A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding

Blood

Volumn 123, Issue 17, 2014, Pages 2722-2731

  Stefanini, Lucia ^a   Ye, Feng ^b   Snider, Adam K ^b   Sarabakhsh, Kasra ^b   Piatt, Raymond ^a   Paul, David S ^a   Bergmeier, Wolfgang ^a   Petrich, Brian G ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHAIIBETA3 INTEGRIN; BETA3 INTEGRIN; TALIN; TALIN 1; UNCLASSIFIED DRUG; CALCIUM; FIBRINOGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTERY THROMBOSIS; ARTICLE; BINDING AFFINITY; BLEEDING; BLOOD CLOTTING; CONTROLLED STUDY; HEMOSTASIS; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; THROMBOCYTE; THROMBOCYTE AGGREGATION; ANIMAL; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; MECHANICAL STRESS; METABOLISM; MUTATION; SHEAR STRENGTH; SURFACE PLASMON RESONANCE; THROMBOSIS; TRANSGENIC MOUSE;

ANIMALS; BLOOD PLATELETS; CALCIUM; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION REGULATION; HEMOSTASIS; MICE; MICE, TRANSGENIC; MUTATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; SHEAR STRENGTH; STRESS, MECHANICAL; SURFACE PLASMON RESONANCE; TALIN; THROMBOSIS;

EID: 84899658422     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-12-543363     Document Type: Article

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