Camptothecins in tumor homing via an RGD sequence mimetic

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 20, 2012, Pages 6509-6512

  Alloatti, Domenico ^a   Giannini, Giuseppe ^a   Vesci, Loredana ^a   Castorina, Massimo ^a   Pisano, Claudio ^a   Badaloni, Elena ^a   Cabri, Walter ^a  

^a Sigma Tau SpA   (Italy)

Author keywords

Anticancer drug delivery system; Camptothecin RGD mimetic conjugate; RGD mimetic and Integrin; Tumor homing; Tumor specific targeting

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CAMPTOTHECIN DERIVATIVE; INTEGRIN; INTEGRIN RECEPTOR; IRINOTECAN; ST 7456CL1; UNCLASSIFIED DRUG; VITRONECTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE METASTASIS; CELL FUNCTION; CELL HOMING; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IC 50; IN VIVO STUDY; KIDNEY CARCINOMA; NONHUMAN; OVARY CARCINOMA; PROSTATE CANCER; RAT; TARGET CELL; TARGET CELL DESTRUCTION; TUMOR CELL;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; INTEGRINS; MALE; OLIGOPEPTIDES; OVARIAN NEOPLASMS; PROSTATIC NEOPLASMS; RATS;

RATTUS;

EID: 84866729904     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.061     Document Type: Article

References (11)

1. Eldar-Boock, A.; Joaquin Sanchis, J.; Ruth Lupu, R.; Vicent, M.J.; Satchi-Fainaro, R. AACR (American Association for Cancer Research) 2012, Abs. 5225.
2. R.M. Sharkey, S.V. Govindan, T.M. Cardillo, and D.M. Goldenberg Mol. Cancer Ther. 11 2012 224
3. S.S. Dharap, Y. Wang, P. Chandna, J.J. Khandare, B. Qiu, S. Gunaseelan, P.J. Sinko, S. Stein, A. Farmanfarmaian, and T. Minko Proc Natl. Acad. Sci. U.S.A. 102 2005 12962
4. P.A. Schornack, and R.J. Gillies Neoplasia 5 2003 135
5. C.N. Liu, B.M. Tadayoni, L.A. Bourret, K.M. Mattocks, S.M. Derr, W.C. Widdison, N.L. Kedersha, P.D. Ariniello, V.S. Goldmacher, J.M. Lambert, W.A. Blattler, and R.V.J. Chari Proc. Natl. Acad. Sci. U.S.A. 93 1996 8618
6. S. Jaracz, J.C. Larisa, V. Kuznetsova, and I. Ojima Bioorg. Med. Chem. Lett. 13 2005 5043
7. M.D. Pierschbacher, and E. Ruoslahti Nature 309 1984 30
8. S. Iwama, T. Kitano, F. Fukuya, Y. Honda, Y. Sato, M. Notako, and T. Morie Bioorg. Med. Chem. Lett. 14 2004 2567
9. S. Gollins, A.S. Myint, B. Haylock, M. Wise, M. Saunders, R. Neupane, S. Essapen, L. Samuel, M. Dougal, and A. Lloyd J. Clin. Oncol. 1042 2011 29
10. N.P. McCabe, S. De, A. Vasanji, J. Brainard, and T.V. Byzova Oncogene 26 2007 6238
11. M. Korhonen, H. Sariola, V.E. Gould, L. Kangas, and I. Virtanen Cancer Res. 54 1994 4532