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Volumn 33, Issue 2, 2013, Pages 312-320

Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis

Author keywords

Antimitochondrial antibody; Autophagy; Biliary epithelial cell; Cellular senescence; Primary biliary cirrhosis

Indexed keywords

CELL ANTIGEN; CELL MARKER; CYTOCHROME C OXIDASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN; MITOCHONDRIAL PROTEIN; PROTEIN P62; PYRUVATE DEHYDROGENASE COMPLEX;

EID: 84872147588     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12049     Document Type: Article
Times cited : (56)

References (47)
  • 1
    • 35148897568 scopus 로고    scopus 로고
    • Diseases of the bile ducts
    • Burt A, Bc P, Ld F, eds. 5th edn. London: Churchill Livingstone
    • Portmann B, Nakanuma Y. Diseases of the bile ducts. In: Burt A, Bc P, Ld F, eds. Pathology of the Liver. 5th edn. London: Churchill Livingstone, 2007: 517-81.
    • (2007) Pathology of the Liver , pp. 517-581
    • Portmann, B.1    Nakanuma, Y.2
  • 2
    • 25144474552 scopus 로고    scopus 로고
    • Primary biliary cirrhosis
    • Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med 2005; 353: 1261-73.
    • (2005) N Engl J Med , vol.353 , pp. 1261-1273
    • Kaplan, M.M.1    Gershwin, M.E.2
  • 4
    • 0018426934 scopus 로고
    • Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis
    • Nakanuma Y, Ohta G. Histometric and serial section observations of the intrahepatic bile ducts in primary biliary cirrhosis. Gastroenterology 1979; 76: 1326-32.
    • (1979) Gastroenterology , vol.76 , pp. 1326-1332
    • Nakanuma, Y.1    Ohta, G.2
  • 5
    • 0024266270 scopus 로고
    • Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis
    • Fussey S, Guest J, James O, Bassendine M, Yeaman S. Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Proc Natl Acad Sci USA 1988; 85: 8654-8.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8654-8658
    • Fussey, S.1    Guest, J.2    James, O.3    Bassendine, M.4    Yeaman, S.5
  • 6
    • 0036246857 scopus 로고    scopus 로고
    • Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
    • Kita H, Matsumura S, He XS, et al. Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest 2002; 109: 1231-40.
    • (2002) J Clin Invest , vol.109 , pp. 1231-1240
    • Kita, H.1    Matsumura, S.2    He, X.S.3
  • 7
    • 7844229417 scopus 로고    scopus 로고
    • Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis
    • Shimoda S, van de Water J, Ansari A, et al. Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis. J Clin Invest 1998; 102: 1831-40.
    • (1998) J Clin Invest , vol.102 , pp. 1831-1840
    • Shimoda, S.1    van de Water, J.2    Ansari, A.3
  • 8
    • 14944376606 scopus 로고    scopus 로고
    • Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss
    • Sasaki M, Ikeda H, Haga H, Manabe T, Nakanuma Y. Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss. J Pathol 2005; 205: 451-9.
    • (2005) J Pathol , vol.205 , pp. 451-459
    • Sasaki, M.1    Ikeda, H.2    Haga, H.3    Manabe, T.4    Nakanuma, Y.5
  • 9
    • 33748784360 scopus 로고    scopus 로고
    • Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis
    • Sasaki M, Ikeda H, Sato Y, Nakanuma Y. Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis. Am J Pathol 2006; 169: 831-45.
    • (2006) Am J Pathol , vol.169 , pp. 831-845
    • Sasaki, M.1    Ikeda, H.2    Sato, Y.3    Nakanuma, Y.4
  • 10
    • 47149088985 scopus 로고    scopus 로고
    • Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence
    • Sasaki M, Ikeda H, Yamaguchi J, Nakada S, Nakanuma Y. Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence. Hepatology 2008; 48: 186-95.
    • (2008) Hepatology , vol.48 , pp. 186-195
    • Sasaki, M.1    Ikeda, H.2    Yamaguchi, J.3    Nakada, S.4    Nakanuma, Y.5
  • 11
    • 43649096428 scopus 로고    scopus 로고
    • Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21(WAF1/Cip1) in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study
    • Sasaki M, Ikeda H, Nakanuma Y. Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21(WAF1/Cip1) in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study. J Autoimmun 2008; 31: 73-8.
    • (2008) J Autoimmun , vol.31 , pp. 73-78
    • Sasaki, M.1    Ikeda, H.2    Nakanuma, Y.3
  • 12
    • 77954601195 scopus 로고    scopus 로고
    • Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis
    • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis. Lab Invest 2010; 90: 835-43.
    • (2010) Lab Invest , vol.90 , pp. 835-843
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 13
    • 84856634376 scopus 로고    scopus 로고
    • A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis
    • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis. Liv Int 2012; 32: 487-99.
    • (2012) Liv Int , vol.32 , pp. 487-499
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3    Nakanuma, Y.4
  • 14
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N, Levine B, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069-75.
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Klionsky, D.J.3
  • 15
    • 0035286734 scopus 로고    scopus 로고
    • Molecular dissection of autophagy: two ubiquitin-like systems
    • Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol 2001; 2: 211-6.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 211-216
    • Ohsumi, Y.1
  • 16
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 17
    • 43949123866 scopus 로고    scopus 로고
    • Autophagy in the liver
    • Yin XM, Ding WX, Gao W. Autophagy in the liver. Hepatology 2008; 47: 1773-85.
    • (2008) Hepatology , vol.47 , pp. 1773-1785
    • Yin, X.M.1    Ding, W.X.2    Gao, W.3
  • 19
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    • Komatsu M, Kurokawa H, Waguri S, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 2010; 12: 213-23.
    • (2010) Nat Cell Biol , vol.12 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3
  • 20
    • 77953601881 scopus 로고    scopus 로고
    • Regulation of innate immune responses by autophagy-related proteins
    • Saitoh T, Akira S. Regulation of innate immune responses by autophagy-related proteins. J Cell Biol 2010; 189: 925-35.
    • (2010) J Cell Biol , vol.189 , pp. 925-935
    • Saitoh, T.1    Akira, S.2
  • 21
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation
    • Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011; 469: 323-35.
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 22
    • 33846224369 scopus 로고    scopus 로고
    • Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
    • Schmid D, Pypaert M, Munz C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 2007; 26: 79-92.
    • (2007) Immunity , vol.26 , pp. 79-92
    • Schmid, D.1    Pypaert, M.2    Munz, C.3
  • 23
    • 12844275079 scopus 로고    scopus 로고
    • Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    • Paludan C, Schmid D, Landthaler M, et al. Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science 2005; 307: 593-6.
    • (2005) Science , vol.307 , pp. 593-596
    • Paludan, C.1    Schmid, D.2    Landthaler, M.3
  • 24
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • Nedjic J, Aichinger M, Emmerich J, Mizushima N, Klein L. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 2008; 455: 396-400.
    • (2008) Nature , vol.455 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3    Mizushima, N.4    Klein, L.5
  • 25
    • 38649125210 scopus 로고    scopus 로고
    • Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    • Harley JB, Alarcon-Riquelme ME, Criswell LA, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008; 40: 204-10.
    • (2008) Nat Genet , vol.40 , pp. 204-210
    • Harley, J.B.1    Alarcon-Riquelme, M.E.2    Criswell, L.A.3
  • 26
    • 77957682295 scopus 로고    scopus 로고
    • ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis
    • 41 e1-2
    • Homer CR, Richmond AL, Rebert NA, Achkar JP, Mcdonald C. ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology 2010; 139: 1630-41, 41 e1-2.
    • (2010) Gastroenterology , vol.139 , pp. 1630-1641
    • Homer, C.R.1    Richmond, A.L.2    Rebert, N.A.3    Achkar, J.P.4    Mcdonald, C.5
  • 27
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    • Cadwell K, Maloney NS, et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 2010; 141: 1135-45.
    • (2010) Cell , vol.141 , pp. 1135-1145
    • Cadwell, K.1    Maloney, N.S.2
  • 28
    • 0027319044 scopus 로고
    • Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2
    • van de Water J, Turchany J, Leung PS, et al. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J Clin Invest 1993; 91: 2653-64.
    • (1993) J Clin Invest , vol.91 , pp. 2653-2664
    • van de Water, J.1    Turchany, J.2    Leung, P.S.3
  • 29
    • 0028939963 scopus 로고
    • Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression
    • Tsuneyama K, van de Water J, Leung PS, et al. Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression. Hepatology 1995; 21: 1031-7.
    • (1995) Hepatology , vol.21 , pp. 1031-1037
    • Tsuneyama, K.1    van de Water, J.2    Leung, P.S.3
  • 30
    • 0035079693 scopus 로고    scopus 로고
    • Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic
    • Migliaccio C, van de Water J, Ansari AA, et al. Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic. Hepatology 2001; 33: 792-801.
    • (2001) Hepatology , vol.33 , pp. 792-801
    • Migliaccio, C.1    van de Water, J.2    Ansari, A.A.3
  • 31
    • 0024321849 scopus 로고
    • Expression of blood-group-related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases
    • Nakanuma Y, Sasaki M. Expression of blood-group-related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases. Hepatology 1989; 10: 174-8.
    • (1989) Hepatology , vol.10 , pp. 174-178
    • Nakanuma, Y.1    Sasaki, M.2
  • 32
    • 2542595537 scopus 로고    scopus 로고
    • Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers
    • Roskams TA, Theise ND, Balabaud C, et al. Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology 2004; 39: 1739-45.
    • (2004) Hepatology , vol.39 , pp. 1739-1745
    • Roskams, T.A.1    Theise, N.D.2    Balabaud, C.3
  • 33
    • 0028235641 scopus 로고
    • Classification of chronic hepatitis: diagnosis, grading and staging
    • Desmet V, Gerber M, Hoofnagle J, Manns M, Scheuer P. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994; 19: 1513-20.
    • (1994) Hepatology , vol.19 , pp. 1513-1520
    • Desmet, V.1    Gerber, M.2    Hoofnagle, J.3    Manns, M.4    Scheuer, P.5
  • 34
    • 0031978211 scopus 로고    scopus 로고
    • Isolation, culture and characterization of biliary epithelial cells from different anatomical levels of the intrahepatic and extrahepatic biliary tree from a mouse
    • Katayanagi K, Kono N, Nakanuma Y. Isolation, culture and characterization of biliary epithelial cells from different anatomical levels of the intrahepatic and extrahepatic biliary tree from a mouse. Liver 1998; 18: 90-8.
    • (1998) Liver , vol.18 , pp. 90-98
    • Katayanagi, K.1    Kono, N.2    Nakanuma, Y.3
  • 35
    • 19944434059 scopus 로고    scopus 로고
    • Inhibition of macroautophagy triggers apoptosis
    • Boya P, Casares N, et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25: 1025-40.
    • (2005) Mol Cell Biol , vol.25 , pp. 1025-1040
    • Boya, P.1    Casares, N.2
  • 36
    • 0020470468 scopus 로고
    • Ultrastructural changes of bile duct epithelium in primary biliary cirrhosis in relation to progression of bile duct loss
    • Nakanuma Y, Kono N, Ohta G, Kato Y, Kobayashi K. Ultrastructural changes of bile duct epithelium in primary biliary cirrhosis in relation to progression of bile duct loss. Virchows Arch A Pathol Anat Histopathol 1982; 398: 149-61.
    • (1982) Virchows Arch A Pathol Anat Histopathol , vol.398 , pp. 149-161
    • Nakanuma, Y.1    Kono, N.2    Ohta, G.3    Kato, Y.4    Kobayashi, K.5
  • 37
    • 0016297490 scopus 로고
    • Ultrastructural aspects of primary biliary cirrhosis and other types of cholestatic liver disease
    • Chedid A, Debeer RA. Ultrastructural aspects of primary biliary cirrhosis and other types of cholestatic liver disease. Gastroenterology 1974; 67: 858-69.
    • (1974) Gastroenterology , vol.67 , pp. 858-869
    • Chedid, A.1    Debeer, R.A.2
  • 38
    • 39549115685 scopus 로고    scopus 로고
    • The causes of primary biliary cirrhosis: convenient and inconvenient truths
    • Gershwin ME, Mackay IR. The causes of primary biliary cirrhosis: convenient and inconvenient truths. Hepatology 2008; 47: 737-45.
    • (2008) Hepatology , vol.47 , pp. 737-745
    • Gershwin, M.E.1    Mackay, I.R.2
  • 39
    • 77956627699 scopus 로고    scopus 로고
    • Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis
    • Lleo A, Yang GX, et al. Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology 2010; 52: 987-98.
    • (2010) Hepatology , vol.52 , pp. 987-998
    • Lleo, A.1    Yang, G.X.2
  • 40
    • 63349090979 scopus 로고    scopus 로고
    • Apotopes and the biliary specificity of primary biliary cirrhosis
    • Lleo A, Selmi C, Invernizzi P, et al. Apotopes and the biliary specificity of primary biliary cirrhosis. Hepatology 2009; 49: 871-9.
    • (2009) Hepatology , vol.49 , pp. 871-879
    • Lleo, A.1    Selmi, C.2    Invernizzi, P.3
  • 41
    • 0034953329 scopus 로고    scopus 로고
    • Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis
    • Odin JA, Huebert RC, Casciola-Rosen L, Larusso NF, Rosen A. Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis. J Clin Invest 2001; 108: 223-32.
    • (2001) J Clin Invest , vol.108 , pp. 223-232
    • Odin, J.A.1    Huebert, R.C.2    Casciola-Rosen, L.3    Larusso, N.F.4    Rosen, A.5
  • 42
    • 0037093695 scopus 로고    scopus 로고
    • Oxidative stress mediates cell surface expression of SS-A/Ro antigen on keratinocytes
    • Saegusa J, Kawano S, Koshiba M, et al. Oxidative stress mediates cell surface expression of SS-A/Ro antigen on keratinocytes. Free Radic Biol Med 2002; 32: 1006-16.
    • (2002) Free Radic Biol Med , vol.32 , pp. 1006-1016
    • Saegusa, J.1    Kawano, S.2    Koshiba, M.3
  • 43
    • 77249112669 scopus 로고    scopus 로고
    • Antigen processing via autophagy-not only for MHC class II presentation anymore?
    • Munz C. Antigen processing via autophagy-not only for MHC class II presentation anymore? Curr Opin Immunol 2010; 22: 89-93.
    • (2010) Curr Opin Immunol , vol.22 , pp. 89-93
    • Munz, C.1
  • 44
    • 17044381835 scopus 로고    scopus 로고
    • Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA
    • Dorfel D, Appel S, Grunebach F, et al. Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA. Blood 2005; 105: 3199-205.
    • (2005) Blood , vol.105 , pp. 3199-3205
    • Dorfel, D.1    Appel, S.2    Grunebach, F.3
  • 45
    • 71849113778 scopus 로고    scopus 로고
    • Autophagy facilitates major histocompatibility complex class I expression induced by IFN-gamma in B16 melanoma cells
    • Li B, Lei Z, Lichty BD, et al. Autophagy facilitates major histocompatibility complex class I expression induced by IFN-gamma in B16 melanoma cells. Cancer Immunol Immunother 2010; 59: 313-21.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 313-321
    • Li, B.1    Lei, Z.2    Lichty, B.D.3
  • 46
    • 52049102433 scopus 로고    scopus 로고
    • Efficient cross-presentation depends on autophagy in tumor cells
    • Li Y, Yang G, Hao F, Urba WJ, Hu HM. Efficient cross-presentation depends on autophagy in tumor cells. Cancer Res 2008; 68: 6889-95.
    • (2008) Cancer Res , vol.68 , pp. 6889-6895
    • Li, Y.1    Yang, G.2    Hao, F.3    Urba, W.J.4    Hu, H.M.5
  • 47
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009; 9: 581-93.
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3


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