Combined directed ortho metalation/cross-coupling strategies: Synthesis of the tetracyclic A/B/C/D ring core of the antitumor agent camptothecin

Journal of Organic Chemistry

Volumn 69, Issue 23, 2004, Pages 7816-7821

  Nguyen, Tam ^a   Wicki, Markus A ^a,c   Snieckus, Victor ^a,b  

^a UNIVERSITY OF WATERLOO   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

^c 3M Canada Company   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIVES; REACTION KINETICS; SYNTHESIS (CHEMICAL);

NEGISHI CROSS-COUPLING; ORTHO METALATION; TETRACYCLIC DERIVATIVES;

ORGANIC COMPOUNDS;

9 AMINOCAMPTOTHECIN; CAMPTOTHECIN; IRINOTECAN; TOPOTECAN;

ARTICLE; CROSS COUPLING REACTION; METALLATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CATALYSIS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;

EID: 8644285382     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo049890h     Document Type: Article

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