RASA3 is a critical inhibitor of RAP1-dependent platelet activation

Journal of Clinical Investigation

Volumn 125, Issue 4, 2015, Pages 1419-1432

  Stefanini, Lucia ^a,b   Paul, David S ^a   Robledo, Raymond F ^c   Chan, E Ricky ^d,e   Getz, Todd M ^a   Campbell, Robert A ^f   Kechele, Daniel O ^a   Casari, Caterina ^a   Piatt, Raymond ^a   Caron, Kathleen M ^a   Mackman, Nigel ^a   Weyrich, Andrew S ^f   Parrott, Matthew C ^a   Boulaftali, Yacine ^a   Adams, Mark D ^d,g   Peters, Luanne L ^c   Bergmeier, Wolfgang ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF READING   (United Kingdom)

^c JACKSON LABORATORY   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e LERNER RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^g J CRAIG VENTER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PURINERGIC P2Y12 RECEPTOR; RAP1 PROTEIN; RASA3 PROTEIN; UNCLASSIFIED DRUG; AKT1 PROTEIN, MOUSE; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; GUANINE NUCLEOTIDE EXCHANGE FACTOR; P2RY12 PROTEIN, MOUSE; PROTEIN KINASE B; RASA3 PROTEIN, MOUSE; RASGRP2 PROTEIN, MOUSE; TICLOPIDINE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MUTANT; CELL STIMULATION; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT; THROMBOCYTE LIFESPAN; THROMBOCYTOPENIA; TURNOVER TIME; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; C57BL MOUSE; CELL AGING; DEFICIENCY; DRUG EFFECTS; GENETICS; HEMOSTASIS; INJURIES; KNOCKOUT MOUSE; LYMPHOCYTOPENIA; PHYSIOLOGY; SAPHENOUS VEIN; SPLENECTOMY; THROMBOCYTOPOIESIS;

ANIMALS; CELL AGING; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEMOSTASIS; LYMPHOPENIA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RAP1 GTP-BINDING PROTEINS; RECEPTORS, PURINERGIC P2Y12; SAPHENOUS VEIN; SPLENECTOMY; THROMBOCYTOPENIA; THROMBOPOIESIS; TICLOPIDINE;

EID: 84926386196     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI77993     Document Type: Article

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