, I.4    Ellis, I.O.5    Scholefield, J.H.6
  • 147
    • 73349138887 scopus 로고    scopus 로고
    • Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas
    • Cathro HP, Smolkin ME, Theodorescu D, Jo VY, Ferrone S, Frierson HF Jr. Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas. Cancer Immunol Immunother (2010) 59:465-72. doi:10.1007/s00262-009-0765-9
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 465-472
    • Cathro, H.P.1    Smolkin, M.E.2    Theodorescu, D.3    Jo, V.Y.4    Ferrone, S.5    Frierson, H.F.6
  • 148
    • 77449133036 scopus 로고    scopus 로고
    • Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer
    • Seliger B, Stoehr R, Handke D, Mueller A, Ferrone S, Wullich B, et al. Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer. Cancer Immunol Immunother (2010) 59:529-40. doi:10.1007/s00262-009-0769-5
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 529-540
    • Seliger, B.1    Stoehr, R.2    Handke, D.3    Mueller, A.4    Ferrone, S.5    Wullich, B.6
  • 149
    • 79551702601 scopus 로고    scopus 로고
    • Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer
    • Ayshamgul H, Ma H, Ilyar S, Zhang LW, Abulizi A. Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer. Chin Med J (Engl) (2011) 124:341-6.
    • (2011) Chin Med J (Engl) , vol.124 , pp. 341-346
    • Ayshamgul, H.1    Ma, H.2    Ilyar, S.3    Zhang, L.W.4    Abulizi, A.5
  • 150
    • 84883157468 scopus 로고    scopus 로고
    • MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells
    • Leone P, Shin EC, Perosa F, Vacca A, Dammacco F, Racanelli V. MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells. J Natl Cancer Inst (2013) 105:1172-87. doi:10.1093/jnci/djt184
    • (2013) J Natl Cancer Inst , vol.105 , pp. 1172-1187
    • Leone, P.1    Shin, E.C.2    Perosa, F.3    Vacca, A.4    Dammacco, F.5    Racanelli, V.6
  • 151
    • 64049100009 scopus 로고    scopus 로고
    • Antigen processing and presentation: TAPping into ABC transporters
    • Procko E, Gaudet R. Antigen processing and presentation: TAPping into ABC transporters. Curr Opin Immunol (2009) 21:84-91. doi:10.1016/j.coi.2009.02.003
    • (2009) Curr Opin Immunol , vol.21 , pp. 84-91
    • Procko, E.1    Gaudet, R.2
  • 152
    • 83555173561 scopus 로고    scopus 로고
    • Combined genetic inactivation of beta2-microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma
    • Challa-Malladi M, Lieu YK, Califano O, Holmes AB, Bhagat G, Murty VV, et al. Combined genetic inactivation of beta2-microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma. Cancer Cell (2011) 20:728-40. doi:10.1016/j.ccr.2011.11.006
    • (2011) Cancer Cell , vol.20 , pp. 728-740
    • Challa-Malladi, M.1    Lieu, Y.K.2    Califano, O.3    Holmes, A.B.4    Bhagat, G.5    Murty, V.V.6
  • 153
    • 84890130945 scopus 로고    scopus 로고
    • Alterations of immune response of non-small cell lung cancer with azacytidine
    • Wrangle J, Wang W, Koch A, Easwaran H, Mohammad HP, Vendetti F, et al. Alterations of immune response of non-small cell lung cancer with azacytidine. Oncotarget (2013) 4:2067-79.
    • (2013) Oncotarget , vol.4 , pp. 2067-2079
    • Wrangle, J.1    Wang, W.2    Koch, A.3    Easwaran, H.4    Mohammad, H.P.5    Vendetti, F.6
  • 155
    • 80755163537 scopus 로고    scopus 로고
    • Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status
    • Simova J, Pollakova V, Indrova M, Mikyskova R, Bieblova J, Stepanek I, et al. Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status. Br J Cancer (2011) 105:1533-41. doi:10.1038/bjc.2011.428
    • (2011) Br J Cancer , vol.105 , pp. 1533-1541
    • Simova, J.1    Pollakova, V.2    Indrova, M.3    Mikyskova, R.4    Bieblova, J.5    Stepanek, I.6
  • 156
    • 84855931820 scopus 로고    scopus 로고
    • Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity
    • Trumpfheller C, Longhi MP, Caskey M, Idoyaga J, Bozzacco L, Keler T, et al. Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity. J Intern Med (2012) 271:183-92. doi:10.1111/j.1365-2796.2011.02496.x
    • (2012) J Intern Med , vol.271 , pp. 183-192
    • Trumpfheller, C.1    Longhi, M.P.2    Caskey, M.3    Idoyaga, J.4    Bozzacco, L.5    Keler, T.6
  • 157
    • 84893442447 scopus 로고    scopus 로고
    • Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells
    • Dilek N, Poirier N, Hulin P, Coulon F, Mary C, Ville S, et al. Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells. PLoS One (2013) 8:e83139. doi:10.1371/journal.pone.0083139
    • (2013) PLoS One , vol.8
    • Dilek, N.1    Poirier, N.2    Hulin, P.3    Coulon, F.4    Mary, C.5    Ville, S.6
  • 158
    • 84877355904 scopus 로고    scopus 로고
    • Low dose decitabine treatment induces CD80 expression in cancer cells and stimulates tumor specific cytotoxic T lymphocyte responses
    • Wang LX, Mei ZY, Zhou JH, Yao YS, Li YH, Xu YH, et al. Low dose decitabine treatment induces CD80 expression in cancer cells and stimulates tumor specific cytotoxic T lymphocyte responses. PLoS One (2013) 8:e62924. doi:10.1371/journal.pone.0062924
    • (2013) PLoS One , vol.8
    • Wang, L.X.1    Mei, Z.Y.2    Zhou, J.H.3    Yao, Y.S.4    Li, Y.H.5    Xu, Y.H.6
  • 159
    • 84905994658 scopus 로고    scopus 로고
    • Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
    • Kim K, Skora AD, Li Z, Liu Q, Tam AJ, Blosser RL, et al. Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells. Proc Natl Acad Sci U S A (2014) 111:11774-9. doi:10.1073/pnas.1410626111
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 11774-11779
    • Kim, K.1    Skora, A.D.2    Li, Z.3    Liu, Q.4    Tam, A.J.5    Blosser, R.L.6
  • 160
    • 84902075577 scopus 로고    scopus 로고
    • Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents
    • Yang H, Bueso-Ramos C, Dinardo C, Estecio MR, Davanlou M, Geng QR, et al. Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents. Leukemia (2014) 28:1280-8. doi:10.1038/leu.2013.355
    • (2014) Leukemia , vol.28 , pp. 1280-1288
    • Yang, H.1    Bueso-Ramos, C.2    Dinardo, C.3    Estecio, M.R.4    Davanlou, M.5    Geng, Q.R.6
  • 162
    • 84872514622 scopus 로고    scopus 로고
    • Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
    • Lipson EJ, Sharfman WH, Drake CG, Wollner I, Taube JM, Anders RA, et al. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res (2013) 19:462-8. doi:10.1158/1078-0432.CCR-12-2625
    • (2013) Clin Cancer Res , vol.19 , pp. 462-468
    • Lipson, E.J.1    Sharfman, W.H.2    Drake, C.G.3    Wollner, I.4    Taube, J.M.5    Anders, R.A.6
  • 163
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res (2014) 20:5064-74. doi:10.1158/1078-0432.CCR-13-3271
    • (2014) Clin Cancer Res , vol.20 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3    Xu, H.4    Pan, X.5    Kim, J.H.6
  • 164
    • 84891276397 scopus 로고    scopus 로고
    • An intact immune system is required for the anticancer activities of histone deacetylase inhibitors
    • West AC, Mattarollo SR, Shortt J, Cluse LA, Christiansen AJ, Smyth MJ, et al. An intact immune system is required for the anticancer activities of histone deacetylase inhibitors. Cancer Res (2013) 73:7265-76. doi:10.1158/0008-5472.CAN-13-0890
    • (2013) Cancer Res , vol.73 , pp. 7265-7276
    • West, A.C.1    Mattarollo, S.R.2    Shortt, J.3    Cluse, L.A.4    Christiansen, A.J.5    Smyth, M.J.6
  • 165
    • 84899063851 scopus 로고    scopus 로고
    • The anticancer effects of HDAC inhibitors require the immune system
    • West AC, Smyth MJ, Johnstone RW. The anticancer effects of HDAC inhibitors require the immune system. Oncoimmunology (2014) 3:e27414. doi:10.4161/onci.27414
    • (2014) Oncoimmunology , vol.3
    • West, A.C.1    Smyth, M.J.2    Johnstone, R.W.3
  • 166
    • 84872224552 scopus 로고    scopus 로고
    • Decitabine has a biphasic effect on natural killer cell viability, phenotype, and function under proliferative conditions
    • Kopp LM, Ray A, Denman CJ, Senyukov VS, Somanchi SS, Zhu S, et al. Decitabine has a biphasic effect on natural killer cell viability, phenotype, and function under proliferative conditions. Mol Immunol (2013) 54:296-301. doi:10.1016/j.molimm.2012.12.012
    • (2013) Mol Immunol , vol.54 , pp. 296-301
    • Kopp, L.M.1    Ray, A.2    Denman, C.J.3    Senyukov, V.S.4    Somanchi, S.S.5    Zhu, S.6
  • 167
    • 84890616179 scopus 로고    scopus 로고
    • Effects of the epigenetic drug MS-275 on the release and function of exosome-related immune molecules in hepatocellular carcinoma cells
    • Xiao W, Dong W, Zhang C, Saren G, Geng P, Zhao H, et al. Effects of the epigenetic drug MS-275 on the release and function of exosome-related immune molecules in hepatocellular carcinoma cells. Eur J Med Res (2013) 18:61. doi:10.1186/2047-783X-18-61
    • (2013) Eur J Med Res , vol.18 , pp. 61
    • Xiao, W.1    Dong, W.2    Zhang, C.3    Saren, G.4    Geng, P.5    Zhao, H.6
  • 168
    • 84977134550 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells
    • Lisiero DN, Soto H, Everson RG, Liau LM, Prins RM. The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells. J Immunother Cancer (2014) 2:8. doi:10.1186/2051-1426-2-8
    • (2014) J Immunother Cancer , vol.2 , pp. 8
    • Lisiero, D.N.1    Soto, H.2    Everson, R.G.3    Liau, L.M.4    Prins, R.M.5
  • 169
    • 50949127683 scopus 로고    scopus 로고
    • Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B)
    • Araki Y, Fann M, Wersto R, Weng NP. Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). J Immunol (2008) 180:8102-8. doi:10.4049/jimmunol.180.12.8102
    • (2008) J Immunol , vol.180 , pp. 8102-8108
    • Araki, Y.1    Fann, M.2    Wersto, R.3    Weng, N.P.4
  • 170
    • 68149138410 scopus 로고    scopus 로고
    • Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory
    • Agarwal P, Raghavan A, Nandiwada SL, Curtsinger JM, Bohjanen PR, Mueller DL, et al. Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory. J Immunol (2009) 183:1695-704. doi:10.4049/jimmunol.0900592
    • (2009) J Immunol , vol.183 , pp. 1695-1704
    • Agarwal, P.1    Raghavan, A.2    Nandiwada, S.L.3    Curtsinger, J.M.4    Bohjanen, P.R.5    Mueller, D.L.6
  • 171
    • 59849085588 scopus 로고    scopus 로고
    • Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
    • Lal G, Zhang N, Van Der Touw W, Ding Y, Ju W, Bottinger EP, et al. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol (2009) 182:259-73. doi:10.4049/jimmunol.182.1.259
    • (2009) J Immunol , vol.182 , pp. 259-273
    • Lal, G.1    Zhang, N.2    Van Der Touw, W.3    Ding, Y.4    Ju, W.5    Bottinger, E.P.6
  • 172
    • 72249084921 scopus 로고    scopus 로고
    • Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824
    • Vo DD, Prins RM, Begley JL, Donahue TR, Morris LF, Bruhn KW, et al. Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824. Cancer Res (2009) 69:8693-9. doi:10.1158/0008-5472.CAN-09-1456
    • (2009) Cancer Res , vol.69 , pp. 8693-8699
    • Vo, D.D.1    Prins, R.M.2    Begley, J.L.3    Donahue, T.R.4    Morris, L.F.5    Bruhn, K.W.6
  • 173
    • 37249067503 scopus 로고    scopus 로고
    • CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer
    • Kiniwa Y, Miyahara Y, Wang HY, Peng W, Peng G, Wheeler TM, et al. CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer. Clin Cancer Res (2007) 13:6947-58. doi:10.1158/1078-0432.CCR-07-0842
    • (2007) Clin Cancer Res , vol.13 , pp. 6947-6958
    • Kiniwa, Y.1    Miyahara, Y.2    Wang, H.Y.3    Peng, W.4    Peng, G.5    Wheeler, T.M.6
  • 174
    • 39749142196 scopus 로고    scopus 로고
    • Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer
    • Yokokawa J, Cereda V, Remondo C, Gulley JL, Arlen PM, Schlom J, et al. Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer. Clin Cancer Res (2008) 14:1032-40. doi:10.1158/1078-0432.CCR-07-2056
    • (2008) Clin Cancer Res , vol.14 , pp. 1032-1040
    • Yokokawa, J.1    Cereda, V.2    Remondo, C.3    Gulley, J.L.4    Arlen, P.M.5    Schlom, J.6
  • 175
    • 81055125529 scopus 로고    scopus 로고
    • Azacitidine favorably modulates PSA kinetics correlating with plasma DNA LINE-1 hypomethylation in men with chemonaïve castration-resistant prostate cancer
    • Sonpavde G, Aparicio AM, Zhan F, North B, Delaune R, Garbo LE, et al. Azacitidine favorably modulates PSA kinetics correlating with plasma DNA LINE-1 hypomethylation in men with chemonaïve castration-resistant prostate cancer. Urol Oncol (2011) 29(6):682-9. doi:10.1016/j.urolonc.2009.09.015
    • (2011) Urol Oncol , vol.29 , Issue.6 , pp. 682-689
    • Sonpavde, G.1    Aparicio, A.M.2    Zhan, F.3    North, B.4    Delaune, R.5    Garbo, L.E.6
  • 176
    • 0031945210 scopus 로고    scopus 로고
    • A phase II study of 5-aza-2'-deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer
    • Thibault A, Figg WD, Bergan RC, Lush RM, Myers CE, Tompkins A, et al. A phase II study of 5-aza-2'-deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer. Tumori (1998) 84:87-9.
    • (1998) Tumori , vol.84 , pp. 87-89
    • Thibault, A.1    Figg, W.D.2    Bergan, R.C.3    Lush, R.M.4    Myers, C.E.5    Tompkins, A.6
  • 177
    • 72249110437 scopus 로고    scopus 로고
    • Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862)
    • Deborah B, Dana R, Rodney D, Walter MS, Glenn L, David CS, et al. Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862). Cancer (2009) 115:5541-9. doi:10.1002/cncr.24597
    • (2009) Cancer , vol.115 , pp. 5541-5549
    • Deborah, B.1    Dana, R.2    Rodney, D.3    Walter, M.S.4    Glenn, L.5    David, C.S.6
  • 178
    • 70349277568 scopus 로고    scopus 로고
    • Short communication: activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphoma
    • Edelstein LC, Micheva-Viteva S, Phelan BD, Dougherty JP. Short communication: activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphoma. AIDS Res Hum Retroviruses (2009) 25:883-7. doi:10.1089/aid.2008.0294
    • (2009) AIDS Res Hum Retroviruses , vol.25 , pp. 883-887
    • Edelstein, L.C.1    Micheva-Viteva, S.2    Phelan, B.D.3    Dougherty, J.P.4
  • 179
    • 70449365376 scopus 로고    scopus 로고
    • Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy a case series report
    • Ritchie D, Piekarz RL, Blombery P, Karai LJ, Pittaluga S, Jaffe ES, et al. Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy a case series report. Haematologica (2009) 94:1618-22. doi:10.3324/haematol.2009.008607
    • (2009) Haematologica , vol.94 , pp. 1618-1622
    • Ritchie, D.1    Piekarz, R.L.2    Blombery, P.3    Karai, L.J.4    Pittaluga, S.5    Jaffe, E.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.