메뉴 건너뛰기




Volumn 3, Issue , 2013, Pages

Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE; MDM2 PROTEIN, HUMAN; PROTEIN MDM2; PROTEIN P53; PYRIMIDIN-2-ONE BETA-RIBOFURANOSIDE; RIBOSOMAL PROTEIN S7; RIBOSOME PROTEIN;

EID: 84889566398     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep03219     Document Type: Article
Times cited : (63)

References (52)
  • 3
    • 0035057219 scopus 로고    scopus 로고
    • Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-Aza-2′-deoxycytidine
    • Karpf, A. R., Moore, B. C., Ririe, T. O. & Jones, D. A. Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine. Mol. Pharmacol. 59, 751-757 (2001) (Pubitemid 32274003)
    • (2001) Molecular Pharmacology , vol.59 , Issue.4 , pp. 751-757
    • Karpf, A.R.1    Moore, B.C.2    Ririe, T.O.3    Jones, D.A.4
  • 4
    • 0026574097 scopus 로고
    • Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase
    • Laliberte, J., Marquez, V. E. & Momparler, R. L. Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase. Cancer Chemother. Pharmacol. 30, 7-11 (1992)
    • (1992) Cancer Chemother. Pharmacol , vol.30 , pp. 7-11
    • Laliberte, J.1    Marquez, V.E.2    Momparler, R.L.3
  • 5
    • 0015821606 scopus 로고
    • Deamination of 5-azacytidine by a human leukemia cell cytidine deaminase
    • Chabner, B. A., Drake, J. C. & Johns, D. G. Deamination of 5-azacytidine by a human leukemia cell cytidine deaminase. Biochem. Pharmacol. 22, 2763-2765 (1973)
    • (1973) Biochem. Pharmacol , vol.22 , pp. 2763-2765
    • Chabner, B.A.1    Drake, J.C.2    Johns, D.G.3
  • 6
    • 58249133996 scopus 로고    scopus 로고
    • Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine
    • Lemaire, M.,Momparler, L. F., Raynal, N. J., Bernstein, M. L. &Momparler, R. L. Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine. Cancer Chemother. Pharmacol. 63, 411-416 (2009)
    • (2009) Cancer Chemother. Pharmacol , vol.63 , pp. 411-416
    • Lemaire, M.1    Momparler, L.F.2    Raynal, N.J.3    Bernstein, M.L.4    Momparler, R.L.5
  • 9
    • 20444428017 scopus 로고    scopus 로고
    • Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells
    • DOI 10.1016/j.bcp.2005.04.010, PII S000629520500239X
    • Ben-Kasus, T., Ben-Zvi, Z., Marquez, V. E., Kelley, J. A. & Agbaria, R. Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells. Biochem. Pharmacol. 70, 121-133 (2005) (Pubitemid 40797876)
    • (2005) Biochemical Pharmacology , vol.70 , Issue.1 , pp. 121-133
    • Ben-Kasus, T.1    Ben-Zvi, Z.2    Marquez, V.E.3    Kelley, J.A.4    Agbaria, R.5
  • 10
    • 0014872738 scopus 로고
    • Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia
    • Li, L. H., Olin, E. J., Buskirk, H. H. & Reineke, L. M. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 30, 2760-2769 (1970)
    • (1970) Cancer Res , vol.30 , pp. 2760-2769
    • Li, L.H.1    Olin, E.J.2    Buskirk, H.H.3    Reineke, L.M.4
  • 11
    • 0016240205 scopus 로고
    • Biological effects of 5-azacytidine in eukaryotes
    • Cihak, A. Biological effects of 5-azacytidine in eukaryotes. Oncology 30, 405-422 (1974)
    • (1974) Oncology , vol.30 , pp. 405-422
    • Cihak, A.1
  • 12
    • 0033229970 scopus 로고    scopus 로고
    • The economics of ribosome biosynthesis in yeast
    • DOI 10.1016/S0968-0004(99)01460-7, PII S0968000499014607
    • Warner, J. R. The economics of ribosome biosynthesis in yeast. Trends Biochem. Sci. 24, 437-440 (1999) (Pubitemid 29528205)
    • (1999) Trends in Biochemical Sciences , vol.24 , Issue.11 , pp. 437-440
    • Warner, J.R.1
  • 13
    • 77749302093 scopus 로고    scopus 로고
    • A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
    • Hollenbach, P. W. et al. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. PLoS ONE 5, e9001 (2010)
    • (2010) PLoS ONE , vol.5
    • Hollenbach, P.W.1
  • 14
    • 84861892178 scopus 로고    scopus 로고
    • RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia
    • Aimiuwu, J. et al. RNA-dependent inhibition of ribonucleotide reductase is a major pathway for 5-azacytidine activity in acute myeloid leukemia. Blood 119, 5229-5238 (2012)
    • (2012) Blood , vol.119 , pp. 5229-5238
    • Aimiuwu, J.1
  • 15
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • DOI 10.1038/nrc864
    • Vousden, K. H. & Lu, X. Live or let die: The cell's response to p53. Nat. Rev. Cancer 2, 594-604 (2002) (Pubitemid 37328926)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.8 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 16
    • 70350497397 scopus 로고    scopus 로고
    • Signaling to p53: Ribosomal proteins find their way
    • Zhang, Y.&Lu, H. Signaling to p53: ribosomal proteins find their way. Cancer Cell 16, 369-377 (2009)
    • (2009) Cancer Cell , vol.16 , pp. 369-377
    • Zhang, Y.1    Lu, H.2
  • 17
    • 79954426157 scopus 로고    scopus 로고
    • Signaling cell death from the endoplasmic reticulum stress response
    • Shore, G. C., Papa, F. R. & Oakes, S. A. Signaling cell death from the endoplasmic reticulum stress response. Curr. Opin. Cell Biol. 23, 143-149 (2011)
    • (2011) Curr. Opin. Cell Biol , vol.23 , pp. 143-149
    • Shore, G.C.1    Papa, F.R.2    Oakes, S.A.3
  • 18
    • 79952264011 scopus 로고    scopus 로고
    • Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
    • Tabas, I. & Ron, D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 13, 184-190 (2011)
    • (2011) Nat. Cell Biol , vol.13 , pp. 184-190
    • Tabas, I.1    Ron, D.2
  • 19
    • 31444449462 scopus 로고    scopus 로고
    • Role of the unfolded protein response in cell death
    • DOI 10.1007/s10495-005-3088-0
    • Kim, R., Emi, M., Tanabe, K. & Murakami, S. Role of the unfolded protein response in cell death. Apoptosis 11, 5-13 (2006) (Pubitemid 43151639)
    • (2006) Apoptosis , vol.11 , Issue.1 , pp. 5-13
    • Kim, R.1    Emi, M.2    Tanabe, K.3    Murakami, S.4
  • 20
    • 80053253225 scopus 로고    scopus 로고
    • Current standards and new trends in the primary treatment of colorectal cancer
    • Stein, A., Atanackovic, D. & Bokemeyer, C. Current standards and new trends in the primary treatment of colorectal cancer. Eur. J. Cancer 47 Suppl 3, S312-314 (2011)
    • (2011) Eur. J. Cancer , vol.47 , Issue.SUPPL. 3
    • Stein, A.1    Atanackovic, D.2    Bokemeyer, C.3
  • 21
    • 0000674897 scopus 로고    scopus 로고
    • Transcription by RNA polymerase I. Front
    • Hannan, K. M., Hannan, R. D. & Rothblum, L. I. Transcription by RNA polymerase I. Front. Biosci. 3, d376-398 (1998)
    • (1998) Biosci , vol.3
    • Hannan, K.M.1    Hannan, R.D.2    Rothblum, L.I.3
  • 22
    • 34547620115 scopus 로고    scopus 로고
    • Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: Binding to MDM2, stabilization of p53 protein, and activation of p53 function
    • DOI 10.1038/sj.onc.1210327, PII 1210327
    • Chen, D. et al. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: Binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene 26, 5029-5037 (2007) (Pubitemid 47206956)
    • (2007) Oncogene , vol.26 , Issue.35 , pp. 5029-5037
    • Chen, D.1    Zhang, Z.2    Li, M.3    Wang, W.4    Li, Y.5    Rayburn, E.R.6    Hill, D.L.7    Wang, H.8    Zhang, R.9
  • 23
    • 68349160548 scopus 로고    scopus 로고
    • Ribosomal protein S7 is both a regulator and a substrate of MDM2
    • Zhu, Y. et al. Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol. Cell 35, 316-326 (2009)
    • (2009) Mol. Cell , vol.35 , pp. 316-326
    • Zhu, Y.1
  • 24
    • 34548037901 scopus 로고    scopus 로고
    • Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium
    • DOI 10.1038/sj.cdd.4402200, PII 4402200
    • Hoyer-Hansen, M. & Jaattela, M. Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death Differ. 14, 1576-1582 (2007) (Pubitemid 47278843)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.9 , pp. 1576-1582
    • Hoyer-Hansen, M.1    Jaattela, M.2
  • 25
  • 26
    • 84862295360 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy
    • Klionsky, D. J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8, 445-544 (2012)
    • (2012) Autophagy , vol.8 , pp. 445-544
    • Klionsky, D.J.1
  • 27
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew, R. et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 137, 1062-1075 (2009)
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1
  • 28
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • DOI 10.1038/nature05372, PII NATURE05372
    • O'Brien, C. A., Pollett, A., Gallinger, S. & Dick, J. E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445, 106-110 (2007) (Pubitemid 46067310)
    • (2007) Nature , vol.445 , Issue.7123 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 32
    • 65949112714 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    • Huang, E. H. et al. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res. 69, 3382-3389 (2009)
    • (2009) Cancer Res , vol.69 , pp. 3382-3389
    • Huang, E.H.1
  • 33
    • 0344237231 scopus 로고    scopus 로고
    • A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    • DOI 10.1111/j.1349-7006.2003.tb01386.x
    • Tanaka, T. et al. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci. 94, 965-973 (2003) (Pubitemid 37508979)
    • (2003) Cancer Science , vol.94 , Issue.11 , pp. 965-973
    • Tanaka, T.1    Kohno, H.2    Suzuki, R.3    Yamada, Y.4    Sugie, S.5    Mori, H.6
  • 36
    • 77951248778 scopus 로고    scopus 로고
    • Chemotherapeutic drugs inhibit ribosome biogenesis at various levels
    • Burger, K. et al. Chemotherapeutic drugs inhibit ribosome biogenesis at various levels. J. Biol. Chem. 285, 12416-12425 (2010)
    • (2010) J. Biol. Chem , vol.285 , pp. 12416-12425
    • Burger, K.1
  • 38
    • 77957367974 scopus 로고    scopus 로고
    • Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies
    • Yang, P. M. et al. Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies. Cancer Res. 70, 7699-7709 (2010)
    • (2010) Cancer Res , vol.70 , pp. 7699-7709
    • Yang, P.M.1
  • 39
    • 66049147774 scopus 로고    scopus 로고
    • PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53
    • Yoon, C.H., Lee, E. S., Lim,D. S. &Bae, Y. S. PKR, a p53 target gene, plays a crucial role in the tumor-suppressor function of p53. Proc. Natl. Acad. Sci. U. S. A. 106, 7852-7857 (2009)
    • (2009) Proc. Natl. Acad. Sci. U. S. A , vol.106 , pp. 7852-7857
    • Yoon, C.H.1    Lee, E.S.2    Lim, D.S.3    Bae, Y.S.4
  • 40
    • 0035144493 scopus 로고    scopus 로고
    • Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state
    • DOI 10.1128/MCB.21.4.1249-1259.2001
    • McCullough, K. D., Martindale, J. L., Klotz, L. O., Aw, T. Y. & Holbrook, N. J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 21, 1249-1259 (2001) (Pubitemid 32114973)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.4 , pp. 1249-1259
    • McCullough, K.D.1    Martindale, J.L.2    Klotz, L.-O.3    Aw, T.-Y.4    Holbrook, N.J.5
  • 42
    • 17144417669 scopus 로고    scopus 로고
    • TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
    • DOI 10.1038/sj.emboj.7600596
    • Ohoka, N., Yoshii, S., Hattori, T., Onozaki, K. & Hayashi, H. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 24, 1243-1255 (2005) (Pubitemid 40516607)
    • (2005) EMBO Journal , vol.24 , Issue.6 , pp. 1243-1255
    • Ohoka, N.1    Yoshii, S.2    Hattori, T.3    Onozaki, K.4    Hayashi, H.5
  • 43
    • 8544283103 scopus 로고    scopus 로고
    • CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
    • DOI 10.1074/jbc.M406933200
    • Yamaguchi, H.&Wang, H. G. CHOP is involved in endoplasmic reticulum stressinduced apoptosis by enhancing DR5 expression in human carcinoma cells. J. Biol. Chem. 279, 45495-45502 (2004) (Pubitemid 39491535)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.44 , pp. 45495-45502
    • Yamaguchi, H.1    Wang, H.-G.2
  • 45
    • 59849105065 scopus 로고    scopus 로고
    • CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade
    • Mungrue, I. N., Pagnon, J., Kohannim, O., Gargalovic, P. S. & Lusis, A. J. CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade. J. Immunol. 182, 466-476 (2009)
    • (2009) J. Immunol , vol.182 , pp. 466-476
    • Mungrue, I.N.1    Pagnon, J.2    Kohannim, O.3    Gargalovic, P.S.4    Lusis, A.J.5
  • 46
    • 0037079142 scopus 로고    scopus 로고
    • The unfolded protein response modulates disease severity in pelizaeus-merzbacher disease
    • DOI 10.1016/S0896-6273(02)01045-0
    • Southwood, C. M., Garbern, J., Jiang, W. & Gow, A. The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease. Neuron 36, 585-596 (2002) (Pubitemid 35350849)
    • (2002) Neuron , vol.36 , Issue.4 , pp. 585-596
    • Southwood, C.M.1    Garbern, J.2    Jiang, W.3    Gow, A.4
  • 47
    • 33846692198 scopus 로고    scopus 로고
    • Signal integration and diversification through the p62 scaffold protein
    • DOI 10.1016/j.tibs.2006.12.002, PII S0968000406003276
    • Moscat, J., Diaz-Meco, M. T. & Wooten, M. W. Signal integration and diversification through the p62 scaffold protein. Trends Biochem. Sci. 32, 95-100 (2007) (Pubitemid 46199192)
    • (2007) Trends in Biochemical Sciences , vol.32 , Issue.2 , pp. 95-100
    • Moscat, J.1    Diaz-Meco, M.T.2    Wooten, M.W.3
  • 48
    • 52649121942 scopus 로고    scopus 로고
    • The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes
    • Shvets, E., Fass, E., Scherz-Shouval, R. & Elazar, Z. The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes. J. Cell Sci. 121, 2685-2695 (2008)
    • (2008) J. Cell Sci , vol.121 , pp. 2685-2695
    • Shvets, E.1    Fass, E.2    Scherz-Shouval, R.3    Elazar, Z.4
  • 49
    • 77958467209 scopus 로고    scopus 로고
    • Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling
    • Wu, M. J. et al. Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling. Mol. Cancer 9, 283 (2010)
    • (2010) Mol. Cancer , vol.9 , pp. 283
    • Wu, M.J.1
  • 50
    • 84873740471 scopus 로고    scopus 로고
    • The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells
    • Galavotti, S. et al. The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Oncogene 32, 699-712 (2013)
    • (2013) Oncogene , vol.32 , pp. 699-712
    • Galavotti, S.1
  • 51
    • 10644256532 scopus 로고    scopus 로고
    • Zebularine: A new drug for epigenetic therapy
    • DOI 10.1042/BST0320910
    • Yoo, C. B., Cheng, J. C. & Jones, P. A. Zebularine: A new drug for epigenetic therapy. Biochem. Soc. Trans. 32, 910-912 (2004) (Pubitemid 39655501)
    • (2004) Biochemical Society Transactions , vol.32 , Issue.6 , pp. 910-912
    • Yoo, C.B.1    Cheng, J.C.2    Jones, P.A.3
  • 52
    • 78649299438 scopus 로고    scopus 로고
    • Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma
    • Liu, Y. L. et al. Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma. Autophagy 6, 1057-1065 (2010)
    • (2010) Autophagy , vol.6 , pp. 1057-1065
    • Liu, Y.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.