The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug release

Organic Letters

Volumn 12, Issue 7, 2010, Pages 1384-1387

  Huang, Baohua ^a   Desai, Ankur ^a   Tang, Shengzhuang ^a   Thomas, Thommey P ^a   Baker Jr , James R ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CYCLO(ARG GLY ASP TYR LYS); CYCLO(ARG-GLY-ASP-TYR-LYS); CYCLOPEPTIDE; DRUG DERIVATIVE; INDOLE DERIVATIVE; PRODRUG; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SN38 GLU; SN38-GLU; VITRONECTIN RECEPTOR;

ARTICLE; CELL PROLIFERATION; CELL STRAIN KB; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; FEMALE; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TIME; UTERINE CERVIX TUMOR;

CAMPTOTHECIN; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDOLEQUINONES; INTEGRIN ALPHAVBETA3; KB CELLS; MOLECULAR STRUCTURE; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION; PEPTIDES, CYCLIC; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 77950254562     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol1002626     Document Type: Article

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