Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane

Biology Open

Volumn 1, Issue 9, 2012, Pages 857-862

  Wang, Jie ^a   Richards, David A ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Lipid raft; PC12 cell; PIP2; PIP3

Indexed keywords

EID: 84964808703     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.20122071     Document Type: Article

References (26)

1. Brown, D. A. and Rose, J. K. (1992). Sorting of GPI-anchored proteins to glycolipidenriched membrane subdomains during transport to the apical cell surface. Cell 68, 533-544.
2. Corbin, J. A., Dirkx, R. A. and Falke, J. J. (2004). GRP1 pleckstrin homology domain: activation parameters and novel search mechanism for rare target lipid. Biochemistry 43, 16161-16173.
3. Di Paolo, G. and De Camilli, P. (2006). Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651-657.
4. Goebbels, S., Oltrogge, J. H., Kemper, R., Heilmann, I., Bormuth, I., Wolfer, S., Wichert, S. P., Möbius, W., Liu, X., Lappe-Siefke, C. et al. (2010). Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination. J. Neurosci. 30, 8953-8964.
5. Gustafsson, M. G., Shao, L., Carlton, P. M., Wang, C. J., Golubovskaya, I. N., Cande, W. Z., Agard, D. A. and Sedat, J. W. (2008). Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination. Biophys. J. 94, 4957-4970.
6. Harris, L. J., Skaletsky, E. and McPherson, A. (1995). Crystallization of intact monoclonal antibodies. Proteins 23, 285-289.
7. Hein, B., Willig, K. I. and Hell, S. W. (2008). Stimulated emission depletion (STED) nanoscopy of a fluorescent protein-labeled organelle inside a living cell. Proc. Natl. Acad. Sci. USA 105, 14271-14276.
8. Huang, B., Babcock, H. and Zhuang, X. (2010). Breaking the diffraction barrier: super-resolution imaging of cells. Cell 143, 1047-1058.
9. Insall, R. H. and Weiner, O. D. (2001). PIP3, PIP2, and cell movement-similar messages, different meanings? Dev. Cell 1, 743-747.
10. Krauß, M. and Haucke, V. (2007). Phosphoinositides: regulators of membrane traffic and protein function. FEBS Lett. 581, 2105-2111.
11. Lee, A. G., Birdsall, N. J., Metcalfe, J. C., Toon, P. A. and Warren, G. B. (1974). Clusters in lipid bilayers and the interpretation of thermal effects in biological membranes. Biochemistry 13, 3699-3705.
12. Leloup, L., Shao, H., Bae, Y. H., Deasy, B., Stolz, D., Roy, P. and Wells, A. (2010). m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate. J. Biol. Chem. 285, 33549-33566.
13. Maffucci, T., Raimondi, C., Abu-Hayyeh, S., Dominguez, V., Sala, G., Zachary, I. and Falasca, M. (2009). A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS ONE 4, e8285.
14. Manley, S., Gillette, J. M., Patterson, G. H., Shroff, H., Hess, H. F., Betzig, E. and Lippincott-Schwartz, J. (2008). High-density mapping of single-molecule trajectories with photoactivated localization microscopy. Nat. Methods 5, 155-157.
15. McLaughlin, S. and Murray, D. (2005). Plasma membrane phosphoinositide organization by protein electrostatics. Nature 438, 605-611.
16. McLaughlin, S., Wang, J., Gambhir, A. and Murray, D. (2002). PIP(2) and proteins: interactions, organization, and information flow. Annu. Rev. Biophys. Biomol. Struct. 31, 151-175.
17. Ménager, C., Arimura, N., Fukata, Y. and Kaibuchi, K. (2004). PIP3 is involved in neuronal polarization and axon formation. J. Neurochem. 89, 109-118.
18. Miao, B., Skidan, I., Yang, J., You, Z., Fu, X., Famulok, M., Schaffhausen, B., Torchilin, V., Yuan, J. and Degterev, A. (2011) Inhibition of cell migration by PITENINs: the role of ARF6. Oncogene [Epub ahead of print].
19. Pike, L. J. (2006). Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function. J. Lipid Res. 47, 1597-1598.
20. Pike, L. J. (2009). The challenge of lipid rafts. J. Lipid Res. 50 Suppl, S323-S328.
21. Rust, M. J., Bates, M. and Zhuang, X. (2006). Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Nat. Methods 3, 793-796.
22. Sieber, J. J., Willig, K. I., Kutzner, C., Gerding-Reimers, C., Harke, B., Donnert, G., Rammner, B., Eggeling, C., Hell, S. W., Grubmüller, H. et al. (2007). Anatomy and dynamics of a supramolecular membrane protein cluster. Science 317, 1072-1076.
23. Singer, S. J. and Nicolson, G. L. (1972). The fluid mosaic model of the structure of cell membranes. Science 175, 720-731.
24. van den Bogaart, G., Meyenberg, K., Risselada, H. J., Amin, H., Willig, K. I., Hubrich, B. E., Dier, M., Hell, S. W., Grubmüller, H., Diederichsen, U. et al. (2011). Membrane protein sequestering by ionic protein-lipid interactions. Nature 479, 552-555.
25. Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J. and Waterfield, M. D. (2001). Synthesis and function of 3-phosphorylated inositol lipids. Annu. Rev. Biochem. 70, 535-602.
26. Wang, Y. H., Collins, A., Guo, L., Smith-Dupont, K. B., Gai, F., Svitkina, T. and Janmey, P. A. (2012). Divalent cation-induced cluster formation by polyphosphoinositides in model membranes. J. Am. Chem. Soc. 134, 3387-3395.