메뉴 건너뛰기




Volumn 62, Issue 4, 2015, Pages 934-945

Autophagy and senescence in fibrosing cholangiopathies

Author keywords

Autophagy; Cellular senescence; Fibrosing cholangiopathy; Innate immunity; Senescence associated secretory phenotype

Indexed keywords

AUTOANTIBODY; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOKERATIN 19; DOUBLE STRANDED RNA; ENDOTOXIN; FRACTALKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MAMMALIAN TARGET OF RAPAMYCIN; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE B; PROTEIN P53; RAS PROTEIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR SNAIL; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UVOMORULIN; VIRUS RNA;

EID: 84926421600     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.11.027     Document Type: Review
Times cited : (72)

References (144)
  • 2
    • 84866626680 scopus 로고    scopus 로고
    • Diseases of the bile duct
    • B.C. Burt, L.D. Ferrell, 6th ed. Churchill Livingstone Freiburg, London, New York, Oxford, Philadelphia, St Louis, Sydney, Toronto
    • Y. Nakanuma, Y. Zen, and B.C. Portman Diseases of the bile duct B.C. Burt, L.D. Ferrell, MacSween's pathology of the liver 6th ed. 2012 Churchill Livingstone Freiburg, London, New York, Oxford, Philadelphia, St Louis, Sydney, Toronto 491 562
    • (2012) MacSween's Pathology of the Liver , pp. 491-562
    • Nakanuma, Y.1    Zen, Y.2    Portman, B.C.3
  • 3
    • 84890927337 scopus 로고    scopus 로고
    • Proposal of a new disease concept "biliary diseases with pancreatic counterparts". Anatomical and pathological bases
    • Y. Nakanuma, K. Harada, M. Sasaki, and Y. Sato Proposal of a new disease concept "biliary diseases with pancreatic counterparts". Anatomical and pathological bases Histol Histopathol 29 2014 1 10
    • (2014) Histol Histopathol , vol.29 , pp. 1-10
    • Nakanuma, Y.1    Harada, K.2    Sasaki, M.3    Sato, Y.4
  • 5
    • 84874105072 scopus 로고    scopus 로고
    • The dynamic biliary epithelia: Molecules, pathways, and disease
    • S.P. O'Hara, J.H. Tabibian, P.L. Splinter, and N.F. LaRusso The dynamic biliary epithelia: molecules, pathways, and disease J Hepatol 58 2013 575 582
    • (2013) J Hepatol , vol.58 , pp. 575-582
    • O'Hara, S.P.1    Tabibian, J.H.2    Splinter, P.L.3    Larusso, N.F.4
  • 8
    • 84863837341 scopus 로고    scopus 로고
    • Cholangiopathy with respect to biliary innate immunity
    • K. Harada, and Y. Nakanuma Cholangiopathy with respect to biliary innate immunity Int J Hepatol 2012 2012 793569 10.1155/2012/793569
    • (2012) Int J Hepatol , vol.2012 , pp. 793569
    • Harada, K.1    Nakanuma, Y.2
  • 9
    • 84904414417 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis and the microbiota: Current knowledge and perspectives on etiopathogenesis and emerging therapies
    • J.H. Tabibian, S.P. O'Hara, and K.D. Lindor Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies Scand J Gastroenterol 49 2014 901 908
    • (2014) Scand J Gastroenterol , vol.49 , pp. 901-908
    • Tabibian, J.H.1    O'Hara, S.P.2    Lindor, K.D.3
  • 10
    • 70349569615 scopus 로고    scopus 로고
    • The immunobiology of primary sclerosing cholangitis
    • J.H. Aron, and C.L. Bowlus The immunobiology of primary sclerosing cholangitis Semin Immunopathol 31 2009 383 397
    • (2009) Semin Immunopathol , vol.31 , pp. 383-397
    • Aron, J.H.1    Bowlus, C.L.2
  • 11
    • 75149151621 scopus 로고    scopus 로고
    • Recent progress in the etiopathogenesis of pediatric biliary disease, particularly Caroli's disease with congenital hepatic fibrosis and biliary atresia
    • Y. Nakanuma, K. Harada, Y. Sato, and H. Ikeda Recent progress in the etiopathogenesis of pediatric biliary disease, particularly Caroli's disease with congenital hepatic fibrosis and biliary atresia Histol Histopathol 25 2010 223 235
    • (2010) Histol Histopathol , vol.25 , pp. 223-235
    • Nakanuma, Y.1    Harada, K.2    Sato, Y.3    Ikeda, H.4
  • 13
    • 36349035570 scopus 로고    scopus 로고
    • Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia
    • K. Harada, Y. Sato, K. Itatsu, K. Isse, H. Ikeda, and M. Yasoshima Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia Hepatology 46 2007 1146 1154
    • (2007) Hepatology , vol.46 , pp. 1146-1154
    • Harada, K.1    Sato, Y.2    Itatsu, K.3    Isse, K.4    Ikeda, H.5    Yasoshima, M.6
  • 14
    • 64549142000 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia
    • K. Harada, Y. Sato, H. Ikeda, K. Isse, S. Ozaki, and M. Enomae Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia J Pathol 217 2009 654 664
    • (2009) J Pathol , vol.217 , pp. 654-664
    • Harada, K.1    Sato, Y.2    Ikeda, H.3    Isse, K.4    Ozaki, S.5    Enomae, M.6
  • 15
    • 0036696548 scopus 로고    scopus 로고
    • The role of reovirus type 3 infection in an established murine model for biliary atresia
    • P.O. Szavay, J. Leonhardt, G. Czech-Schmidt, and C. Petersen The role of reovirus type 3 infection in an established murine model for biliary atresia Eur J Pediatr Surg 12 2002 48 250
    • (2002) Eur J Pediatr Surg , vol.12 , pp. 48-250
    • Szavay, P.O.1    Leonhardt, J.2    Czech-Schmidt, G.3    Petersen, C.4
  • 16
    • 84863842159 scopus 로고    scopus 로고
    • Biliary atresia: Cellular dynamics and immune dysregulation
    • A.G. Feldman, and C.L. Mack Biliary atresia: cellular dynamics and immune dysregulation Semin Pediatr Surg 21 2012 192 200
    • (2012) Semin Pediatr Surg , vol.21 , pp. 192-200
    • Feldman, A.G.1    MacK, C.L.2
  • 17
    • 77957940106 scopus 로고    scopus 로고
    • The biliary HCO(3)(-) umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
    • U. Beuers, S. Hohenester, L.J. de Buy Wenniger, A.E. Kremer, P.L. Jansen, and R.P. Elferink The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies Hepatology 52 2010 1489 1496
    • (2010) Hepatology , vol.52 , pp. 1489-1496
    • Beuers, U.1    Hohenester, S.2    De Buy Wenniger, L.J.3    Kremer, A.E.4    Jansen, P.L.5    Elferink, R.P.6
  • 18
    • 67649205149 scopus 로고    scopus 로고
    • Management of cholestatic liver diseases
    • EASL Clinical Practice Guidelines
    • EASL Clinical Practice Guidelines Management of cholestatic liver diseases J Hepatol 51 2009 237 267
    • (2009) J Hepatol , vol.51 , pp. 237-267
  • 19
    • 84875890982 scopus 로고    scopus 로고
    • The immunobiology and pathophysiology of primary biliary cirrhosis
    • G.M. Hirschfield, and M.E. Gershwin The immunobiology and pathophysiology of primary biliary cirrhosis Annu Rev Pathol 8 2013 303 330
    • (2013) Annu Rev Pathol , vol.8 , pp. 303-330
    • Hirschfield, G.M.1    Gershwin, M.E.2
  • 20
    • 0030663215 scopus 로고    scopus 로고
    • Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis
    • K. Harada, S. Ozaki, M.E. Gershwin, and Y. Nakanuma Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis Hepatology 26 1997 1399 1405
    • (1997) Hepatology , vol.26 , pp. 1399-1405
    • Harada, K.1    Ozaki, S.2    Gershwin, M.E.3    Nakanuma, Y.4
  • 21
    • 83355167520 scopus 로고    scopus 로고
    • Biliary epithelial apoptosis, autophagy, and senescence in primary biliary cirrhosis
    • M. Sasaki, and Y. Nakanuma Biliary epithelial apoptosis, autophagy, and senescence in primary biliary cirrhosis Hepat Res Treat 2010 2010 205128 10.1155/2010/205128
    • (2010) Hepat Res Treat , vol.2010 , pp. 205128
    • Sasaki, M.1    Nakanuma, Y.2
  • 22
    • 20044371208 scopus 로고    scopus 로고
    • Th1 cytokine-induced downregulation of PPARγ in human biliary cells relates to cholangitis in primary biliary cirrhosis
    • K. Harada, K. Isse, T. Kamihira, S. Shimoda, and Y. Nakanuma Th1 cytokine-induced downregulation of PPARγ in human biliary cells relates to cholangitis in primary biliary cirrhosis Hepatology 41 2005 1329 1338
    • (2005) Hepatology , vol.41 , pp. 1329-1338
    • Harada, K.1    Isse, K.2    Kamihira, T.3    Shimoda, S.4    Nakanuma, Y.5
  • 23
    • 0033955026 scopus 로고    scopus 로고
    • Immunohistochemical analysis of cell-matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis
    • M. Yasoshima, K. Tsuneyama, K. Harada, M. Sasaki, M.E. Gershwin, and Y. Nakanuma Immunohistochemical analysis of cell-matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis J Pathol 190 2000 93 99
    • (2000) J Pathol , vol.190 , pp. 93-99
    • Yasoshima, M.1    Tsuneyama, K.2    Harada, K.3    Sasaki, M.4    Gershwin, M.E.5    Nakanuma, Y.6
  • 24
    • 64349105425 scopus 로고    scopus 로고
    • Eating to exit: Autophagy-enabled senescence revealed
    • E. White, and S.W. Low Eating to exit: autophagy-enabled senescence revealed Genes Dev 23 2009 784 787
    • (2009) Genes Dev , vol.23 , pp. 784-787
    • White, E.1    Low, S.W.2
  • 25
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • M. Collado, M.A. Blasco, and M. Serrano Cellular senescence in cancer and aging Cell 130 2007 223 233
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 26
    • 0345932931 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
    • H. Iwasa, J. Han, and F. Ishikawa Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway Genes Cells 8 2003 131 144
    • (2003) Genes Cells , vol.8 , pp. 131-144
    • Iwasa, H.1    Han, J.2    Ishikawa, F.3
  • 27
    • 84906270975 scopus 로고    scopus 로고
    • Caspase-2 regulates oncogene-induced senescence
    • D. Gitenay, H. Lallet-Daher, and D. Bernard Caspase-2 regulates oncogene-induced senescence Oncotarget 5 2014 5845 5847
    • (2014) Oncotarget , vol.5 , pp. 5845-5847
    • Gitenay, D.1    Lallet-Daher, H.2    Bernard, D.3
  • 29
    • 84904462047 scopus 로고    scopus 로고
    • The nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress
    • B. Zhu, C.H. Ferry, L.K. Markell, N. Blazanin, A.B. Glick, and F.J. Gonzalez The nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress J Biol Chem 289 2014 20102 20119
    • (2014) J Biol Chem , vol.289 , pp. 20102-20119
    • Zhu, B.1    Ferry, C.H.2    Markell, L.K.3    Blazanin, N.4    Glick, A.B.5    Gonzalez, F.J.6
  • 30
    • 84880740183 scopus 로고    scopus 로고
    • The role of AKT/mTOR pathway in stress response to UV-irradiation: Implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence
    • E. Strozyk, and D. Kulms The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence Int J Mol Sci 14 2013 15260 15285
    • (2013) Int J Mol Sci , vol.14 , pp. 15260-15285
    • Strozyk, E.1    Kulms, D.2
  • 31
    • 84875103424 scopus 로고    scopus 로고
    • Cell survival and apoptosis signaling as therapeutic target for cancer: Marine bioactive compounds
    • S. Kalimuthu, and K. Se-Kwon Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds Int J Mol Sci 14 2013 2334 2354
    • (2013) Int J Mol Sci , vol.14 , pp. 2334-2354
    • Kalimuthu, S.1    Se-Kwon, K.2
  • 32
    • 38349194472 scopus 로고    scopus 로고
    • Cell death in health and disease
    • R.A. Lockshin, and Z. Zakeri Cell death in health and disease J Cell Mol Med 11 2007 1214 1224
    • (2007) J Cell Mol Med , vol.11 , pp. 1214-1224
    • Lockshin, R.A.1    Zakeri, Z.2
  • 34
    • 43649096428 scopus 로고    scopus 로고
    • Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non- suppurative destructive cholangitis in primary biliary cirrhosis: An immunohistochemical study
    • M. Sasaki, H. Ikeda, and Y. Nakanuma Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non- suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study J Autoimmun 31 2008 73 78
    • (2008) J Autoimmun , vol.31 , pp. 73-78
    • Sasaki, M.1    Ikeda, H.2    Nakanuma, Y.3
  • 35
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • M. Collado, M.A. Blasco, and M. Serrano Cellular senescence in cancer and aging Cell 130 2007 223 233
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 36
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • J.W. Harper, and S.J. Elledge The DNA damage response: ten years after Mol Cell 14 2007 739 745
    • (2007) Mol Cell , vol.14 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 40
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • B. Levine, and G. Kroemer Autophagy in the pathogenesis of disease Cell 132 2008 27 42
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 41
    • 0032974017 scopus 로고    scopus 로고
    • Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events
    • S.H. Sigal, P. Rajvanshi, G.R. Gorla, R.P. Sokhi, R. Saxena, and D.R. Gebhard Jr. Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events Am J Physiol 276 1999 G1260 G1272
    • (1999) Am J Physiol , vol.276 , pp. G1260-G1272
    • Sigal, S.H.1    Rajvanshi, P.2    Gorla, G.R.3    Sokhi, R.P.4    Saxena, R.5    Gebhard, Jr.D.R.6
  • 42
    • 0017622505 scopus 로고
    • Cell polyploidy: Its relation to tissue growth and function
    • W.Y. Brodsky, and I.V. Uryvaeva Cell polyploidy: its relation to tissue growth and function Int Rev Cytol 50 1977 275 332
    • (1977) Int Rev Cytol , vol.50 , pp. 275-332
    • Brodsky, W.Y.1    Uryvaeva, I.V.2
  • 43
  • 44
    • 14944376606 scopus 로고    scopus 로고
    • Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: A possible role in bile duct loss
    • M. Sasaki, H. Ikeda, H. Haga, T. Manabe, and Y. Nakanuma Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss J Pathol 205 2005 451 459
    • (2005) J Pathol , vol.205 , pp. 451-459
    • Sasaki, M.1    Ikeda, H.2    Haga, H.3    Manabe, T.4    Nakanuma, Y.5
  • 45
    • 77955304095 scopus 로고    scopus 로고
    • Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis
    • M. Sasaki, M. Miyakoshi, Y. Sato, and Y. Nakanuma Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis J Hepatol 53 2010 318 325
    • (2010) J Hepatol , vol.53 , pp. 318-325
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 46
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • J.P. Coppé, C.K. Patil, F. Rodier, Y. Sun, D.P. Muñoz, and J. Goldstein Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor PLoS Biol 2 2008 2853 2868
    • (2008) PLoS Biol , vol.2 , pp. 2853-2868
    • Coppé, J.P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Muñoz, D.P.5    Goldstein, J.6
  • 47
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
    • N. Wajapeyee, R.W. Serra, X. Zhu, M. Mahalingam, and M.R. Green Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7 Cell 132 2008 363 374
    • (2008) Cell , vol.132 , pp. 363-374
    • Wajapeyee, N.1    Serra, R.W.2    Zhu, X.3    Mahalingam, M.4    Green, M.R.5
  • 48
    • 84921715676 scopus 로고    scopus 로고
    • Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis
    • J.H. Tabibian, C.E. Trussoni, S.P. O'Hara, P.L. Splinter, J.K. Heimbach, and N.F. LaRusso Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis Lab Invest 94 2014 1126 1133
    • (2014) Lab Invest , vol.94 , pp. 1126-1133
    • Tabibian, J.H.1    Trussoni, C.E.2    O'Hara, S.P.3    Splinter, P.L.4    Heimbach, J.K.5    Larusso, N.F.6
  • 49
    • 84901634043 scopus 로고    scopus 로고
    • Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis
    • J.H. Tabibian, S.P. O'Hara, P.L. Splinter, C.E. Trussoni, and N.F. LaRusso Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis Hepatology 59 2014 2263 2275
    • (2014) Hepatology , vol.59 , pp. 2263-2275
    • Tabibian, J.H.1    O'Hara, S.P.2    Splinter, P.L.3    Trussoni, C.E.4    Larusso, N.F.5
  • 51
    • 44649101304 scopus 로고    scopus 로고
    • Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
    • T. Kuilman, C. Michaloglou, L.C. Vredeveld, S. Douma, R. van Doorn, and C.J. Desmet Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network Cell 133 2008 1019 1031
    • (2008) Cell , vol.133 , pp. 1019-1031
    • Kuilman, T.1    Michaloglou, C.2    Vredeveld, L.C.3    Douma, S.4    Van Doorn, R.5    Desmet, C.J.6
  • 52
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • N. Mizushima Autophagy: process and function Genes Dev 21 2007 2861 2873
    • (2007) Genes Dev , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 53
    • 43949123866 scopus 로고    scopus 로고
    • Autophagy in the liver
    • X.M. Yin, W.X. Ding, and W. Gao Autophagy in the liver Hepatology 47 2008 1773 1785
    • (2008) Hepatology , vol.47 , pp. 1773-1785
    • Yin, X.M.1    Ding, W.X.2    Gao, W.3
  • 54
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • G. Kroemer, G. Mariño, and B. Levine Autophagy and the integrated stress response Mol Cell 40 2010 280 293
    • (2010) Mol Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Mariño, G.2    Levine, B.3
  • 55
    • 80054839348 scopus 로고    scopus 로고
    • Cell death pathology: Cross-talk with autophagy and its clinical implications
    • I. Amelio, G. Melino, and R.A. Knight Cell death pathology: cross-talk with autophagy and its clinical implications Biochem Biophys Res Commun 414 2011 277 281
    • (2011) Biochem Biophys Res Commun , vol.414 , pp. 277-281
    • Amelio, I.1    Melino, G.2    Knight, R.A.3
  • 56
    • 0033916878 scopus 로고    scopus 로고
    • Amplification and sequence analysis of partial bacterial 16S ribosomal RNA gene in gallbladder bile from patients with primary biliary cirrhosis
    • K. Hiramatsu, K. Harada, K. Tsuneyama, M. Sasaki, S. Fujita, and T. Hashimoto Amplification and sequence analysis of partial bacterial 16S ribosomal RNA gene in gallbladder bile from patients with primary biliary cirrhosis J Hepatol 33 2000 9 18
    • (2000) J Hepatol , vol.33 , pp. 9-18
    • Hiramatsu, K.1    Harada, K.2    Tsuneyama, K.3    Sasaki, M.4    Fujita, S.5    Hashimoto, T.6
  • 57
    • 14244261439 scopus 로고    scopus 로고
    • Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts
    • K. Isse, K. Harada, Y. Zen, T. Kamihira, S. Shimoda, and M. Harada Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts Hepatology 41 2005 506 516
    • (2005) Hepatology , vol.41 , pp. 506-516
    • Isse, K.1    Harada, K.2    Zen, Y.3    Kamihira, T.4    Shimoda, S.5    Harada, M.6
  • 58
    • 33748309351 scopus 로고    scopus 로고
    • Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M
    • K. Harada, K. Isse, Y. Sato, S. Ozaki, and Y. Nakanuma Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M Liver Int 26 2006 935 942
    • (2006) Liver Int , vol.26 , pp. 935-942
    • Harada, K.1    Isse, K.2    Sato, Y.3    Ozaki, S.4    Nakanuma, Y.5
  • 59
    • 78650794235 scopus 로고    scopus 로고
    • Significance of periductal Langerhans cells and biliary epithelial cell-derived macrophage inflammatory protein-3α in the pathogenesis of primary biliary cirrhosis
    • K. Harada, S. Shimoda, H. Ikeda, M. Chiba, M. Hsu, and Y. Sato Significance of periductal Langerhans cells and biliary epithelial cell-derived macrophage inflammatory protein-3α in the pathogenesis of primary biliary cirrhosis Liver Int 31 2011 245 253
    • (2011) Liver Int , vol.31 , pp. 245-253
    • Harada, K.1    Shimoda, S.2    Ikeda, H.3    Chiba, M.4    Hsu, M.5    Sato, Y.6
  • 60
    • 79953762710 scopus 로고    scopus 로고
    • Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis
    • S. Shimoda, K. Harada, H. Niiro, K. Shirabe, A. Taketomi, and Y. Maehara Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis Hepatology 53 2011 1270 1281
    • (2011) Hepatology , vol.53 , pp. 1270-1281
    • Shimoda, S.1    Harada, K.2    Niiro, H.3    Shirabe, K.4    Taketomi, A.5    Maehara, Y.6
  • 61
    • 79960724124 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 derived from biliary innate immunity contributes to hepatic fibrogenesis
    • K. Harada, M. Chiba, A. Okamura, M. Hsu, Y. Sato, and S. Igarashi Monocyte chemoattractant protein-1 derived from biliary innate immunity contributes to hepatic fibrogenesis J Clin Pathol 64 2011 660 665
    • (2011) J Clin Pathol , vol.64 , pp. 660-665
    • Harada, K.1    Chiba, M.2    Okamura, A.3    Hsu, M.4    Sato, Y.5    Igarashi, S.6
  • 62
    • 34249045984 scopus 로고    scopus 로고
    • Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture
    • H. Ikeda, M. Sasaki, A. Ishikawa, Y. Sato, K. Harada, and Y. Zen Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture Lab Invest 87 2007 559 571
    • (2007) Lab Invest , vol.87 , pp. 559-571
    • Ikeda, H.1    Sasaki, M.2    Ishikawa, A.3    Sato, Y.4    Harada, K.5    Zen, Y.6
  • 63
    • 48449088578 scopus 로고    scopus 로고
    • Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: A culture study
    • M. Sasaki, H. Ikeda, Y. Sato, and Y. Nakanuma Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: a culture study Free Radic Res 42 2008 625 632
    • (2008) Free Radic Res , vol.42 , pp. 625-632
    • Sasaki, M.1    Ikeda, H.2    Sato, Y.3    Nakanuma, Y.4
  • 64
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • N. Mizushima, B. Levine, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Klionsky, D.J.3
  • 65
    • 84869421637 scopus 로고    scopus 로고
    • Novel approach to bile duct damage in primary biliary cirrhosis: Participation of cellular senescence and autophagy
    • M. Sasaki, and Y. Nakanuma Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy Int J Hepatol 2012 2012 452143 10.1155/2012/452143
    • (2012) Int J Hepatol , vol.2012 , pp. 452143
    • Sasaki, M.1    Nakanuma, Y.2
  • 66
    • 0035071514 scopus 로고    scopus 로고
    • Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: Increased expression of p21WAF1/Cip1 as a disease marker and the influence of immunosuppressive drugs
    • J.G. Lunz III, S. Contrucci, K. Ruppert, K. Ruppert, N. Murase, and J.J. Fung Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21WAF1/Cip1 as a disease marker and the influence of immunosuppressive drugs Am J Pathol 158 2001 1379 1390
    • (2001) Am J Pathol , vol.158 , pp. 1379-1390
    • Lunz, J.G.1    Contrucci, S.2    Ruppert, K.3    Ruppert, K.4    Murase, N.5    Fung, J.J.6
  • 67
    • 84859502562 scopus 로고    scopus 로고
    • Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis
    • M. Sasaki, M. Miyakoshi, Y. Sato, and Y. Nakanuma Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis Dig Dis Sci 57 2012 660 666
    • (2012) Dig Dis Sci , vol.57 , pp. 660-666
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 68
    • 84856634376 scopus 로고    scopus 로고
    • A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis
    • M. Sasaki, M. Miyakoshi, Y. Sato, and Y. Nakanuma A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis Liver Int 32 2012 487 499
    • (2012) Liver Int , vol.32 , pp. 487-499
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 70
    • 0035079864 scopus 로고    scopus 로고
    • Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
    • V. Paradis, N. Youssef, D. Dargère, N. Bâ, F. Bonvoust, and J. Deschatrette Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas Hum Pathol 32 2001 327 332
    • (2001) Hum Pathol , vol.32 , pp. 327-332
    • Paradis, V.1    Youssef, N.2    Dargère, D.3    Bâ, N.4    Bonvoust, F.5    Deschatrette, J.6
  • 71
    • 84882925367 scopus 로고    scopus 로고
    • Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema
    • M. Chilosi, A. Carloni, A. Rossi, and V. Poletti Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema Transl Res 162 2013 156 173
    • (2013) Transl Res , vol.162 , pp. 156-173
    • Chilosi, M.1    Carloni, A.2    Rossi, A.3    Poletti, V.4
  • 72
    • 84906847476 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease
    • M. Kumar, W. Seeger, and R. Voswinckel Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease Am J Respir Cell Mol Biol 51 2014 323 333
    • (2014) Am J Respir Cell Mol Biol , vol.51 , pp. 323-333
    • Kumar, M.1    Seeger, W.2    Voswinckel, R.3
  • 73
    • 84896726055 scopus 로고    scopus 로고
    • Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis
    • M. Sasaki, M. Miyakoshi, Y. Sato, and Y. Nakanuma Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis Dig Dis Sci 59 2014 358 364
    • (2014) Dig Dis Sci , vol.59 , pp. 358-364
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 74
    • 40949118946 scopus 로고    scopus 로고
    • Biliary epithelial cells and primary biliary cirrhosis: The role of liver-infiltrating mononuclear cells
    • S. Shimoda, K. Harada, H. Niiro, T. Yoshizumi, Y. Soejima, and A. Taketomi Biliary epithelial cells and primary biliary cirrhosis: the role of liver-infiltrating mononuclear cells Hepatology 47 2008 958 965
    • (2008) Hepatology , vol.47 , pp. 958-965
    • Shimoda, S.1    Harada, K.2    Niiro, H.3    Yoshizumi, T.4    Soejima, Y.5    Taketomi, A.6
  • 75
    • 0035168848 scopus 로고    scopus 로고
    • Monocyte chemotactic protein-1, -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: Implications for pathogenesis
    • K. Tsuneyama, K. Harada, M. Yasoshima, K. Hiramatsu, C.R. Mackay, and I.R. Mackay Monocyte chemotactic protein-1, -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: implications for pathogenesis J Pathol 193 2001 102 109
    • (2001) J Pathol , vol.193 , pp. 102-109
    • Tsuneyama, K.1    Harada, K.2    Yasoshima, M.3    Hiramatsu, K.4    MacKay, C.R.5    MacKay, I.R.6
  • 76
    • 0031883604 scopus 로고    scopus 로고
    • Increased expression of interleukin-6 and tumor necrosis factor-α in pathologic biliary epithelial cells: In situ and culture study
    • M. Yasoshima, N. Kono, H. Sugawara, K. Katayanagi, K. Harada, and Y. Nakanuma Increased expression of interleukin-6 and tumor necrosis factor-α in pathologic biliary epithelial cells: in situ and culture study Lab Invest 78 1998 89 100
    • (1998) Lab Invest , vol.78 , pp. 89-100
    • Yasoshima, M.1    Kono, N.2    Sugawara, H.3    Katayanagi, K.4    Harada, K.5    Nakanuma, Y.6
  • 77
    • 4644359523 scopus 로고    scopus 로고
    • Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree
    • K. Harada, K. Ohba, S. Ozaki, K. Isse, T. Hirayama, and A. Wada Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree Hepatology 404 2004 925 932
    • (2004) Hepatology , vol.404 , pp. 925-932
    • Harada, K.1    Ohba, K.2    Ozaki, S.3    Isse, K.4    Hirayama, T.5    Wada, A.6
  • 78
    • 0242413703 scopus 로고    scopus 로고
    • Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells
    • K. Harada, S. Ohira, K. Isse, S. Ozaki, Y. Zen, and Y. Sato Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells Lab Invest 83 2003 1657 1667
    • (2003) Lab Invest , vol.83 , pp. 1657-1667
    • Harada, K.1    Ohira, S.2    Isse, K.3    Ozaki, S.4    Zen, Y.5    Sato, Y.6
  • 79
    • 0033966411 scopus 로고    scopus 로고
    • Toll signaling pathways in the innate immune response
    • K.V.A. Anderson Toll signaling pathways in the innate immune response Curr Opin Immunol 12 2000 13 19
    • (2000) Curr Opin Immunol , vol.12 , pp. 13-19
    • Anderson, K.V.A.1
  • 80
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • K. Takeda, and S. Akira Toll-like receptors in innate immunity Int Immunol 17 2005 1 14
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 81
    • 84870273878 scopus 로고    scopus 로고
    • Innate immunity in the pathogenesis of cholangiopathy: A recent update
    • K. Harada, and Y. Nakanuma Innate immunity in the pathogenesis of cholangiopathy: a recent update Inflamm Allergy Drug Targets 11 2012 478 483
    • (2012) Inflamm Allergy Drug Targets , vol.11 , pp. 478-483
    • Harada, K.1    Nakanuma, Y.2
  • 82
    • 0032169557 scopus 로고    scopus 로고
    • Human β-defensin 2 is a salt- sensitive peptide antibiotic expressed in human lung
    • R. Bals, X. Wang, Z. Wu, T. Freeman, V. Bafna, and M. Zasloff Human β-defensin 2 is a salt- sensitive peptide antibiotic expressed in human lung J Clin Invest 102 1998 874 880
    • (1998) J Clin Invest , vol.102 , pp. 874-880
    • Bals, R.1    Wang, X.2    Wu, Z.3    Freeman, T.4    Bafna, V.5    Zasloff, M.6
  • 83
    • 0027932181 scopus 로고
    • Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro
    • K. Matsumoto, H. Fujii, G. Michalopoulos, J.J. Fung, and A.J. Demetris Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro Hepatology 20 1994 376 382
    • (1994) Hepatology , vol.20 , pp. 376-382
    • Matsumoto, K.1    Fujii, H.2    Michalopoulos, G.3    Fung, J.J.4    Demetris, A.J.5
  • 84
    • 28244478101 scopus 로고    scopus 로고
    • Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-κB
    • X.M. Chen, S.P. O'Hara, J.B. Nelson, P.L. Splinter, A.J. Small, and P.S. Tietz Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-κB J Immunol 175 2005 7447 7456
    • (2005) J Immunol , vol.175 , pp. 7447-7456
    • Chen, X.M.1    O'Hara, S.P.2    Nelson, J.B.3    Splinter, P.L.4    Small, A.J.5    Tietz, P.S.6
  • 85
    • 32544446183 scopus 로고    scopus 로고
    • Interferon γ accelerates NF-κB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction
    • K. Harada, K. Isse, and Y. Nakanuma Interferon γ accelerates NF-κB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction J Clin Pathol 59 2006 184 190
    • (2006) J Clin Pathol , vol.59 , pp. 184-190
    • Harada, K.1    Isse, K.2    Nakanuma, Y.3
  • 86
    • 75449089682 scopus 로고    scopus 로고
    • CX3CL1 (fractalkine): A signpost for biliary inflammation in primary biliary cirrhosis
    • S. Shimoda, K. Harada, H. Niiro, K. Shirabe, A. Taketomi, and Y. Maehara CX3CL1 (fractalkine): a signpost for biliary inflammation in primary biliary cirrhosis Hepatology 51 2010 567 575
    • (2010) Hepatology , vol.51 , pp. 567-575
    • Shimoda, S.1    Harada, K.2    Niiro, H.3    Shirabe, K.4    Taketomi, A.5    Maehara, Y.6
  • 87
    • 84874655803 scopus 로고    scopus 로고
    • Participation of natural killer cells in the pathogenesis of bile duct lesions in biliary atresia
    • A. Okamura, K. Harada, M. Nio, and Y. Nakanuma Participation of natural killer cells in the pathogenesis of bile duct lesions in biliary atresia J Clin Pathol 66 2013 99 108
    • (2013) J Clin Pathol , vol.66 , pp. 99-108
    • Okamura, A.1    Harada, K.2    Nio, M.3    Nakanuma, Y.4
  • 88
    • 84880015293 scopus 로고    scopus 로고
    • Interleukin-32 production associated with biliary innate immunity and proinflammatory cytokines contributes to the pathogenesis of cholangitis in biliary atresia
    • A. Okamura, K. Harada, M. Nio, and Y. Nakanuma Interleukin-32 production associated with biliary innate immunity and proinflammatory cytokines contributes to the pathogenesis of cholangitis in biliary atresia Clin Exp Immunol 173 2013 268 275
    • (2013) Clin Exp Immunol , vol.173 , pp. 268-275
    • Okamura, A.1    Harada, K.2    Nio, M.3    Nakanuma, Y.4
  • 89
    • 77956820580 scopus 로고    scopus 로고
    • Biliary innate immunity: Function and modulation
    • K. Harada, and Y. Nakanuma Biliary innate immunity: function and modulation Mediators Inflamm 2010 2010 10.1155/2010/373878 pii: 373878
    • (2010) Mediators Inflamm , vol.2010
    • Harada, K.1    Nakanuma, Y.2
  • 90
    • 80052230924 scopus 로고    scopus 로고
    • Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation
    • S.P. O'Hara, P.L. Splinter, C.E. Trussoni, G.B. Gajdos, P.N. Lineswala, and N.F. LaRusso Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation J Biol Chem 286 2011 30352 30360
    • (2011) J Biol Chem , vol.286 , pp. 30352-30360
    • O'Hara, S.P.1    Splinter, P.L.2    Trussoni, C.E.3    Gajdos, G.B.4    Lineswala, P.N.5    Larusso, N.F.6
  • 91
    • 0032171526 scopus 로고    scopus 로고
    • Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis
    • K. Sasatomi, K. Noguchi, S. Sakisaka, M. Sata, and K. Tanikawa Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis J Hepatol 29 1998 409 416
    • (1998) J Hepatol , vol.29 , pp. 409-416
    • Sasatomi, K.1    Noguchi, K.2    Sakisaka, S.3    Sata, M.4    Tanikawa, K.5
  • 92
    • 0035129896 scopus 로고    scopus 로고
    • Molecular identification of bacterial 16S ribosomal RNA gene in liver tissue of primary biliary cirrhosis: Is Propionibacterium acnes involved in granuloma formation?
    • K. Harada, K. Tsuneyama, Y. Sudo, S. Masuda, and Y. Nakanuma Molecular identification of bacterial 16S ribosomal RNA gene in liver tissue of primary biliary cirrhosis: is Propionibacterium acnes involved in granuloma formation? Hepatology 33 2001 530 536
    • (2001) Hepatology , vol.33 , pp. 530-536
    • Harada, K.1    Tsuneyama, K.2    Sudo, Y.3    Masuda, S.4    Nakanuma, Y.5
  • 93
    • 0035196753 scopus 로고    scopus 로고
    • Risk factors for primary biliary cirrhosis in a cohort of patients from the United States
    • A. Parikh-Patel, E.B. Gold, H. Worman, K.E. Krivy, and M.E. Gershwin Risk factors for primary biliary cirrhosis in a cohort of patients from the United States Hepatology 33 2001 16 21
    • (2001) Hepatology , vol.33 , pp. 16-21
    • Parikh-Patel, A.1    Gold, E.B.2    Worman, H.3    Krivy, K.E.4    Gershwin, M.E.5
  • 94
    • 67650668741 scopus 로고    scopus 로고
    • Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis
    • K. Harada, S. Shimoda, Y. Sato, K. Isse, H. Ikeda, and Y. Nakanuma Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis Clin Exp Immunol 157 2009 261 262
    • (2009) Clin Exp Immunol , vol.157 , pp. 261-262
    • Harada, K.1    Shimoda, S.2    Sato, Y.3    Isse, K.4    Ikeda, H.5    Nakanuma, Y.6
  • 95
    • 47149088985 scopus 로고    scopus 로고
    • Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence
    • M. Sasaki, H. Ikeda, J. Yamaguchi, S. Nakada, and Y. Nakanuma Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence Hepatology 48 2008 186 195
    • (2008) Hepatology , vol.48 , pp. 186-195
    • Sasaki, M.1    Ikeda, H.2    Yamaguchi, J.3    Nakada, S.4    Nakanuma, Y.5
  • 96
    • 33748784360 scopus 로고    scopus 로고
    • Decreased expression of Bmi1 is closely associated with cellular senes-cence in small bile ducts in primary biliary cirrhosis
    • M. Sasaki, H. Ikeda, Y. Sato, and Y. Nakanuma Decreased expression of Bmi1 is closely associated with cellular senes-cence in small bile ducts in primary biliary cirrhosis Am J Pathol 169 2006 831 845
    • (2006) Am J Pathol , vol.169 , pp. 831-845
    • Sasaki, M.1    Ikeda, H.2    Sato, Y.3    Nakanuma, Y.4
  • 97
    • 84901680229 scopus 로고    scopus 로고
    • Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and in biliary epithelial layer may be involved in the pathogenesis in primary biliary cirrhosis
    • M. Sasaki, Y. Kakuda, M. Miyakoshi, Y. Sato, and Y. Nakanuma Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and in biliary epithelial layer may be involved in the pathogenesis in primary biliary cirrhosis J Clin Pathol 67 2014 470 476
    • (2014) J Clin Pathol , vol.67 , pp. 470-476
    • Sasaki, M.1    Kakuda, Y.2    Miyakoshi, M.3    Sato, Y.4    Nakanuma, Y.5
  • 98
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • J.P. Coppe, C.K. Patil, F. Rodier, Y. Sun, D.P. Munoz, and J. Goldstein Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor PLoS Biol 6 2008 2853 2868
    • (2008) PLoS Biol , vol.6 , pp. 2853-2868
    • Coppe, J.P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Munoz, D.P.5    Goldstein, J.6
  • 100
    • 84872147588 scopus 로고    scopus 로고
    • Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis
    • M. Sasaki, M. Miyakoshi, Y. Sato, and Y. Nakanuma Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis Liver Int 33 2013 312 320
    • (2013) Liver Int , vol.33 , pp. 312-320
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 101
    • 77954601195 scopus 로고    scopus 로고
    • Autophagy mediates the process of cellular senescence char-acterizing bile duct damages in primary biliary cirrhosis
    • M. Sasaki, M. Miyakoshi, Y. Sato, and Y. Nakanuma Autophagy mediates the process of cellular senescence char-acterizing bile duct damages in primary biliary cirrhosis Lab Invest 90 2010 835 843
    • (2010) Lab Invest , vol.90 , pp. 835-843
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 103
    • 77953601881 scopus 로고    scopus 로고
    • Regulation of innate immune responses by autophagy-related proteins
    • T. Saitoh, and S. Akira Regulation of innate immune responses by autophagy-related proteins J Cell Biol 189 2010 925 935
    • (2010) J Cell Biol , vol.189 , pp. 925-935
    • Saitoh, T.1    Akira, S.2
  • 104
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • M. Komatsu, H. Kurokawa, S. Waguri, K. Taguchi, A. Kobayashi, and Y. Ichimura The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Nat Cell Biol 12 2010 213 223
    • (2010) Nat Cell Biol , vol.12 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3    Taguchi, K.4    Kobayashi, A.5    Ichimura, Y.6
  • 105
    • 84872147588 scopus 로고    scopus 로고
    • Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis
    • M. Sasaki, M. Miyakoshi, Y. Sato, and Y. Nakanuma Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis Liver Int 3 2013 312 320
    • (2013) Liver Int , vol.3 , pp. 312-320
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 106
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • J. Nedjic, M. Aichinger, J. Emmerich, N. Mizushima, and L. Klein Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance Nature 455 2008 396 400
    • (2008) Nature , vol.455 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3    Mizushima, N.4    Klein, L.5
  • 107
    • 12844275079 scopus 로고    scopus 로고
    • Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    • C. Paludan, D. Schmid, M. Landthaler, M. Vockerodt, D. Kube, and T. Tuschl Endogenous MHC class II processing of a viral nuclear antigen after autophagy Science 307 2005 593 596
    • (2005) Science , vol.307 , pp. 593-596
    • Paludan, C.1    Schmid, D.2    Landthaler, M.3    Vockerodt, M.4    Kube, D.5    Tuschl, T.6
  • 108
    • 77249112669 scopus 로고    scopus 로고
    • Antigen processing via autophagy-not only for MHC class II presentation anymore?
    • C. Munz Antigen processing via autophagy-not only for MHC class II presentation anymore? Curr Opin Immunol 22 2010 89 93
    • (2010) Curr Opin Immunol , vol.22 , pp. 89-93
    • Munz, C.1
  • 109
    • 0028820957 scopus 로고
    • Biliary epithelial expression of pyruvate dehydrogenase complex in primary biliary cirrhosis: An immunohistochemical and immunoelectron microscopic study
    • Y. Nakanuma, K. Tsuneyama, N. Kono, M. Hoso, J. Van de Water, and M.E. Gershwin Biliary epithelial expression of pyruvate dehydrogenase complex in primary biliary cirrhosis: an immunohistochemical and immunoelectron microscopic study Hum Pathol 26 1995 92 98
    • (1995) Hum Pathol , vol.26 , pp. 92-98
    • Nakanuma, Y.1    Tsuneyama, K.2    Kono, N.3    Hoso, M.4    Van De Water, J.5    Gershwin, M.E.6
  • 110
    • 84923249916 scopus 로고    scopus 로고
    • TLR4, TLR9, and NLRP3 in biliary epithelial cells of primary sclerosing cholangitis: Relationship with clinical characteristics
    • in press
    • H. Matsushita, Y. Miyake, A. Takaki, T. Yasunaka, K. Koike, and F. Ikeda TLR4, TLR9, and NLRP3 in biliary epithelial cells of primary sclerosing cholangitis: relationship with clinical characteristics J Gastroenterol Hepatol 2014 in press
    • (2014) J Gastroenterol Hepatol
    • Matsushita, H.1    Miyake, Y.2    Takaki, A.3    Yasunaka, T.4    Koike, K.5    Ikeda, F.6
  • 111
    • 33644617718 scopus 로고    scopus 로고
    • Etiopathogenesis of primary sclerosing cholangitis
    • C.A. O'Mahony, and J.M. Vierling Etiopathogenesis of primary sclerosing cholangitis Semin Liver Dis 26 2006 3 21
    • (2006) Semin Liver Dis , vol.26 , pp. 3-21
    • O'Mahony, C.A.1    Vierling, J.M.2
  • 112
    • 84883150093 scopus 로고    scopus 로고
    • Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management
    • J.E. Eaton, J.A. Talwalkar, K.N. Lazaridis, G.J. Gores, and K.D. Lindor Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management Gastroenterology 145 2013 521 536
    • (2013) Gastroenterology , vol.145 , pp. 521-536
    • Eaton, J.E.1    Talwalkar, J.A.2    Lazaridis, K.N.3    Gores, G.J.4    Lindor, K.D.5
  • 113
    • 0030615212 scopus 로고    scopus 로고
    • Preferential v beta3 usage by hepatic T lymphocytes in patients with primary sclerosing cholangitis
    • U. Broomé, J. Grunewald, A. Scheynius, O. Olerup, and R. Hultcrantz Preferential V beta3 usage by hepatic T lymphocytes in patients with primary sclerosing cholangitis J Hepatol 26 1997 527 534
    • (1997) J Hepatol , vol.26 , pp. 527-534
    • Broomé, U.1    Grunewald, J.2    Scheynius, A.3    Olerup, O.4    Hultcrantz, R.5
  • 114
    • 0041665087 scopus 로고    scopus 로고
    • IgA class antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and autoimmune hepatitis
    • C. Schwarze, B. Terjung, P. Lilienweiss, U. Beuers, V. Herzog, and T. Sauerbruch IgA class antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and autoimmune hepatitis Clin Exp Immunol 133 2003 283 289
    • (2003) Clin Exp Immunol , vol.133 , pp. 283-289
    • Schwarze, C.1    Terjung, B.2    Lilienweiss, P.3    Beuers, U.4    Herzog, V.5    Sauerbruch, T.6
  • 115
    • 0027955159 scopus 로고
    • Selby WS Anti-neutrophil cytoplasmic antibody: A prognostic indicator in primary sclerosing cholangitis
    • C.S. Pokorny, I.D. Norton, and G.W. McCaughan Selby WS Anti-neutrophil cytoplasmic antibody: a prognostic indicator in primary sclerosing cholangitis J Gastroenterol Hepatol 9 1994 40 44
    • (1994) J Gastroenterol Hepatol , vol.9 , pp. 40-44
    • Pokorny, C.S.1    Norton, I.D.2    McCaughan, G.W.3
  • 116
    • 77953718694 scopus 로고    scopus 로고
    • P-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ
    • B. Terjung, J. Söhne, B. Lechtenberg, J. Gottwein, M. Muennich, and V. Herzog P-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ Gut 59 2010 808 816
    • (2010) Gut , vol.59 , pp. 808-816
    • Terjung, B.1    Söhne, J.2    Lechtenberg, B.3    Gottwein, J.4    Muennich, M.5    Herzog, V.6
  • 117
    • 10644245899 scopus 로고    scopus 로고
    • Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis
    • B. Eksteen, A.J. Grant, A. Miles, S.M. Curbishley, P.F. Lalor, and S.G. Hübscher Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis J Exp Med 200 2004 1511 1517
    • (2004) J Exp Med , vol.200 , pp. 1511-1517
    • Eksteen, B.1    Grant, A.J.2    Miles, A.3    Curbishley, S.M.4    Lalor, P.F.5    Hübscher, S.G.6
  • 118
    • 84893667590 scopus 로고    scopus 로고
    • CD8 T cells primed in the gut-associated lymphoid tissue induce immune-mediated cholangitis in mice
    • D. Seidel, I. Eickmeier, A.A. Kühl, A. Hamann, C. Loddenkemper, and E. Schott CD8 T cells primed in the gut-associated lymphoid tissue induce immune-mediated cholangitis in mice Hepatology 59 2014 601 611
    • (2014) Hepatology , vol.59 , pp. 601-611
    • Seidel, D.1    Eickmeier, I.2    Kühl, A.A.3    Hamann, A.4    Loddenkemper, C.5    Schott, E.6
  • 119
    • 84886291634 scopus 로고    scopus 로고
    • Mucosal immunity in liver autoimmunity: A comprehensive review
    • P.J. Trivedi, and D.H. Adams Mucosal immunity in liver autoimmunity: a comprehensive review J Autoimmun 46 2013 97 111
    • (2013) J Autoimmun , vol.46 , pp. 97-111
    • Trivedi, P.J.1    Adams, D.H.2
  • 120
    • 80054897554 scopus 로고    scopus 로고
    • Cutting edge issues in primary sclerosing cholangitis
    • C.L. Bowlus Cutting edge issues in primary sclerosing cholangitis Clin Rev Allergy Immunol 41 2011 139 150
    • (2011) Clin Rev Allergy Immunol , vol.41 , pp. 139-150
    • Bowlus, C.L.1
  • 121
    • 38549143883 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease
    • K.A. Rygiel, H. Robertson, H.L. Marshall, M. Pekalski, L. Zhao, and T.A. Booth Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease Lab Invest 88 2008 112 123
    • (2008) Lab Invest , vol.88 , pp. 112-123
    • Rygiel, K.A.1    Robertson, H.2    Marshall, H.L.3    Pekalski, M.4    Zhao, L.5    Booth, T.A.6
  • 122
    • 80053991368 scopus 로고    scopus 로고
    • Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis
    • T. Mueller, C. Beutler, A.H. Picó, O. Shibolet, D.S. Pratt, and A. Pascher Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis Liver Int 31 2011 1574 1588
    • (2011) Liver Int , vol.31 , pp. 1574-1588
    • Mueller, T.1    Beutler, C.2    Picó, A.H.3    Shibolet, O.4    Pratt, D.S.5    Pascher, A.6
  • 123
    • 0029864461 scopus 로고    scopus 로고
    • Importance of antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and ulcerative colitis: Prevalence, titre, and IgG subclass
    • D.S. Bansi, K.A. Fleming, and R.W. Chapman Importance of antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis and ulcerative colitis: prevalence, titre, and IgG subclass Gut 38 1996 384 389
    • (1996) Gut , vol.38 , pp. 384-389
    • Bansi, D.S.1    Fleming, K.A.2    Chapman, R.W.3
  • 124
    • 34247196579 scopus 로고    scopus 로고
    • Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis
    • A. Karrar, U. Broomé, T. Södergren, M. Jaksch, A. Bergquist, and M. Björnstedt Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis Gastroenterology 132 2007 1504 1514
    • (2007) Gastroenterology , vol.132 , pp. 1504-1514
    • Karrar, A.1    Broomé, U.2    Södergren, T.3    Jaksch, M.4    Bergquist, A.5    Björnstedt, M.6
  • 125
    • 0036296996 scopus 로고    scopus 로고
    • High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin 6
    • B. Xu, U. Broome, B.G. Ericzon, and S. Sumitran-Holgersson High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin 6 Gut 51 2002 120 127
    • (2002) Gut , vol.51 , pp. 120-127
    • Xu, B.1    Broome, U.2    Ericzon, B.G.3    Sumitran-Holgersson, S.4
  • 126
    • 34447100540 scopus 로고    scopus 로고
    • Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia
    • C.L. Mack, M.T. Falta, A.K. Sullivan, F. Karrer, R.J. Sokol, and B.M. Freed Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia Gastroenterology 133 2007 278 287
    • (2007) Gastroenterology , vol.133 , pp. 278-287
    • MacK, C.L.1    Falta, M.T.2    Sullivan, A.K.3    Karrer, F.4    Sokol, R.J.5    Freed, B.M.6
  • 127
    • 78049468248 scopus 로고    scopus 로고
    • Viruses and autoantibodies in biliary atresia
    • C. Selmi, D. Vergani, and G. Mieli-Vergani Viruses and autoantibodies in biliary atresia Gastroenterology 139 2010 1461 1464
    • (2010) Gastroenterology , vol.139 , pp. 1461-1464
    • Selmi, C.1    Vergani, D.2    Mieli-Vergani, G.3
  • 128
    • 42149119483 scopus 로고    scopus 로고
    • Biliary atresia: Is lack of innate immune response tolerance key to pathogenesis?
    • S.S. Glaser Biliary atresia: is lack of innate immune response tolerance key to pathogenesis? Liver Int 28 2008 587 588
    • (2008) Liver Int , vol.28 , pp. 587-588
    • Glaser, S.S.1
  • 129
    • 42149181761 scopus 로고    scopus 로고
    • Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia
    • K. Harada, Y. Sato, K. Isse, H. Ikeda, and Y. Nakanuma Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia Liver Int 28 2008 614 621
    • (2008) Liver Int , vol.28 , pp. 614-621
    • Harada, K.1    Sato, Y.2    Isse, K.3    Ikeda, H.4    Nakanuma, Y.5
  • 130
    • 33746575627 scopus 로고    scopus 로고
    • Implication of innate immunity in the pathogenesis of biliary atresia
    • J.H. Chuang, M.H. Chou, C.L. Wu, and Y.Y. Du Implication of innate immunity in the pathogenesis of biliary atresia Chang Gung Med J 29 2006 240 250
    • (2006) Chang Gung Med J , vol.29 , pp. 240-250
    • Chuang, J.H.1    Chou, M.H.2    Wu, C.L.3    Du, Y.Y.4
  • 131
    • 79955120145 scopus 로고    scopus 로고
    • Is it the end of the line for the EMT?
    • T. Kisseleva, and D.A. Brenner Is it the end of the line for the EMT? Hepatology 53 2011 1433 1435
    • (2011) Hepatology , vol.53 , pp. 1433-1435
    • Kisseleva, T.1    Brenner, D.A.2
  • 132
    • 79955123951 scopus 로고    scopus 로고
    • Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
    • A.S. Chu, R. Diaz, J.J. Hui, K. Yanger, Y. Zong, and G. Alpini Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis Hepatology 53 2011 1685 1695
    • (2011) Hepatology , vol.53 , pp. 1685-1695
    • Chu, A.S.1    Diaz, R.2    Hui, J.J.3    Yanger, K.4    Zong, Y.5    Alpini, G.6
  • 133
    • 48549103201 scopus 로고    scopus 로고
    • Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression
    • E. Patsenker, Y. Popov, F. Stickel, A. Jonczyk, S.L. Goodman, and D. Schuppan Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression Gastroenterology 135 2008 660 670
    • (2008) Gastroenterology , vol.135 , pp. 660-670
    • Patsenker, E.1    Popov, Y.2    Stickel, F.3    Jonczyk, A.4    Goodman, S.L.5    Schuppan, D.6
  • 135
    • 84906957504 scopus 로고    scopus 로고
    • Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma
    • T. Nitta, Y. Sato, X.S. Ren, K. Harada, M. Sasaki, and S. Hirano Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma Int J Clin Exp Pathol 7 2014 4913 4921
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 4913-4921
    • Nitta, T.1    Sato, Y.2    Ren, X.S.3    Harada, K.4    Sasaki, M.5    Hirano, S.6
  • 136
    • 55549140795 scopus 로고    scopus 로고
    • New light on anion exchangers in primary biliary cirrhosis
    • U. Beuers, and R.P. Oude-Elferink New light on anion exchangers in primary biliary cirrhosis J Hepatol 49 2008 881 883
    • (2008) J Hepatol , vol.49 , pp. 881-883
    • Beuers, U.1    Oude-Elferink, R.P.2
  • 137
    • 84155175630 scopus 로고    scopus 로고
    • A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes
    • S. Hohenester, L.M. Wenniger, C.C. Paulusma, S.J. van Vliet, D.M. Jefferson, and R.P. Elferink A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes Hepatology 55 2012 173 183
    • (2012) Hepatology , vol.55 , pp. 173-183
    • Hohenester, S.1    Wenniger, L.M.2    Paulusma, C.C.3    Van Vliet, S.J.4    Jefferson, D.M.5    Elferink, R.P.6
  • 139
    • 0027325467 scopus 로고
    • Abnormal expression of anion exchanger genes in primary biliary cirrhosis
    • J. Prieto, C. Qian, N. García, J. Díez, and J.F. Medina Abnormal expression of anion exchanger genes in primary biliary cirrhosis Gastroenterology 105 1993 572 578
    • (1993) Gastroenterology , vol.105 , pp. 572-578
    • Prieto, J.1    Qian, C.2    García, N.3    Díez, J.4    Medina, J.F.5
  • 141
    • 54449098345 scopus 로고    scopus 로고
    • A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults
    • D. Gotthardt, H. Runz, V. Keitel, C. Fischer, C. Flechtenmacher, and M. Wirtenberger A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults Hepatology 48 2008 1157 1166
    • (2008) Hepatology , vol.48 , pp. 1157-1166
    • Gotthardt, D.1    Runz, H.2    Keitel, V.3    Fischer, C.4    Flechtenmacher, C.5    Wirtenberger, M.6
  • 142
    • 84883792441 scopus 로고    scopus 로고
    • Increased TERC gene copy number and cells in senescence in primary sclerosing cholangitis compared to colitis and control patients
    • I. Laish, H. Katz, Y. Sulayev, M. Liberman, T. Naftali, and F. Benjaminov Increased TERC gene copy number and cells in senescence in primary sclerosing cholangitis compared to colitis and control patients Gene 529 2013 245 249
    • (2013) Gene , vol.529 , pp. 245-249
    • Laish, I.1    Katz, H.2    Sulayev, Y.3    Liberman, M.4    Naftali, T.5    Benjaminov, F.6
  • 143
    • 84864134596 scopus 로고    scopus 로고
    • Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells
    • M. Tkach, L. Coria, C. Rosemblit, M.A. Rivas, C.J. Proietti, and M.C. Díaz Flaqué Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells J Immunol 189 2012 1162 1172
    • (2012) J Immunol , vol.189 , pp. 1162-1172
    • Tkach, M.1    Coria, L.2    Rosemblit, C.3    Rivas, M.A.4    Proietti, C.J.5    Díaz Flaqué, M.C.6
  • 144
    • 84872857051 scopus 로고    scopus 로고
    • The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence
    • M. Wall, G. Poortinga, K.L. Stanley, R.K. Lindemann, M. Bots, and C.J. Chan The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence Cancer Discov 3 2013 82 95
    • (2013) Cancer Discov , vol.3 , pp. 82-95
    • Wall, M.1    Poortinga, G.2    Stanley, K.L.3    Lindemann, R.K.4    Bots, M.5    Chan, C.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.