Direct fluorescence monitoring of the delivery and cellular uptake of a cancer-targeted RGD peptide-appended naphthalimide theragnostic prodrug

Journal of the American Chemical Society

Volumn 134, Issue 30, 2012, Pages 12668-12674

  Lee, Min Hee ^a   Kim, Jin Young ^b   Han, Ji Hye ^b   Bhuniya, Sankarprasad ^a   Sessler, Jonathan L ^c,d   Kang, Chulhun ^b   Kim, Jong Seung ^a  

^a Korea University   (South Korea)

^b Kyung Hee University   (South Korea)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^d Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE AGENTS; AQUEOUS MEDIA; BIOLOGICAL EVALUATION; C6 CELLS; CAMPTOTHECIN (CPT); CANCER-TARGETING; CELLULAR UPTAKE; CO-LOCALIZATION STUDIES; CYCLIC PEPTIDES; DISULFIDE BONDS; DOSAGE LEVELS; DRUG DELIVERY SYSTEM; ENDOPLASMIC RETICULUM; FLUORESCENT REPORTER; IMAGING INFORMATION; IN-VITRO; MULTI-FUNCTIONAL MOLECULES; MULTICOMPONENTS; NAPHTHALIMIDE; OKADAIC ACID; PRECISE MONITORING; PRODRUGS; RED-SHIFTED FLUORESCENCE; RELEASE MECHANISM; SPECTROSCOPIC CHARACTERIZATION; SUB-CELLULAR; SYNTHETIC STRATEGIES; THERAPEUTIC AGENTS; THERAPEUTIC EFFECTS;

CELL MEMBRANES; COVALENT BONDS; DISEASES; DRUG DELIVERY; EXPERIMENTS; MOLECULAR BIOLOGY; PEPTIDES; SYNTHESIS (CHEMICAL);

FLUORESCENCE;

ARGINYLGLYCYLASPARTIC ACID; CAMPTOTHECIN; NAPHTHALIMIDE DERIVATIVE; OKADAIC ACID;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CELL LINE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; DISULFIDE BOND; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG RELEASE; DRUG SCREENING; DRUG SYNTHESIS; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PH; RAT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; MICROSCOPY, CONFOCAL; NAPHTHALIMIDES; NEOPLASMS; OLIGOPEPTIDES; PRODRUGS;

EID: 84864456950     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja303998y     Document Type: Article

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