DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1α gene locus

Nucleic Acids Research

Volumn 38, Issue 1, 2009, Pages 159-171

  Baranello, Laura ^a   Bertozzi, Davide ^a   Fogli, Maria Vittoria ^a   Pommier, Yves ^b   Capranico, Giovanni ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; COMPLEMENTARY RNA; CYCLIN DEPENDENT KINASE; DNA TOPOISOMERASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; RNA POLYMERASE II;

ACETYLATION; ALTERNATIVE RNA SPLICING; ARTICLE; CANCER CELL; CELL DENSITY; CELL HYPOXIA; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; DEREGULATION; DNA DAMAGE; DNA HISTONE INTERACTION; DNA REPLICATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXON; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE LOCUS; HUMAN; HUMAN CELL; INTRON; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

ACETYLATION; CAMPTOTHECIN; CELL LINE, TUMOR; CHROMATIN; CYCLIN-DEPENDENT KINASES; DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; GENETIC LOCI; HISTONES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PROMOTER REGIONS, GENETIC; RNA POLYMERASE II; RNA, ANTISENSE; TRANSCRIPTION, GENETIC;

EID: 74949123158     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp817     Document Type: Article

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