Effect of mucoadhesive polymers on the in vitro performance of insulin-loaded silica nanoparticles: Interactions with mucin and biomembrane models

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 93, Issue , 2015, Pages 118-126

  Andreani, Tatiana ^a,b   Miziara, Leonardo ^c   Lorenzón, Esteban N ^c   De Souza, Ana Luiza R ^c   Kiill, Charlene P ^c   Fangueiro, Joana F ^d   Garcia, Maria L ^e   Gremião, Palmira D ^c   Silva, Amélia M ^a,b   Souto, Eliana B ^f,g  

^a UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^b UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^d UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^e UNIVERSITY OF BARCELONA   (Spain)

^f UNIVERSITY OF COIMBRA   (Portugal)

^g UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Biomembranes; Insulin; Mucoadhesion; Oral delivery; Silica nanoparticles; Thermal denaturation

Indexed keywords

ALGINIC ACID; CHITOSAN; DIPALMITOYLPHOSPHATIDYLCHOLINE; DRUG CARRIER; INSULIN; MACROGOL 20000; MACROGOL 6000; MUCIN; POLYMER; SILICA NANOPARTICLE; ANTIDIABETIC AGENT; ARTIFICIAL MEMBRANE; GLUCURONIC ACID; HEXURONIC ACID; MACROGOL DERIVATIVE; NANOPARTICLE; SILICON DIOXIDE;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; DENATURATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG COATING; DRUG EFFECT; HIGH TEMPERATURE; HYDROGEN BOND; IN VITRO STUDY; INTESTINE MUCOSA; MEAN RESIDENCE TIME; MOLECULAR WEIGHT; MUCOADHESION; PARTICLE SIZE; PROTEIN INTERACTION; STATIC ELECTRICITY; ADHESION; ARTIFICIAL MEMBRANE; CHEMICAL PHENOMENA; CHEMISTRY; MEDICINAL CHEMISTRY; NANOMEDICINE; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PROCEDURES; SURFACE PROPERTY; TEMPERATURE;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ADHESIVENESS; ADMINISTRATION, ORAL; ALGINATES; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CIRCULAR DICHROISM; DRUG CARRIERS; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYPOGLYCEMIC AGENTS; INSULIN; MEMBRANES, ARTIFICIAL; MOLECULAR WEIGHT; MUCINS; NANOMEDICINE; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; SILICON DIOXIDE; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 84926472510     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.03.027     Document Type: Article

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