Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

Nature Structural and Molecular Biology

Volumn 20, Issue 1, 2013, Pages 46-52

  Baker, Rachael ^a   Lewis, Steven M ^a   Sasaki, Atsuo T ^b,d   Wilkerson, Emily M ^a   Locasale, Jason W ^b   Cantley, Lewis C ^b   Kuhlman, Brian ^a,c   Dohlman, Henrik G ^a,c   Campbell, Sharon L ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; RAS PROTEIN; UBIQUITIN;

ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONFORMATIONAL TRANSITION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; NITROGEN NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; SIGNAL TRANSDUCTION; THERMOSTABILITY; UBIQUITINATION;

CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; GUANINE; HEK293 CELLS; HUMANS; RAS GTPASE-ACTIVATING PROTEINS; RAS PROTEINS; SIGNAL TRANSDUCTION; UBIQUITINATION;

MAMMALIA;

EID: 84872027352     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2430     Document Type: Article

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