Noninvasive imaging oral absorption of insulin delivered by nanoparticles and its stimulated glucose utilization in controlling postprandial hyperglycemia during OGTT in diabetic rats

Journal of Controlled Release

Volumn 172, Issue 2, 2013, Pages 513-522

  Chuang, Er Yuan ^a   Lin, Kun Ju ^b,c   Su, Fang Yi ^a   Mi, Fwu Long ^d   Maiti, Barnali ^a   Chen, Chiung Tong ^e   Wey, Shiaw Pyng ^b   Yen, Tzu Chen ^c   Juang, Jyuhn Huarng ^f   Sung, Hsing Wen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^f CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Chitosan PGA EGTA nanoparticles; Diabetes mellitus; Glucose utilization; Oral insulin absorption; Postprandial hyperglycemia

Indexed keywords

DIABETES MELLITUS; EFFECTIVE ABSORPTION; NON-INVASIVE IMAGING; ORAL GLUCOSE TOLERANCE TESTS; ORAL INSULIN DELIVERY; POSTPRANDIAL HYPERGLYCEMIA; RESONANCE ENERGY TRANSFER; SYSTEMIC CIRCULATION;

AMINO ACIDS; CHITOSAN; ENERGY TRANSFER; ETHYLENE GLYCOL; GLUCOSE; NANOPARTICLES; POSITRON EMISSION TOMOGRAPHY; RATS;

INSULIN;

CALCIUM; CHITOSAN; EGTAZIC ACID; FLUORODEOXYGLUCOSE F 18; GALLIUM 68; GLUCOSE; INSULIN; POLYGLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CT SPECT SCANNER; DIABETES MELLITUS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; ENERGY TRANSFER; FEMALE; FORELIMB; GLUCOSE UTILIZATION; HEART MUSCLE; HINDLIMB; HYPERGLYCEMIA; IMAGING SOFTWARE; INSULIN DEGRADATION; INTESTINE ABSORPTION; INTESTINE LOOP; MALE; MAXIMUM PLASMA CONCENTRATION; MEAL; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PET SCANNER; PH; POSITRON EMISSION TOMOGRAPHY; POSTPRANDIAL STATE; PRIORITY JOURNAL; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SKELETAL MUSCLE; SYSTEMIC CIRCULATION; THORAX WALL; TIME TO MAXIMUM PLASMA CONCENTRATION; WHOLE BODY CT;

CHITOSAN-ΓPGA-EGTA NANOPARTICLES; DIABETES MELLITUS; GLUCOSE UTILIZATION; ORAL INSULIN ABSORPTION; POSTPRANDIAL HYPERGLYCEMIA;

ADMINISTRATION, ORAL; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; EGTAZIC ACID; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GLUCOSE; GLUCOSE TOLERANCE TEST; HYDROGEN-ION CONCENTRATION; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; MALE; NANOPARTICLES; POLYGLUTAMIC ACID; RATS; RATS, WISTAR;

EID: 84887045291     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.05.006     Document Type: Article

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