메뉴 건너뛰기




Volumn 120, Issue 3, 2010, Pages 581-592

Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells

Author keywords

Breast cancer; DNA methyltransferase; Epigenetic; Estrogen receptor; Zebularine

Indexed keywords

CYCLIN D; PROTEIN P21; ZEBULARINE;

EID: 77950867869     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-009-0420-3     Document Type: Article
Times cited : (112)

References (42)
  • 2
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer a mechanism for early oncogenic pathway addiction?
    • doi:10.1038/nrc1799
    • Baylin SB, Ohm JE (2006) Epigenetic gene silencing in cancer a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 6:107-116. doi:10.1038/nrc1799
    • (2006) Nat Rev Cancer , vol.6 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 3
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • doi: 10.1016/j.cell.2007.01.029
    • Jones PA, Baylin SB (2007) The epigenomics of cancer. Cell 128:683-692. doi: 10.1016/j.cell.2007.01.029
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 4
    • 0018725613 scopus 로고
    • Synergistic action of 5-aza-2′-deoxycytidine and 3-deazauridine on L1210 leukemic cells and EMT6 tumor cells
    • Momparler RL, Vesely J, Momparler LF, Rivard GE (1979) Synergistic action of 5-aza-2′-deoxycytidine and 3-deazauridine on L1210 leukemic cells and EMT6 tumor cells. Cancer Res 39:3822-3827
    • (1979) Cancer Res , vol.39 , pp. 3822-3827
    • Momparler, R.L.1    Vesely, J.2    Momparler, L.F.3    Rivard, G.E.4
  • 6
    • 0018087974 scopus 로고
    • Phenotypic conversion of cultured mouse embryo cells by aza pyrimidine nucleosides
    • doi: 10.1016/0012-1606(78) 90273-7
    • Constantinides PG, Taylor SM, Jones PA (1978) Phenotypic conversion of cultured mouse embryo cells by aza pyrimidine nucleosides. Dev Biol 66:57-71. doi: 10.1016/0012-1606(78) 90273-7
    • (1978) Dev Biol , vol.66 , pp. 57-71
    • Constantinides, P.G.1    Taylor, S.M.2    Jones, P.A.3
  • 7
    • 0028920604 scopus 로고
    • The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor
    • Gabbara S, Bhagwat AS (1995) The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor. Biochem J 307:87-92
    • (1995) Biochem J , vol.307 , pp. 87-92
    • Gabbara, S.1    Bhagwat, A.S.2
  • 8
    • 0017801980 scopus 로고
    • Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine
    • doi:10.1021/jm00200a012
    • Beisler JA (1978) Isolation, characterization, and properties of a labile hydrolysis product of the antitumor nucleoside, 5-azacytidine. J Med Chem 21:204-208. doi:10.1021/jm00200a012
    • (1978) J Med Chem , vol.21 , pp. 204-208
    • Beisler, J.A.1
  • 9
    • 0017409254 scopus 로고
    • Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment
    • doi:10.1038/267364a0
    • Constantinides PG, Jones PA, Gevers W (1977) Functional striated muscle cells from non-myoblast precursors following 5-azacytidine treatment. Nature 267:364-366. doi:10.1038/267364a0
    • (1977) Nature , vol.267 , pp. 364-366
    • Constantinides, P.G.1    Jones, P.A.2    Gevers, W.3
  • 10
    • 0018878649 scopus 로고
    • Synthesis of 1, 3-diazepin-2-one nucleosides as transitionstate inhibitors of cytidine deaminase
    • doi:10.1021/jm00181a001
    • Marquez VE, Liu PS, Kelley JA, Driscoll JS, McCormack JJ (1980) Synthesis of 1, 3-diazepin-2-one nucleosides as transitionstate inhibitors of cytidine deaminase. J Med Chem 23:713-715. doi:10.1021/jm00181a001
    • (1980) J Med Chem , vol.23 , pp. 713-715
    • Marquez, V.E.1    Liu, P.S.2    Kelley, J.A.3    Driscoll, J.S.4    McCormack, J.J.5
  • 11
    • 0022519219 scopus 로고
    • Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase
    • doi:10.1021/jm00158a009
    • Kim CH, Marquez VE, Mao DT, Haines DR, McCormack JJ (1986) Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase. J Med Chem 29:1374-1380. doi:10.1021/jm00158a009
    • (1986) J Med Chem , vol.29 , pp. 1374-1380
    • Kim, C.H.1    Marquez, V.E.2    Mao, D.T.3    Haines, D.R.4    McCormack, J.J.5
  • 12
    • 0026574097 scopus 로고
    • Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2′-deoxycytidine by human cytidine deaminase
    • doi:10.1007/BF00686478
    • Laliberte J, Marquez VE, Momparler RL (1992) Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2′-deoxycytidine by human cytidine deaminase. Cancer Chemother Pharmacol 30:7-11. doi:10.1007/BF00686478
    • (1992) Cancer Chemother Pharmacol , vol.30 , pp. 7-11
    • Laliberte, J.1    Marquez, V.E.2    Momparler, R.L.3
  • 13
    • 26644460450 scopus 로고    scopus 로고
    • Zebularine: A unique molecule for an epigenetically based strategy in cancer chemotherapy. the magic of its chemistry and biology
    • doi:10.1081/NCN-200059765
    • Marquez VE, Barchi JJ Jr, Kelley JA et al (2005) Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology. Nucleosides Nucleotides Nucleic Acids 24:305-318. doi:10.1081/NCN-200059765
    • (2005) Nucleosides Nucleotides Nucleic Acids , vol.24 , pp. 305-318
    • Marquez, V.E.1    Barchi Jr., J.J.2    Kelley, J.A.3
  • 14
    • 0033582720 scopus 로고    scopus 로고
    • Mechanismbased inhibition of CV-cytosine DNA methyltransferases by 2-H pyrimidinone
    • doi:10.1006/jmbi.1998. 2491
    • Hurd PJ, Whitmarsh AJ, Baldwin GS et al (1999) Mechanismbased inhibition of CV-cytosine DNA methyltransferases by 2-H pyrimidinone. J Mol Biol 286:389-401. doi:10.1006/jmbi.1998. 2491
    • (1999) J Mol Biol , vol.286 , pp. 389-401
    • Hurd, P.J.1    Whitmarsh, A.J.2    Baldwin, G.S.3
  • 15
    • 0037420191 scopus 로고    scopus 로고
    • Inhibition of DNA methylation and reactivation of silenced genes by zebularine
    • Cheng JC, Matsen CB, Gonzales FA et al (2003) Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst 95:399-409
    • (2003) J Natl Cancer Inst , vol.95 , pp. 399-409
    • Cheng, J.C.1    Matsen, C.B.2    Gonzales, F.A.3
  • 16
    • 33846362233 scopus 로고    scopus 로고
    • Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression
    • DOI 10.1016/j.exphem.2006.10.005, PII S0301472X06006540
    • 16. Scott SA, Lakshimikuttysamma A, Sheridan DP, Sanche SE, Geyer CR, DeCoteau JF (2007) Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with pl5INK4B demethylation and reexpression. Exp Hematol 35:263-273. doi: 10.1016/j.exphem.2006.10.005 (Pubitemid 46135814)
    • (2007) Experimental Hematology , vol.35 , Issue.2 , pp. 263-273
    • Scott, S.A.1    Lakshimikuttysamma, A.2    Sheridan, D.P.3    Sanche, S.E.4    Geyer, C.R.5    Decoteau, J.F.6
  • 17
    • 33846796029 scopus 로고    scopus 로고
    • Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells
    • DOI 10.1186/1476-4598-6-3
    • 17. Rao SP, Rechsteiner MP, Berger C, Sigrist JA, Nadal D, Bernasconi M (2007) Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells. Mol Cancer 6:6 (Pubitemid 46210991)
    • (2007) Molecular Cancer , vol.6 , pp. 3
    • Rao, S.P.1    Rechsteiner, M.P.2    Berger, C.3    Sigrist, J.A.4    Nadal, D.5    Bernasconi, M.6
  • 18
    • 1642499364 scopus 로고    scopus 로고
    • Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells
    • doi: 1.0.1128/MCB.24.3.1270-1278.2004
    • Cheng JC, Weisenberger DJ, Gonzales FA et al (2004) Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol 24:1270-1278. doi: 1.0.1128/MCB.24.3.1270-1278.2004
    • (2004) Mol Cell Biol , vol.24 , pp. 1270-1278
    • Cheng, J.C.1    Weisenberger, D.J.2    Gonzales, F.A.3
  • 19
    • 5144228492 scopus 로고    scopus 로고
    • Preferential response of cancer cells to zebularine
    • doi: 10.1016/j.ccr.2004.06.023
    • Cheng JC, Yoo CB, Weisenberger DJ et al (2004) Preferential response of cancer cells to zebularine. Cancer Cell 6:151-158. doi: 10.1016/j.ccr.2004.06. 023
    • (2004) Cancer Cell , vol.6 , pp. 151-158
    • Cheng, J.C.1    Yoo, C.B.2    Weisenberger, D.J.3
  • 21
    • 0035120259 scopus 로고    scopus 로고
    • Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines
    • Hahm HA, Dunn VR, Butash KA et al (2001) Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines. Clin Cancer Res 7:391-399
    • (2001) Clin Cancer Res , vol.7 , pp. 391-399
    • Hahm, H.A.1    Dunn, V.R.2    Butash, K.A.3
  • 23
    • 0242330341 scopus 로고    scopus 로고
    • A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine
    • doi: 10.1023/A: 1026146524737
    • Keen JC, Yan L, Mack KM et al (2003) A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine. Breast Cancer Res Treat 81:177-186. doi: 10.1023/A: 1026146524737
    • (2003) Breast Cancer Res Treat , vol.81 , pp. 177-186
    • Keen, J.C.1    Yan, L.2    Mack, K.M.3
  • 24
    • 0029002319 scopus 로고
    • Demethylation of the estrogen receptor gene in estrogen receptornegative breast cancer cells can reactivate estrogen receptor gene expression
    • Ferguson AT, Lapidus RG, Baylin SB, Davidson NE (1995) Demethylation of the estrogen receptor gene in estrogen receptornegative breast cancer cells can reactivate estrogen receptor gene expression. Cancer Res 55:2279-2283
    • (1995) Cancer Res , vol.55 , pp. 2279-2283
    • Ferguson, A.T.1    Lapidus, R.G.2    Baylin, S.B.3    Davidson, N.E.4
  • 25
    • 22444433425 scopus 로고    scopus 로고
    • Release of methyl CpG binding proteins and histone deacetylase 1 from the estrogen receptor α (ER) promoter upon reactivation in ER-negative human breast cancer cells
    • DOI 10.1210/me.2004-0011
    • 25. Sharma D, Blum J, Yang X, Beaulieu N, Macleod AR, Davidson NE (2005) Release of methyl CpG binding proteins and histone deacetylase 1 from the Estrogen receptor alpha (ER) promoter upon reactivation in ER-negative human breast cancer cells. Mol Endocrinol 19:1740-1751. doi:10.1210/me.2004-0011. (Pubitemid 41007887)
    • (2005) Molecular Endocrinology , vol.19 , Issue.7 , pp. 1740-1751
    • Sharma, D.1    Blum, J.2    Yang, X.3    Beaulieu, N.4    Macleod, A.R.5    Davidson, N.E.6
  • 26
    • 0142182098 scopus 로고    scopus 로고
    • IP1 gene expression and the antiproliferative activity of histone deacetylase inhibitors in human breast cancer cells
    • DOI 10.1677/joe.0.1790041
    • 26. Margueron R, Licznar A, Lazennec G, Vignon F, Cavailles V (2003) Oestrogen receptor alpha increases p21(WAF1/CIP1) gene expression and the antiproliferative activity of histone deacetylase inhibitors in human breast cancer cells. J Endocrinol 179:41-53. doi:10.1677/joe.0.1790041 (Pubitemid 37321566)
    • (2003) Journal of Endocrinology , vol.179 , Issue.1 , pp. 41-53
    • Margueron, R.1    Licznar, A.2    Lazennec, G.3    Vignon, F.4    Cavailles, V.5
  • 27
    • 0028281941 scopus 로고
    • Expression of estrogen receptors in estrogen receptor-negative human breast carcinoma cells: Modulation of epidermal growth factor-receptor (EGF-R) and transforming growth factor α (TGFα) gene expression
    • 27. Sheikh MS, Shao ZM, Chen JC, Li XS, Hussain A, Fontana JA (1994) Expression of estrogen receptors in estrogen receptornegative human breast carcinoma cells: modulation of epidermal growth factor-receptor (EGF-R) and transforming growth, factor alpha (TGF alpha) gene expression. J Cell Biochem 54:289-298. doi:10.1002/jcb.240540305 (Pubitemid 24097225)
    • (1994) Journal of Cellular Biochemistry , vol.54 , Issue.3 , pp. 289-298
    • Sheikh, M.S.1    Shao, Z.-M.2    Chen, J.-C.3    Li, X.-S.4    Hussain, A.5    Fontana, J.A.6
  • 28
    • 0026575027 scopus 로고
    • The decomposition of 1 -(beta-D-ribofuranosyl)-1, 2-dihydropyrimidin-2- one (zebularine) in alkali - Mechanism, and products
    • doi:10.1021/jo00028a026
    • Barchi JJ, Musser S, Marquez VE (1992) The decomposition of 1 -(beta-D-ribofuranosyl)-1, 2-dihydropyrimidin-2-one (zebularine) in alkali - mechanism, and products. J Org Chem 57:536541. doi:10.1021/jo00028a026
    • (1992) J Org Chem , vol.57 , pp. 536541
    • Barchi, J.J.1    Musser, S.2    Marquez, V.E.3
  • 29
    • 10644256532 scopus 로고    scopus 로고
    • Zebularine: A new drug for epigenetic therapy
    • DOI 10.1042/BST0320910
    • 29. Yoo CB, Cheng JC, Jones PA (2004) Zebularine: a new drug for epigenetic therapy. Biochem Soc Trans 32:910-912. doi: 10.1042/BST0320910 (Pubitemid 39655501)
    • (2004) Biochemical Society Transactions , vol.32 , Issue.6 , pp. 910-912
    • Yoo, C.B.1    Cheng, J.C.2    Jones, P.A.3
  • 30
    • 20444428017 scopus 로고    scopus 로고
    • Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells
    • DOI 10.1016/j.bcp.2005.04.010, PII S000629520500239X
    • 30. Ben-Kasus T, Ben-Zvi Z, Marquez VE, Kelley JA, Agbaria R (2005) Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells. Biochem Pharmacol 70:121-133. doi:10.1016/j.bcp.2005. 04.010 (Pubitemid 40797876)
    • (2005) Biochemical Pharmacology , vol.70 , Issue.1 , pp. 121-133
    • Ben-Kasus, T.1    Ben-Zvi, Z.2    Marquez, V.E.3    Kelley, J.A.4    Agbaria, R.5
  • 31
    • 34147135143 scopus 로고    scopus 로고
    • Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines
    • DOI 10.1158/1535-7163.MCT-06-0494
    • 31. Pledgie-Tracy A, Sobolewski MD, Davidson NE (2007) Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol Cancer Ther 6:1013-1021, doi: 10.1158/ 1535-7163.MCT-06-0494 (Pubitemid 46554571)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.3 , pp. 1013-1021
    • Pledgie-Tracy, A.1    Sobolewski, M.D.2    Davidson, N.E.3
  • 32
    • 29144500326 scopus 로고    scopus 로고
    • Decitabine activates specific caspases downstream of p73 in myeloid leukemia
    • DOI 10.1007/s00277-005-0013-0
    • 32. Tamm I, Wagner M, Schmelz K (2005) Decitabine activates specific caspases downstream of p73 in myeloid leukemia. Ann Hematol 84:47-53. doi:10,1007/s00277-005-0013-20 (Pubitemid 44419739)
    • (2005) Annals of Hematology , vol.84 , Issue.SUPPL. 13 , pp. 47-53
    • Tamm, I.1    Wagner, M.2    Schmelz, K.3
  • 34
    • 0037291295 scopus 로고    scopus 로고
    • Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest
    • DOI 10.1016/S1097-2765(03)00037-6
    • 34. Ye X, Franco AA, Santos H, Nelson DM, Kaufman PD, Adams PD (2003) Defective S phase chromatin assembly causes DNA damage, activation of the S phase checkpoint, and S phase arrest. Mol Cell 11:341-351. doi: 10.1016/S1097-2765(03)00037-6 (Pubitemid 36293829)
    • (2003) Molecular Cell , vol.11 , Issue.2 , pp. 341-351
    • Ye, X.1    Franco, A.A.2    Santos, H.3    Nelson, D.M.4    Kaufman, P.D.5    Adams, P.D.6
  • 35
    • 0036837867 scopus 로고    scopus 로고
    • Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/ cdk2 activity
    • doi: 10,1128/MCB, 22.21,7459-7472.2002
    • Nelson DM, Ye X, Hall C et al (2002) Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/ cdk2 activity. Mol. Cell Biol 22:7459-7472. doi: 10,1128/MCB, 22.21,7459-7472.2002
    • (2002) Mol. Cell Biol , vol.22 , pp. 7459-7472
    • Nelson, D.M.1    Ye, X.2    Hall, C.3
  • 36
    • 0038341137 scopus 로고    scopus 로고
    • Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes
    • DOI 10.1074/jbc.M213219200
    • 36. Milutinovic S, Zhuang Q, Niveleau A, Szyf M (2003) Epigenomic stress response. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes. J Biol Chem 278:14985-14995. doi: 10.1074/jbc,M213219200 (Pubitemid 36799830)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.17 , pp. 14985-14995
    • Milutinovic, S.1    Zhuang, Q.2    Niveleau, A.3    Szyf, M.4
  • 37
    • 67349200930 scopus 로고    scopus 로고
    • The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
    • doi:10.1038/leu.2008.397
    • Flotho C, Claus R, Batz C et al. (2009) The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. doi:10.1038/leu.2008.397
    • (2009) Leukemia
    • Flotho, C.1    Claus, R.2    Batz, C.3
  • 40
    • 61549106628 scopus 로고    scopus 로고
    • Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice
    • doi: 10.1158/1940-6207.CAPR-07-0008
    • Yoo CB, Chuang JC, Byun HM et al (2008) Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res 1:233-240. doi: 10.1158/1940-6207.CAPR-07-0008
    • (2008) Cancer Prev Res , vol.1 , pp. 233-240
    • Yoo, C.B.1    Chuang, J.C.2    Byun, H.M.3
  • 41
    • 0031658826 scopus 로고    scopus 로고
    • Drug resistance to 5-aza-2′-deoxycytidine, 2′, 2′-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells
    • doi:10.1007/s002800050832
    • Eliopoulos N, Cournoyer D, Momparler RL (1998) Drug resistance to 5-aza-2′-deoxycytidine, 2′, 2′-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells. Cancer Chemother Pharmacol. 42:373-378. doi:10.1007/s002800050832
    • (1998) Cancer Chemother Pharmacol , vol.42 , pp. 373-378
    • Eliopoulos, N.1    Cournoyer, D.2    Momparler, R.L.3
  • 42
    • 14144255400 scopus 로고    scopus 로고
    • Enhancement of antineoplastic action of 5-aza2′-deoxycytidine by zebularine on L1210 leukemia
    • doi: 10.1097/00001813-200503000-00009
    • Lemaire M., Momparler LF, Bernstein ML, Marquez VE, Momparler RL (2005) Enhancement of antineoplastic action of 5-aza2′-deoxycytidine by zebularine on L1210 leukemia. Anticancer Drugs 16:301-308. doi: 10.1097/00001813-200503000-00009
    • (2005) Anticancer Drugs , vol.16 , pp. 301-308
    • Lemaire, M.1    Momparler, L.F.2    Bernstein, M.L.3    Marquez, V.E.4    Momparler, R.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.