Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Nature

Volumn 481, Issue 7380, 2012, Pages 185-191

  Huang, Hsien Sung ^a   Allen, John A ^a   Mabb, Angela M ^a   King, Ian F ^a   Miriyala, Jayalakshmi ^a   Taylor Blake, Bonnie ^a   Sciaky Jr , Noah ^a   Dutton, J Walter ^a   Lee, Hyeong Min ^a   Chen, Xin ^b   Jin, Jian ^b   Bridges, Arlene S ^a   Zylka, Mark J ^a   Roth, Bryan L ^a,b   Philpot, Benjamin D ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 HYDROXY CAMPOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; 7 ETHYL CAMPOTHECIN; AMSACRINE; BELOTECAN; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; COMPLEMENTARY RNA; DNA TOPOISOMERASE INHIBITOR; ENZYME INHIBITOR; ETOPOSIDE; IRINOTECAN; ISOQUINOLINE DERIVATIVE; RAZOXANE; RUBITECAN; SILATECAN; TOPOTECAN; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE E3A; UNCLASSIFIED DRUG;

ALLELE; ENZYME ACTIVITY; GENE EXPRESSION; INHIBITION; INHIBITOR; MUTATION; NERVOUS SYSTEM; NEUROLOGY; PATERNAL EFFECT; PROTEIN;

ALLELE; ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CATALYSIS; CEREBELLUM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS STRIATUM; DOWN REGULATION; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG MEGADOSE; DRUG METABOLISM; DRUG POTENCY; ENZYME INHIBITION; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HAPPY PUPPET SYNDROME; HIPPOCAMPUS; MALE; MOUSE; NEOCORTEX; NERVE CELL; NONHUMAN; PATERNALISM; PRIORITY JOURNAL; SPINAL CORD; SPINAL CORD NERVE CELL; TREATMENT WITHDRAWAL; UPREGULATION;

ALLELES; ANGELMAN SYNDROME; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; DRUG EVALUATION, PRECLINICAL; FATHERS; FEMALE; GENE SILENCING; GENOMIC IMPRINTING; MALE; MICE; MICE, INBRED C57BL; MOTHERS; NEURONS; SMALL MOLECULE LIBRARIES; TOPOISOMERASE INHIBITORS; TOPOTECAN; UBIQUITIN-PROTEIN LIGASES;

MUS;

EID: 84855807682     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10726     Document Type: Article

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