Cellular senescence in livers from children with end stage liver disease

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Gutierrez Reyes, Gabriela ^a   de Leon, Maria del Carmen Garcia ^a   Varela Fascinetto, Gustavo ^b   Valencia, Pedro ^b   Tamayo, Ruy Pérez ^a   Rosado, Claudia Gonzalez ^a   Labonne, Blanca Farfan ^a   Rochilin, Norma Morales ^a   Garcia, Rosalinda Martinez ^a   Valadez, Jonathan Aguirre ^a   Latour, Gabriela Togno ^a   Corona, Dana Lau ^a   Diaz, Guillermo Robles ^a   Zlotnik, Albert ^c   Kershenobich, David ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN P53; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A;

ARTICLE; BILE DUCT; BILE DUCT ATRESIA; CELL AGING; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; HEPATITIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; LIVER FAILURE; LIVER INJURY; LIVER PARENCHYMA; LIVER TRANSPLANTATION; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TYROSINEMIA; ACUTE LIVER FAILURE; LIVER; PATHOLOGY;

BILIARY ATRESIA; CELL AGING; CHILD; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER FAILURE; LIVER FAILURE, ACUTE; LIVER TRANSPLANTATION; TUMOR SUPPRESSOR PROTEIN P53; TYROSINEMIAS;

EID: 77956307394     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010231     Document Type: Article

References (26)

1. Hayflick L, Moorhead PS (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25: 585-621.
2. Dimri GP, Lee X, Basile G, Acosta M, Scott G, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367.
3. Maier A, Westendorp R, Van Heemst D (2007) Beta-galactosidase activity as a biomarker of replicative senescence during the course of human fibroblast cultures. Ann N Y Acad Sci 1100: 323-32.
4. Zhang H (2007) Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging. J Cell Physiol 210: 567-574.
5. Campisi J (2000) Cancer, aging and cellular senescence. In Vivo 14: 183-188.
6. Paradis V, Youssef N, Dargère D, Bâ N, Bonvoust F, et al. (2001) Replicative senescence in normal liver, chronic hepatitis C and hepatocellular carcinomas. Hum Pathol 32: 327-332.
7. Wiemann SU, Satyanarayana A, Tsahuridu M, Tillmann HL, Zender L, et al. (2002) Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J 16: 935-942.
8. Shawi M, Autexier C (2008) Telomerase, senescence and ageing. Mech Ageing Dev 129: 3-10.
9. Passos JF, Saretzki G, von Zglinicki T (2007) DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res 35: 7505-7513.
10. Trak-Smayra V, Contreras J, Dondero F, Durand F, Dubois S, et al. (2004) Role of replicative senescence in the progression of fibrosis in hepatitis C virus (HCV) recurrence after liver transplantation. Transplantation 77: 1755-1760.
11. Kiss A, Schnur J, Szabó Z, Nagy P (2001) Immunohistochemical analysis of atypical ductular reaction in the human liver, with special emphasis on the presence of growth factors and their receptors. Liver 21: 237-246.
12. Seki S, Kitada T, Sakaguchi H, Iwai S, Kawada N, et al. (2003) Expression of progenitor cell markers in livers with fulminant massive necrosis. Hepatol Res 25: 149-157.
13. Martien S, Abbadie C (2007) Acquisition of oxidative DNA damage during senescence: the first step toward carcinogenesis? Ann N Y Acad Sci 1119: 51-63.
14. Chen JH, Ozanne SE, Hales CN (2007) Methods of cellular senescence induction using oxidative stress. Methods Mol Biol 371: 179-189.
15. Courtois-Cox S, Jones SL, Cichowski K (2008) Many roads lead to oncogeneinduced senescence. Oncogene 27: 2801-2809.
16. Yang S, Koteish A, Lin H, Huang J, Roskams T, et al. (2004) Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. Hepatology 39: 403-411.
17. Obata M, Imamura E, Yoshida Y, Goto J, Kishibe K, et al. (2001) Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16(Ink4a), p19(Arf), p53 and p21(Waf 1/Cip1). Mol Carcinog 32: 9-18.
18. Chen J, Huang X, Halicka D, Brodsky S, Avram A, et al. (2006) Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53. Am J Physiol Heart Circ Physiol 290: H1575-H1586.
19. Kuhlmann WD, Peschke P (2006) Hepatic progenitor cells, stem cells and AFP expression in models of liver injury. Int J Exp Pathol 87: 343-359.
20. Watanabe H, Hata M, Terada N, Ueda H, Yamada N, et al. (2008) Transdifferentiation into biliary ductular cells of hepatocytes transplanted into the spleen. Pathology 40: 272-276.
21. Bringold F, Serrano M (2000) Tumor suppressors and oncogenes in cellular senescence. Exp Gerontol 35: 317-329.
22. Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, et al. (2006) Mitogenic signaling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 8: 1291-1297.
23. Kenyon J, Gerson SL (2007) The role of DNA damage repair in aging of adult stem cells. Nucleic Acids Res 35: 7557-7565.
24. Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, et al. (2006) Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence. Exp Mol Med 38: 686-693.
25. Prieur A, Peeper DS (2008) Cellular senescence in vivo: a barrier to tumorigenesis. Curr Opin Cell Biol 20: 150-155.
26. Zwerschke W, Mazurek S, Stöckl P, Hütter E, Eigenbrodt E, et al. (2003) Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. Biochem J 376: 403-411.