The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress

Journal of Biological Chemistry

Volumn 289, Issue 29, 2014, Pages 20102-20119

  Zhu, Bokai ^a   Ferry, Christina H ^a   Markell, Lauren K ^a   Blazanin, Nicholas ^a   Glick, Adam B ^a   Gonzalez, Frank J ^b   Peters, Jeffrey M ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CELL PROLIFERATION; CYTOLOGY; ENZYMES; PHOSPHORYLATION; PROTEINS;

CELLULAR SENESCENCE; ENDOPLASMIC RETICULUM STRESS; EXTRACELLULAR SIGNAL-REGULATED KINASE; FEEDFORWARD LOOPS; NUCLEAR RECEPTORS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PHOSPHORYLATED PROTEINS; UNFOLDED PROTEIN RESPONSE;

TUMORS;

GUANINE NUCLEOTIDE BINDING PROTEIN; H RAS PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL AGING; CELL PROLIFERATION; ENDOPLASMIC RETICULUM STRESS; ENZYME INDUCTION; GENE REPRESSION; H RAS GENE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NEWBORN; NONHUMAN; ONCOGENE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SKIN TUMOR; TUMOR PROMOTION; UNFOLDED PROTEIN RESPONSE;

CANCER; CANCER BIOLOGY; CANCER THERAPY; H-RAS-INDUCED SENESCENCE; KERATINOCYTE; ONCOGENE-INDUCED ENDOPLASMIC RETICULUM STRESS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Β/Δ; TUMOR SUPPRESSOR GENE;

ACTIVATING TRANSCRIPTION FACTOR 4; ADENOMA; ANIMALS; CELL AGING; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; GENES, P53; GENES, RAS; HEAT-SHOCK PROTEINS; HUMANS; KERATINOCYTES; MICE; MODELS, BIOLOGICAL; PPAR DELTA; PPAR-BETA; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84904462047     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.551069     Document Type: Article

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