Rapid Ca2+-mediated activation of Rap1 in human platelets

EMBO Journal

Volumn 16, Issue 2, 1997, Pages 252-259

  Franke, Barbara ^a,b   Akkerman, Jan Willem N ^b   Bos, Johannes L ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Calcium; GTPase; Platelet; Rap1; Thrombin

Indexed keywords

CALCIUM CHELATING AGENT; CALCIUM ION; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; PROSTACYCLIN; RAP1; THROMBIN; THROMBOCYTE ENZYME; UNCLASSIFIED DRUG; 1 (6 ((3 METHOXYESTRA 1,3,5(10) TRIEN 17 YL)AMINO)HEXYL) 1H PYRROLE 2,5 DIONE; 1,2 BIS(2 AMINOPHENOXY)ETHANE N,N,N',N' TETRAACETIC ACID ACETOXYMETHYL ESTER; 1,2-BIS(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID ACETOXYMETHYL ESTER; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; CALCIUM; CHELATING AGENT; DRUG DERIVATIVE; EGTAZIC ACID; ESTRANE DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHOLIPASE C; PROTEIN KINASE C; RAP PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME BINDING; ENZYME INDUCTION; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TRANSPORT; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION;

BLOOD PLATELETS; CALCIUM; CHELATING AGENTS; EGTAZIC ACID; EPOPROSTENOL; ESTRENES; GTP-BINDING PROTEINS; HUMANS; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASE C; PLATELET AGGREGATION; PROTEIN KINASE C; PYRROLIDINONES; RAL GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAP GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; THROMBIN; TRANSCRIPTION FACTORS;

EID: 0031014969     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.2.252     Document Type: Article

References (50)

1. Altschuler, D.L., Peterson, S.N., Ostrowski, M.C. and Lapetina, E.G. (1995) Cyclic AMP-dependent activation of Rap1b. J. Cell Biol., 270, 10373-10376.
2. Ammit, A.J. and O'Neill, C. (1991) Rapid and selective measurement of platelet-activating factor using a quantitative bioassay of platelet aggregation. J. Pharmacol. Methods, 26, 7-21.
3. 2+ pools and relevance in platelet activation. Biochem. J., 294, 119-126.
4. Benton, A.M., Gerrard, J.M., Michiel, T. and Kindon, S.E. (1982) Are lysophosphatidic acids or phosphatic acids involved in stimulus activation coupling in platelets? Blood, 60, 642-649.
5. ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSOS nucleotide exchange factor. EMBO J., 12, 4211-1220.
6. Calvete, J.J. (1994) Clues for understanding the structure and function of a prototypic human integrin: the platelet glycoprotein IIb/IIIa complex. Thromb. Haemostasis, 72, 1-15.
7. Campa, M.J., Chang, K.J., Molina y Vedia, L., Reep, B.R. and Lapetina, E.G. (1991) Inhibition of Ras-induced germinal vesicle breakdown in Xenopus oocytes by Rap-1B. Biochem. Biophys. Res. Commun., 174, 1-5.
8. Cavallini, L. and Alexandre, A. (1994) Calcium efflux from platelets. Eur. J. Biochem., 222, 693-702.
9. 2+ stores in platelets, as identified by their differential sensitivity to 2,5-di-(tert-butyl)-1,4-benzohydroquinone and thapsigargin. Biochem. J., 310, 449-452.
10. Cook, S.J. and McCormick, F. (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science, 262, 1069-1072.
11. Cook, S., Rubinfeld, B., Albert, I. and McCormick, F. (1993) RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J., 12, 3475-3485.
12. Dash, D., Aepfelbacher, M. and Siess, W. (1995) Integrin αIIbβ3-mediated translocation of CDC42Hs to the cytoskeleton in stimulated human platelets. J. Biol. Chem., 270, 17321-17326.
13. 2+ influx in platelets: activation by thrombin and by the depletion of the stores. Effect of cyclic nucleotides. Biochem. J., 303, 599-605.
14. Fischer, T.H., Gatling, M.N., Lacal, J.-C. and White, G.C.,II (1990) Rap1B, a cAMP-dependent protein kinase substrate, associates with the platelet cytoskeleton. J. Biol. Chem., 265, 19405-19408.
15. Fischer, T.H., Gatling, M.N., McCormick, F., Duffy, C.M. and White, G.C.,II (1994) Incorporation of Rap1b into the platelet cytoskeleton is dependent on thrombin activation and extracellular calcium. J. Biol. Chem., 269, 17257-17261.
16. Fox, J.E.B. (1993) The platelet cytoskeleton. Thromb. Haemostasis, 70, 884-893.
17. Frech, M., John, J., Pizon, V., Chardin, P. Tavitian, A., Clark, R., McCormick, F. and Wittinghofer, A. (1990) Inhibition of GTPase activating protein stimulation of ras-p21 GTPase by the Krev-1 gene product. Science, 249, 169-171.
18. Gabig, T.G., Crean, C.D., Mantel, P.L. and Rosli, R. (1995) Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation. Blood, 85, 804-811.
19. Grünberg, B., Kruse, H.-J., Negrescu, E.V. and Siess, W. (1995) Platelet Rap1B phosphorylation is a sensitive marker for the action of cyclic AMP- and cyclic GMP-increasing platelet inhibitors and vasodilators. J. Cardiovasc. Pharmacol., 25, 545-551.
20. Hartwig, J.H. (1992) Mechanisms of actin rearrangements mediating platelet activation. J. Cell Biol., 118, 1421-1442.
21. Hata, Y., Kikuchi, A., Sasaki, T., Schaber, M.D., Gibbs, J.B. and Takai, Y. (1990) Inhibition of the ras p21 GTPase-activating protem-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s. J. Cell Biol., 265, 7104-7107.
22. Herrmann, C., Horn, G., Spaargaren, M. and Wittinghofer, A. (1996) Differential interaction of the Ras family GTP-bmding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. J. Biol. Chem., 271, 6794-6800.
23. Hynes, R.O. (1992) Integrins: versality, modulation, and signaling in cell adhesion. Cell, 69, 11-25.
24. Inazu, T., Taniguchi, T., Ohta, S., Miyabo, S. and Yamamura, H. (1991) The lectin wheat germ agglutinin induces rapid protein-tyrosine phosphorylation in human platelets. Biochem. Biophys. Res. Commun., 174, 1154-1158.
25. 1 in intact human platelets. J. Biol. Chem., 264, 15688-15695.
26. Kroll, M.H. and Schafer, A.I. (1989) Biochemical mechanisms of platelet activation. Blood, 74, 1181-1195.
27. Lapetina, E.G., Lacal, J.C., Reep, B.R. and Molina y Vedia, L. (1989) A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets. Proc. Natl Acad. Sci. USA, 86, 3131-3134.
28. 2+ entry in human platelets. Biochem. J., 310, 263-269.
29. Nassar, N., Horn, G., Herrmann, C., Scherer, A., McCormick, F. and Wittinghofer, A. (1995) The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP-analogue. Nature, 375, 554-560.
30. Noda, M. (1993) Structures and functions of the Krev-1 transformation suppressor gene and its relatives. Biochim. Biophys. Acta, 1155, 97-109.
31. 2+ entry in human platelets is resistant to nitric oxide. Biochem. Biophys. Res. Commun., 212, 90-96.
32. cdc2 kinase in vitro. J. Biol. Chem., 267, 10780-10785.
33. Quinn, M., Parkos, C.A., Walker, L., Orkin, S.H., Dinauer, M.C. and Jesaitis, A.J. (1989) Association of a Ras-related protein with cytochrome b of human neutrophils, Nature, 342, 198-200.
34. Rubinfeld, B., Crosier, W.J., Albert, I., Conroy, L., Clark, R., McCormick, F. and Polakis, P. (1992) Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis. Mol. Cell. Biol., 12, 4634-4642.
35. Shen, T.Y. and Winter, C.A. (1977) Chemical and biological studies on indomethacin, sulindac and their analogs. Adv. Drug Res., 12, 89-245.
36. Siess, W. (1989) Molecular mechanisms of platelet activation. Physiol. Rev., 69, 58-178.
37. Siess, W. and Grünberg, B. (1993) Phosphorylation of rap1B by protein kinase A is not involved in platelet inhibition by cyclic AMP. Cell Signal., 5, 209-214.
38. 2+-dependent protein kinases. Biochem. J., 258, 57-65.
39. Siess, W., Winegar, D.A. and Lapetina, E.G. (1990) Rap1-B is phosphorylated by protein kinase A in intact human platelets. Biochem. Biophys. Res. Commun., 170, 944-950.
40. Spaargaren, M. and Bischoff, J.R. (1994) Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap. Proc. Natl Acad. Sci. USA, 91, 12609-12613.
41. Tamaoki, T. (1991) Use and specificity of staurosporine, UCN-01, and calphostin C as protein kinase inhibitors. Methods Enzymol., 201, 340-347.
42. ras GTPase-activating protein in the regulation of phospholipase C-γ1 in human platelets. Proc. Natl Acad. Sci. USA, 89, 7796-7800.
43. Torti, M. and Lapetina, E.G. (1994) Structure and function of rap proteins in human platelets. Thromb. Haemostasis, 71, 533-543.
44. Toullec, D. et al. (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem., 266, 15771-15781.
45. 3 subunit. Biochem. J., 314, 769-779.
46. 2+ entry. Mol. Pharmacol., 47, 823-830.
47. Wittinghofer, A. and Herrmann, C. (1995) Ras-effector interactions, the problem of specificity. FEBS Lett., 369, 52-56.
48. Wu, J., Dent, P., Jelinek, T., Wolfman, A., Weber, M.J. and Sturgill, T.W. (1993) Inhibition of the EGF-activated Map kinase signal pathway by adenosine 3′,5′-monophosphate. Science, 262, 1065-1069.
49. Yoshida, Y., Kawata, M., Miura, Y., Musha, T., Sasaki, T., Kikuchi, A. and Takai, Y. (1992) Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes. Mol. Cell. Biol., 12, 3407-3414.
50. Zhang, Z., Vuori, K., Wang, H.-G., Reed, J.C. and Ruoslahti, E. (1996) Integrin activation by R-ras. Cell, 85, 61-69.