Mechanisms of resistance to topoisomerase I-targeting drugs

Oncogene

Volumn 22, Issue 47, 2003, Pages 7296-7304

  Rasheed, Zeshaan A ^a   Rubin, Eric H ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Camptothecin; Drug resistance; Irinotecan; Topoisomerase I; Topotecan

Indexed keywords

6 FORMYLAMINO 12,13 DIHYDRO 1,11 DIHYDROXY 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H) DIONE 13 GLUCOSIDE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTHRACYCLINE DERIVATIVE; CAMPTOTHECIN DERIVATIVE; CARBAZOLE DERIVATIVE; CYTARABINE; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; GIMATECAN; IRINOTECAN; KARENITECIN; MITOXANTRONE; TOPOTECAN;

CANCER; CANCER RESISTANCE; COLORECTAL CANCER; DNA DRUG COMPLEX; DRUG ACCUMULATION; DRUG GLUCURONIDATION; DRUG TARGETING; DRUG TRANSPORT; EFFUSION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; LUNG SMALL CELL CANCER; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW;

ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; DNA; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DRUG RESISTANCE, NEOPLASM; HUMANS; MOLECULAR CONFORMATION;

EID: 0344394180     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206935     Document Type: Review

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