Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells

International Journal of Oncology

Volumn 41, Issue 3, 2012, Pages 1101-1109

  Wang, Jing ^a   Kim, Tae Hyung ^a   Ahn, Mee Young ^a   Lee, Jaewon ^a   Jung, Jee H ^a   Choi, Wahn Soo ^b   Lee, Byung Mu ^c   Yoon, Kyuing Sil ^d   Yoon, Sungpil ^d   Kim, Hyung Sik ^a  

^a Pusan National University   (South Korea)

^b Konkuk University   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d National Cancer Center   (South Korea)

Author keywords

Apoptosis; Autophagy; Breast cancer; Histone deacetylase inhibitor; Sirtinol; Sirtuin

Indexed keywords

3 METHYLADENINE; ACRIDINE ORANGE; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; DANSYLCADAVERINE; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SIRTINOL; SIRTUIN 1; SIRTUIN 2;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE G1 PHASE; CELL DEATH; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; UPREGULATION;

ACETYLATION; ADENINE; APOPTOSIS; AUTOPHAGY; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BENZAMIDES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DOWN-REGULATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; HISTONE DEACETYLASE INHIBITORS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NAPHTHOLS; SIRTUINS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84865037340     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1534     Document Type: Article

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