Surface engineering of silica nanoparticles for oral insulin delivery: Characterization and cell toxicity studies

Colloids and Surfaces B: Biointerfaces

Volumn 123, Issue , 2014, Pages 916-923

  Andreani, Tatiana ^a,b,c   Kiill, Charlene P ^d   Souza, Ana Luiza R de ^d   Fangueiro, Joana F ^c   Fernandes, Lisete ^a   Doktorovová, Slavomira ^e   Santos, Dario L ^a,b   Garcia, Maria L ^f   Gremião, Maria Palmira D ^d   Souto, Eliana B ^g   Silva, Amélia M ^a,b  

^a UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^b UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^c UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^d SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^e RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^f UNIVERSITY OF BARCELONA   (Spain)

^g UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Caco 2 cell; Coated SiNPs; HepG2 cell; Insulin; Mucoadhesive polymers; Silica nanoparticles

Indexed keywords

BIOCHEMISTRY; BIOCOMPATIBILITY; CELL CULTURE; CELLS; DIFFERENTIAL SCANNING CALORIMETRY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; INSULIN; NANOPARTICLES; PLASTIC COATINGS; POLYMERS; SILICA; TOXICITY;

CACO-2 CELLS; COATED-SINPS; HEP-G2 CELLS; MUCOADHESIVE POLYMERS; SILICA NANOPARTICLES;

CELL ENGINEERING;

ALGINIC ACID; AMIDE; CHITOSAN; INSULIN; MACROGOL; NANOPARTICLE; POLYMER; SILICA NANOPARTICLE; TETRAETHOXYSILANE; UNCLASSIFIED DRUG;

ABSORPTION; ARTICLE; BIOCOMPATIBILITY; CELL MEDIATED CYTOTOXICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; INTESTINE MUCOSA; MATERIAL COATING; PHYSICAL CHEMISTRY; X RAY DIFFRACTION;

EID: 84915737304     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2014.10.047     Document Type: Article

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