Sequential regulation of the small GTPase Rap1 in human platelets

Molecular and Cellular Biology

Volumn 20, Issue 3, 2000, Pages 779-785

  Franke, Barbara ^a   Van Triest, Miranda ^a   De Bruijn, Kim M T ^a   Van Willigen, Gijsbert ^a   Nieuwenhuis, H Karel ^a   Negrier, Claude ^b   Akkerman, Jan Willem N ^a   Bos, Johannes L ^a,c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b EDOUARD HERRIOT HOSPITAL   (France)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BISINDOLYLMALEIMIDE; CALCIUM ION; GUANOSINE TRIPHOSPHATASE; INTEGRIN; MONOCLONAL ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; RAP1 PROTEIN; THROMBIN; TRITON X 100; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; GLANZMANN DISEASE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE AGGREGATION;

ANTIBODIES, MONOCLONAL; BLOOD PLATELETS; CALCIUM; CYTOSKELETON; HUMANS; INDOLES; MALEIMIDES; PHOSPHOLIPASE C; PLATELET ACTIVATING FACTOR; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN KINASE C; RAP1 GTP-BINDING PROTEINS; REFERENCE VALUES; TETRADECANOYLPHORBOL ACETATE; THROMBASTHENIA; THROMBIN;

EID: 0033967470     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.3.779-785.2000     Document Type: Article

References (32)

1. Alig, L., A. Edenhofer, P. Hadvary, M. Huerzeler, D. Knopp, M. Mueller, B. Steiner, A. Trzeciak, and T. Weller. 1992. Low molecular weight, non-peptide fibrinogen receptor antagonists. J. Med. Chem. 35:4393-4407.
2. Altschuler, D. L., S. N. Peterson, M. C. Ostrowski, and E. C. Lapetina. 1995. Cyclic AMP-dependent activation of Rap1b. J. Biol. Chem. 270:10373-10376.
3. Bochetti, D., G. Fantin, and M. G. Doni. 1984. Influence of the pure synthetic PAF (platelet aggregating factor) on clot retraction and platelet aggregation. Scand. J. Haematol. 32:33-40.
4. Bos, J. L. 1998. All in the family? - new insights and questions regarding interconnectivity of Ras, Rap, and Ral. EMBO J. 17:6776-6782.
5. Calvete, J. J. 1994. Clues for understanding the structure and function of a prototypical human integrin: the platelet glycoprotein IIb/IIIa complex. Thromb. Haemostasis 72:1-15.
6. Chenevert, J., K. Corrado, A. Bender, J. R. Pringle, and I. Herskowitz. 1992. A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains. Nature 356:77-79.
7. de Rooij, J., F. J. T. Zwartkruis, M. H. G. Verheijen, R. H. Cool, S. M. B. Nijman, A. Wittinghofer, and J. L. Bos. 1998. Epac is a Rap1 guanine nucleotide-exchange factor directly activated by cyclic AMP. Nature 396: 474-477.
8. Fischer, T. H., M. N. Gatling, F. McCormick, C. M. Duffy, and G. C. White II. 1994. Incorporation of Rap 1b into the platelet cytoskeleton is dependent on thrombin activation and extracellular calcium. J. Biol. Chem. 269:17257-17261.
9. 2+-mediated activation of Rap1 in human platelets. EMBO J. 16:252-259.
10. 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function. J. Biol. Chem. 266:17106-17111.
11. Gotoh, T., S. Hattori, S. Nakamura, H. Kitayama, M. Noda, Y. Takai, K. Kaibuchi, H. Matsui, O. Hatase, H. Takahasi, T. Kurata, and M. Matsuda. 1995. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol. Cell. Biol. 15:6746-6753.
12. Hacking, C. M., M. Huigsloot, M. W. Pladet, H. K. Nieuwenhuis, H. J. van Rijn, and J. W. N. Akkerman. 1999. Low-density lipoprotein enhances platelet secretion via integrin-αIIbβ3-mediated signaling. Arterioscler. Thromb. Vasc. Biol. 19:239-247.
13. Kawasaki, H., G. M. Springett, S. Toki, J. J. Canales, P. Harlan, J. P. Blumenstiel, E. J. Chen, A. Bany, N. Mochizuki, A. Ashbacher, M. Matsuda, D. E. Housman, and A. M. Graybiel. 1998. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc. Natl. Acad. Sci. USA 95:13278-13283.
14. Kawasaki, H., G. M. Springett, N. Mochizuki, S. Toki, M. Nakaya, M. Matsuda, D. E. Housman, and A. M. Graybiel. 1998. A family of cAMP-binding proteins that directly activate RAP1. Science 282:2275-2279.
15. Kitayama, H., Y. Sugimoto, T. Matsuzaki, Y. Ikawa, and M. Noda. 1989. A RAS-related gene with transformation suppressor activity. Cell 56:77-84.
16. Kiyokawa, E., N. Mochizuki, T. Kurata, and M. Matsuda. 1997. Role of Crk oncogene product in physiologic signaling. Crit. Rev. Oncog. 8:329-342.
17. McLeod, S. J., R. J. Ingham, J. L. Bos, T. Kurosaki, and M. Gold. 1998. Activation of the Rap1 GTPase by the B cell antigen receptor. J. Biol. Chem. 273:29218-29223.
18. M'Rabet, L., P. Coffer, F. Zwartkruis, B. Franke, L. Koenderman, and J. L. Bos. 1998. Activation of Rap1 in human neutrophils. Blood 92:2133-2140.
19. Noda, M. 1993. Structures and functions of the Krev-1 transformation suppressor and its relatives. Biophys. Biochim. Acta 1155:95-105.
20. Park, H. O., J. Chant, and I. Herskowitz. 1993. BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast. Nature 365:269-274.
21. Park, H. O., E. Bi, J. R. Pringle, and I. Herskowitz. 1997. Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity. Proc. Natl. Acad. Sci. USA 94:4463-4468.
22. Phillips, D. R., L. F. Charo, and R. M. Scarborough. 1991. GPIIb-IIIa: the responsive integrin. Cell 65:359-362.
23. Posern, G., C. K. Weber, U. R. Rapp, and S. M. Feller. 1998. Activity of Rap1 is regulated by bombesin, cell adhesion, and cell density in N1H3T3 fibroblasts. J. Biol. Chem. 273:24297-24300.
24. Reedquist, K. A., and J. L. Bos. 1998. Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes. J. Biol. Chem. 273:4944-4949.
25. Schlegel, N., O. Gayet, M. C. Morel-Kopp, B. Wyler, M. F. Hurtaud-Roux, C. Kaplan, and J. McGregor. 1995. The molecular genetic basis of Glanzmann's thrombasthenia in a gypsy population in France: identification of a new mutation on the alpha IIb gene. Blood 86:977-982.
26. Torti, M., and E. G. Lapetina. 1994. Structure and function of Rap proteins in human platelets. Thromb. Haemostasis 71:533-543.
27. Tsukamoto, N., M. Hattori, H. Yang, J. L. Bos, and N. Minato. 1999. Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. J. Biol. Chem. 274:18463-18469.
28. van den Berghe, N., R. H. Cool, G. Horn, and A. Wittinghofer. 1997. Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N). Oncogene 15:845-850.
29. 3 subunit. Biochem. J. 314:769-779.
30. Wang, H.-Y., and E. Friedman. 1990. Protein kinase C translocation in human platelets. Life Sci. 47:1419-1425.
31. Wolthuis, R. M. F., B. Franke, M. H. van Triest, B. Bauer, R. H. Cool, J. H. Camonis, J. W. N. Akkerman, and J. L. Bos. 1998. Activation of the small GTPase Ral in platelets. Mol. Cell. Biol. 18:2486-2491.
32. Zwartkruis, F. J. T., R. M. F. Wolthuis, N. M. J. M. Nabben, B. Franke, and J. L. Bos. 1998. Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling. EMBO J. 17:5905-5912.