Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy

Cancer

Volumn 117, Issue 19, 2011, Pages 4424-4438

  Chen, Min Yu ^a,b   Liao, Warren S L ^a   Lu, Zhen ^a   Bornmann, William G ^a   Hennessey, Violeta ^a   Washington, Michele N ^a   Rosner, Gary L ^a,c   Yu, Yinhua ^a   Ahmed, Ahmed Ashour ^a   Bast Jr , Robert C ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

ARHI; autophagy; decitabine; imprinted tumor suppressor genes; ovarian cancer; PEG3; suberoylanilide hydroxamic acid

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; TRICHOSTATIN A; VORINOSTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DRUG POTENTIATION; FEMALE; GENE EXPRESSION; GROWTH INHIBITION; GUANOSINE TRIPHOSPHATE BINDING DI RAS LIKE 3 GENE; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY CANCER; PATERNALLY EXPRESSED 3 GENE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; AUTOPHAGY; AZACITIDINE; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; EPIGENOMICS; FEMALE; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GENOMIC IMPRINTING; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; MICE; MICE, INBRED BALB C; MICE, NUDE; OVARIAN NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS;

EID: 80052927231     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.26073     Document Type: Article

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