CalDAG-GEFI is at the nexus of calcium-dependent platelet activation

Blood

Volumn 114, Issue 12, 2009, Pages 2506-2514

  Stefanini, Lucia ^a   Roden, R Claire ^a   Bergmeier, Wolfgang ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; DIACYLGLYCEROL; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; INTEGRIN; PHOSPHOLIPASE C; PROTEIN KINASE C; PURINERGIC P2Y12 RECEPTOR; RAP1 PROTEIN; THROMBOXANE A2; 1,2-DIACYLGLYCEROL; ADENOSINE DIPHOSPHATE; CALCIUM; COLLAGEN; COLLAGEN RECEPTOR GLYCOPROTEIN VI, MOUSE; FIBRINOGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; SEROTONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVATION; ENZYME KINETICS; ENZYME RELEASE; FEEDBACK SYSTEM; GRANULE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBUS; ANIMAL; C57BL MOUSE; CELL PROLIFERATION; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; MALE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; THROMBOCYTE; WESTERN BLOTTING;

ADENOSINE DIPHOSPHATE; ANIMALS; BLOOD PLATELETS; BLOTTING, WESTERN; CALCIUM; CELL PROLIFERATION; COLLAGEN; DIGLYCERIDES; FEMALE; FLOW CYTOMETRY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET MEMBRANE GLYCOPROTEINS; RAP1 GTP-BINDING PROTEINS; SEROTONIN; THROMBOXANE A2;

EID: 70350511423     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-04-218768     Document Type: Article

References (62)

1. Savage B, Almus-Jacobs F, Ruggeri ZM. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell. 1998;94:657-666. (Pubitemid 28427584)
2. 1 integrin is essential for platelet interaction with collagen. EMBO J. 2001;20:2120-2130.
3. FitzGerald GA. Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists. Am J Cardiol. 1991;68:11B-15B.
4. Cosemans JM, Munnix IC, Wetzker R, Heller R, Jackson SP, Heemskerk JW. Continuous signaling via PI3K isoforms β and γ is required for platelet ADP receptor function in dynamic thrombus stabilization. Blood. 2006;108:3045-3052. (Pubitemid 44776943)
5. 3 activation: association with Rap1B activation. J Thromb Haemost. 2006;4: 1379-1387.
6. Harper MT, Poole AW. Isoform-specific functions of protein kinase C: the platelet paradigm. Biochem Soc Trans. 2007;35:1005-1008. (Pubitemid 350206414)
7. Konopatskaya O, Gilio K, Harper MT, et al. PKCα regulates platelet granule secretion and thrombus formation in mice. J Clin Invest. 2009;119:399-407.
8. Chari R, Getz T, Nagy B Jr, et al. Protein kinase Cδ differentially regulates platelet functional responses. Arterioscler Thromb Vasc Biol. 2009;29: 699-705.
9. Nagy B Jr, Bhavaraju K, Getz T, Bynagari YS, Kim S, Kunapuli SP. Impaired activation of platelets lacking protein kinase Cθ isoform. Blood. 2009;113:2557-2567.
10. Bynagari YS, Nagy B Jr, Tuluc F, et al. Mechanism of activation and functional role of protein kinase Cη in human platelets. J Biol Chem. 2009; 284:13413-13421.
11. Worner P, Brossmer R. Platelet aggregation and the release induced by inophores for divalent cations. Thromb Res. 1975;6:295-305.
12. Feinstein MB, Becker EL, Fraser C. Thrombin, collagen and A23187 stimulated endogenous platelet arachidonate metabolism: differential inhibition by PGE1, local anesthetics and a serineprotease inhibitor. Prostaglandins. 1977;14:1075-1093. (Pubitemid 8260077)
13. Feinstein MB, Fraser C. Human platelet secretion and aggregation induced by calcium ionophores: inhibition by PGE1 and dibutyryl cyclic AMP. J Gen Physiol. 1975;66:561-581.
14. Quinton TM, Kim S, Dangelmaier C, et al. Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation. Biochem J. 2002;368:535-543. (Pubitemid 35454531)
15. Quinton TM, Ozdener F, Dangelmaier C, Daniel JL, Kunapuli SP. Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP. Blood. 2002;99:3228-3234. (Pubitemid 34525302)
16. Crittenden JR, Bergmeier W, Zhang Y, et al. CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med. 2004;10:982-986. (Pubitemid 39273740)
17. 3 in platelets. Blood. 2008;112:1696-1703.
18. Kawasaki H, Springett GM, Toki S, et al. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci U S A. 1998;95:13278-13283. (Pubitemid 28509562)
19. Torti M, Lapetina EG. Structure and function of rap proteins in human platelets. Thromb Haemostasis. 1994;71:533-543. (Pubitemid 24132947)
20. Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC II. Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest. 2005;115:680-687. (Pubitemid 40322242)
21. Caloca MJ, Zugaza JL, Bustelo XR. Exchange factors of the RasGRP family mediate Ras activation in the Golgi. J Biol Chem. 2003;278:33465-33473. (Pubitemid 37055801)
22. Clyde-Smith J, Silins G, Gartside M, et al. Characterization of RasGRP2, a plasma membranetargeted, dual specificity Ras/Rap exchange factor. J Biol Chem. 2000;275:32260-32267. (Pubitemid 30782120)
23. Bos JL. Linking Rap to cell adhesion. Curr Opin Cell Biol. 2005;17:123-128.
24. York RD, Yao H, Dillon T, et al. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature. 1998;392:622-626. (Pubitemid 28207722)
25. Stork PJ, Dillon TJ. Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Blood. 2005;106:2952-2961.
26. Crittenden JR, Cantuti-Castelvetri I, Saka E, et al. Dysregulation of CalDAG-GEFI and CalDAGGEFII predicts the severity of motor side-effects induced by anti-Parkinsonian therapy. Proc Natl Acad Sci U S A. 2009;106:2892-2896.
27. Guo FF, Kumahara E, Saffen D. A CalDAG-GEFI/ Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2. J Biol Chem. 2001;276:25568-25581. (Pubitemid 37413047)
28. Lin LL, Wartmann M, Lin AY, Knopf JL, Seth A, Davis RJ. cPLA2 is phosphorylated and activated by MAP kinase. Cell. 1993;72:269-278. (Pubitemid 23044941)
29. Arita H, Nakano T, Hanasaki K. Thromboxane A2: its generation and role in platelet activation. Prog Lipid Res. 1989;28:273-301.
30. Garcia A, Quinton TM, Dorsam RT, Kunapuli SP. Src family kinase-mediated and Erk-mediated thromboxane A2 generation are essential for VWF/GPIb-induced fibrinogen receptor activation in human platelets. Blood. 2005;106:3410-3414. (Pubitemid 41609175)
31. Shankar H, Garcia A, Prabhakar J, Kim S, Kunapuli SP. P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation. J Thromb Haemost. 2006;4: 638-647.
32. Nadal-Wollbold F, Pawlowski M, Levy-Toledano S, Berrou E, Rosa JP, Bryckaert M. Platelet ERK2 activation by thrombin is dependent on calcium and conventional protein kinases C but not Raf-1 or B-Raf. FEBS Lett. 2002;531:475-482. (Pubitemid 35336072)
33. 3 with a novel monoclonal antibody. Cytometry. 2002;48:80-86.
34. Duncia JV, Santella JB, Higley CA III, et al. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett. 1998;8:2839-2844.
35. Guidetti GF, Lova P, Bernardi B, et al. The Gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets. J Biol Chem. 2008;283:28795-28805.
36. Hechler B, Cattaneo M, Gachet C. The P2 receptors in platelet function. Semin Thromb Hemostasis. 2005;31:150-161.
37. Woulfe D, Jiang H, Mortensen R, Yang J, Brass LF. Activation of Rap1B by Gi family members in platelets. J Biol Chem. 2002;277:23382-23390. (Pubitemid 34952169)
38. Eto K, Murphy R, Kerrigan SW, et al. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci U S A. 2002;99:12819-12824.
39. 3, and the actin cytoskeleton. J Biol Chem. 2002;277:25715-25721.
40. Watanabe N, Bodin L, Pandey M, et al. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3. J Cell Biol. 2008;181:1211-1222. (Pubitemid 351915493)
41. Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH. RIAM activates integrins by linking talin to Ras GTPase membrane-targeting sequences. J Biol Chem. 2009;284:5119-5127.
42. Kitayama H, Sugimoto Y, Matsuzaki T, Ikawa Y, Noda M. A ras-related gene with transformation suppressor activity. Cell. 1989;56:77-84. (Pubitemid 19033515)
43. Schmitt JM, Stork PJ. Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1. Mol Cell Biol. 2001;21:3671-3683.
44. Vossler MR, Yao H, York RD, Pan MG, Rim CS, Stork PJ. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell. 1997;89:73-82. (Pubitemid 27180587)
45. Ye X, Shobe JL, Sharma SK, Marina A, Carew TJ. Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia. Proc Natl Acad Sci U S A. 2008;105:20511- 20516.
46. Garcia J, de Gunzburg J, Eychene A, Gisselbrecht S, Porteu F. Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-MpL cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways. Mol Cell Biol. 2001;21:2659-2670. (Pubitemid 32244911)
47. Ezumi Y, Uchiyama T, Takayama H. Thrombopoietin potentiates the protein-kinase-C-mediated activation of mitogen-activated protein kinase/ ERK kinases and extracellular signal-regulated kinases in human platelets. Eur J Biochem. 1998; 258:976-985. (Pubitemid 29013535)
48. 1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo. FASEB J. 2003; 17:685-687.
49. 3. Blood. 2006;107:2728-2735.
50. 1 in thrombus stabilization and embolization: contribution of thromboxane A2. Thromb Haemostasis. 2007;98:1072-1080.
51. Bugaud F, Nadal-Wollbold F, Levy-Toledano S, Rosa JP, Bryckaert M. Regulation of c-jun-NH2 terminal kinase and extracellular-signal regulated kinase in human platelets. Blood. 1999;94:3800-3805.
52. Kramer RM, Roberts EF, Strifler BA, Johnstone EM. Thrombin induces activation of p38 MAP kinase in human platelets. J Biol Chem. 1995;270: 27395-27398.
53. Kauskot A, Adam F, Mazharian A, et al. Involvement of the mitogen-activated protein kinase c- Jun NH2-terminal kinase 1 in thrombus formation. J Biol Chem. 2007;282:31990-31999. (Pubitemid 350106462)
54. Borsch-Haubold AG, Bartoli F, Asselin J, et al. Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. J Biol Chem. 1998; 273:4449-4458. (Pubitemid 28103183)
55. Canobbio I, Reineri S, Sinigaglia F, Balduini C, Torti M. A role for p38 MAP kinase in platelet activation by von Willebrand factor. Thromb Haemostasis. 2004;91:102-110. (Pubitemid 38111227)
56. 3 signaling in platelets. Blood. 2009;113:447-457.
57. 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood. 2003;101:2646-2651.
58. Cowan DH. Platelet adherence to collagen: role of prostaglandin- thromboxane synthesis. Br J Haematol. 1981;49:425-434. (Pubitemid 11027837)
59. Michelson AD. P2Y12 antagonism: promises and challenges. Arterioscler Thromb Vasc Biol. 2008; 28:s33-s38.
60. Schultess J, Danielewski O, Smolenski AP. Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets. Blood. 2005; 105:3185-3192. (Pubitemid 40504338)
61. Lorenowicz MJ, van Gils J, de Boer M, Hordijk PL, Fernandez-Borja M. Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis. J Leukocyte Biol. 2006;80:1542-1552. (Pubitemid 44904993)
62. He JC, Neves SR, Jordan JD, Iyengar R. Role of the Go/i signaling network in the regulation of neurite outgrowth. Can J Physiol Pharmacol. 2006;84:687-694. (Pubitemid 44897889)